OPENSEQ.org - YJAB - ECOLI GREMLIN

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YJAB - Uncharacterized N-acetyltransferase YjaB

UniProt:	P09163	Sequence MVISIRRSRHEEGEELVAIWCRSVDATHDFLSAEYRTELEDLVRSFLPEAPLWVAVNERDQPVGFMLLSGQHMDALFIDPDVRGCGVGRVLVEHALSMAPELTTNVNEQNEQAVGFYKKVGFKVTGRSEVDDLGKPYPLLNLAYVGA	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG11207
Length:	147 (141)
Sequences:	10745
Seq/Len:	76.21

YJAB
Paralog alert: 0.86 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: ATDA PHNO RIMI RIMJ RIML YAFP YEDL YHHY YIAC YJAB YJGM YNCA YPEA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
6_R	56_V	3.836	1.00
22_R	79_D	2.972	1.00
89_R	120_V	2.95	1.00
6_R	12_E	2.851	1.00
96_L	122_F	2.811	1.00
66_M	95_A	2.464	1.00
89_R	119_K	2.415	1.00
55_A	87_V	2.392	1.00
53_W	94_H	2.308	1.00
63_V	82_V	2.26	1.00
94_H	97_S	2.212	1.00
114_V	118_K	2.174	1.00
8_S	16_L	2.039	1.00
118_K	124_V	1.996	1.00
54_V	62_P	1.94	1.00
93_E	120_V	1.933	1.00
124_V	127_R	1.884	1.00
115_G	118_K	1.774	1.00
92_V	120_V	1.76	1.00
82_V	85_C	1.731	1.00
15_E	18_A	1.705	1.00
57_N	63_V	1.688	1.00
96_L	144_Y	1.643	1.00
64_G	78_I	1.618	1.00
94_H	98_M	1.579	1.00
111_E	115_G	1.545	1.00
57_N	82_V	1.527	1.00
57_N	85_C	1.508	1.00
96_L	102_L	1.506	1.00
56_V	60_D	1.486	1.00
89_R	93_E	1.483	1.00
15_E	62_P	1.433	1.00
68_L	95_A	1.421	1.00
61_Q	81_D	1.403	0.99
114_V	124_V	1.365	0.99
22_R	80_P	1.363	0.99
18_A	22_R	1.317	0.99
108_E	127_R	1.315	0.99
52_L	67_L	1.315	0.99
83_R	112_Q	1.314	0.99
61_Q	79_D	1.31	0.99
4_S	56_V	1.295	0.99
106_V	110_N	1.292	0.99
56_V	62_P	1.289	0.99
78_I	87_V	1.277	0.99
86_G	89_R	1.219	0.98
18_A	79_D	1.218	0.98
53_W	98_M	1.214	0.98
15_E	19_I	1.212	0.98
7_R	98_M	1.212	0.98
66_M	91_L	1.208	0.98
92_V	122_F	1.201	0.98
17_V	21_C	1.194	0.98
8_S	54_V	1.173	0.98
15_E	61_Q	1.171	0.98
5_I	53_W	1.135	0.97
71_Q	99_A	1.132	0.97
79_D	82_V	1.128	0.97
113_A	117_Y	1.107	0.96
10_H	44_R	1.102	0.96
63_V	87_V	1.092	0.96
84_G	112_Q	1.091	0.96
104_T	117_Y	1.083	0.96
68_L	99_A	1.078	0.95
8_S	52_L	1.077	0.95
19_I	23_S	1.069	0.95
23_S	77_F	1.058	0.95
21_C	25_D	1.058	0.95
127_R	138_P	1.051	0.94
124_V	140_L	1.048	0.94
22_R	81_D	1.039	0.94
111_E	114_V	1.033	0.94
6_R	54_V	1.03	0.94
15_E	79_D	1.012	0.93
3_I	57_N	1.006	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
2kcwA	1	0.9932	99.9	0.215	Contact Map	0.641
2j8mA	2	0.9932	99.8	0.256	Contact Map	0.723
3dr6A	3	0.9932	99.8	0.277	Contact Map	0.837
3fncA	2	0.9864	99.8	0.277	Contact Map	0.73
3i9sA	4	0.966	99.8	0.292	Contact Map	0.599
1tiqA	2	0.9932	99.8	0.296	Contact Map	0.72
1u6mA	4	0.9728	99.8	0.309	Contact Map	0.694
3blnA	1	0.9252	99.8	0.311	Contact Map	0.667
3kkwA	1	0.9864	99.8	0.313	Contact Map	0.63
2fiwA	1	0.9932	99.8	0.317	Contact Map	0.677

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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