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OPENSEQ.org
HYCB - Formate hydrogenlyase subunit 2
UniProt: P0AAK1 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10475
Length: 203 (193)
Sequences: 671
Seq/Len: 3.48
HYCB
Paralog alert: 0.72 [within 20: 0.35] - ratio of genomes with paralogs
Cluster includes: DMSB HYCB HYDN HYFA NRFC YDHX YDHY YGFS YNFG YSAA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
25_T 148_F 2.854 1.00
49_Q 184_F 2.783 1.00
68_I 97_I 2.686 1.00
62_V 87_L 2.547 1.00
149_D 157_R 2.464 1.00
12_C 18_C 2.323 1.00
7_A 164_L 2.202 1.00
153_P 156_V 2.193 1.00
12_C 159_C 2.153 1.00
12_C 15_C 2.143 1.00
15_C 18_C 2.075 1.00
15_C 159_C 2.042 1.00
18_C 159_C 2.039 1.00
183_T 186_T 2.034 1.00
6_I 172_I 1.946 1.00
69_T 78_N 1.854 0.99
21_A 158_M 1.687 0.99
79_E 139_I 1.615 0.98
135_G 141_V 1.593 0.98
100_S 141_V 1.565 0.98
156_V 164_L 1.565 0.98
27_R 141_V 1.559 0.98
63_C 82_C 1.544 0.97
86_K 99_F 1.476 0.96
5_V 169_N 1.468 0.96
173_A 176_S 1.459 0.96
149_D 154_A 1.457 0.96
65_V 68_I 1.42 0.95
82_C 88_C 1.415 0.95
63_C 88_C 1.407 0.95
7_A 50_L 1.395 0.95
14_G 18_C 1.394 0.95
89_G 140_A 1.391 0.94
153_P 164_L 1.379 0.94
86_K 101_G 1.362 0.94
13_I 161_T 1.355 0.93
168_D 171_D 1.304 0.92
14_G 159_C 1.298 0.91
74_A 150_E 1.293 0.91
152_G 156_V 1.267 0.90
53_H 76_Q 1.243 0.89
68_I 77_L 1.239 0.89
116_A 120_P 1.238 0.88
60_A 68_I 1.232 0.88
23_S 28_Q 1.231 0.88
175_V 178_R 1.215 0.87
189_G 192_T 1.214 0.87
63_C 85_C 1.197 0.86
70_R 75_V 1.197 0.86
79_E 97_I 1.194 0.86
183_T 191_L 1.181 0.85
184_F 190_D 1.171 0.84
60_A 70_R 1.159 0.84
53_H 75_V 1.148 0.83
26_H 148_F 1.137 0.82
116_A 122_A 1.128 0.81
115_K 119_A 1.118 0.80
87_L 97_I 1.115 0.80
36_R 141_V 1.111 0.80
38_R 117_P 1.108 0.80
27_R 135_G 1.106 0.79
82_C 85_C 1.102 0.79
39_V 53_H 1.094 0.78
37_L 164_L 1.092 0.78
16_H 44_K 1.082 0.77
34_M 38_R 1.077 0.77
21_A 154_A 1.076 0.77
112_N 116_A 1.072 0.76
87_L 90_I 1.069 0.76
73_G 167_V 1.066 0.76
85_C 91_A 1.066 0.76
100_S 135_G 1.064 0.76
143_C 146_C 1.064 0.76
97_I 166_L 1.059 0.75
27_R 100_S 1.058 0.75
1_M 170_T 1.056 0.75
62_V 91_A 1.055 0.75
83_V 86_K 1.055 0.75
11_L 174_R 1.044 0.74
190_D 193_L 1.035 0.73
55_E 178_R 1.033 0.73
37_L 48_P 1.027 0.72
110_N 113_T 1.023 0.72
122_A 125_R 1.018 0.71
110_N 114_P 1.012 0.70
69_T 81_L 1.008 0.70
14_G 17_T 1.007 0.70
74_A 145_L 1.006 0.70
3_R 70_R 1.004 0.70
28_Q 100_S 1.003 0.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ti6B60.82271000.448Contact Map0.483
2ivfB10.82761000.481Contact Map0.487
1h0hB20.82761000.509Contact Map0.418
1kqfB10.82761000.526Contact Map0.452
2vpzB20.81281000.53Contact Map0.497
1q16B10.83251000.593Contact Map0.423
3mm5B20.832599.70.733Contact Map0.172
2fgoA10.394199.20.81Contact Map0.216
1rgvA10.384299.20.811Contact Map0.228
2zvsA30.403999.20.813Contact Map0.307
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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