OPENSEQ.org - YEDL - ECOLI GREMLIN

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YEDL - Uncharacterized N-acetyltransferase YedL

UniProt:	P76319	Sequence MFTIKTDDLTHPAVQALVAYHISGMLQQSPPESSHALDVQKLRNPTVTFWSVWEGEQLAGIGALKLLDDKHGELKSMRTAPNYLRRGVASLILRHILQVAQDRCLHRLSLETGTQAGFTACHQLYLKHGFADCEPFADYRLDPHSRFLSLTLCENNELP	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG13279
Length:	159 (150)
Sequences:	13003
Seq/Len:	86.69

YEDL
Paralog alert: 0.85 [within 20: 0.19] - ratio of genomes with paralogs
Cluster includes: ATDA PHNO RIMI RIMJ RIML YAFP YEDL YHHY YIAC YJAB YJGM YNCA YPEA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
5_K	53_W	3.682	1.00
20_Y	80_A	2.749	1.00
62_G	96_I	2.623	1.00
90_S	128_H	2.554	1.00
97_L	130_F	2.527	1.00
97_L	150_L	2.411	1.00
90_S	127_K	2.384	1.00
52_V	88_V	2.352	1.00
95_H	98_Q	2.326	1.00
5_K	11_H	2.312	1.00
59_A	83_Y	2.268	1.00
107_R	149_S	2.219	1.00
126_L	132_D	2.148	1.00
50_W	95_H	2.115	1.00
122_H	126_L	2.091	1.00
51_S	58_L	2.028	1.00
99_V	102_D	1.944	1.00
99_V	103_R	1.874	1.00
7_D	14_V	1.821	1.00
94_R	128_H	1.82	1.00
93_L	128_H	1.782	1.00
97_L	108_L	1.76	1.00
123_Q	126_L	1.749	1.00
54_E	59_A	1.707	1.00
13_A	16_A	1.69	1.00
60_G	79_T	1.679	1.00
83_Y	86_R	1.656	1.00
95_H	99_V	1.61	1.00
54_E	83_Y	1.584	1.00
110_L	125_Y	1.554	1.00
54_E	86_R	1.518	1.00
90_S	94_R	1.452	1.00
64_L	96_I	1.424	1.00
122_H	132_D	1.417	1.00
50_W	99_V	1.412	1.00
133_C	149_S	1.405	0.99
57_Q	82_N	1.389	0.99
53_W	58_L	1.384	0.99
57_Q	80_A	1.365	0.99
16_A	20_Y	1.361	0.99
132_D	146_R	1.354	0.99
119_T	123_Q	1.353	0.99
49_F	63_A	1.353	0.99
53_W	56_E	1.344	0.99
132_D	135_P	1.335	0.99
72_G	100_A	1.303	0.99
79_T	88_V	1.301	0.99
87_G	90_S	1.292	0.99
112_T	118_F	1.292	0.99
3_T	53_W	1.28	0.99
13_A	58_L	1.275	0.99
62_G	92_I	1.266	0.99
98_Q	102_D	1.257	0.99
48_T	103_R	1.248	0.99
16_A	80_A	1.246	0.98
84_L	120_A	1.245	0.98
72_G	105_L	1.222	0.98
20_Y	81_P	1.218	0.98
7_D	51_S	1.203	0.98
114_T	144_H	1.193	0.98
80_A	83_Y	1.175	0.98
100_A	108_L	1.143	0.97
6_T	99_V	1.135	0.97
119_T	122_H	1.11	0.96
66_L	105_L	1.106	0.96
13_A	17_L	1.095	0.96
20_Y	82_N	1.085	0.96
122_H	148_L	1.082	0.96
15_Q	19_A	1.067	0.95
12_P	34_S	1.061	0.95
64_L	100_A	1.05	0.94
112_T	122_H	1.047	0.94
91_L	95_H	1.044	0.94
13_A	57_Q	1.04	0.94
121_C	125_Y	1.023	0.93
93_L	130_F	1.021	0.93
59_A	88_V	1.017	0.93
19_A	23_S	1.016	0.93
97_L	101_Q	1.013	0.93
74_L	93_L	1.01	0.93
52_V	60_G	1.007	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
3dr6A	3	0.9874	99.8	0.254	Contact Map	0.851
2j8mA	2	0.9874	99.8	0.258	Contact Map	0.731
3lodA	1	0.9811	99.8	0.259	Contact Map	0.729
3d8pA	2	0.9497	99.8	0.28	Contact Map	0.768
2fiaA	2	0.9748	99.8	0.285	Contact Map	0.741
1tiqA	2	0.9874	99.8	0.29	Contact Map	0.735
1n71A	4	0.956	99.8	0.295	Contact Map	0.77
4kvxA	2	0.9182	99.8	0.296	Contact Map	0.719
2oh1A	4	0.9245	99.8	0.298	Contact Map	0.721
2cntA	4	0.9308	99.8	0.298	Contact Map	0.761

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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