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LSRB - Autoinducer 2-binding protein LsrB
UniProt: P76142 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13809
Length: 340 (293)
Sequences: 3307
Seq/Len: 11.29
LSRB
Paralog alert: 0.78 [within 20: 0.15] - ratio of genomes with paralogs
Cluster includes: ALSB ARAF ASCG CRA CYTR DGAL EBGR GALR GALS GNTR IDNR LACI LSRB MALI PURR RBSB RBSR TORT TRER XYLF YCJW YPHF YTFQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
154_K 186_E 4.293 1.00
281_A 286_G 3.888 1.00
204_A 217_I 3.841 1.00
87_A 279_A 3.531 1.00
233_E 259_T 3.374 1.00
142_D 146_R 2.999 1.00
103_K 107_Q 2.849 1.00
52_A 55_E 2.827 1.00
81_V 110_V 2.8 1.00
154_K 213_D 2.787 1.00
31_A 80_F 2.754 1.00
134_A 176_A 2.713 1.00
144_A 216_A 2.653 1.00
194_Y 199_K 2.496 1.00
135_Q 138_G 2.488 1.00
138_G 176_A 2.485 1.00
78_N 104_R 2.41 1.00
50_Q 54_K 2.329 1.00
29_R 59_D 2.209 1.00
172_K 176_A 2.153 1.00
280_D 284_K 2.144 1.00
46_G 50_Q 2.118 1.00
232_A 240_V 2.06 1.00
253_P 257_R 2.036 1.00
33_I 76_L 1.999 1.00
152_K 184_G 1.978 1.00
88_I 105_A 1.971 1.00
277_Y 281_A 1.919 1.00
47_N 50_Q 1.91 1.00
274_I 277_Y 1.907 1.00
52_A 273_K 1.835 1.00
158_F 228_A 1.832 1.00
138_G 177_K 1.804 1.00
52_A 277_Y 1.784 1.00
89_I 275_S 1.783 1.00
156_A 207_I 1.776 1.00
31_A 85_Y 1.718 1.00
156_A 214_L 1.639 1.00
232_A 242_I 1.623 1.00
138_G 142_D 1.622 1.00
201_L 234_N 1.613 1.00
143_M 146_R 1.605 1.00
270_Q 273_K 1.589 1.00
80_F 85_Y 1.582 1.00
176_A 180_K 1.574 1.00
51_Q 55_E 1.559 1.00
141_V 177_K 1.557 1.00
134_A 172_K 1.546 1.00
174_A 218_I 1.543 1.00
81_V 108_R 1.538 1.00
61_T 83_Q 1.522 1.00
28_E 283_L 1.522 1.00
145_A 182_H 1.508 1.00
171_V 175_K 1.498 1.00
201_L 230_Q 1.496 1.00
53_G 276_V 1.483 1.00
196_D 199_K 1.476 1.00
175_K 190_T 1.47 1.00
205_E 234_N 1.458 1.00
52_A 56_L 1.447 1.00
251_M 260_V 1.44 1.00
105_A 112_V 1.434 1.00
201_L 205_E 1.431 1.00
51_Q 54_K 1.415 1.00
174_A 178_I 1.407 0.99
160_S 195_N 1.402 0.99
72_G 76_L 1.389 0.99
113_L 282_L 1.365 0.99
227_A 231_A 1.363 0.99
29_R 61_T 1.36 0.99
205_E 231_A 1.352 0.99
136_L 245_F 1.348 0.99
106_M 125_S 1.342 0.99
134_A 138_G 1.342 0.99
154_K 215_D 1.339 0.99
156_A 204_A 1.338 0.99
149_N 152_K 1.309 0.99
255_V 263_F 1.307 0.99
198_T 202_Q 1.304 0.99
77_I 101_A 1.296 0.99
74_V 78_N 1.29 0.99
96_D 120_K 1.289 0.99
254_Y 259_T 1.285 0.99
81_V 105_A 1.263 0.99
102_L 112_V 1.251 0.99
51_Q 269_V 1.248 0.99
58_V 280_D 1.247 0.99
53_G 60_V 1.245 0.98
253_P 256_E 1.241 0.98
33_I 80_F 1.218 0.98
48_G 272_G 1.212 0.98
49_A 276_V 1.209 0.98
143_M 147_Q 1.207 0.98
47_N 51_Q 1.202 0.98
27_A 59_D 1.198 0.98
201_L 231_A 1.195 0.98
193_G 224_A 1.194 0.98
79_N 83_Q 1.181 0.98
191_Q 203_T 1.179 0.98
49_A 60_V 1.179 0.98
142_D 177_K 1.179 0.98
195_N 224_A 1.167 0.97
28_E 86_N 1.166 0.97
193_G 200_S 1.163 0.97
99_C 103_K 1.162 0.97
177_K 181_E 1.162 0.97
77_I 88_I 1.161 0.97
148_V 215_D 1.159 0.97
75_Q 78_N 1.159 0.97
77_I 90_V 1.159 0.97
79_N 206_G 1.158 0.97
56_L 280_D 1.153 0.97
202_Q 205_E 1.148 0.97
85_Y 88_I 1.148 0.97
256_E 336_G 1.147 0.97
141_V 174_A 1.143 0.97
81_V 85_Y 1.128 0.97
143_M 262_E 1.126 0.97
98_L 101_A 1.122 0.97
175_K 179_A 1.119 0.96
140_L 243_V 1.115 0.96
273_K 277_Y 1.112 0.96
199_K 202_Q 1.108 0.96
73_Q 76_L 1.101 0.96
221_D 246_S 1.099 0.96
104_R 108_R 1.099 0.96
78_N 205_E 1.091 0.96
63_D 79_N 1.089 0.96
87_A 283_L 1.081 0.95
148_V 216_A 1.078 0.95
32_F 49_A 1.073 0.95
49_A 89_I 1.067 0.95
141_V 145_A 1.06 0.95
222_A 251_M 1.057 0.95
116_D 132_T 1.054 0.95
169_Q 172_K 1.046 0.94
207_I 211_Y 1.046 0.94
69_S 72_G 1.043 0.94
139_M 142_D 1.041 0.94
115_W 275_S 1.035 0.94
87_A 113_L 1.033 0.94
85_Y 110_V 1.026 0.94
63_D 80_F 1.025 0.93
42_F 91_S 1.016 0.93
142_D 181_E 1.011 0.93
145_A 177_K 1.008 0.93
204_A 232_A 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1tjyA10.92651000.29Contact Map0.711
4kvfA10.93241000.356Contact Map0.682
3d02A10.88531000.377Contact Map0.69
8abpA10.82351000.437Contact Map0.574
3uugA20.87061000.439Contact Map0.75
2driA10.79711000.445Contact Map0.808
3g1wA20.86761000.446Contact Map0.827
4kzkA10.91000.447Contact Map0.62
2h3hA20.86181000.451Contact Map0.813
2rjoA10.85291000.452Contact Map0.677
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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