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YCJP - Inner membrane ABC transporter permease protein YcjP
UniProt: P77716 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13913
Length: 280 (266)
Sequences: 22361
Seq/Len: 84.06
YCJP
Paralog alert: 0.96 [within 20: 0.84] - ratio of genomes with paralogs
Cluster includes: CYST CYSW MALG MODB POTB POTC POTH POTI PSTA PSTC UGPA UGPE YCJO YCJP YDCU YDCV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
185_Q 189_R 4.593 1.00
35_S 59_Y 3.797 1.00
75_R 79_V 3.242 1.00
182_N 185_Q 2.914 1.00
184_L 188_F 2.779 1.00
57_E 60_V 2.724 1.00
177_M 186_I 2.624 1.00
57_E 61_D 2.59 1.00
173_E 191_T 2.572 1.00
162_K 166_D 2.546 1.00
72_D 75_R 2.422 1.00
87_V 150_V 2.389 1.00
69_P 75_R 2.364 1.00
161_L 199_L 2.358 1.00
93_I 187_I 2.303 1.00
73_Y 232_G 2.302 1.00
101_R 173_E 2.233 1.00
60_V 64_N 2.215 1.00
183_R 186_I 2.206 1.00
165_F 195_A 2.183 1.00
85_S 203_F 2.099 1.00
32_L 252_L 2.063 1.00
176_A 186_I 2.057 1.00
83_V 146_I 2.03 1.00
181_L 185_Q 2.015 1.00
185_Q 188_F 1.96 1.00
157_A 202_V 1.958 1.00
100_S 166_D 1.884 1.00
227_F 235_A 1.868 1.00
72_D 76_N 1.851 1.00
104_F 107_R 1.849 1.00
93_I 195_A 1.778 1.00
164_Y 198_G 1.772 1.00
81_S 207_F 1.762 1.00
92_G 157_A 1.76 1.00
172_I 194_L 1.75 1.00
59_Y 252_L 1.74 1.00
177_M 183_R 1.73 1.00
89_V 203_F 1.728 1.00
33_M 37_K 1.726 1.00
29_F 33_M 1.713 1.00
176_A 181_L 1.712 1.00
192_V 199_L 1.684 1.00
173_E 186_I 1.683 1.00
93_I 161_L 1.682 1.00
61_D 246_R 1.677 1.00
243_I 246_R 1.668 1.00
79_V 83_V 1.596 1.00
56_L 60_V 1.528 1.00
103_R 107_R 1.503 1.00
79_V 142_E 1.496 1.00
95_G 158_V 1.494 1.00
232_G 236_L 1.486 1.00
173_E 177_M 1.48 1.00
84_S 210_A 1.469 1.00
100_S 162_K 1.465 1.00
55_T 58_H 1.46 1.00
101_R 170_D 1.446 1.00
157_A 206_C 1.446 1.00
201_S 205_Y 1.443 1.00
58_H 245_G 1.415 1.00
214_Y 234_N 1.412 1.00
26_F 30_V 1.409 1.00
106_G 109_T 1.392 0.99
182_N 186_I 1.389 0.99
99_L 158_V 1.376 0.99
161_L 202_V 1.372 0.99
214_Y 218_S 1.371 0.99
96_A 161_L 1.362 0.99
133_I 144_A 1.356 0.99
90_F 94_L 1.342 0.99
176_A 190_I 1.337 0.99
143_M 147_I 1.334 0.99
170_D 173_E 1.32 0.99
78_L 82_V 1.308 0.99
140_D 223_S 1.304 0.99
168_I 194_L 1.3 0.99
142_E 226_N 1.291 0.99
165_F 191_T 1.274 0.99
62_I 253_V 1.271 0.99
59_Y 249_A 1.268 0.99
36_F 54_W 1.25 0.99
77_S 230_P 1.247 0.99
30_V 34_T 1.243 0.98
61_D 64_N 1.239 0.98
148_T 220_F 1.238 0.98
194_L 197_S 1.234 0.98
164_Y 195_A 1.233 0.98
34_T 248_M 1.224 0.98
181_L 186_I 1.219 0.98
216_F 220_F 1.218 0.98
74_F 229_L 1.216 0.98
171_E 174_E 1.207 0.98
228_T 231_V 1.205 0.98
93_I 199_L 1.204 0.98
187_I 192_V 1.201 0.98
88_A 92_G 1.167 0.97
88_A 206_C 1.159 0.97
76_N 79_V 1.157 0.97
31_M 252_L 1.154 0.97
80_V 228_T 1.153 0.97
83_V 86_V 1.142 0.97
61_D 243_I 1.139 0.97
161_L 198_G 1.138 0.97
83_V 87_V 1.13 0.97
82_V 86_V 1.126 0.97
126_V 219_I 1.116 0.96
109_T 113_S 1.102 0.96
94_L 98_A 1.097 0.96
173_E 183_R 1.097 0.96
168_I 195_A 1.092 0.96
236_L 250_A 1.085 0.96
61_D 65_P 1.08 0.95
223_S 226_N 1.078 0.95
97_Y 165_F 1.076 0.95
87_V 146_I 1.073 0.95
63_F 69_P 1.068 0.95
84_S 149_M 1.067 0.95
154_L 158_V 1.067 0.95
196_M 199_L 1.062 0.95
14_Y 18_A 1.051 0.94
75_R 78_L 1.047 0.94
109_T 112_A 1.045 0.94
86_V 90_F 1.042 0.94
79_V 82_V 1.039 0.94
18_A 22_I 1.032 0.94
97_Y 187_I 1.031 0.94
81_S 85_S 1.021 0.93
111_N 162_K 1.02 0.93
67_I 72_D 1.019 0.93
145_L 217_A 1.018 0.93
149_M 210_A 1.009 0.93
30_V 33_M 1.009 0.93
89_V 199_L 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3rlfG10.97861000.321Contact Map0.768
2onkC40.91431000.384Contact Map0.745
3d31C20.91431000.4Contact Map0.665
3rlfF10.96791000.437Contact Map0.639
3tuiA40.746499.90.581Contact Map0.739
3mktA20.546440.962Contact Map0.468
3hd7A20.13572.90.965Contact Map0.613
2k1eA40.36072.70.965Contact Map0.366
4irlA30.20712.20.966Contact Map0.458
2wswA10.79291.70.969Contact Map0.326
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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