| UniProt: | Q46812 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13062 | ||
| Length: | 442 (423) | ||
| Sequences: | 9788 | ||
| Seq/Len: | 23.14 |
| SSNA
Paralog alert: 0.79 [within 20: 0.28] - ratio of genomes with paralogs Cluster includes: ALLB CODA GUAD IADA NAGA PHNM PHYDA SSNA YAHJ |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 404_M | 409_M | 5.043 | 1.00 | |
| 4_L | 49_M | 4.863 | 1.00 | |
| 362_L | 367_Y | 4.354 | 1.00 | |
| 402_S | 409_M | 4.13 | 1.00 | |
| 26_E | 31_V | 4.015 | 1.00 | |
| 57_G | 120_T | 3.995 | 1.00 | |
| 52_R | 401_H | 3.891 | 1.00 | |
| 49_M | 373_I | 3.755 | 1.00 | |
| 7_V | 49_M | 3.574 | 1.00 | |
| 364_E | 367_Y | 3.405 | 1.00 | |
| 32_A | 365_A | 3.349 | 1.00 | |
| 336_L | 339_D | 3.08 | 1.00 | |
| 55_M | 374_C | 3.045 | 1.00 | |
| 23_I | 54_V | 3.036 | 1.00 | |
| 5_K | 46_F | 2.961 | 1.00 | |
| 368_K | 406_N | 2.955 | 1.00 | |
| 3_I | 24_A | 2.789 | 1.00 | |
| 54_V | 373_I | 2.716 | 1.00 | |
| 363_L | 371_L | 2.693 | 1.00 | |
| 55_M | 372_T | 2.676 | 1.00 | |
| 25_I | 371_L | 2.654 | 1.00 | |
| 251_A | 279_R | 2.525 | 1.00 | |
| 371_L | 404_M | 2.52 | 1.00 | |
| 6_N | 48_E | 2.515 | 1.00 | |
| 339_D | 342_A | 2.478 | 1.00 | |
| 28_D | 368_K | 2.462 | 1.00 | |
| 23_I | 363_L | 2.439 | 1.00 | |
| 45_S | 412_E | 2.438 | 1.00 | |
| 306_N | 350_E | 2.402 | 1.00 | |
| 2_L | 404_M | 2.376 | 1.00 | |
| 5_K | 22_D | 2.371 | 1.00 | |
| 216_A | 219_A | 2.33 | 1.00 | |
| 29_V | 368_K | 2.309 | 1.00 | |
| 403_V | 411_Y | 2.281 | 1.00 | |
| 7_V | 54_V | 2.246 | 1.00 | |
| 33_I | 365_A | 2.171 | 1.00 | |
| 347_N | 350_E | 2.142 | 1.00 | |
| 29_V | 359_K | 2.138 | 1.00 | |
| 4_L | 25_I | 2.122 | 1.00 | |
| 346_T | 362_L | 2.105 | 1.00 | |
| 115_I | 410_V | 2.105 | 1.00 | |
| 18_Q | 21_V | 2.085 | 1.00 | |
| 342_A | 346_T | 2.077 | 1.00 | |
| 28_D | 406_N | 2.073 | 1.00 | |
| 54_V | 371_L | 2.049 | 1.00 | |
| 379_P | 392_A | 2.038 | 1.00 | |
| 375_D | 401_H | 1.998 | 1.00 | |
| 52_R | 375_D | 1.993 | 1.00 | |
| 52_R | 373_I | 1.964 | 1.00 | |
| 34_G | 37_L | 1.913 | 1.00 | |
| 24_A | 32_A | 1.903 | 1.00 | |
| 372_T | 400_V | 1.888 | 1.00 | |
| 9_A | 23_I | 1.887 | 1.00 | |
| 49_M | 54_V | 1.872 | 1.00 | |
| 360_F | 368_K | 1.848 | 1.00 | |
| 172_E | 175_R | 1.837 | 1.00 | |
| 13_H | 364_E | 1.836 | 1.00 | |
| 9_A | 21_V | 1.805 | 1.00 | |
| 99_D | 102_S | 1.801 | 1.00 | |
| 4_L | 371_L | 1.8 | 1.00 | |
| 211_E | 252_Q | 1.786 | 1.00 | |
| 116_K | 420_C | 1.775 | 1.00 | |
| 116_K | 411_Y | 1.756 | 1.00 | |
| 359_K | 368_K | 1.732 | 1.00 | |
| 104_Y | 108_L | 1.722 | 1.00 | |
| 409_M | 412_E | 1.717 | 1.00 | |
| 59_V | 348_G | 1.709 | 1.00 | |
| 217_V | 224_L | 1.684 | 1.00 | |
| 23_I | 371_L | 1.647 | 1.00 | |
| 265_G | 283_L | 1.641 | 1.00 | |
| 55_M | 58_I | 1.634 | 1.00 | |
| 215_E | 219_A | 1.633 | 1.00 | |
| 285_H | 289_S | 1.616 | 1.00 | |
| 3_I | 22_D | 1.598 | 1.00 | |
| 61_S | 284_V | 1.589 | 1.00 | |
| 308_A | 351_L | 1.587 | 1.00 | |
| 282_F | 351_L | 1.581 | 1.00 | |
| 358_A | 367_Y | 1.566 | 1.00 | |
| 402_S | 412_E | 1.564 | 1.00 | |
| 274_T | 278_Q | 1.563 | 1.00 | |
| 284_V | 308_A | 1.56 | 1.00 | |
| 61_S | 308_A | 1.552 | 1.00 | |
| 25_I | 404_M | 1.543 | 1.00 | |
| 405_V | 410_V | 1.535 | 1.00 | |
| 4_L | 404_M | 1.534 | 1.00 | |
| 244_K | 252_Q | 1.526 | 1.00 | |
| 31_V | 365_A | 1.526 | 1.00 | |
| 2_L | 25_I | 1.518 | 1.00 | |
| 211_E | 215_E | 1.513 | 1.00 | |
| 271_D | 274_T | 1.512 | 1.00 | |
| 2_L | 45_S | 1.495 | 1.00 | |
| 174_I | 219_A | 1.494 | 1.00 | |
| 108_L | 145_K | 1.482 | 1.00 | |
| 356_F | 360_F | 1.476 | 1.00 | |
| 270_K | 303_D | 1.469 | 1.00 | |
| 236_S | 240_H | 1.469 | 1.00 | |
| 350_E | 357_G | 1.467 | 1.00 | |
| 373_I | 404_M | 1.461 | 1.00 | |
| 21_V | 33_I | 1.45 | 1.00 | |
| 24_A | 44_A | 1.444 | 1.00 | |
| 149_R | 406_N | 1.434 | 1.00 | |
| 308_A | 347_N | 1.425 | 1.00 | |
| 55_M | 341_F | 1.419 | 1.00 | |
| 61_S | 348_G | 1.405 | 0.99 | |
| 212_M | 215_E | 1.405 | 0.99 | |
| 342_A | 347_N | 1.402 | 0.99 | |
| 346_T | 350_E | 1.395 | 0.99 | |
| 24_A | 31_V | 1.387 | 0.99 | |
| 341_F | 345_L | 1.381 | 0.99 | |
| 149_R | 370_D | 1.373 | 0.99 | |
| 275_L | 278_Q | 1.368 | 0.99 | |
| 104_Y | 141_D | 1.367 | 0.99 | |
| 47_K | 404_M | 1.356 | 0.99 | |
| 216_A | 220_T | 1.355 | 0.99 | |
| 115_I | 405_V | 1.354 | 0.99 | |
| 59_V | 121_S | 1.338 | 0.99 | |
| 380_T | 399_S | 1.337 | 0.99 | |
| 7_V | 373_I | 1.335 | 0.99 | |
| 382_L | 393_F | 1.331 | 0.99 | |
| 282_F | 306_N | 1.328 | 0.99 | |
| 372_T | 403_V | 1.327 | 0.99 | |
| 30_I | 363_L | 1.322 | 0.99 | |
| 206_P | 209_G | 1.315 | 0.99 | |
| 346_T | 367_Y | 1.314 | 0.99 | |
| 275_L | 279_R | 1.311 | 0.99 | |
| 47_K | 402_S | 1.309 | 0.99 | |
| 401_H | 413_D | 1.303 | 0.99 | |
| 137_S | 141_D | 1.294 | 0.99 | |
| 13_H | 16_K | 1.29 | 0.99 | |
| 354_R | 360_F | 1.284 | 0.99 | |
| 123_I | 352_M | 1.282 | 0.99 | |
| 207_D | 211_E | 1.282 | 0.99 | |
| 115_I | 403_V | 1.276 | 0.99 | |
| 22_D | 37_L | 1.275 | 0.99 | |
| 53_I | 376_Y | 1.275 | 0.99 | |
| 225_H | 263_A | 1.274 | 0.99 | |
| 400_V | 403_V | 1.274 | 0.99 | |
| 59_V | 349_N | 1.27 | 0.99 | |
| 114_A | 122_V | 1.265 | 0.99 | |
| 6_N | 20_G | 1.265 | 0.99 | |
| 4_L | 47_K | 1.253 | 0.99 | |
| 141_D | 145_K | 1.248 | 0.99 | |
| 286_N | 289_S | 1.234 | 0.98 | |
| 373_I | 402_S | 1.233 | 0.98 | |
| 353_S | 357_G | 1.229 | 0.98 | |
| 59_V | 360_F | 1.228 | 0.98 | |
| 21_V | 35_D | 1.226 | 0.98 | |
| 374_C | 400_V | 1.222 | 0.98 | |
| 411_Y | 416_F | 1.217 | 0.98 | |
| 6_N | 50_H | 1.206 | 0.98 | |
| 223_G | 353_S | 1.199 | 0.98 | |
| 308_A | 348_G | 1.196 | 0.98 | |
| 6_N | 49_M | 1.196 | 0.98 | |
| 138_T | 142_A | 1.192 | 0.98 | |
| 221_G | 259_K | 1.183 | 0.98 | |
| 210_L | 226_I | 1.182 | 0.98 | |
| 248_A | 252_Q | 1.171 | 0.98 | |
| 268_L | 304_I | 1.162 | 0.97 | |
| 276_L | 283_L | 1.155 | 0.97 | |
| 30_I | 371_L | 1.152 | 0.97 | |
| 237_Y | 240_H | 1.151 | 0.97 | |
| 375_D | 378_S | 1.149 | 0.97 | |
| 262_V | 265_G | 1.142 | 0.97 | |
| 115_I | 411_Y | 1.141 | 0.97 | |
| 6_N | 51_G | 1.132 | 0.97 | |
| 23_I | 33_I | 1.131 | 0.97 | |
| 65_F | 122_V | 1.127 | 0.97 | |
| 8_T | 18_Q | 1.124 | 0.97 | |
| 120_T | 403_V | 1.121 | 0.97 | |
| 8_T | 20_G | 1.118 | 0.96 | |
| 153_C | 198_G | 1.112 | 0.96 | |
| 64_H | 312_D | 1.108 | 0.96 | |
| 251_A | 275_L | 1.107 | 0.96 | |
| 4_L | 54_V | 1.107 | 0.96 | |
| 168_E | 172_E | 1.107 | 0.96 | |
| 419_D | 422_S | 1.106 | 0.96 | |
| 138_T | 141_D | 1.106 | 0.96 | |
| 344_A | 348_G | 1.103 | 0.96 | |
| 362_L | 365_A | 1.096 | 0.96 | |
| 218_K | 259_K | 1.088 | 0.96 | |
| 21_V | 34_G | 1.087 | 0.96 | |
| 422_S | 426_Q | 1.085 | 0.96 | |
| 121_S | 151_M | 1.075 | 0.95 | |
| 349_N | 361_G | 1.066 | 0.95 | |
| 121_S | 360_F | 1.061 | 0.95 | |
| 65_F | 110_C | 1.061 | 0.95 | |
| 207_D | 252_Q | 1.056 | 0.95 | |
| 217_V | 222_R | 1.054 | 0.95 | |
| 5_K | 48_E | 1.045 | 0.94 | |
| 169_G | 172_E | 1.04 | 0.94 | |
| 227_H | 312_D | 1.037 | 0.94 | |
| 270_K | 300_H | 1.018 | 0.93 | |
| 288_R | 324_F | 1.015 | 0.93 | |
| 276_L | 280_D | 1.009 | 0.93 | |
| 149_R | 405_V | 1.008 | 0.93 | |
| 370_D | 405_V | 1.001 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4dzhA | 1 | 0.9525 | 100 | 0.233 | Contact Map | 0.754 |
| 3ls9A | 2 | 0.957 | 100 | 0.259 | Contact Map | 0.786 |
| 4gbdA | 2 | 0.948 | 100 | 0.262 | Contact Map | 0.791 |
| 3lnpA | 1 | 0.957 | 100 | 0.263 | Contact Map | 0.798 |
| 4f0rA | 1 | 0.9525 | 100 | 0.275 | Contact Map | 0.818 |
| 2pajA | 1 | 0.9729 | 100 | 0.28 | Contact Map | 0.732 |
| 3h4uA | 2 | 0.9638 | 100 | 0.283 | Contact Map | 0.764 |
| 4f0lA | 2 | 0.9389 | 100 | 0.312 | Contact Map | 0.606 |
| 1p1mA | 1 | 0.8937 | 100 | 0.312 | Contact Map | 0.756 |
| 3mduA | 1 | 0.9412 | 100 | 0.32 | Contact Map | 0.623 |
Sequence Conservation (Image Generated using WebLogo v3)