OPENSEQ.org - YIAC - ECOLI GREMLIN

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YIAC - Uncharacterized N-acetyltransferase YiaC

UniProt:	P37664	Sequence MIREAQRSELPAILELWLESTTWGHPFIKANYWRDCIPLVRDAYLANAQNWVWEEDGKLLGFVSIMEGRFLAAMFVAPKAVRRGIGKALMQYVQQRHPHLMLEVYQKNQPAINFYQAQGFHIVDCAWQDETQLPTWIMSWPVVQTL	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG12270
Length:	146 (142)
Sequences:	10402
Seq/Len:	73.25

YIAC
Paralog alert: 0.85 [within 20: 0.17] - ratio of genomes with paralogs
Cluster includes: ATDA PHNO RIMI RIMJ RIML YAFP YEDL YHHY YIAC YJAB YJGM YNCA YPEA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
3_R	54_E	3.915	1.00
3_R	9_E	2.861	1.00
19_E	77_A	2.84	1.00
87_K	118_Q	2.816	1.00
94_Q	120_F	2.582	1.00
53_W	85_I	2.5	1.00
51_W	92_Y	2.461	1.00
87_K	117_A	2.448	1.00
63_V	93_V	2.419	1.00
60_L	80_A	2.184	1.00
112_I	116_Q	2.159	1.00
94_Q	140_W	2.102	1.00
92_Y	95_Q	2.097	1.00
52_V	59_L	2.052	1.00
5_A	13_I	2.034	1.00
116_Q	122_I	1.952	1.00
91_Q	118_Q	1.942	1.00
55_E	60_L	1.862	1.00
122_I	125_C	1.822	1.00
90_M	118_Q	1.785	1.00
12_A	15_E	1.731	1.00
80_A	83_R	1.714	1.00
113_N	116_Q	1.687	1.00
94_Q	100_L	1.653	1.00
55_E	80_A	1.652	1.00
61_G	76_V	1.61	1.00
122_I	136_W	1.603	1.00
65_I	93_V	1.564	1.00
55_E	83_R	1.56	1.00
123_V	139_S	1.539	1.00
87_K	91_Q	1.52	1.00
109_Q	113_N	1.517	1.00
99_H	139_S	1.488	1.00
92_Y	96_R	1.467	1.00
12_A	59_L	1.436	1.00
15_E	19_E	1.432	1.00
58_K	79_K	1.42	1.00
102_L	115_Y	1.417	1.00
19_E	78_P	1.392	0.99
54_E	57_G	1.39	0.99
58_K	77_A	1.345	0.99
112_I	122_I	1.31	0.99
51_W	96_R	1.304	0.99
106_Q	125_C	1.289	0.99
104_V	108_N	1.287	0.99
81_V	110_P	1.252	0.99
125_C	134_P	1.244	0.98
12_A	16_L	1.198	0.98
50_N	64_S	1.198	0.98
76_V	85_I	1.195	0.98
106_Q	134_P	1.195	0.98
15_E	77_A	1.173	0.98
12_A	58_K	1.171	0.98
54_E	59_L	1.17	0.97
14_L	18_L	1.165	0.97
90_M	120_F	1.158	0.97
7_R	41_R	1.139	0.97
5_A	52_V	1.137	0.97
109_Q	112_I	1.136	0.97
2_I	51_W	1.132	0.97
77_A	80_A	1.124	0.97
84_G	87_K	1.119	0.96
60_L	85_I	1.113	0.96
63_V	89_L	1.113	0.96
111_A	115_Y	1.11	0.96
4_E	96_R	1.104	0.96
20_S	75_F	1.097	0.96
112_I	138_M	1.087	0.96
16_L	20_S	1.057	0.95
82_R	110_P	1.038	0.94
18_L	22_T	1.036	0.94
106_Q	136_W	1.029	0.94
9_E	54_E	1.028	0.94
1_M	54_E	1.009	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
3dr6A	3	1	99.8	0.222	Contact Map	0.856
2j8mA	2	1	99.8	0.229	Contact Map	0.75
4e2aA	2	0.9795	99.8	0.269	Contact Map	0.778
3kkwA	1	0.9795	99.8	0.275	Contact Map	0.654
4l8aA	1	0.9795	99.8	0.278	Contact Map	0.66
1tiqA	2	1	99.7	0.282	Contact Map	0.736
2cy2A	1	1	99.7	0.284	Contact Map	0.658
2kcwA	1	0.9658	99.7	0.284	Contact Map	0.619
3d8pA	2	0.9863	99.7	0.288	Contact Map	0.728
2pc1A	1	0.9658	99.7	0.293	Contact Map	0.702

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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