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PURR - HTH-type transcriptional repressor PurR
UniProt: P0ACP7 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10800
Length: 341 (334)
Sequences: 13790
Seq/Len: 41.29
PURR
Paralog alert: 0.91 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: ALSB ARAF ASCG CRA CYTR DGAL EBGR GALR GALS GNTR IDNR LACI LSRB MALI PURR RBSB RBSR TORT TRER XYLF YCJW YPHF YTFQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
163_F 202_K 3.652 1.00
178_H 241_T 3.495 1.00
264_R 267_Q 3.469 1.00
10_R 42_E 3.425 1.00
169_A 272_I 3.054 1.00
276_N 291_H 2.755 1.00
38_A 42_E 2.631 1.00
178_H 270_S 2.55 1.00
258_A 269_V 2.506 1.00
197_L 201_M 2.488 1.00
30_E 34_N 2.485 1.00
80_A 298_G 2.465 1.00
34_N 38_A 2.449 1.00
167_Y 206_E 2.395 1.00
118_G 305_L 2.38 1.00
171_R 175_E 2.26 1.00
84_N 303_N 2.23 1.00
300_T 303_N 2.218 1.00
156_D 308_R 2.184 1.00
166_G 170_G 2.149 1.00
227_Y 260_E 2.102 1.00
167_Y 202_K 2.099 1.00
84_N 87_Q 2.093 1.00
33_R 37_W 2.088 1.00
21_V 36_V 2.087 1.00
165_G 274_Y 2.021 1.00
235_S 261_M 2.01 1.00
85_C 302_F 1.941 1.00
230_M 243_V 1.941 1.00
174_I 207_A 1.925 1.00
22_I 40_I 1.901 1.00
164_E 168_M 1.889 1.00
167_Y 203_A 1.881 1.00
264_R 268_D 1.84 1.00
171_R 203_A 1.834 1.00
166_G 244_F 1.822 1.00
83_K 295_D 1.814 1.00
263_L 268_D 1.804 1.00
226_G 253_G 1.802 1.00
291_H 324_R 1.788 1.00
167_Y 171_R 1.757 1.00
171_R 207_A 1.744 1.00
231_Q 261_M 1.742 1.00
176_R 331_V 1.727 1.00
5_K 15_T 1.721 1.00
170_G 174_I 1.719 1.00
7_V 39_A 1.714 1.00
163_F 198_A 1.681 1.00
170_G 200_F 1.676 1.00
84_N 299_E 1.671 1.00
227_Y 257_A 1.667 1.00
231_Q 257_A 1.657 1.00
230_M 254_A 1.654 1.00
11_A 39_A 1.652 1.00
307_D 312_K 1.646 1.00
62_I 85_C 1.624 1.00
37_W 41_K 1.602 1.00
293_P 296_S 1.601 1.00
286_A 329_R 1.591 1.00
173_L 242_A 1.583 1.00
145_M 301_A 1.574 1.00
37_W 40_I 1.569 1.00
172_Y 331_V 1.562 1.00
276_N 328_R 1.561 1.00
198_A 202_K 1.558 1.00
21_V 40_I 1.546 1.00
80_A 295_D 1.538 1.00
84_N 302_F 1.533 1.00
7_V 11_A 1.527 1.00
296_S 299_E 1.512 1.00
184_I 254_A 1.506 1.00
174_I 203_A 1.506 1.00
172_Y 176_R 1.501 1.00
199_G 203_A 1.493 1.00
161_N 164_E 1.488 1.00
245_C 254_A 1.478 1.00
272_I 288_T 1.461 1.00
171_R 206_E 1.458 1.00
10_R 39_A 1.454 1.00
183_V 246_G 1.446 1.00
168_M 323_P 1.442 1.00
182_G 240_P 1.438 1.00
259_D 284_T 1.435 1.00
63_G 116_V 1.433 1.00
88_K 306_L 1.422 1.00
303_N 307_D 1.421 1.00
231_Q 260_E 1.41 1.00
296_S 300_T 1.408 1.00
257_A 261_M 1.402 0.99
180_E 239_R 1.401 0.99
64_L 81_V 1.399 0.99
178_H 242_A 1.398 0.99
166_G 199_G 1.394 0.99
255_L 271_L 1.393 0.99
164_E 167_Y 1.387 0.99
39_A 43_L 1.384 0.99
170_G 203_A 1.382 0.99
258_A 263_L 1.382 0.99
212_P 215_W 1.381 0.99
257_A 260_E 1.374 0.99
60_K 90_Y 1.362 0.99
81_V 120_L 1.361 0.99
170_G 199_G 1.356 0.99
48_S 51_A 1.355 0.99
248_D 289_T 1.337 0.99
29_A 32_T 1.32 0.99
195_G 198_A 1.312 0.99
85_C 92_L 1.307 0.99
182_G 233_I 1.303 0.99
230_M 258_A 1.293 0.99
6_D 9_K 1.292 0.99
165_G 323_P 1.29 0.99
84_N 88_K 1.286 0.99
4_I 18_V 1.285 0.99
10_R 43_L 1.272 0.99
172_Y 175_E 1.272 0.99
7_V 43_L 1.263 0.99
174_I 209_I 1.245 0.98
293_P 321_V 1.234 0.98
172_Y 327_E 1.229 0.98
63_G 111_M 1.217 0.98
95_G 111_M 1.216 0.98
60_K 117_D 1.211 0.98
255_L 265_V 1.204 0.98
48_S 54_L 1.203 0.98
243_V 254_A 1.2 0.98
64_L 92_L 1.199 0.98
181_I 204_M 1.198 0.98
5_K 9_K 1.194 0.98
201_M 205_E 1.193 0.98
253_G 257_A 1.188 0.98
30_E 33_R 1.182 0.98
200_F 204_M 1.178 0.98
237_P 240_P 1.171 0.98
32_T 35_A 1.165 0.97
273_G 289_T 1.165 0.97
224_E 228_R 1.161 0.97
39_A 42_E 1.157 0.97
4_I 15_T 1.157 0.97
81_V 302_F 1.156 0.97
298_G 302_F 1.146 0.97
176_R 327_E 1.145 0.97
51_A 54_L 1.138 0.97
204_M 209_I 1.131 0.97
132_A 136_E 1.124 0.97
217_V 232_Q 1.123 0.97
270_S 331_V 1.119 0.96
227_Y 256_C 1.119 0.96
203_A 206_E 1.118 0.96
38_A 41_K 1.118 0.96
248_D 273_G 1.114 0.96
169_A 244_F 1.105 0.96
34_N 37_W 1.102 0.96
95_G 107_Y 1.101 0.96
35_A 39_A 1.098 0.96
245_C 251_A 1.097 0.96
228_R 232_Q 1.094 0.96
176_R 270_S 1.09 0.96
180_E 241_T 1.089 0.96
220_D 225_S 1.088 0.96
168_M 171_R 1.085 0.96
181_I 242_A 1.084 0.96
163_F 195_G 1.083 0.96
169_A 290_I 1.078 0.95
24_K 33_R 1.076 0.95
120_L 301_A 1.071 0.95
163_F 199_G 1.07 0.95
59_T 117_D 1.064 0.95
21_V 28_V 1.062 0.95
82_E 86_F 1.06 0.95
2_A 43_L 1.055 0.95
276_N 280_A 1.05 0.94
202_K 206_E 1.043 0.94
20_H 25_T 1.04 0.94
50_V 53_S 1.038 0.94
230_M 234_L 1.035 0.94
17_T 20_H 1.032 0.94
180_E 212_P 1.03 0.94
227_Y 231_Q 1.027 0.94
83_K 299_E 1.026 0.94
300_T 319_I 1.02 0.93
248_D 251_A 1.019 0.93
175_E 207_A 1.018 0.93
306_L 310_V 1.017 0.93
163_F 167_Y 1.014 0.93
88_K 303_N 1.007 0.93
64_L 78_I 1.003 0.93
81_V 298_G 1.002 0.92
300_T 304_M 1.002 0.92
255_L 283_F 1.001 0.92
226_G 230_M 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1qpzA10.99411000.043Contact Map0.782
3dbiA30.97651000.06Contact Map0.746
2hsgA10.96771000.061Contact Map0.777
2o20A80.96191000.064Contact Map0.852
3bilA20.98241000.072Contact Map0.676
3ctpA20.96481000.073Contact Map0.741
3kjxA40.97651000.077Contact Map0.788
3e3mA40.99411000.084Contact Map0.813
3h5oA20.98241000.089Contact Map0.781
3jvdA20.95891000.096Contact Map0.681
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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