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EBGR - HTH-type transcriptional regulator EbgR
UniProt: P06846 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10254
Length: 327 (320)
Sequences: 13160
Seq/Len: 41.12
EBGR
Paralog alert: 0.90 [within 20: 0.47] - ratio of genomes with paralogs
Cluster includes: ALSB ARAF ASCG CRA CYTR DGAL EBGR GALR GALS GNTR IDNR LACI LSRB MALI PURR RBSB RBSR TORT TRER XYLF YCJW YPHF YTFQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
174_V 236_K 3.721 1.00
159_A 198_E 3.525 1.00
259_N 262_Q 3.443 1.00
10_E 44_K 3.399 1.00
165_I 267_I 3.089 1.00
271_D 286_R 2.81 1.00
174_V 265_S 2.701 1.00
40_E 44_K 2.605 1.00
253_I 264_I 2.528 1.00
193_E 197_A 2.448 1.00
32_E 36_H 2.435 1.00
36_H 40_E 2.416 1.00
88_G 293_G 2.411 1.00
163_K 202_L 2.361 1.00
117_G 300_V 2.324 1.00
167_D 171_N 2.271 1.00
152_D 303_K 2.228 1.00
21_V 38_I 2.137 1.00
92_Q 298_N 2.134 1.00
162_S 166_I 2.131 1.00
295_Q 298_N 2.13 1.00
35_K 39_L 2.092 1.00
92_Q 95_K 2.029 1.00
161_I 269_V 2.016 1.00
222_Y 255_E 2.007 1.00
53_R 56_Q 1.995 1.00
163_K 198_E 1.977 1.00
230_A 256_R 1.959 1.00
22_L 42_A 1.934 1.00
172_Q 326_T 1.918 1.00
170_I 203_K 1.893 1.00
93_C 297_V 1.885 1.00
225_A 238_L 1.872 1.00
162_S 239_F 1.869 1.00
221_G 248_G 1.862 1.00
160_R 164_E 1.842 1.00
259_N 263_D 1.833 1.00
286_R 319_K 1.8 1.00
258_L 263_D 1.771 1.00
167_D 199_Y 1.766 1.00
5_K 15_L 1.764 1.00
226_K 256_R 1.762 1.00
7_I 41_I 1.756 1.00
167_D 203_K 1.751 1.00
163_K 167_D 1.75 1.00
91_T 290_E 1.746 1.00
166_I 196_F 1.725 1.00
163_K 199_Y 1.713 1.00
166_I 170_I 1.663 1.00
11_A 41_I 1.658 1.00
7_I 11_A 1.655 1.00
288_H 291_M 1.651 1.00
25_D 29_N 1.636 1.00
222_Y 252_A 1.631 1.00
281_P 324_G 1.619 1.00
225_A 249_V 1.609 1.00
271_D 323_R 1.604 1.00
21_V 42_A 1.594 1.00
168_F 326_T 1.59 1.00
92_Q 294_S 1.583 1.00
39_L 43_E 1.576 1.00
39_L 42_A 1.576 1.00
226_K 252_A 1.572 1.00
65_I 93_C 1.563 1.00
92_Q 297_V 1.563 1.00
195_A 199_Y 1.561 1.00
159_A 194_V 1.556 1.00
267_I 283_S 1.549 1.00
254_H 279_F 1.537 1.00
180_I 249_V 1.531 1.00
157_D 160_R 1.525 1.00
142_I 296_G 1.518 1.00
88_G 290_E 1.486 1.00
207_R 210_D 1.484 1.00
291_M 294_S 1.479 1.00
240_V 249_V 1.478 1.00
168_F 172_Q 1.475 1.00
164_E 318_S 1.473 1.00
66_L 115_V 1.465 1.00
167_D 202_L 1.464 1.00
194_V 198_E 1.444 1.00
174_V 237_A 1.436 1.00
170_I 199_Y 1.435 1.00
253_I 258_L 1.426 1.00
169_Y 237_A 1.425 1.00
302_E 307_G 1.424 1.00
179_F 241_A 1.419 1.00
162_S 195_A 1.404 0.99
10_E 41_I 1.4 0.99
298_N 302_E 1.387 0.99
41_I 45_L 1.38 0.99
166_I 195_A 1.378 0.99
252_A 256_R 1.374 0.99
89_I 119_L 1.374 0.99
252_A 255_E 1.37 0.99
250_L 266_L 1.367 0.99
178_G 235_P 1.365 0.99
67_A 89_I 1.353 0.99
96_L 301_Y 1.346 0.99
291_M 295_Q 1.336 0.99
166_I 199_Y 1.332 0.99
243_D 284_T 1.331 0.99
225_A 253_I 1.323 0.99
160_R 163_K 1.32 0.99
31_K 34_T 1.309 0.99
226_K 255_E 1.304 0.99
4_L 18_V 1.301 0.99
6_D 9_I 1.296 0.99
93_C 100_L 1.295 0.99
7_I 45_L 1.295 0.99
161_I 318_S 1.283 0.99
176_R 234_Y 1.277 0.99
26_P 29_N 1.27 0.99
10_E 45_L 1.268 0.99
265_S 326_T 1.261 0.99
191_I 194_V 1.26 0.99
92_Q 96_L 1.258 0.99
250_L 260_I 1.25 0.99
63_H 98_I 1.249 0.99
50_S 53_R 1.247 0.99
178_G 228_M 1.241 0.98
168_F 322_L 1.221 0.98
238_L 249_V 1.216 0.98
172_Q 265_S 1.205 0.98
288_H 316_V 1.204 0.98
232_E 235_P 1.193 0.98
172_Q 322_L 1.191 0.98
293_G 297_V 1.191 0.98
52_A 55_L 1.19 0.98
168_F 171_N 1.188 0.98
248_G 252_A 1.184 0.98
170_I 205_V 1.179 0.98
34_T 37_R 1.175 0.98
5_K 9_I 1.172 0.98
196_F 200_G 1.172 0.98
4_L 15_L 1.167 0.97
63_H 116_T 1.163 0.97
177_I 200_G 1.162 0.97
20_R 25_D 1.155 0.97
40_E 43_E 1.144 0.97
50_S 56_Q 1.141 0.97
32_E 35_K 1.136 0.97
177_I 237_A 1.133 0.97
200_G 205_V 1.132 0.97
243_D 268_S 1.131 0.97
41_I 44_K 1.12 0.96
197_A 201_R 1.103 0.96
219_S 223_E 1.101 0.96
271_D 275_A 1.1 0.96
268_S 284_T 1.099 0.96
240_V 246_A 1.099 0.96
17_T 20_R 1.094 0.96
24_D 35_K 1.094 0.96
67_A 100_L 1.094 0.96
165_I 239_F 1.086 0.96
223_E 227_Q 1.077 0.95
21_V 30_V 1.077 0.95
37_R 41_I 1.076 0.95
212_W 227_Q 1.073 0.95
165_I 285_V 1.071 0.95
164_E 167_D 1.067 0.95
89_I 297_V 1.066 0.95
36_H 39_L 1.063 0.95
171_N 203_K 1.06 0.95
119_L 296_G 1.049 0.94
159_A 191_I 1.049 0.94
215_G 220_S 1.031 0.94
250_L 278_T 1.029 0.94
42_A 45_L 1.027 0.94
159_A 195_A 1.025 0.93
199_Y 202_L 1.02 0.93
176_R 236_K 1.016 0.93
243_D 246_A 1.014 0.93
295_Q 314_V 1.014 0.93
198_E 202_L 1.014 0.93
2_A 45_L 1.006 0.93
91_T 294_S 1.005 0.93
130_A 134_A 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3dbiA30.97251000.043Contact Map0.761
2hsgA10.97551000.044Contact Map0.794
2o20A80.96941000.047Contact Map0.862
1qpzA10.97251000.05Contact Map0.776
3bilA20.96641000.059Contact Map0.672
3kjxA40.97551000.061Contact Map0.78
3e3mA40.97551000.065Contact Map0.828
3h5oA20.96941000.067Contact Map0.796
3ctpA20.95721000.068Contact Map0.748
3jvdA20.9481000.073Contact Map0.686
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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