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OPENSEQ.org
YGHQ - Inner membrane protein YghQ
UniProt: Q46841 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13001
Length: 355 (341)
Sequences: 4537
Seq/Len: 13.30
YGHQ
Paralog alert: 0.70 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: DINF MDTK MURJ RFBX WZXC WZXE YEEO YGHQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
259_S 275_F 3.665 1.00
160_R 163_L 3.366 1.00
45_K 345_G 3.108 1.00
56_V 276_K 3.065 1.00
81_G 157_A 2.855 1.00
274_L 350_E 2.79 1.00
263_V 267_L 2.762 1.00
337_K 341_S 2.677 1.00
331_A 335_V 2.619 1.00
116_I 136_A 2.497 1.00
118_L 121_F 2.362 1.00
48_T 51_M 2.326 1.00
336_G 352_Y 2.3 1.00
24_W 162_D 2.294 1.00
226_L 232_A 2.095 1.00
268_G 271_A 2.031 1.00
349_L 352_Y 2.017 1.00
159_D 302_R 2.006 1.00
89_N 92_Q 1.925 1.00
263_V 272_A 1.895 1.00
312_L 316_K 1.869 1.00
77_V 100_S 1.849 1.00
338_P 341_S 1.845 1.00
119_L 136_A 1.821 1.00
154_I 158_V 1.803 1.00
57_I 264_G 1.798 1.00
267_L 271_A 1.792 1.00
346_V 349_L 1.75 1.00
335_V 339_L 1.733 1.00
31_V 169_A 1.722 1.00
270_A 274_L 1.692 1.00
257_S 260_T 1.626 1.00
262_L 266_V 1.601 1.00
340_I 351_A 1.595 1.00
191_G 195_A 1.584 1.00
309_R 313_L 1.576 1.00
55_L 59_Q 1.566 1.00
277_I 344_F 1.565 1.00
182_A 187_F 1.561 1.00
329_A 333_L 1.53 1.00
259_S 279_M 1.52 1.00
303_L 309_R 1.519 1.00
236_K 240_S 1.515 1.00
162_D 166_V 1.51 1.00
188_G 191_G 1.5 1.00
175_R 199_S 1.498 1.00
35_L 176_A 1.497 1.00
302_R 306_R 1.486 1.00
82_T 157_A 1.476 1.00
306_R 309_R 1.453 1.00
297_Y 301_M 1.438 1.00
40_L 344_F 1.437 1.00
79_Q 83_P 1.42 1.00
49_P 274_L 1.405 0.99
39_A 176_A 1.403 0.99
132_S 136_A 1.401 0.99
296_F 317_S 1.399 0.99
335_V 338_P 1.395 0.99
233_R 241_F 1.392 0.99
92_Q 95_N 1.39 0.99
339_L 343_V 1.388 0.99
53_G 272_A 1.378 0.99
48_T 347_K 1.377 0.99
32_S 172_P 1.375 0.99
28_S 165_A 1.352 0.99
166_V 170_T 1.341 0.99
30_V 34_L 1.336 0.99
232_A 236_K 1.332 0.99
259_S 262_L 1.318 0.99
311_W 315_V 1.311 0.99
327_L 331_A 1.307 0.99
73_T 100_S 1.306 0.99
264_G 272_A 1.291 0.99
332_V 339_L 1.29 0.99
309_R 312_L 1.289 0.99
181_V 185_F 1.283 0.99
16_R 20_R 1.282 0.99
44_G 52_F 1.267 0.99
117_A 120_P 1.265 0.99
42_C 180_V 1.264 0.99
322_G 326_I 1.259 0.99
48_T 348_Y 1.254 0.99
143_I 146_M 1.253 0.99
340_I 352_Y 1.246 0.98
37_L 41_S 1.241 0.98
194_I 197_Y 1.238 0.98
328_V 331_A 1.227 0.98
57_I 272_A 1.227 0.98
116_I 120_P 1.226 0.98
105_I 109_A 1.222 0.98
49_P 348_Y 1.218 0.98
40_L 280_T 1.208 0.98
49_P 347_K 1.203 0.98
58_V 138_L 1.202 0.98
54_V 269_P 1.201 0.98
241_F 244_S 1.201 0.98
263_V 268_G 1.198 0.98
323_G 327_L 1.197 0.98
70_K 74_W 1.196 0.98
273_G 277_I 1.193 0.98
115_G 139_Y 1.191 0.98
277_I 348_Y 1.186 0.98
120_P 136_A 1.186 0.98
25_L 165_A 1.178 0.98
258_C 262_L 1.177 0.98
145_S 200_N 1.176 0.98
178_G 182_A 1.176 0.98
137_A 141_T 1.173 0.98
161_F 295_S 1.171 0.98
268_G 272_A 1.17 0.97
333_L 336_G 1.17 0.97
308_T 312_L 1.166 0.97
114_G 118_L 1.166 0.97
102_S 106_V 1.164 0.97
97_V 154_I 1.164 0.97
300_V 310_P 1.161 0.97
91_Q 95_N 1.159 0.97
159_D 299_E 1.157 0.97
23_A 27_S 1.157 0.97
350_E 353_D 1.155 0.97
73_T 103_L 1.144 0.97
41_S 343_V 1.141 0.97
49_P 273_G 1.137 0.97
275_F 279_M 1.134 0.97
77_V 96_V 1.13 0.97
41_S 44_G 1.128 0.97
82_T 301_M 1.128 0.97
199_S 203_G 1.127 0.97
341_S 349_L 1.124 0.97
25_L 161_F 1.124 0.97
179_S 195_A 1.123 0.97
195_A 199_S 1.122 0.97
167_Q 207_Y 1.115 0.96
35_L 173_F 1.115 0.96
151_P 208_W 1.105 0.96
243_W 247_I 1.094 0.96
26_G 291_L 1.093 0.96
180_V 184_Y 1.09 0.96
299_E 303_L 1.088 0.96
277_I 280_T 1.085 0.96
70_K 104_D 1.081 0.95
22_S 292_L 1.08 0.95
278_A 351_A 1.073 0.95
21_N 159_D 1.072 0.95
81_G 93_F 1.058 0.95
55_L 192_F 1.057 0.95
44_G 344_F 1.056 0.95
44_G 277_I 1.055 0.95
274_L 351_A 1.053 0.95
42_C 46_G 1.046 0.94
303_L 306_R 1.046 0.94
177_A 181_V 1.044 0.94
67_D 70_K 1.035 0.94
181_V 184_Y 1.034 0.94
76_L 80_Y 1.033 0.94
225_K 229_F 1.031 0.94
112_I 143_I 1.029 0.94
109_A 113_V 1.029 0.94
276_K 280_T 1.017 0.93
156_R 161_F 1.016 0.93
226_L 229_F 1.012 0.93
35_L 172_P 1.012 0.93
57_I 126_L 1.012 0.93
46_G 49_P 1.012 0.93
41_S 45_K 1.01 0.93
333_L 337_K 1.01 0.93
242_V 245_T 1.008 0.93
167_Q 203_G 1.007 0.93
78_V 297_Y 1.005 0.93
43_A 52_F 1.005 0.93
117_A 121_F 1.003 0.93
45_K 336_G 1.003 0.93
51_M 189_F 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3w4tA10.98591000.455Contact Map0.541
4lz6A10.98311000.459Contact Map0.483
4humA10.98031000.485Contact Map0.259
3mktA20.96621000.492Contact Map0.334
2zjsY10.38594.40.961Contact Map0.183
3wdoA10.85074.30.962Contact Map0.276
3hzqA10.25922.60.965Contact Map0.269
1nkzB30.11552.30.966Contact Map0.247
3dinC20.38592.30.966Contact Map0.35
3dl8G20.388720.967Contact Map0.003
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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