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OPENSEQ.org
TORT - Periplasmic protein TorT
UniProt: P38683 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12616
Length: 342 (278)
Sequences: 10724
Seq/Len: 38.58
TORT
Paralog alert: 0.89 [within 20: 0.45] - ratio of genomes with paralogs
Cluster includes: ALSB ARAF ASCG CRA CYTR DGAL EBGR GALR GALS GNTR IDNR LACI LSRB MALI PURR RBSB RBSR TORT TRER XYLF YCJW YPHF YTFQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
148_F 190_A 3.909 1.00
166_P 227_D 3.467 1.00
105_A 289_A 2.935 1.00
154_P 253_V 2.683 1.00
243_G 250_L 2.553 1.00
185_V 189_R 2.547 1.00
257_L 275_S 2.475 1.00
156_R 160_Q 2.446 1.00
69_A 72_R 2.372 1.00
152_Y 190_A 2.372 1.00
152_Y 194_G 2.359 1.00
65_G 282_G 2.346 1.00
69_A 287_E 2.322 1.00
216_L 229_V 2.285 1.00
166_P 251_T 2.263 1.00
284_L 287_E 2.246 1.00
141_S 292_Q 2.227 1.00
213_R 245_N 2.187 1.00
151_G 155_G 2.079 1.00
291_R 296_Q 2.078 1.00
70_A 286_V 2.054 1.00
152_Y 191_A 2.023 1.00
158_L 228_V 2.008 1.00
68_E 279_V 1.936 1.00
150_M 255_F 1.921 1.00
152_Y 156_R 1.91 1.00
149_Q 153_Q 1.897 1.00
69_A 283_E 1.863 1.00
48_C 103_A 1.821 1.00
186_E 190_A 1.816 1.00
156_R 191_A 1.809 1.00
148_F 186_E 1.804 1.00
212_Q 238_A 1.775 1.00
213_R 242_E 1.772 1.00
159_V 195_S 1.772 1.00
151_G 230_A 1.76 1.00
168_N 225_E 1.757 1.00
149_Q 152_Y 1.719 1.00
275_S 307_L 1.717 1.00
155_G 188_F 1.704 1.00
168_N 198_R 1.672 1.00
48_C 98_C 1.657 1.00
156_R 195_S 1.654 1.00
172_M 239_A 1.649 1.00
157_Y 161_W 1.637 1.00
49_A 66_M 1.624 1.00
157_Y 160_Q 1.621 1.00
277_Q 280_W 1.618 1.00
170_L 219_M 1.616 1.00
159_V 191_A 1.605 1.00
216_L 239_A 1.604 1.00
217_Q 242_E 1.602 1.00
155_G 159_V 1.562 1.00
280_W 283_E 1.558 1.00
146_P 149_Q 1.541 1.00
156_R 194_G 1.539 1.00
47_L 70_A 1.53 1.00
170_L 226_I 1.527 1.00
69_A 286_V 1.524 1.00
65_G 279_V 1.499 1.00
287_E 291_R 1.491 1.00
130_L 285_A 1.485 1.00
161_W 314_A 1.477 1.00
206_D 211_I 1.456 1.00
217_Q 245_N 1.453 1.00
70_A 77_L 1.45 1.00
153_Q 306_I 1.442 1.00
244_R 269_R 1.44 1.00
69_A 73_Y 1.44 1.00
290_I 294_Q 1.428 1.00
253_V 272_M 1.423 1.00
73_Y 290_I 1.407 0.99
80_L 98_C 1.406 0.99
187_G 191_A 1.379 0.99
189_R 193_A 1.377 0.99
157_Y 314_A 1.374 0.99
280_W 284_L 1.372 0.99
257_L 311_P 1.369 0.99
216_L 243_G 1.364 0.99
242_E 245_N 1.347 0.99
240_M 252_V 1.345 0.99
96_D 120_K 1.334 0.99
155_G 191_A 1.332 0.99
155_G 187_G 1.329 0.99
233_A 273_A 1.324 0.99
231_G 239_A 1.318 0.99
46_K 76_D 1.312 0.99
168_N 227_D 1.307 0.99
151_G 187_G 1.299 0.99
210_E 214_N 1.299 0.99
183_E 186_E 1.289 0.99
166_P 228_V 1.277 0.99
67_Q 71_R 1.27 0.99
213_R 217_Q 1.269 0.99
188_F 192_I 1.265 0.99
150_M 306_I 1.256 0.99
107_L 285_A 1.255 0.99
233_A 236_A 1.251 0.99
238_A 242_E 1.248 0.99
157_Y 310_T 1.243 0.98
45_W 104_E 1.239 0.98
277_Q 304_P 1.235 0.98
148_F 152_Y 1.233 0.98
45_W 75_V 1.231 0.98
205_G 235_A 1.229 0.98
66_M 286_V 1.228 0.98
244_R 267_R 1.225 0.98
223_H 226_I 1.216 0.98
49_A 77_L 1.216 0.98
159_V 197_V 1.21 0.98
174_G 207_N 1.196 0.98
213_R 241_G 1.185 0.98
161_W 310_T 1.184 0.98
148_F 183_E 1.145 0.97
99_K 125_L 1.142 0.97
214_N 218_E 1.136 0.97
188_F 230_A 1.13 0.97
243_G 252_V 1.128 0.97
168_N 200_V 1.117 0.96
203_A 218_E 1.111 0.96
254_S 273_A 1.104 0.96
153_Q 156_R 1.095 0.96
216_L 220_L 1.091 0.96
161_W 251_T 1.089 0.96
283_E 287_E 1.087 0.96
233_A 254_S 1.086 0.96
66_M 107_L 1.083 0.96
80_L 94_Q 1.08 0.95
66_M 282_G 1.077 0.95
192_I 197_V 1.075 0.95
284_L 288_Q 1.067 0.95
190_A 194_G 1.066 0.95
63_N 67_Q 1.064 0.95
154_P 274_A 1.063 0.95
263_R 267_R 1.052 0.95
171_L 185_V 1.05 0.94
231_G 235_A 1.049 0.94
229_V 239_A 1.048 0.94
64_Y 68_E 1.042 0.94
279_V 283_E 1.033 0.94
72_R 283_E 1.027 0.94
68_E 72_R 1.023 0.93
214_N 217_Q 1.023 0.93
256_Y 276_D 1.019 0.93
167_L 227_D 1.018 0.93
64_Y 67_Q 1.017 0.93
157_Y 272_M 1.017 0.93
73_Y 287_E 1.015 0.93
211_I 214_N 1.012 0.93
191_A 194_G 1.01 0.93
154_P 230_A 1.002 0.92
46_K 78_K 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2hsgA10.89471000.239Contact Map0.759
3dbiA30.90641000.24Contact Map0.711
1qpzA10.9241000.241Contact Map0.777
3bilA20.92981000.244Contact Map0.676
2o20A80.88891000.251Contact Map0.825
3kjxA40.90351000.251Contact Map0.781
3e3mA40.92111000.254Contact Map0.8
3ctpA20.89471000.255Contact Map0.723
3h5oA20.90941000.255Contact Map0.768
1jyeA10.94441000.261Contact Map0.778
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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