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OPENSEQ.org
YNCA - N-acyltransferase YncA
UniProt: P76112 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13770
Length: 172 (164)
Sequences: 14399
Seq/Len: 87.80
YNCA
Paralog alert: 0.88 [within 20: 0.26] - ratio of genomes with paralogs
Cluster includes: ATDA PHNO RIMI RIMJ RIML YAFP YEDL YHHY YIAC YJAB YJGM YNCA YPEA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
98_R 133_S 2.863 1.00
4_R 10_D 2.844 1.00
4_R 57_E 2.679 1.00
139_T 159_Q 2.44 1.00
138_V 141_Q 2.378 1.00
118_A 131_H 2.261 1.00
105_I 136_F 2.214 1.00
128_L 132_Q 2.161 1.00
103_R 106_D 2.16 1.00
20_H 88_H 2.157 1.00
138_V 156_T 2.09 1.00
98_R 134_L 2.073 1.00
63_T 91_H 2.068 1.00
66_A 104_L 2 1.00
132_Q 138_V 1.988 1.00
129_H 132_Q 1.983 1.00
12_A 36_A 1.82 1.00
105_I 160_L 1.792 1.00
101_L 134_L 1.78 1.00
115_V 159_Q 1.769 1.00
105_I 116_M 1.746 1.00
20_H 89_P 1.654 1.00
13_A 16_E 1.587 1.00
120_I 128_L 1.583 1.00
106_D 110_D 1.56 1.00
141_Q 154_D 1.549 1.00
68_F 108_A 1.542 1.00
122_S 154_D 1.54 1.00
36_A 40_I 1.534 1.00
55_V 62_V 1.501 1.00
102_S 134_L 1.484 1.00
120_I 131_H 1.483 1.00
128_L 138_V 1.465 1.00
141_Q 156_T 1.456 1.00
125_Q 129_H 1.453 1.00
128_L 156_T 1.448 1.00
54_L 103_R 1.44 1.00
13_A 62_V 1.422 1.00
81_V 113_K 1.421 1.00
147_T 152_W 1.406 0.99
66_A 100_L 1.397 0.99
128_L 158_M 1.397 0.99
88_H 91_H 1.381 0.99
35_D 38_N 1.361 0.99
87_V 97_G 1.358 0.99
114_H 144_Q 1.357 0.99
6_A 14_I 1.356 0.99
98_R 102_S 1.354 0.99
6_A 55_V 1.349 0.99
58_E 63_T 1.345 0.99
8_K 44_E 1.337 0.99
127_S 131_H 1.336 0.99
2_S 57_E 1.335 0.99
61_V 90_D 1.334 0.99
13_A 61_V 1.33 0.99
108_A 116_M 1.324 0.99
123_Q 153_L 1.322 0.99
92_Q 126_A 1.311 0.99
56_S 96_L 1.303 0.99
144_Q 163_D 1.298 0.99
107_E 110_D 1.294 0.99
68_F 104_L 1.29 0.99
91_H 94_K 1.287 0.99
107_E 111_C 1.284 0.99
109_R 162_L 1.263 0.99
125_Q 128_L 1.257 0.99
122_S 156_T 1.255 0.99
138_V 158_M 1.248 0.99
122_S 141_Q 1.238 0.98
103_R 107_E 1.225 0.98
8_K 40_I 1.217 0.98
64_G 87_V 1.209 0.98
87_V 96_L 1.19 0.98
22_V 89_P 1.186 0.98
61_V 88_H 1.184 0.98
15_A 19_N 1.17 0.97
96_L 99_K 1.155 0.97
16_E 20_H 1.138 0.97
85_V 131_H 1.126 0.97
16_E 88_H 1.124 0.97
83_H 101_L 1.117 0.96
58_E 94_K 1.084 0.96
57_E 60_G 1.075 0.95
12_A 16_E 1.071 0.95
101_L 136_F 1.067 0.95
54_L 107_E 1.048 0.94
115_V 139_T 1.039 0.94
40_I 44_E 1.037 0.94
99_K 103_R 1.037 0.94
65_Y 86_Y 1.033 0.94
61_V 91_H 1.029 0.94
97_G 130_L 1.021 0.93
11_C 40_I 1.002 0.92
93_G 126_A 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3dr6A30.994299.90.2Contact Map0.845
2j8mA20.982699.90.208Contact Map0.764
3r9fA20.930299.90.249Contact Map0.777
1nslA60.965199.90.251Contact Map0.849
3pzjA20.959399.90.257Contact Map0.724
3tthA120.93699.90.265Contact Map0.742
1s7kA10.941999.90.266Contact Map0.738
3fbuA20.918699.90.266Contact Map0.8
2vzyA40.970999.90.271Contact Map0.738
2fckA10.924499.90.272Contact Map0.715
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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