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OPENSEQ.org
ASCG - HTH-type transcriptional regulator AscG
UniProt: P24242 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10087
Length: 336 (331)
Sequences: 13296
Seq/Len: 40.17
ASCG
Paralog alert: 0.91 [within 20: 0.48] - ratio of genomes with paralogs
Cluster includes: ALSB ARAF ASCG CRA CYTR DGAL EBGR GALR GALS GNTR IDNR LACI LSRB MALI PURR RBSB RBSR TORT TRER XYLF YCJW YPHF YTFQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
179_H 242_S 3.683 1.00
164_K 203_D 3.588 1.00
265_A 268_E 3.461 1.00
10_R 42_E 3.431 1.00
170_A 273_I 3.13 1.00
277_D 292_K 2.814 1.00
179_H 271_S 2.655 1.00
38_Q 42_E 2.654 1.00
259_L 270_V 2.559 1.00
30_Q 34_D 2.505 1.00
198_L 202_K 2.453 1.00
82_H 299_I 2.443 1.00
34_D 38_Q 2.429 1.00
120_A 306_L 2.394 1.00
168_F 207_Q 2.365 1.00
157_H 309_M 2.307 1.00
172_A 176_N 2.272 1.00
86_M 304_G 2.237 1.00
301_E 304_G 2.202 1.00
167_S 171_V 2.186 1.00
21_V 36_V 2.118 1.00
33_K 37_F 2.091 1.00
86_M 89_E 2.082 1.00
228_A 261_E 2.058 1.00
166_T 275_F 2.024 1.00
236_E 262_R 2.006 1.00
168_F 203_D 2.003 1.00
22_L 40_V 1.944 1.00
231_V 244_L 1.925 1.00
175_I 208_H 1.922 1.00
87_A 303_I 1.891 1.00
167_S 245_V 1.866 1.00
227_G 254_G 1.856 1.00
177_A 331_L 1.855 1.00
165_Q 169_N 1.855 1.00
265_A 269_Q 1.838 1.00
168_F 204_A 1.834 1.00
172_A 204_A 1.823 1.00
264_V 269_Q 1.813 1.00
85_R 296_T 1.782 1.00
292_K 324_K 1.779 1.00
172_A 208_H 1.76 1.00
232_E 262_R 1.738 1.00
168_F 172_A 1.735 1.00
171_V 201_Y 1.731 1.00
7_V 39_A 1.73 1.00
5_L 15_K 1.73 1.00
171_V 175_I 1.684 1.00
11_A 39_A 1.679 1.00
294_P 297_E 1.676 1.00
231_V 255_A 1.671 1.00
228_A 258_A 1.661 1.00
86_M 300_Q 1.648 1.00
287_A 329_D 1.64 1.00
7_V 11_A 1.63 1.00
173_E 331_L 1.613 1.00
37_F 41_E 1.61 1.00
164_K 199_A 1.602 1.00
62_L 87_A 1.591 1.00
277_D 328_R 1.59 1.00
21_V 40_V 1.589 1.00
232_E 258_A 1.583 1.00
86_M 303_I 1.567 1.00
37_F 40_V 1.558 1.00
273_I 289_S 1.552 1.00
200_G 204_A 1.551 1.00
162_D 165_Q 1.536 1.00
185_L 255_A 1.528 1.00
173_E 177_A 1.522 1.00
82_H 296_T 1.52 1.00
147_L 302_I 1.519 1.00
175_I 204_A 1.512 1.00
260_H 285_V 1.5 1.00
172_A 207_Q 1.486 1.00
169_N 323_G 1.484 1.00
174_L 243_A 1.477 1.00
199_A 203_D 1.469 1.00
167_S 200_G 1.458 1.00
246_A 255_A 1.456 1.00
297_E 300_Q 1.45 1.00
184_F 247_S 1.439 1.00
183_A 241_F 1.437 1.00
259_L 264_V 1.422 1.00
64_L 83_A 1.412 1.00
171_V 200_G 1.407 0.99
10_R 39_A 1.403 0.99
63_G 118_C 1.4 0.99
258_A 262_R 1.398 0.99
256_M 272_V 1.398 0.99
83_A 122_M 1.397 0.99
258_A 261_E 1.396 0.99
179_H 243_A 1.394 0.99
90_K 307_I 1.386 0.99
297_E 301_E 1.382 0.99
304_G 308_F 1.382 0.99
165_Q 168_F 1.381 0.99
39_A 43_S 1.38 0.99
171_V 204_A 1.377 0.99
249_D 290_S 1.368 0.99
48_N 51_A 1.364 0.99
213_N 216_L 1.362 0.99
232_E 261_E 1.34 0.99
60_Q 92_R 1.33 0.99
29_S 32_T 1.328 0.99
4_M 18_V 1.326 0.99
181_E 240_K 1.32 0.99
87_A 94_L 1.319 0.99
166_T 323_G 1.318 0.99
6_E 9_K 1.312 0.99
231_V 259_L 1.275 0.99
294_P 321_F 1.273 0.99
48_N 54_L 1.268 0.99
10_R 43_S 1.267 0.99
86_M 90_K 1.263 0.99
256_M 266_V 1.261 0.99
7_V 43_S 1.258 0.99
196_E 199_A 1.245 0.98
182_I 205_L 1.241 0.98
173_E 176_N 1.236 0.98
173_E 327_R 1.225 0.98
175_I 210_I 1.218 0.98
5_L 9_K 1.215 0.98
244_L 255_A 1.204 0.98
271_S 331_L 1.201 0.98
97_A 113_L 1.189 0.98
60_Q 119_D 1.185 0.98
183_A 234_L 1.184 0.98
274_G 290_S 1.183 0.98
238_G 241_F 1.179 0.98
254_G 258_A 1.177 0.98
201_Y 205_L 1.177 0.98
4_M 15_K 1.174 0.98
30_Q 33_K 1.17 0.97
249_D 274_G 1.166 0.97
32_T 35_R 1.166 0.97
64_L 94_L 1.162 0.97
97_A 109_A 1.16 0.97
205_L 210_I 1.159 0.97
177_A 327_R 1.156 0.97
39_A 42_E 1.153 0.97
202_K 206_A 1.149 0.97
299_I 303_I 1.138 0.97
51_A 54_L 1.136 0.97
182_I 243_A 1.128 0.97
204_A 207_Q 1.119 0.96
225_A 229_E 1.118 0.96
38_Q 41_E 1.116 0.96
35_R 39_A 1.113 0.96
63_G 113_L 1.106 0.96
229_E 233_M 1.102 0.96
20_R 25_N 1.1 0.96
34_D 37_F 1.1 0.96
177_A 271_S 1.092 0.96
170_A 245_V 1.09 0.96
83_A 303_I 1.09 0.96
218_A 233_M 1.086 0.96
246_A 252_A 1.084 0.96
170_A 291_V 1.081 0.95
24_G 33_K 1.079 0.95
277_D 281_A 1.075 0.95
249_D 252_A 1.073 0.95
176_N 208_H 1.072 0.95
64_L 80_L 1.072 0.95
181_E 242_S 1.067 0.95
17_T 20_R 1.064 0.95
169_N 172_A 1.063 0.95
164_K 196_E 1.054 0.95
21_V 28_V 1.046 0.94
85_R 300_Q 1.046 0.94
59_T 119_D 1.036 0.94
122_M 302_I 1.032 0.94
50_L 53_N 1.03 0.94
228_A 257_K 1.03 0.94
164_K 200_G 1.027 0.94
2_T 43_S 1.027 0.94
84_A 88_E 1.027 0.94
181_E 213_N 1.026 0.94
221_K 226_S 1.026 0.94
256_M 284_T 1.016 0.93
227_G 231_V 1.016 0.93
231_V 235_L 1.013 0.93
184_F 198_L 1.01 0.93
11_A 18_V 1.009 0.93
203_D 207_Q 1.007 0.93
40_V 43_S 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3dbiA311000.017Contact Map0.755
1qpzA10.98811000.034Contact Map0.782
2hsgA10.97921000.035Contact Map0.771
2o20A80.97321000.039Contact Map0.848
3kjxA40.98811000.046Contact Map0.8
3e3mA40.99111000.046Contact Map0.821
3bilA20.97921000.049Contact Map0.672
3ctpA20.97021000.053Contact Map0.738
3h5oA20.98511000.057Contact Map0.796
1jyeA10.97921000.061Contact Map0.779
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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