| UniProt: | P25524 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11326 | ||
| Length: | 427 (405) | ||
| Sequences: | 11246 | ||
| Seq/Len: | 27.77 |
| CODA
Paralog alert: 0.83 [within 20: 0.29] - ratio of genomes with paralogs Cluster includes: ALLB CODA GUAD IADA NAGA PHNM PHYDA SSNA YAHJ |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 399_V | 404_V | 4.974 | 1.00 | |
| 9_I | 49_A | 4.804 | 1.00 | |
| 397_Y | 404_V | 3.966 | 1.00 | |
| 26_Q | 31_S | 3.913 | 1.00 | |
| 49_A | 379_I | 3.904 | 1.00 | |
| 52_G | 396_R | 3.895 | 1.00 | |
| 57_P | 118_Q | 3.691 | 1.00 | |
| 370_A | 373_N | 3.559 | 1.00 | |
| 12_A | 49_A | 3.556 | 1.00 | |
| 32_A | 371_A | 3.514 | 1.00 | |
| 23_I | 54_V | 3.399 | 1.00 | |
| 346_Q | 349_D | 3.34 | 1.00 | |
| 55_I | 380_L | 3.185 | 1.00 | |
| 264_R | 305_S | 2.992 | 1.00 | |
| 10_I | 46_S | 2.962 | 1.00 | |
| 374_S | 401_G | 2.961 | 1.00 | |
| 300_K | 304_E | 2.889 | 1.00 | |
| 369_I | 377_L | 2.819 | 1.00 | |
| 54_V | 379_I | 2.765 | 1.00 | |
| 235_H | 269_S | 2.759 | 1.00 | |
| 25_L | 377_L | 2.756 | 1.00 | |
| 8_T | 24_H | 2.685 | 1.00 | |
| 45_N | 407_S | 2.613 | 1.00 | |
| 28_G | 374_S | 2.599 | 1.00 | |
| 349_D | 352_N | 2.592 | 1.00 | |
| 12_A | 54_V | 2.527 | 1.00 | |
| 204_L | 207_K | 2.514 | 1.00 | |
| 55_I | 378_I | 2.483 | 1.00 | |
| 364_L | 367_Y | 2.47 | 1.00 | |
| 308_N | 360_R | 2.416 | 1.00 | |
| 11_N | 48_D | 2.405 | 1.00 | |
| 52_G | 381_P | 2.396 | 1.00 | |
| 377_L | 399_V | 2.393 | 1.00 | |
| 29_K | 374_S | 2.391 | 1.00 | |
| 54_V | 377_L | 2.307 | 1.00 | |
| 7_Q | 399_V | 2.296 | 1.00 | |
| 10_I | 22_Q | 2.262 | 1.00 | |
| 23_I | 369_I | 2.248 | 1.00 | |
| 381_P | 396_R | 2.173 | 1.00 | |
| 398_S | 406_A | 2.163 | 1.00 | |
| 352_N | 356_H | 2.16 | 1.00 | |
| 114_A | 406_A | 2.133 | 1.00 | |
| 357_H | 360_R | 2.096 | 1.00 | |
| 9_I | 25_L | 2.062 | 1.00 | |
| 33_I | 371_A | 2.061 | 1.00 | |
| 367_Y | 374_S | 2.051 | 1.00 | |
| 52_G | 379_I | 2.019 | 1.00 | |
| 34_D | 37_S | 1.997 | 1.00 | |
| 263_F | 305_S | 1.994 | 1.00 | |
| 28_G | 401_G | 1.977 | 1.00 | |
| 113_I | 405_I | 1.899 | 1.00 | |
| 24_H | 32_A | 1.835 | 1.00 | |
| 378_I | 395_V | 1.823 | 1.00 | |
| 7_Q | 25_L | 1.758 | 1.00 | |
| 264_R | 268_M | 1.755 | 1.00 | |
| 205_A | 212_I | 1.748 | 1.00 | |
| 272_N | 361_T | 1.748 | 1.00 | |
| 49_A | 54_V | 1.73 | 1.00 | |
| 97_T | 100_D | 1.725 | 1.00 | |
| 298_R | 301_E | 1.718 | 1.00 | |
| 14_L | 23_I | 1.714 | 1.00 | |
| 303_L | 349_D | 1.709 | 1.00 | |
| 379_I | 399_V | 1.706 | 1.00 | |
| 23_I | 377_L | 1.69 | 1.00 | |
| 59_V | 358_S | 1.673 | 1.00 | |
| 253_S | 301_E | 1.67 | 1.00 | |
| 356_H | 373_N | 1.668 | 1.00 | |
| 310_C | 361_T | 1.662 | 1.00 | |
| 265_L | 269_S | 1.656 | 1.00 | |
| 8_T | 22_Q | 1.656 | 1.00 | |
| 14_L | 21_W | 1.655 | 1.00 | |
| 302_M | 307_I | 1.64 | 1.00 | |
| 55_I | 58_F | 1.611 | 1.00 | |
| 61_P | 274_V | 1.611 | 1.00 | |
| 265_L | 268_M | 1.599 | 1.00 | |
| 61_P | 310_C | 1.592 | 1.00 | |
| 404_V | 407_S | 1.582 | 1.00 | |
| 102_K | 106_W | 1.575 | 1.00 | |
| 248_T | 273_F | 1.57 | 1.00 | |
| 47_L | 399_V | 1.562 | 1.00 | |
| 59_V | 359_A | 1.559 | 1.00 | |
| 397_Y | 407_S | 1.544 | 1.00 | |
| 200_K | 203_A | 1.538 | 1.00 | |
| 135_K | 139_E | 1.521 | 1.00 | |
| 199_H | 203_A | 1.507 | 1.00 | |
| 203_A | 207_K | 1.507 | 1.00 | |
| 9_I | 377_L | 1.506 | 1.00 | |
| 400_R | 405_I | 1.496 | 1.00 | |
| 352_N | 357_H | 1.491 | 1.00 | |
| 53_L | 382_A | 1.437 | 1.00 | |
| 195_V | 199_H | 1.431 | 1.00 | |
| 301_E | 305_S | 1.423 | 1.00 | |
| 232_A | 236_H | 1.421 | 1.00 | |
| 209_D | 242_R | 1.421 | 1.00 | |
| 112_Q | 120_V | 1.418 | 1.00 | |
| 25_L | 399_V | 1.416 | 1.00 | |
| 12_A | 379_I | 1.411 | 1.00 | |
| 9_I | 399_V | 1.405 | 0.99 | |
| 61_P | 358_S | 1.399 | 0.99 | |
| 102_K | 139_E | 1.397 | 0.99 | |
| 31_S | 371_A | 1.392 | 0.99 | |
| 136_A | 139_E | 1.387 | 0.99 | |
| 24_H | 31_S | 1.387 | 0.99 | |
| 267_K | 307_I | 1.382 | 0.99 | |
| 386_F | 394_P | 1.379 | 0.99 | |
| 174_L | 210_R | 1.379 | 0.99 | |
| 55_I | 351_L | 1.379 | 0.99 | |
| 139_E | 143_E | 1.377 | 0.99 | |
| 301_E | 304_E | 1.362 | 0.99 | |
| 310_C | 357_H | 1.354 | 0.99 | |
| 359_A | 368_G | 1.352 | 0.99 | |
| 360_R | 365_Q | 1.35 | 0.99 | |
| 7_Q | 45_N | 1.348 | 0.99 | |
| 356_H | 360_R | 1.346 | 0.99 | |
| 121_R | 362_L | 1.346 | 0.99 | |
| 139_E | 142_Q | 1.344 | 0.99 | |
| 378_I | 398_S | 1.329 | 0.99 | |
| 380_L | 395_V | 1.327 | 0.99 | |
| 274_V | 310_C | 1.327 | 0.99 | |
| 267_K | 309_V | 1.311 | 0.99 | |
| 21_W | 33_I | 1.306 | 0.99 | |
| 365_Q | 373_N | 1.305 | 0.99 | |
| 22_Q | 37_S | 1.302 | 0.99 | |
| 351_L | 355_T | 1.301 | 0.99 | |
| 395_V | 398_S | 1.299 | 0.99 | |
| 6_L | 24_H | 1.298 | 0.99 | |
| 11_N | 50_E | 1.292 | 0.99 | |
| 24_H | 44_E | 1.285 | 0.99 | |
| 113_I | 400_R | 1.284 | 0.99 | |
| 113_I | 148_I | 1.267 | 0.99 | |
| 59_V | 119_H | 1.261 | 0.99 | |
| 171_E | 208_Y | 1.258 | 0.99 | |
| 47_L | 397_Y | 1.255 | 0.99 | |
| 224_S | 228_E | 1.248 | 0.99 | |
| 379_I | 397_Y | 1.242 | 0.98 | |
| 272_N | 308_N | 1.242 | 0.98 | |
| 6_L | 26_Q | 1.227 | 0.98 | |
| 396_R | 408_T | 1.224 | 0.98 | |
| 251_M | 302_M | 1.221 | 0.98 | |
| 332_L | 350_G | 1.215 | 0.98 | |
| 61_P | 362_L | 1.213 | 0.98 | |
| 21_W | 35_A | 1.212 | 0.98 | |
| 13_R | 18_E | 1.212 | 0.98 | |
| 13_R | 20_L | 1.207 | 0.98 | |
| 366_D | 373_N | 1.203 | 0.98 | |
| 381_P | 384_N | 1.2 | 0.98 | |
| 204_L | 208_Y | 1.196 | 0.98 | |
| 30_I | 377_L | 1.181 | 0.98 | |
| 12_A | 377_L | 1.177 | 0.98 | |
| 376_N | 400_R | 1.173 | 0.98 | |
| 113_I | 398_S | 1.168 | 0.97 | |
| 172_E | 176_L | 1.158 | 0.97 | |
| 140_V | 143_E | 1.157 | 0.97 | |
| 267_K | 305_S | 1.153 | 0.97 | |
| 211_L | 363_N | 1.149 | 0.97 | |
| 30_I | 369_I | 1.147 | 0.97 | |
| 65_L | 108_T | 1.143 | 0.97 | |
| 137_M | 141_K | 1.141 | 0.97 | |
| 205_A | 210_R | 1.13 | 0.97 | |
| 7_Q | 47_L | 1.129 | 0.97 | |
| 45_N | 404_V | 1.127 | 0.97 | |
| 23_I | 33_I | 1.125 | 0.97 | |
| 60_E | 63_I | 1.121 | 0.97 | |
| 336_L | 350_G | 1.121 | 0.97 | |
| 225_R | 228_E | 1.12 | 0.96 | |
| 194_G | 197_S | 1.118 | 0.96 | |
| 199_H | 233_L | 1.117 | 0.96 | |
| 310_C | 358_S | 1.116 | 0.96 | |
| 11_N | 20_L | 1.115 | 0.96 | |
| 10_I | 48_D | 1.114 | 0.96 | |
| 199_H | 236_H | 1.103 | 0.96 | |
| 65_L | 120_V | 1.089 | 0.96 | |
| 59_V | 367_Y | 1.084 | 0.96 | |
| 113_I | 406_A | 1.083 | 0.96 | |
| 263_F | 302_M | 1.08 | 0.95 | |
| 35_A | 38_G | 1.074 | 0.95 | |
| 64_H | 314_D | 1.071 | 0.95 | |
| 266_L | 273_F | 1.064 | 0.95 | |
| 245_A | 248_T | 1.06 | 0.95 | |
| 213_D | 246_S | 1.059 | 0.95 | |
| 175_R | 208_Y | 1.057 | 0.95 | |
| 196_E | 199_H | 1.05 | 0.94 | |
| 167_E | 171_E | 1.042 | 0.94 | |
| 206_Q | 243_V | 1.04 | 0.94 | |
| 11_N | 49_A | 1.035 | 0.94 | |
| 118_Q | 398_S | 1.034 | 0.94 | |
| 198_L | 214_V | 1.034 | 0.94 | |
| 308_N | 357_H | 1.033 | 0.94 | |
| 11_N | 51_Q | 1.032 | 0.94 | |
| 263_F | 301_E | 1.03 | 0.94 | |
| 171_E | 204_L | 1.023 | 0.93 | |
| 9_I | 54_V | 1.019 | 0.93 | |
| 171_E | 207_K | 1.017 | 0.93 | |
| 235_H | 265_L | 1.015 | 0.93 | |
| 169_L | 172_E | 1.013 | 0.93 | |
| 119_H | 367_Y | 1.013 | 0.93 | |
| 385_G | 392_Q | 1.013 | 0.93 | |
| 244_T | 361_T | 1.013 | 0.93 | |
| 171_E | 175_R | 1.005 | 0.93 | |
| 13_R | 53_L | 1.004 | 0.93 | |
| 24_H | 34_D | 1.002 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1ra0A | 1 | 0.9977 | 100 | 0.212 | Contact Map | 0.774 |
| 4dzhA | 1 | 0.9274 | 100 | 0.317 | Contact Map | 0.779 |
| 2qt3A | 2 | 0.9133 | 100 | 0.319 | Contact Map | 0.827 |
| 4gbdA | 2 | 0.9274 | 100 | 0.335 | Contact Map | 0.798 |
| 4f0rA | 1 | 0.9274 | 100 | 0.339 | Contact Map | 0.809 |
| 3lnpA | 1 | 0.9274 | 100 | 0.346 | Contact Map | 0.795 |
| 3ls9A | 2 | 0.9227 | 100 | 0.351 | Contact Map | 0.79 |
| 2pajA | 1 | 0.9344 | 100 | 0.356 | Contact Map | 0.75 |
| 3h4uA | 2 | 0.9415 | 100 | 0.362 | Contact Map | 0.775 |
| 4aqlA | 1 | 0.897 | 100 | 0.363 | Contact Map | 0.731 |
Sequence Conservation (Image Generated using WebLogo v3)