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DINF - DNA-damage-inducible protein F
UniProt: P28303 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11491
Length: 459 (428)
Sequences: 11701
Seq/Len: 27.34
DINF
Paralog alert: 0.89 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: DINF MDTK MURJ RFBX WZXC WZXE YEEO YGHQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
99_N 102_A 4.808 1.00
321_D 324_Q 3.974 1.00
159_A 217_Y 3.548 1.00
250_R 254_A 3.511 1.00
175_Y 178_A 3.42 1.00
128_I 131_L 3.124 1.00
67_A 289_A 3.08 1.00
148_R 206_Q 3.023 1.00
350_A 353_H 2.989 1.00
355_I 368_A 2.986 1.00
147_R 151_E 2.865 1.00
130_D 147_R 2.819 1.00
92_A 314_G 2.807 1.00
87_T 110_P 2.514 1.00
351_G 373_I 2.396 1.00
27_K 31_H 2.36 1.00
423_G 426_A 2.346 1.00
65_G 145_Q 2.275 1.00
316_A 324_Q 2.243 1.00
94_A 102_A 2.234 1.00
351_G 369_D 2.196 1.00
287_V 367_L 2.161 1.00
130_D 134_H 2.139 1.00
189_L 218_A 2.134 1.00
196_W 201_L 2.101 1.00
152_I 206_Q 2.019 1.00
396_T 399_T 2.017 1.00
246_R 250_R 1.998 1.00
309_V 332_A 1.988 1.00
53_V 195_V 1.942 1.00
177_R 181_I 1.939 1.00
362_T 366_Q 1.938 1.00
105_R 245_W 1.934 1.00
53_V 198_V 1.913 1.00
348_L 373_I 1.902 1.00
352_E 356_A 1.88 1.00
152_I 209_A 1.866 1.00
186_G 219_T 1.831 1.00
155_L 158_P 1.83 1.00
352_E 369_D 1.812 1.00
162_A 220_L 1.807 1.00
330_R 334_R 1.792 1.00
182_L 222_I 1.789 1.00
139_S 282_S 1.78 1.00
400_E 403_N 1.779 1.00
317_Y 325_L 1.774 1.00
144_E 148_R 1.766 1.00
369_D 373_I 1.764 1.00
34_L 38_F 1.759 1.00
159_A 220_L 1.757 1.00
145_Q 148_R 1.745 1.00
370_R 425_H 1.745 1.00
37_I 304_G 1.742 1.00
114_A 165_V 1.74 1.00
125_R 154_W 1.707 1.00
91_T 172_G 1.702 1.00
129_I 147_R 1.698 1.00
203_M 210_L 1.692 1.00
50_D 212_T 1.69 1.00
426_A 430_A 1.678 1.00
322_G 326_L 1.671 1.00
194_D 208_A 1.663 1.00
182_L 223_G 1.661 1.00
94_A 99_N 1.651 1.00
54_I 208_A 1.647 1.00
156_S 213_V 1.643 1.00
374_W 429_L 1.622 1.00
313_S 325_L 1.616 1.00
193_L 211_A 1.611 1.00
344_S 348_L 1.6 1.00
316_A 321_D 1.593 1.00
107_L 169_W 1.593 1.00
126_T 151_E 1.589 1.00
33_A 308_A 1.572 1.00
221_L 225_L 1.551 1.00
152_I 210_L 1.535 1.00
143_L 147_R 1.532 1.00
422_L 429_L 1.521 1.00
59_S 62_Y 1.518 1.00
206_Q 210_L 1.512 1.00
141_A 144_E 1.509 1.00
134_H 143_L 1.484 1.00
129_I 151_E 1.479 1.00
95_Y 103_L 1.476 1.00
363_Q 366_Q 1.471 1.00
329_W 388_L 1.468 1.00
60_P 361_L 1.452 1.00
188_I 192_V 1.451 1.00
53_V 194_D 1.447 1.00
323_S 327_D 1.446 1.00
50_D 190_N 1.445 1.00
402_R 406_A 1.437 1.00
152_I 213_V 1.433 1.00
166_L 223_G 1.427 1.00
90_L 106_T 1.418 1.00
93_Q 97_A 1.411 1.00
198_V 208_A 1.405 0.99
61_V 141_A 1.405 0.99
381_V 436_A 1.399 0.99
317_Y 395_A 1.398 0.99
327_D 330_R 1.396 0.99
400_E 445_I 1.389 0.99
181_I 185_V 1.386 0.99
326_L 330_R 1.385 0.99
131_L 134_H 1.382 0.99
371_Y 424_N 1.377 0.99
329_W 391_M 1.371 0.99
51_T 293_T 1.368 0.99
69_G 150_L 1.368 0.99
192_V 196_W 1.363 0.99
140_E 144_E 1.361 0.99
96_G 319_A 1.349 0.99
327_D 331_A 1.339 0.99
195_V 199_M 1.332 0.99
38_F 180_V 1.33 0.99
102_A 105_R 1.329 0.99
334_R 338_I 1.319 0.99
283_D 363_Q 1.319 0.99
190_N 212_T 1.319 0.99
440_L 444_A 1.317 0.99
353_H 356_A 1.314 0.99
366_Q 370_R 1.309 0.99
195_V 198_V 1.302 0.99
312_H 328_V 1.291 0.99
197_L 203_M 1.279 0.99
90_L 255_L 1.271 0.99
96_G 318_G 1.269 0.99
277_G 427_L 1.266 0.99
315_Q 319_A 1.265 0.99
196_W 200_G 1.261 0.99
294_L 354_I 1.257 0.99
367_L 370_R 1.256 0.99
94_A 97_A 1.253 0.99
122_A 158_P 1.252 0.99
245_W 248_N 1.252 0.99
178_A 226_M 1.25 0.99
122_A 126_T 1.244 0.98
430_A 434_F 1.235 0.98
353_H 357_L 1.231 0.98
133_L 143_L 1.226 0.98
192_V 195_V 1.222 0.98
348_L 376_V 1.22 0.98
257_R 261_L 1.218 0.98
113_L 249_F 1.217 0.98
193_L 214_I 1.209 0.98
174_Q 315_Q 1.208 0.98
116_G 120_L 1.206 0.98
42_T 184_V 1.192 0.98
30_W 34_L 1.189 0.98
276_L 416_L 1.185 0.98
130_D 144_E 1.17 0.97
338_I 342_L 1.165 0.97
66_V 205_V 1.165 0.97
93_Q 251_R 1.16 0.97
346_V 350_A 1.159 0.97
134_H 140_E 1.158 0.97
374_W 425_H 1.157 0.97
163_N 219_T 1.152 0.97
281_G 284_I 1.152 0.97
197_L 214_I 1.139 0.97
291_L 371_Y 1.136 0.97
133_L 146_A 1.134 0.97
406_A 410_A 1.13 0.97
94_A 106_T 1.13 0.97
101_Q 105_R 1.129 0.97
365_Q 368_A 1.126 0.97
123_L 127_P 1.126 0.97
110_P 252_L 1.122 0.97
378_L 382_G 1.121 0.97
206_Q 209_A 1.119 0.96
189_L 193_L 1.119 0.96
356_A 365_Q 1.118 0.96
379_P 382_G 1.111 0.96
87_T 91_T 1.105 0.96
276_L 420_P 1.104 0.96
170_L 227_V 1.099 0.96
175_Y 179_P 1.098 0.96
131_L 135_I 1.095 0.96
444_A 447_R 1.095 0.96
374_W 432_T 1.089 0.96
150_L 154_W 1.088 0.96
127_P 131_L 1.086 0.96
100_P 104_A 1.085 0.96
284_I 424_N 1.079 0.95
194_D 211_A 1.078 0.95
56_H 360_S 1.07 0.95
350_A 354_I 1.068 0.95
41_I 45_L 1.067 0.95
422_L 426_A 1.054 0.95
345_V 349_L 1.053 0.95
109_Q 249_F 1.051 0.94
366_Q 369_D 1.047 0.94
316_A 328_V 1.039 0.94
115_L 162_A 1.034 0.94
204_N 207_G 1.033 0.94
304_G 308_A 1.032 0.94
391_M 395_A 1.03 0.94
166_L 220_L 1.027 0.94
336_S 387_L 1.026 0.94
39_S 183_L 1.023 0.93
93_Q 317_Y 1.02 0.93
130_D 151_E 1.019 0.93
278_A 285_I 1.017 0.93
95_Y 315_Q 1.016 0.93
195_V 200_G 1.015 0.93
247_G 250_R 1.012 0.93
273_I 416_L 1.011 0.93
185_V 222_I 1.01 0.93
29_L 332_A 1.01 0.93
56_H 199_M 1.009 0.93
182_L 226_M 1.007 0.93
51_T 63_L 1.006 0.93
324_Q 327_D 1.005 0.93
105_R 109_Q 1.003 0.93
54_I 66_V 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4humA10.9631000.326Contact Map0.302
3mktA20.95641000.327Contact Map0.389
4lz6A10.95211000.331Contact Map0.59
3w4tA10.96951000.345Contact Map0.727
4apsA20.87587.60.968Contact Map0.111
3wdoA10.82575.50.97Contact Map0.259
1vpzA20.05665.20.97Contact Map
2cfqA10.85194.60.971Contact Map0.144
2btiA20.05663.80.972Contact Map
2knpA10.0243.60.972Contact Map
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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