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MDTK - Multidrug resistance protein MdtK
UniProt: P37340 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12400
Length: 457 (433)
Sequences: 13281
Seq/Len: 30.67
MDTK
Paralog alert: 0.92 [within 20: 0.15] - ratio of genomes with paralogs
Cluster includes: DINF MDTK MURJ RFBX WZXC WZXE YEEO YGHQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
80_R 83_R 4.41 1.00
307_S 310_D 3.987 1.00
236_K 240_Q 3.52 1.00
140_G 202_W 3.386 1.00
156_K 159_P 3.319 1.00
48_A 275_Q 3.164 1.00
108_N 111_Y 2.957 1.00
341_A 354_A 2.862 1.00
336_L 339_Q 2.795 1.00
128_V 132_R 2.73 1.00
129_G 191_V 2.728 1.00
110_G 128_V 2.522 1.00
73_A 300_G 2.512 1.00
68_L 91_G 2.36 1.00
9_R 13_A 2.352 1.00
337_R 359_L 2.344 1.00
383_D 386_S 2.238 1.00
337_R 355_A 2.23 1.00
417_G 420_G 2.228 1.00
273_G 353_L 2.187 1.00
232_P 236_K 2.141 1.00
86_H 231_D 2.07 1.00
302_R 310_D 2.031 1.00
75_L 83_R 2.031 1.00
46_A 126_K 2.024 1.00
367_S 430_T 2.013 1.00
338_E 342_L 1.993 1.00
334_V 359_L 1.976 1.00
133_A 191_V 1.958 1.00
170_V 203_V 1.955 1.00
110_G 114_R 1.952 1.00
385_R 389_Y 1.896 1.00
158_K 162_V 1.856 1.00
356_H 419_A 1.847 1.00
355_A 359_L 1.846 1.00
163_M 208_M 1.817 1.00
295_V 318_G 1.812 1.00
348_P 352_T 1.802 1.00
163_M 207_A 1.797 1.00
338_E 355_A 1.792 1.00
316_R 320_M 1.763 1.00
303_L 381_Y 1.757 1.00
35_M 176_Y 1.731 1.00
136_W 139_P 1.717 1.00
360_L 423_I 1.708 1.00
35_M 179_I 1.706 1.00
167_G 204_M 1.704 1.00
315_A 374_G 1.673 1.00
420_G 424_G 1.67 1.00
19_I 290_S 1.663 1.00
383_D 439_R 1.66 1.00
72_I 153_G 1.66 1.00
140_G 205_F 1.644 1.00
315_A 377_I 1.641 1.00
133_A 194_G 1.634 1.00
125_D 129_G 1.632 1.00
143_F 205_F 1.629 1.00
303_L 311_A 1.618 1.00
308_T 312_Q 1.617 1.00
126_K 129_G 1.615 1.00
188_L 195_V 1.611 1.00
394_A 432_A 1.592 1.00
416_M 423_I 1.583 1.00
88_V 150_Q 1.573 1.00
109_A 128_V 1.565 1.00
302_R 307_S 1.56 1.00
109_A 132_R 1.549 1.00
120_D 268_I 1.542 1.00
95_A 146_V 1.535 1.00
16_I 20_L 1.534 1.00
231_D 234_V 1.531 1.00
174_V 196_A 1.529 1.00
137_G 198_A 1.527 1.00
330_A 334_V 1.525 1.00
40_S 43_D 1.515 1.00
191_V 195_V 1.51 1.00
41_A 347_N 1.508 1.00
313_T 317_T 1.504 1.00
155_A 301_Y 1.494 1.00
36_A 193_C 1.491 1.00
206_L 210_S 1.48 1.00
312_Q 316_R 1.48 1.00
75_L 80_R 1.475 1.00
175_N 193_C 1.474 1.00
357_L 418_P 1.452 1.00
83_R 86_H 1.444 1.00
309_L 313_T 1.43 1.00
15_A 294_A 1.419 1.00
313_T 316_R 1.414 1.00
76_N 84_I 1.408 1.00
247_L 388_F 1.404 0.99
124_A 128_V 1.401 0.99
299_V 311_A 1.397 0.99
339_Q 342_L 1.396 0.99
133_A 195_V 1.388 0.99
390_I 435_M 1.388 0.99
74_Q 78_S 1.387 0.99
42_T 122_A 1.382 0.99
122_A 125_D 1.374 0.99
424_G 428_G 1.373 0.99
111_Y 114_R 1.365 0.99
389_Y 393_T 1.358 0.99
267_G 270_D 1.357 0.99
262_L 407_A 1.351 0.99
32_D 197_T 1.349 0.99
24_A 165_F 1.347 0.99
114_R 124_A 1.346 0.99
263_V 421_F 1.345 0.99
71_V 87_Q 1.341 0.99
398_L 431_S 1.336 0.99
106_L 132_R 1.333 0.99
74_Q 382_K 1.331 0.99
33_T 279_N 1.327 0.99
349_E 352_T 1.327 0.99
162_V 166_I 1.326 0.99
178_F 188_L 1.322 0.99
50_G 131_L 1.322 0.99
322_G 369_S 1.321 0.99
147_A 208_M 1.319 0.99
71_V 241_L 1.314 0.99
402_S 424_G 1.299 0.99
94_L 235_M 1.298 0.99
301_Y 305_Q 1.298 0.99
176_Y 179_I 1.286 0.99
189_G 192_G 1.284 0.99
360_L 419_A 1.283 0.99
262_L 403_G 1.28 0.99
269_V 349_E 1.278 0.99
35_M 175_N 1.278 0.99
169_L 173_P 1.276 0.99
32_D 171_N 1.274 0.99
173_P 177_I 1.273 0.99
133_A 198_A 1.27 0.99
332_F 336_L 1.27 0.99
320_M 324_C 1.266 0.99
434_I 438_L 1.251 0.99
179_I 193_C 1.242 0.98
20_L 161_M 1.238 0.98
277_A 357_L 1.235 0.98
352_T 356_H 1.227 0.98
77_G 304_G 1.218 0.98
353_L 356_H 1.216 0.98
243_L 247_L 1.21 0.98
259_V 403_G 1.204 0.98
176_Y 180_Y 1.203 0.98
159_P 211_Y 1.203 0.98
401_P 405_I 1.2 0.98
407_A 421_F 1.199 0.98
75_L 78_S 1.197 0.98
173_P 176_Y 1.197 0.98
210_S 214_R 1.181 0.98
111_Y 115_S 1.176 0.98
103_M 139_P 1.173 0.98
12_L 16_I 1.173 0.98
298_R 314_A 1.172 0.98
398_L 402_S 1.171 0.98
416_M 420_G 1.169 0.97
38_G 346_D 1.169 0.97
77_G 305_Q 1.168 0.97
270_D 418_P 1.159 0.97
97_F 101_L 1.155 0.97
68_L 72_I 1.154 0.97
367_S 433_A 1.153 0.97
121_P 125_D 1.152 0.97
393_T 397_V 1.144 0.97
81_R 85_A 1.137 0.97
376_G 380_G 1.136 0.97
397_V 401_P 1.136 0.97
339_Q 343_L 1.131 0.97
322_G 373_I 1.125 0.97
403_G 407_A 1.123 0.97
324_C 328_L 1.122 0.97
259_V 274_H 1.121 0.97
47_V 190_G 1.117 0.96
113_I 124_A 1.11 0.96
402_S 427_I 1.108 0.96
251_F 392_F 1.102 0.96
177_I 181_G 1.101 0.96
82_E 86_H 1.095 0.96
110_G 125_D 1.093 0.96
334_V 362_A 1.089 0.96
330_A 366_I 1.085 0.96
171_N 197_T 1.084 0.96
103_M 106_L 1.082 0.96
280_F 340_I 1.08 0.95
310_D 313_T 1.079 0.95
336_L 340_I 1.073 0.95
175_N 196_A 1.07 0.95
174_V 199_A 1.07 0.95
75_L 87_Q 1.069 0.95
114_R 121_P 1.065 0.95
352_T 355_A 1.065 0.95
326_A 369_S 1.063 0.95
91_G 238_L 1.06 0.95
86_H 90_Q 1.058 0.95
311_A 381_Y 1.057 0.95
250_F 254_T 1.05 0.94
406_L 424_G 1.049 0.94
110_G 132_R 1.049 0.94
360_L 426_I 1.048 0.94
163_M 211_Y 1.048 0.94
176_Y 182_H 1.046 0.94
21_A 164_G 1.043 0.94
170_V 174_V 1.043 0.94
342_L 351_V 1.038 0.94
299_V 380_G 1.037 0.94
351_V 354_A 1.033 0.94
113_I 127_A 1.033 0.94
108_N 112_I 1.032 0.94
438_L 441_R 1.031 0.94
90_Q 235_M 1.028 0.94
74_Q 237_R 1.025 0.93
263_V 274_H 1.024 0.93
23_I 27_A 1.018 0.93
10_L 13_A 1.017 0.93
406_L 416_M 1.016 0.93
263_V 418_P 1.012 0.93
233_A 236_K 1.011 0.93
156_K 160_G 1.003 0.93
136_W 198_A 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4humA10.98471000.22Contact Map0.325
3mktA20.99781000.227Contact Map0.401
4lz6A10.9541000.254Contact Map0.585
3w4tA10.97591000.261Contact Map0.736
3wdoA10.853445.20.947Contact Map0.252
2cfqA10.875344.60.947Contact Map0.158
2xutA30.89535.80.95Contact Map0.181
4apsA20.892828.20.952Contact Map0.12
1pw4A10.866525.90.953Contact Map0.159
4ikvA10.899317.10.957Contact Map0.159
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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