| UniProt: | P77377 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13576 | ||
| Length: | 492 (465) | ||
| Sequences: | 12011 | ||
| Seq/Len: | 25.83 |
| WZXC
Paralog alert: 0.91 [within 20: 0.14] - ratio of genomes with paralogs Cluster includes: DINF MDTK MURJ RFBX WZXC WZXE YEEO YGHQ |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 278_D | 281_K | 4.01 | 1.00 | |
| 207_A | 211_R | 3.761 | 1.00 | |
| 45_T | 247_N | 3.56 | 1.00 | |
| 98_L | 101_L | 3.483 | 1.00 | |
| 140_E | 143_K | 3.404 | 1.00 | |
| 112_A | 116_K | 2.879 | 1.00 | |
| 312_V | 323_I | 2.838 | 1.00 | |
| 307_V | 310_N | 2.833 | 1.00 | |
| 124_V | 181_A | 2.832 | 1.00 | |
| 308_S | 324_I | 2.606 | 1.00 | |
| 308_S | 328_Q | 2.593 | 1.00 | |
| 100_D | 112_A | 2.54 | 1.00 | |
| 379_G | 382_G | 2.509 | 1.00 | |
| 203_L | 207_A | 2.499 | 1.00 | |
| 113_P | 170_M | 2.483 | 1.00 | |
| 352_R | 355_I | 2.463 | 1.00 | |
| 245_G | 322_S | 2.279 | 1.00 | |
| 324_I | 328_Q | 2.212 | 1.00 | |
| 309_N | 313_P | 2.198 | 1.00 | |
| 305_M | 328_Q | 2.181 | 1.00 | |
| 5_E | 9_S | 2.153 | 1.00 | |
| 336_L | 392_I | 2.056 | 1.00 | |
| 154_A | 182_V | 2.027 | 1.00 | |
| 96_F | 116_K | 2.019 | 1.00 | |
| 275_I | 281_K | 2.001 | 1.00 | |
| 354_D | 358_K | 1.997 | 1.00 | |
| 99_S | 116_K | 1.975 | 1.00 | |
| 95_V | 119_S | 1.973 | 1.00 | |
| 382_G | 386_G | 1.972 | 1.00 | |
| 117_T | 170_M | 1.967 | 1.00 | |
| 286_F | 343_I | 1.965 | 1.00 | |
| 142_N | 146_M | 1.948 | 1.00 | |
| 100_D | 104_D | 1.892 | 1.00 | |
| 363_K | 394_N | 1.876 | 1.00 | |
| 287_Y | 291_S | 1.831 | 1.00 | |
| 329_L | 385_L | 1.83 | 1.00 | |
| 31_V | 160_V | 1.812 | 1.00 | |
| 147_I | 186_L | 1.806 | 1.00 | |
| 168_L | 171_T | 1.789 | 1.00 | |
| 67_I | 273_A | 1.787 | 1.00 | |
| 124_V | 184_T | 1.778 | 1.00 | |
| 309_N | 324_I | 1.774 | 1.00 | |
| 378_A | 385_L | 1.765 | 1.00 | |
| 325_P | 381_I | 1.744 | 1.00 | |
| 15_A | 263_I | 1.733 | 1.00 | |
| 286_F | 346_L | 1.725 | 1.00 | |
| 117_T | 173_I | 1.725 | 1.00 | |
| 202_S | 205_S | 1.717 | 1.00 | |
| 268_L | 289_L | 1.716 | 1.00 | |
| 31_V | 163_A | 1.711 | 1.00 | |
| 279_T | 283_R | 1.7 | 1.00 | |
| 218_A | 357_F | 1.689 | 1.00 | |
| 99_S | 112_A | 1.688 | 1.00 | |
| 158_C | 175_G | 1.685 | 1.00 | |
| 233_V | 371_I | 1.684 | 1.00 | |
| 139_L | 274_K | 1.68 | 1.00 | |
| 284_V | 288_K | 1.666 | 1.00 | |
| 37_D | 40_Q | 1.646 | 1.00 | |
| 147_I | 187_F | 1.645 | 1.00 | |
| 303_G | 453_I | 1.629 | 1.00 | |
| 127_H | 184_T | 1.624 | 1.00 | |
| 416_L | 420_L | 1.622 | 1.00 | |
| 230_S | 246_Y | 1.618 | 1.00 | |
| 283_R | 287_Y | 1.596 | 1.00 | |
| 29_M | 251_N | 1.591 | 1.00 | |
| 280_E | 284_V | 1.577 | 1.00 | |
| 272_F | 282_L | 1.57 | 1.00 | |
| 12_K | 16_I | 1.563 | 1.00 | |
| 366_L | 393_I | 1.559 | 1.00 | |
| 375_G | 383_V | 1.556 | 1.00 | |
| 230_S | 371_I | 1.556 | 1.00 | |
| 120_L | 123_V | 1.551 | 1.00 | |
| 161_V | 165_F | 1.548 | 1.00 | |
| 121_A | 177_L | 1.546 | 1.00 | |
| 159_T | 172_A | 1.54 | 1.00 | |
| 83_L | 206_V | 1.539 | 1.00 | |
| 170_M | 174_L | 1.539 | 1.00 | |
| 370_A | 386_G | 1.522 | 1.00 | |
| 28_Q | 155_G | 1.503 | 1.00 | |
| 301_L | 305_M | 1.502 | 1.00 | |
| 11_A | 267_V | 1.498 | 1.00 | |
| 20_I | 149_T | 1.481 | 1.00 | |
| 297_N | 338_S | 1.48 | 1.00 | |
| 284_V | 287_Y | 1.465 | 1.00 | |
| 233_V | 375_G | 1.458 | 1.00 | |
| 359_F | 397_L | 1.451 | 1.00 | |
| 75_L | 202_S | 1.447 | 1.00 | |
| 62_I | 65_S | 1.434 | 1.00 | |
| 28_Q | 176_Y | 1.432 | 1.00 | |
| 146_M | 150_S | 1.427 | 1.00 | |
| 151_A | 183_R | 1.424 | 1.00 | |
| 185_L | 189_Y | 1.413 | 1.00 | |
| 326_V | 380_A | 1.412 | 1.00 | |
| 358_K | 362_F | 1.407 | 0.99 | |
| 275_I | 278_D | 1.405 | 0.99 | |
| 303_G | 307_V | 1.4 | 0.99 | |
| 329_L | 381_I | 1.399 | 0.99 | |
| 282_L | 350_K | 1.392 | 0.99 | |
| 428_T | 456_G | 1.391 | 0.99 | |
| 131_F | 187_F | 1.382 | 0.99 | |
| 62_I | 80_L | 1.379 | 0.99 | |
| 84_N | 130_Q | 1.374 | 0.99 | |
| 310_N | 313_P | 1.358 | 0.99 | |
| 374_G | 386_G | 1.356 | 0.99 | |
| 234_L | 238_L | 1.353 | 0.99 | |
| 303_G | 428_T | 1.35 | 0.99 | |
| 234_L | 383_V | 1.349 | 0.99 | |
| 431_V | 459_A | 1.346 | 0.99 | |
| 374_G | 378_A | 1.34 | 0.99 | |
| 204_A | 207_A | 1.339 | 0.99 | |
| 103_G | 111_L | 1.335 | 0.99 | |
| 424_L | 463_M | 1.332 | 0.99 | |
| 153_L | 157_T | 1.328 | 0.99 | |
| 155_G | 176_Y | 1.327 | 0.99 | |
| 386_G | 390_V | 1.326 | 0.99 | |
| 157_T | 161_V | 1.324 | 0.99 | |
| 167_P | 174_L | 1.321 | 0.99 | |
| 117_T | 174_L | 1.321 | 0.99 | |
| 160_V | 164_H | 1.315 | 0.99 | |
| 293_V | 338_S | 1.315 | 0.99 | |
| 47_S | 115_I | 1.302 | 0.99 | |
| 366_L | 370_A | 1.301 | 0.99 | |
| 222_I | 361_V | 1.299 | 0.99 | |
| 239_G | 242_V | 1.295 | 0.99 | |
| 32_L | 172_A | 1.285 | 0.99 | |
| 92_C | 123_V | 1.279 | 0.99 | |
| 163_A | 172_A | 1.278 | 0.99 | |
| 291_S | 295_I | 1.27 | 0.99 | |
| 233_V | 372_V | 1.264 | 0.99 | |
| 281_K | 284_V | 1.263 | 0.99 | |
| 374_G | 382_G | 1.262 | 0.99 | |
| 100_D | 116_K | 1.259 | 0.99 | |
| 79_T | 206_V | 1.258 | 0.99 | |
| 31_V | 159_T | 1.255 | 0.99 | |
| 234_L | 380_A | 1.253 | 0.99 | |
| 371_I | 375_G | 1.252 | 0.99 | |
| 201_F | 206_V | 1.252 | 0.99 | |
| 293_V | 342_P | 1.252 | 0.99 | |
| 336_L | 395_T | 1.249 | 0.99 | |
| 44_L | 169_A | 1.249 | 0.99 | |
| 369_P | 373_I | 1.246 | 0.98 | |
| 302_L | 429_L | 1.246 | 0.98 | |
| 101_L | 104_D | 1.237 | 0.98 | |
| 365_F | 369_P | 1.236 | 0.98 | |
| 159_T | 175_G | 1.235 | 0.98 | |
| 214_A | 218_A | 1.233 | 0.98 | |
| 158_C | 178_V | 1.232 | 0.98 | |
| 230_S | 387_F | 1.231 | 0.98 | |
| 329_L | 388_L | 1.228 | 0.98 | |
| 94_A | 98_L | 1.227 | 0.98 | |
| 234_L | 246_Y | 1.223 | 0.98 | |
| 312_V | 324_I | 1.211 | 0.98 | |
| 215_W | 357_F | 1.21 | 0.98 | |
| 249_A | 326_V | 1.202 | 0.98 | |
| 367_F | 390_V | 1.195 | 0.98 | |
| 367_F | 387_F | 1.194 | 0.98 | |
| 77_L | 134_L | 1.193 | 0.98 | |
| 457_V | 461_V | 1.192 | 0.98 | |
| 271_A | 285_N | 1.191 | 0.98 | |
| 96_F | 100_D | 1.189 | 0.98 | |
| 162_S | 167_P | 1.176 | 0.98 | |
| 16_I | 145_G | 1.174 | 0.98 | |
| 242_V | 380_A | 1.169 | 0.97 | |
| 175_G | 179_N | 1.168 | 0.97 | |
| 34_R | 317_G | 1.167 | 0.97 | |
| 208_P | 351_A | 1.165 | 0.97 | |
| 305_M | 331_C | 1.165 | 0.97 | |
| 320_W | 323_I | 1.163 | 0.97 | |
| 295_I | 464_I | 1.163 | 0.97 | |
| 98_L | 102_I | 1.16 | 0.97 | |
| 238_L | 242_V | 1.158 | 0.97 | |
| 70_K | 73_S | 1.152 | 0.97 | |
| 310_N | 314_L | 1.152 | 0.97 | |
| 245_G | 323_I | 1.149 | 0.97 | |
| 424_L | 428_T | 1.148 | 0.97 | |
| 17_A | 148_E | 1.146 | 0.97 | |
| 38_N | 318_E | 1.146 | 0.97 | |
| 275_I | 285_N | 1.142 | 0.97 | |
| 362_F | 365_F | 1.142 | 0.97 | |
| 117_T | 177_L | 1.135 | 0.97 | |
| 428_T | 432_S | 1.135 | 0.97 | |
| 13_W | 142_N | 1.133 | 0.97 | |
| 80_L | 209_N | 1.132 | 0.97 | |
| 8_I | 12_K | 1.126 | 0.97 | |
| 301_L | 335_L | 1.125 | 0.97 | |
| 234_L | 243_A | 1.124 | 0.97 | |
| 167_P | 171_T | 1.12 | 0.96 | |
| 92_C | 96_F | 1.118 | 0.96 | |
| 385_L | 389_L | 1.116 | 0.96 | |
| 321_N | 325_P | 1.115 | 0.96 | |
| 322_S | 325_P | 1.112 | 0.96 | |
| 340_G | 391_Q | 1.108 | 0.96 | |
| 42_G | 244_G | 1.107 | 0.96 | |
| 370_A | 389_L | 1.106 | 0.96 | |
| 93_V | 97_L | 1.106 | 0.96 | |
| 429_L | 433_Y | 1.106 | 0.96 | |
| 235_A | 243_A | 1.105 | 0.96 | |
| 86_G | 90_V | 1.097 | 0.96 | |
| 378_A | 382_G | 1.097 | 0.96 | |
| 212_F | 353_V | 1.094 | 0.96 | |
| 359_F | 398_S | 1.094 | 0.96 | |
| 427_P | 463_M | 1.09 | 0.96 | |
| 19_V | 23_G | 1.089 | 0.96 | |
| 307_V | 311_F | 1.087 | 0.96 | |
| 309_N | 328_Q | 1.087 | 0.96 | |
| 463_M | 467_S | 1.087 | 0.96 | |
| 222_I | 357_F | 1.085 | 0.96 | |
| 345_S | 349_A | 1.084 | 0.96 | |
| 50_I | 115_I | 1.078 | 0.95 | |
| 73_S | 76_E | 1.076 | 0.95 | |
| 432_S | 456_G | 1.07 | 0.95 | |
| 154_A | 158_C | 1.067 | 0.95 | |
| 253_A | 330_L | 1.067 | 0.95 | |
| 339_V | 395_T | 1.066 | 0.95 | |
| 417_S | 420_L | 1.066 | 0.95 | |
| 158_C | 162_S | 1.063 | 0.95 | |
| 134_L | 138_E | 1.059 | 0.95 | |
| 147_I | 190_F | 1.057 | 0.95 | |
| 128_G | 183_R | 1.053 | 0.95 | |
| 38_N | 241_G | 1.048 | 0.94 | |
| 299_P | 302_L | 1.048 | 0.94 | |
| 37_D | 320_W | 1.043 | 0.94 | |
| 101_L | 105_V | 1.042 | 0.94 | |
| 221_I | 225_L | 1.038 | 0.94 | |
| 372_V | 376_Q | 1.038 | 0.94 | |
| 171_T | 175_G | 1.036 | 0.94 | |
| 150_S | 186_L | 1.03 | 0.94 | |
| 205_S | 208_P | 1.029 | 0.94 | |
| 7_T | 11_A | 1.025 | 0.93 | |
| 131_F | 191_G | 1.021 | 0.93 | |
| 367_F | 371_I | 1.019 | 0.93 | |
| 46_V | 235_A | 1.016 | 0.93 | |
| 121_A | 180_S | 1.014 | 0.93 | |
| 373_I | 377_M | 1.014 | 0.93 | |
| 321_N | 324_I | 1.012 | 0.93 | |
| 229_L | 368_I | 1.011 | 0.93 | |
| 304_L | 331_C | 1.011 | 0.93 | |
| 326_V | 384_T | 1.01 | 0.93 | |
| 333_V | 336_L | 1.008 | 0.93 | |
| 154_A | 179_N | 1.008 | 0.93 | |
| 370_A | 374_G | 1.005 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4lz6A | 1 | 0.8333 | 100 | 0.408 | Contact Map | 0.552 |
| 4humA | 1 | 0.8455 | 100 | 0.417 | Contact Map | 0.293 |
| 3w4tA | 1 | 0.8455 | 100 | 0.418 | Contact Map | 0.699 |
| 3mktA | 2 | 0.8415 | 100 | 0.425 | Contact Map | 0.376 |
| 2cfqA | 1 | 0.7988 | 4.1 | 0.969 | Contact Map | 0.214 |
| 3zuxA | 1 | 0.4187 | 2.6 | 0.972 | Contact Map | 0.186 |
| 1rdtE | 1 | 0.0407 | 2 | 0.974 | Contact Map | |
| 4apsA | 2 | 0.4065 | 1.9 | 0.974 | Contact Map | 0.154 |
| 3wdoA | 1 | 0.4126 | 1.7 | 0.975 | Contact Map | 0.193 |
| 3o7qA | 1 | 0.4512 | 1.5 | 0.976 | Contact Map | 0.273 |
Sequence Conservation (Image Generated using WebLogo v3)