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OPENSEQ.org
POTH - Putrescine transport system permease protein PotH
UniProt: P31135 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11631
Length: 317 (277)
Sequences: 19913
Seq/Len: 71.89
POTH
Paralog alert: 0.93 [within 20: 0.71] - ratio of genomes with paralogs
Cluster includes: CYST CYSW MALG MODB POTB POTC POTH POTI PSTA PSTC UGPA UGPE YCJO YCJP YDCU YDCV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
227_K 231_T 4.48 1.00
55_S 86_F 3.78 1.00
100_L 104_Q 3.236 1.00
224_R 227_K 2.967 1.00
226_L 230_F 2.951 1.00
84_G 88_Q 2.665 1.00
219_L 228_T 2.656 1.00
84_G 87_L 2.597 1.00
215_V 233_I 2.575 1.00
203_I 241_I 2.485 1.00
204_Y 208_I 2.439 1.00
126_H 215_V 2.422 1.00
112_C 192_V 2.393 1.00
98_A 273_V 2.384 1.00
97_D 100_L 2.342 1.00
96_F 100_L 2.335 1.00
87_L 91_D 2.261 1.00
118_Y 229_F 2.232 1.00
225_P 228_T 2.232 1.00
207_L 237_T 2.226 1.00
108_I 188_Y 2.119 1.00
218_A 228_T 2.001 1.00
110_T 245_S 1.995 1.00
52_F 292_I 1.989 1.00
223_A 227_K 1.959 1.00
125_A 208_I 1.931 1.00
268_I 276_Q 1.931 1.00
86_F 292_I 1.92 1.00
118_Y 237_T 1.898 1.00
199_M 244_G 1.88 1.00
227_K 230_F 1.88 1.00
168_L 173_V 1.827 1.00
214_L 236_L 1.772 1.00
53_K 57_A 1.75 1.00
117_G 199_M 1.742 1.00
129_P 132_R 1.741 1.00
106_A 249_F 1.732 1.00
283_D 286_V 1.724 1.00
97_D 101_Q 1.721 1.00
114_L 245_S 1.7 1.00
49_L 53_K 1.691 1.00
118_Y 203_I 1.689 1.00
218_A 223_A 1.682 1.00
234_V 241_I 1.678 1.00
88_Q 286_V 1.667 1.00
206_A 240_G 1.647 1.00
158_L 186_A 1.646 1.00
219_L 225_P 1.637 1.00
215_V 228_T 1.629 1.00
128_K 132_R 1.582 1.00
104_Q 108_I 1.548 1.00
125_A 204_Y 1.524 1.00
256_F 275_W 1.513 1.00
85_N 285_P 1.51 1.00
120_L 200_V 1.506 1.00
157_I 164_L 1.504 1.00
199_M 248_V 1.501 1.00
82_N 85_N 1.496 1.00
243_A 247_L 1.494 1.00
121_A 203_I 1.474 1.00
83_L 87_L 1.474 1.00
124_V 200_V 1.46 1.00
165_N 180_I 1.449 1.00
126_H 212_Y 1.449 1.00
46_L 50_I 1.444 1.00
215_V 219_L 1.427 1.00
104_Q 184_N 1.426 1.00
224_R 228_T 1.403 0.99
102_S 271_G 1.396 0.99
203_I 244_G 1.395 0.99
86_F 289_A 1.395 0.99
256_F 260_E 1.392 0.99
185_L 189_I 1.39 0.99
210_I 236_L 1.378 0.99
89_L 293_I 1.374 0.99
109_S 252_A 1.373 0.99
115_L 119_P 1.369 0.99
50_I 54_I 1.362 0.99
131_T 134_I 1.337 0.99
184_N 267_S 1.33 0.99
218_A 232_V 1.313 0.99
190_G 262_L 1.311 0.99
167_F 171_L 1.31 0.99
207_L 233_I 1.296 0.99
103_L 107_A 1.287 0.99
206_A 237_T 1.287 0.99
56_L 81_L 1.283 0.99
236_L 239_G 1.275 0.99
118_Y 241_I 1.269 0.99
165_N 168_L 1.262 0.99
212_Y 215_V 1.249 0.99
303_M 307_K 1.248 0.99
105_V 269_M 1.234 0.98
269_M 272_R 1.229 0.98
229_F 234_V 1.224 0.98
51_V 292_I 1.203 0.98
99_Y 270_I 1.196 0.98
223_A 228_T 1.195 0.98
107_A 111_F 1.19 0.98
122_W 207_L 1.184 0.98
166_N 170_W 1.184 0.98
88_Q 91_D 1.178 0.98
88_Q 283_D 1.178 0.98
54_I 288_S 1.17 0.97
113_C 117_G 1.153 0.97
258_I 262_L 1.137 0.97
273_V 290_V 1.133 0.97
210_I 237_T 1.131 0.97
196_V 200_V 1.131 0.97
277_E 290_V 1.117 0.96
108_I 112_C 1.113 0.96
109_S 191_I 1.103 0.96
134_I 138_L 1.097 0.96
213_S 216_E 1.093 0.96
307_K 310_Q 1.08 0.95
167_F 170_W 1.079 0.95
113_C 248_V 1.074 0.95
90_T 96_F 1.073 0.95
100_L 103_L 1.073 0.95
102_S 270_I 1.073 0.95
51_V 288_S 1.072 0.95
108_I 111_F 1.062 0.95
277_E 283_D 1.058 0.95
268_I 272_R 1.056 0.95
151_V 261_L 1.052 0.95
56_L 82_N 1.04 0.94
136_L 204_Y 1.04 0.94
101_Q 104_Q 1.039 0.94
238_K 241_I 1.035 0.94
122_W 229_F 1.035 0.94
277_E 281_N 1.034 0.94
278_F 287_A 1.033 0.94
273_V 277_E 1.03 0.94
132_R 208_I 1.03 0.94
88_Q 92_D 1.024 0.93
134_I 137_L 1.023 0.93
255_E 259_P 1.022 0.93
199_M 203_I 1.014 0.93
166_N 169_L 1.008 0.93
215_V 225_P 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2onkC40.88641000.389Contact Map0.745
3d31C20.90221000.412Contact Map0.663
3rlfG10.8771000.447Contact Map0.772
3rlfF10.96531000.467Contact Map0.633
3tuiA40.662599.90.609Contact Map0.756
2l9uA20.11673.80.968Contact Map0.623
3tx3A20.2242.70.97Contact Map0.238
2rddB10.09782.60.97Contact Map0.485
2l6wA20.1232.20.972Contact Map0.566
3dh4A40.19872.20.972Contact Map0.706
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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