| UniProt: | P76352 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13383 | ||
| Length: | 495 (440) | ||
| Sequences: | 12673 | ||
| Seq/Len: | 28.80 |
| YEEO
Paralog alert: 0.91 [within 20: 0.14] - ratio of genomes with paralogs Cluster includes: DINF MDTK MURJ RFBX WZXC WZXE YEEO YGHQ |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 111_D | 114_R | 4.549 | 1.00 | |
| 341_Q | 344_Q | 3.823 | 1.00 | |
| 270_W | 274_G | 3.519 | 1.00 | |
| 173_A | 235_Y | 3.402 | 1.00 | |
| 189_N | 192_I | 3.377 | 1.00 | |
| 140_F | 143_Q | 3.188 | 1.00 | |
| 79_G | 309_F | 3.12 | 1.00 | |
| 370_F | 373_V | 2.887 | 1.00 | |
| 375_A | 388_V | 2.84 | 1.00 | |
| 162_T | 224_V | 2.768 | 1.00 | |
| 161_L | 165_E | 2.727 | 1.00 | |
| 104_A | 334_G | 2.628 | 1.00 | |
| 142_E | 161_L | 2.62 | 1.00 | |
| 371_A | 393_W | 2.426 | 1.00 | |
| 99_T | 122_S | 2.368 | 1.00 | |
| 40_R | 44_P | 2.271 | 1.00 | |
| 371_A | 389_V | 2.268 | 1.00 | |
| 447_G | 450_G | 2.24 | 1.00 | |
| 307_G | 387_V | 2.171 | 1.00 | |
| 266_F | 270_W | 2.152 | 1.00 | |
| 106_S | 114_R | 2.129 | 1.00 | |
| 417_D | 420_Y | 2.108 | 1.00 | |
| 117_V | 265_N | 2.085 | 1.00 | |
| 142_E | 146_D | 2.066 | 1.00 | |
| 77_G | 159_L | 2.062 | 1.00 | |
| 401_I | 460_A | 2.051 | 1.00 | |
| 336_R | 344_Q | 2.017 | 1.00 | |
| 203_L | 236_I | 1.99 | 1.00 | |
| 166_L | 224_V | 1.983 | 1.00 | |
| 372_G | 376_S | 1.938 | 1.00 | |
| 368_A | 393_W | 1.921 | 1.00 | |
| 66_L | 209_G | 1.915 | 1.00 | |
| 191_K | 195_L | 1.857 | 1.00 | |
| 137_I | 168_V | 1.845 | 1.00 | |
| 372_G | 389_V | 1.831 | 1.00 | |
| 390_I | 449_V | 1.825 | 1.00 | |
| 196_I | 240_A | 1.819 | 1.00 | |
| 382_P | 386_H | 1.811 | 1.00 | |
| 419_R | 423_W | 1.801 | 1.00 | |
| 196_I | 241_I | 1.794 | 1.00 | |
| 329_S | 352_V | 1.791 | 1.00 | |
| 103_V | 186_G | 1.779 | 1.00 | |
| 138_H | 165_E | 1.775 | 1.00 | |
| 417_D | 469_R | 1.773 | 1.00 | |
| 389_V | 393_W | 1.767 | 1.00 | |
| 200_L | 237_G | 1.766 | 1.00 | |
| 350_R | 354_W | 1.762 | 1.00 | |
| 169_L | 172_P | 1.745 | 1.00 | |
| 66_L | 212_I | 1.733 | 1.00 | |
| 394_L | 453_M | 1.728 | 1.00 | |
| 173_A | 238_A | 1.71 | 1.00 | |
| 450_G | 454_G | 1.702 | 1.00 | |
| 166_L | 227_G | 1.697 | 1.00 | |
| 158_A | 162_T | 1.677 | 1.00 | |
| 337_L | 415_A | 1.669 | 1.00 | |
| 337_L | 345_A | 1.663 | 1.00 | |
| 50_F | 324_A | 1.644 | 1.00 | |
| 349_L | 408_L | 1.642 | 1.00 | |
| 141_G | 165_E | 1.641 | 1.00 | |
| 210_I | 215_L | 1.634 | 1.00 | |
| 153_T | 302_T | 1.633 | 1.00 | |
| 159_L | 162_T | 1.628 | 1.00 | |
| 221_L | 228_L | 1.624 | 1.00 | |
| 126_M | 179_I | 1.612 | 1.00 | |
| 446_W | 453_M | 1.601 | 1.00 | |
| 67_V | 226_A | 1.599 | 1.00 | |
| 349_L | 411_G | 1.595 | 1.00 | |
| 176_I | 238_A | 1.595 | 1.00 | |
| 342_I | 346_E | 1.591 | 1.00 | |
| 72_K | 381_D | 1.59 | 1.00 | |
| 119_T | 183_A | 1.588 | 1.00 | |
| 47_V | 51_M | 1.572 | 1.00 | |
| 207_I | 229_G | 1.568 | 1.00 | |
| 141_G | 161_L | 1.562 | 1.00 | |
| 336_R | 341_Q | 1.556 | 1.00 | |
| 71_G | 74_A | 1.549 | 1.00 | |
| 63_S | 230_L | 1.545 | 1.00 | |
| 106_S | 111_D | 1.544 | 1.00 | |
| 265_N | 268_I | 1.538 | 1.00 | |
| 170_S | 231_T | 1.534 | 1.00 | |
| 239_V | 243_W | 1.519 | 1.00 | |
| 364_A | 368_A | 1.512 | 1.00 | |
| 224_V | 228_L | 1.512 | 1.00 | |
| 428_S | 462_R | 1.508 | 1.00 | |
| 347_I | 351_H | 1.471 | 1.00 | |
| 208_S | 226_A | 1.463 | 1.00 | |
| 166_L | 228_L | 1.462 | 1.00 | |
| 46_A | 328_A | 1.461 | 1.00 | |
| 107_L | 115_A | 1.461 | 1.00 | |
| 343_A | 347_I | 1.456 | 1.00 | |
| 296_F | 441_G | 1.453 | 1.00 | |
| 73_D | 155_E | 1.45 | 1.00 | |
| 105_F | 109_K | 1.445 | 1.00 | |
| 346_E | 350_R | 1.432 | 1.00 | |
| 146_D | 157_K | 1.429 | 1.00 | |
| 347_I | 350_R | 1.426 | 1.00 | |
| 391_L | 448_V | 1.425 | 1.00 | |
| 114_R | 117_V | 1.406 | 0.99 | |
| 333_T | 345_A | 1.403 | 0.99 | |
| 157_K | 161_L | 1.39 | 0.99 | |
| 166_L | 231_T | 1.383 | 0.99 | |
| 102_V | 118_A | 1.379 | 0.99 | |
| 212_I | 226_A | 1.377 | 0.99 | |
| 195_L | 199_S | 1.364 | 0.99 | |
| 63_S | 204_N | 1.361 | 0.99 | |
| 464_V | 468_W | 1.359 | 0.99 | |
| 155_E | 158_A | 1.354 | 0.99 | |
| 383_Q | 386_H | 1.353 | 0.99 | |
| 373_V | 376_S | 1.35 | 0.99 | |
| 64_T | 313_S | 1.346 | 0.99 | |
| 143_Q | 146_D | 1.336 | 0.99 | |
| 439_V | 444_L | 1.335 | 0.99 | |
| 81_A | 164_L | 1.329 | 0.99 | |
| 105_F | 416_R | 1.326 | 0.99 | |
| 188_G | 335_R | 1.326 | 0.99 | |
| 66_L | 208_S | 1.321 | 0.99 | |
| 311_A | 391_L | 1.315 | 0.99 | |
| 180_G | 241_I | 1.306 | 0.99 | |
| 454_G | 458_D | 1.3 | 0.99 | |
| 125_I | 269_I | 1.299 | 0.99 | |
| 202_I | 206_I | 1.298 | 0.99 | |
| 356_S | 403_S | 1.297 | 0.99 | |
| 296_F | 437_G | 1.293 | 0.99 | |
| 55_C | 198_G | 1.286 | 0.99 | |
| 281_V | 422_M | 1.283 | 0.99 | |
| 303_S | 383_Q | 1.282 | 0.99 | |
| 335_R | 339_V | 1.281 | 0.99 | |
| 206_I | 210_I | 1.281 | 0.99 | |
| 423_W | 427_L | 1.27 | 0.99 | |
| 354_W | 358_L | 1.269 | 0.99 | |
| 297_V | 451_V | 1.267 | 0.99 | |
| 108_G | 338_G | 1.265 | 0.99 | |
| 432_C | 461_V | 1.262 | 0.99 | |
| 102_V | 275_I | 1.261 | 0.99 | |
| 356_S | 407_V | 1.251 | 0.99 | |
| 387_V | 390_I | 1.249 | 0.99 | |
| 394_L | 449_V | 1.241 | 0.98 | |
| 435_V | 439_V | 1.237 | 0.98 | |
| 332_I | 348_Q | 1.233 | 0.98 | |
| 277_I | 281_V | 1.232 | 0.98 | |
| 211_L | 221_L | 1.227 | 0.98 | |
| 424_V | 465_L | 1.227 | 0.98 | |
| 431_G | 435_V | 1.22 | 0.98 | |
| 222_G | 225_G | 1.214 | 0.98 | |
| 51_M | 194_L | 1.212 | 0.98 | |
| 437_G | 441_G | 1.209 | 0.98 | |
| 439_V | 443_M | 1.208 | 0.98 | |
| 441_G | 451_V | 1.205 | 0.98 | |
| 128_L | 132_L | 1.204 | 0.98 | |
| 209_G | 213_Y | 1.199 | 0.98 | |
| 301_G | 304_V | 1.199 | 0.98 | |
| 386_H | 390_I | 1.198 | 0.98 | |
| 108_G | 339_V | 1.198 | 0.98 | |
| 154_T | 158_A | 1.196 | 0.98 | |
| 106_S | 109_K | 1.196 | 0.98 | |
| 446_W | 450_G | 1.194 | 0.98 | |
| 134_A | 172_P | 1.193 | 0.98 | |
| 145_I | 157_K | 1.192 | 0.98 | |
| 366_L | 370_F | 1.185 | 0.98 | |
| 192_I | 244_V | 1.177 | 0.98 | |
| 427_L | 431_G | 1.177 | 0.98 | |
| 358_L | 362_A | 1.176 | 0.98 | |
| 134_A | 138_H | 1.158 | 0.97 | |
| 112_R | 116_R | 1.157 | 0.97 | |
| 206_I | 209_G | 1.155 | 0.97 | |
| 99_T | 103_V | 1.148 | 0.97 | |
| 142_E | 158_A | 1.145 | 0.97 | |
| 468_W | 472_T | 1.14 | 0.97 | |
| 210_I | 214_G | 1.132 | 0.97 | |
| 401_I | 463_A | 1.13 | 0.97 | |
| 204_N | 230_L | 1.127 | 0.97 | |
| 209_G | 212_I | 1.127 | 0.97 | |
| 78_V | 223_F | 1.121 | 0.97 | |
| 368_A | 396_A | 1.12 | 0.96 | |
| 146_D | 154_T | 1.113 | 0.96 | |
| 106_S | 118_A | 1.11 | 0.96 | |
| 293_T | 437_G | 1.098 | 0.96 | |
| 304_V | 448_V | 1.098 | 0.96 | |
| 135_T | 139_H | 1.093 | 0.96 | |
| 140_F | 144_I | 1.091 | 0.96 | |
| 432_C | 436_V | 1.091 | 0.96 | |
| 43_T | 47_V | 1.09 | 0.96 | |
| 314_I | 374_M | 1.086 | 0.96 | |
| 208_S | 229_G | 1.086 | 0.96 | |
| 122_S | 272_V | 1.086 | 0.96 | |
| 345_A | 415_A | 1.086 | 0.96 | |
| 142_E | 165_E | 1.085 | 0.96 | |
| 370_F | 374_M | 1.082 | 0.96 | |
| 373_V | 377_F | 1.081 | 0.95 | |
| 113_R | 117_V | 1.074 | 0.95 | |
| 121_Q | 269_I | 1.07 | 0.95 | |
| 436_V | 454_G | 1.069 | 0.95 | |
| 207_I | 232_I | 1.065 | 0.95 | |
| 364_A | 400_P | 1.064 | 0.95 | |
| 386_H | 389_V | 1.054 | 0.95 | |
| 360_L | 403_S | 1.054 | 0.95 | |
| 105_F | 337_L | 1.053 | 0.95 | |
| 333_T | 414_G | 1.053 | 0.95 | |
| 336_R | 339_V | 1.05 | 0.94 | |
| 376_S | 385_K | 1.047 | 0.94 | |
| 145_I | 160_A | 1.035 | 0.94 | |
| 203_L | 207_I | 1.033 | 0.94 | |
| 410_A | 414_G | 1.028 | 0.94 | |
| 54_A | 58_L | 1.028 | 0.94 | |
| 189_N | 193_P | 1.026 | 0.94 | |
| 105_F | 271_E | 1.024 | 0.93 | |
| 379_T | 382_P | 1.023 | 0.93 | |
| 344_Q | 347_I | 1.022 | 0.93 | |
| 143_Q | 147_F | 1.022 | 0.93 | |
| 209_G | 215_L | 1.02 | 0.93 | |
| 69_W | 380_Q | 1.02 | 0.93 | |
| 405_S | 459_W | 1.019 | 0.93 | |
| 440_L | 446_W | 1.017 | 0.93 | |
| 139_H | 143_Q | 1.015 | 0.93 | |
| 293_T | 308_N | 1.014 | 0.93 | |
| 436_V | 457_A | 1.012 | 0.93 | |
| 92_F | 175_A | 1.009 | 0.93 | |
| 440_L | 454_G | 1.007 | 0.93 | |
| 39_W | 351_H | 1.005 | 0.93 | |
| 196_I | 244_V | 1.004 | 0.93 | |
| 394_L | 456_F | 1.003 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3mktA | 2 | 0.9192 | 100 | 0.362 | Contact Map | 0.399 |
| 4humA | 1 | 0.9253 | 100 | 0.364 | Contact Map | 0.318 |
| 4lz6A | 1 | 0.897 | 100 | 0.373 | Contact Map | 0.586 |
| 3w4tA | 1 | 0.9131 | 100 | 0.373 | Contact Map | 0.73 |
| 3wdoA | 1 | 0.798 | 61 | 0.953 | Contact Map | 0.254 |
| 2xutA | 3 | 0.8424 | 55.5 | 0.954 | Contact Map | 0.16 |
| 1pw4A | 1 | 0.8343 | 55 | 0.954 | Contact Map | 0.137 |
| 4apsA | 2 | 0.8404 | 49.3 | 0.956 | Contact Map | 0.12 |
| 4av3A | 2 | 0.2869 | 25.9 | 0.962 | Contact Map | 0.231 |
| 3fnnA | 1 | 0.1212 | 25.8 | 0.962 | Contact Map | 0 |
Sequence Conservation (Image Generated using WebLogo v3)