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OPENSEQ.org
UGPA - sn-glycerol-3-phosphate transport system permease protein UgpA
UniProt: P10905 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11046
Length: 295 (280)
Sequences: 22487
Seq/Len: 80.31
UGPA
Paralog alert: 0.96 [within 20: 0.78] - ratio of genomes with paralogs
Cluster includes: CYST CYSW MALG MODB POTB POTC POTH POTI PSTA PSTC UGPA UGPE YCJO YCJP YDCU YDCV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
201_R 205_K 4.692 1.00
40_S 59_F 3.718 1.00
73_W 77_K 3.329 1.00
200_I 204_F 2.987 1.00
198_G 201_R 2.936 1.00
57_D 60_V 2.762 1.00
193_A 202_R 2.732 1.00
178_Y 182_Q 2.658 1.00
57_D 61_T 2.648 1.00
189_I 207_A 2.624 1.00
69_L 73_W 2.463 1.00
70_D 73_W 2.437 1.00
177_F 215_S 2.407 1.00
85_S 166_V 2.403 1.00
181_L 211_I 2.39 1.00
199_P 202_R 2.31 1.00
91_L 203_F 2.306 1.00
60_V 64_H 2.292 1.00
99_Y 189_I 2.288 1.00
192_A 202_R 2.186 1.00
81_F 162_V 2.143 1.00
197_A 201_R 2.119 1.00
83_T 219_L 2.033 1.00
201_R 204_F 2.023 1.00
37_L 271_V 1.96 1.00
98_E 182_Q 1.951 1.00
91_L 211_I 1.885 1.00
173_N 218_L 1.884 1.00
188_L 210_L 1.857 1.00
157_A 246_T 1.854 1.00
59_F 271_V 1.836 1.00
193_A 199_P 1.822 1.00
87_L 219_L 1.819 1.00
192_A 197_A 1.813 1.00
180_A 214_V 1.812 1.00
90_S 173_N 1.808 1.00
70_D 74_T 1.807 1.00
262_D 265_S 1.799 1.00
34_G 38_W 1.784 1.00
141_L 146_Y 1.77 1.00
101_V 104_S 1.763 1.00
79_S 223_L 1.76 1.00
38_W 42_Q 1.737 1.00
91_L 177_F 1.729 1.00
189_I 202_R 1.718 1.00
61_T 265_S 1.705 1.00
208_L 215_S 1.641 1.00
77_K 81_F 1.619 1.00
100_I 104_S 1.582 1.00
71_S 250_I 1.574 1.00
56_L 60_V 1.561 1.00
93_F 174_F 1.522 1.00
198_G 202_R 1.519 1.00
217_F 221_V 1.517 1.00
189_I 193_A 1.507 1.00
247_T 255_R 1.506 1.00
55_G 58_N 1.506 1.00
82_V 226_A 1.48 1.00
98_E 178_Y 1.469 1.00
58_N 264_A 1.46 1.00
88_L 92_F 1.444 1.00
99_Y 186_R 1.407 0.99
130_F 160_L 1.405 0.99
94_A 177_F 1.394 0.99
97_V 174_F 1.391 0.99
192_A 206_I 1.378 0.99
181_L 207_A 1.376 0.99
184_I 210_L 1.364 0.99
173_N 222_N 1.362 0.99
103_G 106_F 1.358 0.99
177_F 218_L 1.349 0.99
186_R 189_I 1.349 0.99
159_F 163_F 1.336 0.99
31_W 35_E 1.335 0.99
41_L 54_V 1.326 0.99
77_K 158_M 1.305 0.99
35_E 39_Y 1.286 0.99
62_L 272_V 1.285 0.99
61_T 64_H 1.281 0.99
76_I 80_T 1.275 0.99
91_L 215_S 1.274 0.99
233_V 237_A 1.269 0.99
282_V 286_R 1.264 0.99
210_L 213_P 1.261 0.99
180_A 211_I 1.25 0.99
203_F 208_L 1.243 0.98
187_S 190_E 1.24 0.98
59_F 268_A 1.239 0.98
138_T 241_G 1.235 0.98
197_A 202_R 1.221 0.98
106_F 110_L 1.216 0.98
231_F 235_D 1.208 0.98
80_T 84_V 1.205 0.98
252_K 256_E 1.202 0.98
86_G 90_S 1.199 0.98
74_T 77_K 1.197 0.98
230_T 234_I 1.195 0.98
39_Y 267_A 1.177 0.98
158_M 162_V 1.174 0.98
81_F 85_S 1.168 0.97
170_I 174_F 1.167 0.97
230_T 233_V 1.157 0.97
140_F 144_F 1.153 0.97
108_Q 178_Y 1.152 0.97
153_N 156_Q 1.149 0.97
43_S 52_Q 1.143 0.97
81_F 84_V 1.138 0.97
129_L 137_I 1.137 0.97
36_A 271_V 1.133 0.97
95_A 181_L 1.125 0.97
61_T 262_D 1.125 0.97
189_I 199_P 1.123 0.97
138_T 141_L 1.118 0.96
77_K 80_T 1.118 0.96
63_F 69_L 1.113 0.96
173_N 177_F 1.112 0.96
231_F 254_Y 1.103 0.96
256_E 260_G 1.099 0.96
82_V 165_S 1.092 0.96
106_F 109_T 1.087 0.96
139_H 143_E 1.085 0.96
184_I 211_I 1.083 0.96
177_F 214_V 1.076 0.95
61_T 65_D 1.075 0.95
41_L 55_G 1.074 0.95
95_A 203_F 1.07 0.95
36_A 267_A 1.065 0.95
86_G 222_N 1.062 0.95
87_L 215_S 1.059 0.95
79_S 83_T 1.056 0.95
73_W 76_I 1.04 0.94
85_S 162_V 1.029 0.94
203_F 207_A 1.026 0.94
67_Y 70_D 1.025 0.93
92_F 96_L 1.023 0.93
212_A 215_S 1.012 0.93
149_N 152_Q 1.01 0.93
23_I 27_I 1.005 0.93
84_V 88_L 1.003 0.93
35_E 38_W 1.002 0.92
204_F 208_L 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2onkC40.90171000.346Contact Map0.726
3rlfF10.98641000.359Contact Map0.622
3d31C20.90851000.363Contact Map0.653
3rlfG10.93561000.402Contact Map0.747
3tuiA40.708599.90.57Contact Map0.761
2l6wA20.13222.10.966Contact Map0.923
3tx3A20.35251.90.967Contact Map0.461
3hd7A20.11861.70.968Contact Map0.083
2m20A20.11861.30.97Contact Map0.254
2k9pA10.15251.20.971Contact Map0.674
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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