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OPENSEQ.org
PHYDA - D-phenylhydantoinase
UniProt: Q46806 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13056
Length: 461 (445)
Sequences: 7761
Seq/Len: 17.44
PHYDA
Paralog alert: 0.78 [within 20: 0.20] - ratio of genomes with paralogs
Cluster includes: ALLB CODA GUAD IADA NAGA PHNM PHYDA SSNA YAHJ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
5_I 46_A 4.818 1.00
429_L 434_T 4.558 1.00
49_C 426_V 3.966 1.00
24_E 29_R 3.719 1.00
30_Q 385_P 3.686 1.00
21_L 51_V 3.619 1.00
427_R 434_T 3.611 1.00
382_L 387_S 3.533 1.00
8_G 46_A 3.483 1.00
383_L 391_V 3.467 1.00
54_G 88_T 3.457 1.00
46_A 393_I 3.345 1.00
42_E 437_C 3.26 1.00
8_G 51_V 3.095 1.00
358_T 361_R 3.012 1.00
51_V 393_I 3.012 1.00
361_R 364_E 2.96 1.00
384_A 387_S 2.946 1.00
399_S 420_T 2.933 1.00
140_P 174_E 2.81 1.00
4_L 22_L 2.804 1.00
3_V 429_L 2.803 1.00
23_I 391_V 2.743 1.00
6_K 43_E 2.729 1.00
52_F 394_I 2.618 1.00
52_F 392_V 2.534 1.00
228_Q 255_N 2.523 1.00
6_K 20_D 2.416 1.00
84_C 436_F 2.4 1.00
388_D 431_R 2.395 1.00
428_T 436_F 2.389 1.00
26_G 388_D 2.373 1.00
31_L 385_P 2.32 1.00
49_C 393_I 2.266 1.00
292_V 296_D 2.237 1.00
10_V 21_L 2.22 1.00
27_I 388_D 2.202 1.00
376_L 380_K 2.191 1.00
369_M 372_R 2.177 1.00
3_V 23_I 2.158 1.00
263_T 267_Y 2.142 1.00
49_C 395_D 2.141 1.00
32_G 35_I 2.14 1.00
395_D 426_V 2.116 1.00
391_V 429_L 2.097 1.00
27_I 379_Q 2.088 1.00
2_R 24_E 2.057 1.00
7_N 45_D 2.057 1.00
21_L 383_L 2.046 1.00
380_K 388_D 2.03 1.00
220_I 245_G 2.014 1.00
400_Q 424_A 2.008 1.00
5_I 23_I 1.999 1.00
247_D 251_L 1.998 1.00
83_A 120_I 1.994 1.00
51_V 391_V 1.975 1.00
364_E 368_A 1.896 1.00
172_L 179_T 1.888 1.00
221_A 248_Y 1.865 1.00
250_R 304_D 1.839 1.00
10_V 19_Q 1.822 1.00
143_V 177_A 1.817 1.00
144_E 175_S 1.807 1.00
2_R 22_L 1.797 1.00
171_R 174_E 1.778 1.00
83_A 435_I 1.766 1.00
140_P 144_E 1.76 1.00
22_L 30_Q 1.757 1.00
46_A 51_V 1.755 1.00
167_Q 170_R 1.751 1.00
8_G 393_I 1.75 1.00
91_I 374_F 1.733 1.00
236_Y 260_W 1.723 1.00
299_W 303_S 1.712 1.00
58_V 309_V 1.703 1.00
121_D 431_R 1.652 1.00
368_A 372_R 1.649 1.00
434_T 437_C 1.635 1.00
309_V 373_L 1.608 1.00
402_I 421_C 1.608 1.00
19_Q 31_L 1.606 1.00
4_L 20_D 1.599 1.00
403_Q 406_H 1.594 1.00
44_I 429_L 1.588 1.00
253_R 308_D 1.588 1.00
255_N 259_V 1.558 1.00
430_S 435_I 1.552 1.00
292_V 295_Q 1.54 1.00
138_E 141_M 1.527 1.00
426_V 438_D 1.523 1.00
395_D 398_Q 1.523 1.00
56_V 371_A 1.508 1.00
372_R 382_L 1.502 1.00
76_F 80_R 1.491 1.00
307_I 372_R 1.488 1.00
52_F 55_G 1.478 1.00
427_R 437_C 1.476 1.00
393_I 429_L 1.471 1.00
368_A 382_L 1.466 1.00
243_G 293_R 1.465 1.00
58_V 374_F 1.462 1.00
404_H 417_E 1.458 1.00
9_T 18_K 1.455 1.00
379_Q 388_D 1.449 1.00
5_I 51_V 1.443 1.00
364_E 369_M 1.441 1.00
300_C 304_D 1.432 1.00
258_P 373_L 1.41 1.00
201_L 222_R 1.408 1.00
108_E 112_G 1.406 0.99
436_F 441_F 1.404 0.99
5_I 391_V 1.387 0.99
250_R 306_A 1.383 0.99
221_A 255_N 1.377 0.99
264_C 267_Y 1.375 0.99
399_S 422_Q 1.367 0.99
16_Q 360_E 1.357 0.99
83_A 428_T 1.356 0.99
363_V 367_S 1.353 0.99
50_Y 396_P 1.35 0.99
62_F 90_I 1.35 0.99
23_I 429_L 1.343 0.99
56_V 370_P 1.339 0.99
109_V 113_Y 1.335 0.99
44_I 427_R 1.335 0.99
392_V 425_I 1.326 0.99
26_G 431_R 1.326 0.99
109_V 112_G 1.324 0.99
247_D 304_D 1.319 0.99
350_S 354_T 1.311 0.99
58_V 262_E 1.306 0.99
398_Q 426_V 1.303 0.99
5_I 393_I 1.286 0.99
378_P 387_S 1.285 0.99
268_L 298_L 1.279 0.99
285_L 337_L 1.269 0.99
29_R 385_P 1.264 0.99
166_L 170_R 1.263 0.99
21_L 391_V 1.261 0.99
172_L 177_A 1.258 0.99
251_L 255_N 1.253 0.99
140_P 171_R 1.224 0.98
20_D 35_I 1.218 0.98
9_T 16_Q 1.217 0.98
56_V 89_T 1.215 0.98
224_I 259_V 1.21 0.98
62_F 78_G 1.205 0.98
8_G 391_V 1.2 0.98
21_L 31_L 1.197 0.98
240_L 249_L 1.196 0.98
88_T 428_T 1.173 0.98
301_G 306_A 1.172 0.98
297_K 300_C 1.168 0.97
401_Q 420_T 1.168 0.97
136_L 167_Q 1.167 0.97
393_I 427_R 1.165 0.97
140_P 175_S 1.161 0.97
22_L 41_Y 1.158 0.97
105_H 109_V 1.15 0.97
270_L 346_L 1.15 0.97
16_Q 19_Q 1.149 0.97
7_N 47_T 1.146 0.97
4_L 43_E 1.145 0.97
84_C 408_H 1.142 0.97
347_L 366_T 1.141 0.97
22_L 29_R 1.139 0.97
3_V 42_E 1.128 0.97
246_L 304_D 1.126 0.97
244_L 247_D 1.121 0.97
5_I 429_L 1.118 0.96
7_N 18_K 1.113 0.96
260_W 373_L 1.109 0.96
371_A 381_G 1.101 0.96
300_C 303_S 1.096 0.96
392_V 428_T 1.095 0.96
425_I 428_T 1.094 0.96
309_V 369_M 1.088 0.96
251_L 254_A 1.083 0.96
58_V 370_P 1.083 0.96
398_Q 424_A 1.08 0.95
162_D 222_R 1.076 0.95
262_E 309_V 1.075 0.95
52_F 363_V 1.068 0.95
42_E 434_T 1.064 0.95
170_R 174_E 1.063 0.95
20_D 32_G 1.06 0.95
205_R 276_D 1.056 0.95
71_S 74_D 1.054 0.95
196_F 202_T 1.049 0.94
291_N 294_E 1.049 0.94
89_T 390_D 1.045 0.94
143_V 175_S 1.041 0.94
150_F 177_A 1.032 0.94
46_A 427_R 1.027 0.94
372_R 377_W 1.027 0.94
55_G 366_T 1.022 0.93
44_I 434_T 1.017 0.93
133_H 137_D 1.016 0.93
51_V 383_L 1.015 0.93
2_R 41_Y 1.013 0.93
249_L 261_V 1.011 0.93
357_I 365_L 1.009 0.93
368_A 387_S 1.004 0.93
194_A 198_A 1.003 0.93
83_A 430_S 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ftyA40.99781000.209Contact Map0.777
3dc8A20.98261000.217Contact Map0.808
4b90A20.99351000.22Contact Map0.791
1nfgA40.98261000.222Contact Map0.798
4bknA20.99351000.226Contact Map0.815
2ftwA10.99131000.228Contact Map0.767
4gz7A10.99351000.23Contact Map0.804
1gkpA60.98481000.23Contact Map0.819
4lcqA10.99351000.233Contact Map0.791
2vr2A10.99351000.233Contact Map0.786
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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