May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
NRFC - Protein NrfC
UniProt: P0AAK7 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11946
Length: 223 (214)
Sequences: 1245
Seq/Len: 5.82
NRFC
Paralog alert: 0.66 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: DMSB HYCB HYDN HYFA NRFC YDHX YDHY YGFS YNFG YSAA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
112_D 115_S 4.818 1.00
109_S 140_R 2.528 1.00
103_V 130_Y 2.413 1.00
59_V 157_K 2.225 1.00
184_D 187_S 2.202 1.00
40_V 189_I 2.175 1.00
200_R 203_L 2.159 1.00
98_A 111_R 2.155 1.00
166_P 169_V 2.128 1.00
129_Q 142_I 2.114 1.00
132_I 149_A 2.042 1.00
187_S 190_S 2.033 1.00
39_M 154_F 2.028 1.00
101_V 109_S 1.979 1.00
112_D 161_Q 1.959 1.00
169_V 177_L 1.931 1.00
103_V 134_A 1.904 1.00
38_G 182_L 1.886 1.00
121_N 124_L 1.859 1.00
154_F 211_L 1.742 1.00
68_R 150_D 1.731 1.00
143_H 150_D 1.729 1.00
91_S 211_L 1.718 1.00
40_V 192_L 1.717 1.00
129_Q 132_I 1.696 1.00
78_G 81_P 1.655 1.00
112_D 117_I 1.639 1.00
186_N 191_Q 1.57 0.99
96_D 210_K 1.555 0.99
91_S 177_L 1.552 0.99
40_V 214_V 1.551 0.99
159_N 164_K 1.548 0.99
99_P 207_T 1.547 0.99
41_H 177_L 1.528 0.99
69_L 177_L 1.48 0.99
46_C 52_C 1.476 0.99
117_I 160_L 1.466 0.99
46_C 49_C 1.456 0.99
89_R 213_R 1.443 0.99
200_R 208_K 1.436 0.98
109_S 120_V 1.43 0.98
104_C 125_C 1.405 0.98
49_C 52_C 1.397 0.98
96_D 208_K 1.389 0.98
119_D 153_D 1.338 0.97
35_V 183_D 1.336 0.97
46_C 172_C 1.332 0.97
125_C 131_C 1.308 0.97
104_C 131_C 1.304 0.97
49_C 172_C 1.285 0.96
47_I 174_T 1.268 0.96
55_A 171_A 1.265 0.96
159_N 170_E 1.256 0.96
90_K 201_Y 1.254 0.96
185_P 190_S 1.237 0.95
52_C 172_C 1.235 0.95
36_R 96_D 1.227 0.95
43_E 89_R 1.221 0.95
112_D 119_D 1.217 0.95
165_L 169_V 1.211 0.94
188_E 191_Q 1.198 0.94
178_T 192_L 1.195 0.94
193_L 198_T 1.194 0.94
165_L 170_E 1.183 0.93
191_Q 195_Q 1.179 0.93
137_Y 209_P 1.163 0.93
117_I 154_F 1.152 0.92
190_S 193_L 1.147 0.92
48_G 176_A 1.143 0.92
200_R 212_Y 1.139 0.92
130_Y 133_A 1.136 0.91
185_P 189_I 1.131 0.91
106_T 126_V 1.123 0.91
129_Q 144_P 1.12 0.91
193_L 212_Y 1.117 0.91
38_G 210_K 1.101 0.90
106_T 109_S 1.097 0.90
7_Q 11_G 1.09 0.89
178_T 188_E 1.089 0.89
156_R 161_Q 1.082 0.89
36_R 210_K 1.08 0.89
89_R 177_L 1.079 0.88
36_R 183_D 1.079 0.88
22_A 28_K 1.073 0.88
75_E 81_P 1.07 0.88
78_G 82_D 1.063 0.87
30_L 33_N 1.058 0.87
59_V 159_N 1.058 0.87
88_F 201_Y 1.055 0.87
142_I 149_A 1.055 0.87
129_Q 149_A 1.05 0.87
15_L 27_A 1.049 0.87
181_N 184_D 1.046 0.86
190_S 194_R 1.034 0.85
20_G 24_R 1.023 0.85
37_Y 160_L 1.021 0.84
97_H 102_D 1.018 0.84
17_A 20_G 1.012 0.84
122_P 148_T 1.005 0.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ivfB10.91481000.42Contact Map0.744
1ti6B60.82511000.421Contact Map0.691
2vpzB20.83411000.481Contact Map0.762
1h0hB20.83861000.482Contact Map0.617
1kqfB10.93271000.491Contact Map0.65
1q16B10.8611000.562Contact Map0.724
3mm5B20.950799.80.753Contact Map0.316
3gyxB60.614399.30.817Contact Map0.452
1jnrB20.600999.30.817Contact Map0.428
3i9v920.623399.30.817Contact Map0.254
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0267 seconds.