| UniProt: | P76641 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13066 | ||
| Length: | 439 (420) | ||
| Sequences: | 8380 | ||
| Seq/Len: | 19.95 |
| GUAD
Paralog alert: 0.75 [within 20: 0.27] - ratio of genomes with paralogs Cluster includes: ALLB CODA GUAD IADA NAGA PHNM PHYDA SSNA YAHJ |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 429_Y | 434_L | 4.75 | 1.00 | |
| 379_N | 384_K | 4.493 | 1.00 | |
| 43_K | 48_E | 4.117 | 1.00 | |
| 69_Y | 390_V | 4.048 | 1.00 | |
| 77_G | 136_T | 4.014 | 1.00 | |
| 72_K | 426_Y | 3.801 | 1.00 | |
| 427_R | 434_L | 3.697 | 1.00 | |
| 263_H | 291_T | 3.282 | 1.00 | |
| 49_W | 382_P | 3.26 | 1.00 | |
| 381_L | 384_K | 3.215 | 1.00 | |
| 355_S | 358_E | 3.168 | 1.00 | |
| 380_F | 388_F | 2.962 | 1.00 | |
| 74_I | 390_V | 2.941 | 1.00 | |
| 10_A | 69_Y | 2.935 | 1.00 | |
| 358_E | 361_Y | 2.9 | 1.00 | |
| 40_L | 74_I | 2.83 | 1.00 | |
| 75_V | 391_M | 2.782 | 1.00 | |
| 286_D | 318_K | 2.77 | 1.00 | |
| 385_E | 431_D | 2.747 | 1.00 | |
| 75_V | 389_V | 2.74 | 1.00 | |
| 42_I | 388_F | 2.707 | 1.00 | |
| 313_K | 317_Q | 2.61 | 1.00 | |
| 65_R | 437_E | 2.553 | 1.00 | |
| 428_T | 436_Y | 2.474 | 1.00 | |
| 45_G | 385_E | 2.442 | 1.00 | |
| 46_K | 385_E | 2.439 | 1.00 | |
| 366_G | 369_K | 2.331 | 1.00 | |
| 225_L | 228_E | 2.328 | 1.00 | |
| 388_F | 429_Y | 2.318 | 1.00 | |
| 50_F | 382_P | 2.313 | 1.00 | |
| 35_I | 38_G | 2.275 | 1.00 | |
| 321_K | 369_K | 2.273 | 1.00 | |
| 373_L | 377_I | 2.27 | 1.00 | |
| 51_G | 54_E | 2.187 | 1.00 | |
| 40_L | 380_F | 2.186 | 1.00 | |
| 377_I | 385_E | 2.183 | 1.00 | |
| 220_A | 264_Q | 2.149 | 1.00 | |
| 282_E | 314_K | 2.115 | 1.00 | |
| 72_K | 390_V | 2.101 | 1.00 | |
| 361_Y | 365_L | 2.086 | 1.00 | |
| 392_E | 426_Y | 2.058 | 1.00 | |
| 72_K | 392_E | 2.003 | 1.00 | |
| 69_Y | 74_I | 1.983 | 1.00 | |
| 132_R | 436_Y | 1.926 | 1.00 | |
| 81_T | 296_A | 1.922 | 1.00 | |
| 311_N | 314_K | 1.919 | 1.00 | |
| 74_I | 388_F | 1.901 | 1.00 | |
| 13_G | 69_Y | 1.9 | 1.00 | |
| 131_L | 435_V | 1.888 | 1.00 | |
| 15_F | 38_G | 1.882 | 1.00 | |
| 297_F | 301_S | 1.85 | 1.00 | |
| 13_G | 74_I | 1.821 | 1.00 | |
| 365_L | 379_N | 1.82 | 1.00 | |
| 285_W | 318_K | 1.819 | 1.00 | |
| 190_K | 228_E | 1.81 | 1.00 | |
| 41_L | 49_W | 1.805 | 1.00 | |
| 46_K | 376_L | 1.796 | 1.00 | |
| 376_L | 385_E | 1.778 | 1.00 | |
| 226_K | 234_V | 1.776 | 1.00 | |
| 45_G | 431_D | 1.773 | 1.00 | |
| 188_Q | 191_E | 1.765 | 1.00 | |
| 369_K | 374_D | 1.762 | 1.00 | |
| 40_L | 388_F | 1.733 | 1.00 | |
| 315_A | 320_V | 1.693 | 1.00 | |
| 81_T | 323_G | 1.687 | 1.00 | |
| 314_K | 318_K | 1.636 | 1.00 | |
| 430_V | 435_V | 1.629 | 1.00 | |
| 390_V | 429_Y | 1.624 | 1.00 | |
| 8_L | 429_Y | 1.598 | 1.00 | |
| 79_V | 367_G | 1.591 | 1.00 | |
| 375_D | 384_K | 1.587 | 1.00 | |
| 73_L | 393_P | 1.579 | 1.00 | |
| 220_A | 224_R | 1.566 | 1.00 | |
| 67_R | 429_Y | 1.561 | 1.00 | |
| 154_E | 158_H | 1.546 | 1.00 | |
| 150_D | 154_E | 1.545 | 1.00 | |
| 280_L | 315_A | 1.545 | 1.00 | |
| 316_W | 358_E | 1.541 | 1.00 | |
| 39_L | 54_E | 1.522 | 1.00 | |
| 389_V | 425_I | 1.519 | 1.00 | |
| 296_A | 323_G | 1.482 | 1.00 | |
| 246_A | 250_S | 1.479 | 1.00 | |
| 79_V | 368_A | 1.478 | 1.00 | |
| 15_F | 40_L | 1.474 | 1.00 | |
| 277_C | 295_I | 1.474 | 1.00 | |
| 42_I | 429_Y | 1.467 | 1.00 | |
| 365_L | 369_K | 1.466 | 1.00 | |
| 283_K | 286_D | 1.461 | 1.00 | |
| 38_G | 50_F | 1.46 | 1.00 | |
| 294_S | 370_S | 1.437 | 1.00 | |
| 194_E | 229_Y | 1.435 | 1.00 | |
| 139_L | 371_L | 1.425 | 1.00 | |
| 85_Y | 126_F | 1.419 | 1.00 | |
| 434_L | 437_E | 1.415 | 1.00 | |
| 130_L | 138_A | 1.41 | 1.00 | |
| 155_A | 158_H | 1.408 | 1.00 | |
| 48_E | 382_P | 1.407 | 0.99 | |
| 224_R | 228_E | 1.402 | 0.99 | |
| 14_S | 35_I | 1.402 | 0.99 | |
| 286_D | 290_E | 1.397 | 0.99 | |
| 231_D | 271_N | 1.394 | 0.99 | |
| 75_V | 78_F | 1.388 | 0.99 | |
| 361_Y | 366_G | 1.387 | 0.99 | |
| 282_E | 311_N | 1.385 | 0.99 | |
| 260_D | 283_K | 1.381 | 0.99 | |
| 274_F | 277_C | 1.38 | 0.99 | |
| 221_M | 224_R | 1.373 | 0.99 | |
| 120_R | 155_A | 1.363 | 0.99 | |
| 287_R | 290_E | 1.36 | 0.99 | |
| 151_A | 155_A | 1.355 | 0.99 | |
| 360_F | 364_T | 1.35 | 0.99 | |
| 131_L | 428_T | 1.35 | 0.99 | |
| 81_T | 367_G | 1.333 | 0.99 | |
| 323_G | 366_G | 1.328 | 0.99 | |
| 323_G | 370_S | 1.327 | 0.99 | |
| 166_G | 207_T | 1.322 | 0.99 | |
| 298_C | 301_S | 1.322 | 0.99 | |
| 289_S | 320_V | 1.312 | 0.99 | |
| 254_D | 264_Q | 1.308 | 0.99 | |
| 294_S | 321_K | 1.304 | 0.99 | |
| 190_K | 225_L | 1.304 | 0.99 | |
| 289_S | 322_V | 1.304 | 0.99 | |
| 368_A | 378_G | 1.298 | 0.99 | |
| 427_R | 437_E | 1.289 | 0.99 | |
| 9_K | 41_L | 1.286 | 0.99 | |
| 276_H | 327_D | 1.274 | 0.99 | |
| 40_L | 50_F | 1.267 | 0.99 | |
| 183_E | 187_H | 1.266 | 0.99 | |
| 67_R | 427_R | 1.264 | 0.99 | |
| 263_H | 287_R | 1.263 | 0.99 | |
| 235_H | 275_A | 1.262 | 0.99 | |
| 314_K | 317_Q | 1.254 | 0.99 | |
| 85_Y | 138_A | 1.253 | 0.99 | |
| 390_V | 427_R | 1.242 | 0.98 | |
| 389_V | 428_T | 1.242 | 0.98 | |
| 289_S | 318_K | 1.237 | 0.98 | |
| 85_Y | 127_I | 1.233 | 0.98 | |
| 392_E | 395_A | 1.23 | 0.98 | |
| 79_V | 137_T | 1.227 | 0.98 | |
| 131_L | 430_V | 1.224 | 0.98 | |
| 227_E | 271_N | 1.224 | 0.98 | |
| 220_A | 265_Y | 1.222 | 0.98 | |
| 81_T | 371_L | 1.22 | 0.98 | |
| 215_S | 218_Q | 1.219 | 0.98 | |
| 41_L | 48_E | 1.21 | 0.98 | |
| 41_L | 64_I | 1.205 | 0.98 | |
| 75_V | 360_F | 1.2 | 0.98 | |
| 120_R | 154_E | 1.199 | 0.98 | |
| 137_T | 387_D | 1.187 | 0.98 | |
| 12_R | 68_D | 1.186 | 0.98 | |
| 323_G | 367_G | 1.179 | 0.98 | |
| 181_T | 184_S | 1.179 | 0.98 | |
| 190_K | 194_E | 1.178 | 0.98 | |
| 193_I | 232_T | 1.178 | 0.98 | |
| 131_L | 436_Y | 1.173 | 0.98 | |
| 193_I | 229_Y | 1.171 | 0.98 | |
| 47_V | 388_F | 1.168 | 0.97 | |
| 340_L | 359_A | 1.163 | 0.97 | |
| 136_T | 428_T | 1.161 | 0.97 | |
| 391_M | 425_I | 1.155 | 0.97 | |
| 425_I | 428_T | 1.147 | 0.97 | |
| 84_H | 276_H | 1.142 | 0.97 | |
| 137_T | 164_I | 1.132 | 0.97 | |
| 151_A | 154_E | 1.13 | 0.97 | |
| 115_D | 118_Y | 1.128 | 0.97 | |
| 187_H | 191_E | 1.12 | 0.96 | |
| 13_G | 390_V | 1.114 | 0.96 | |
| 285_W | 315_A | 1.111 | 0.96 | |
| 287_R | 291_T | 1.107 | 0.96 | |
| 162_R | 431_D | 1.106 | 0.96 | |
| 365_L | 384_K | 1.104 | 0.96 | |
| 39_L | 51_G | 1.092 | 0.96 | |
| 226_K | 232_T | 1.092 | 0.96 | |
| 84_H | 327_D | 1.09 | 0.96 | |
| 337_L | 340_L | 1.086 | 0.96 | |
| 11_V | 39_L | 1.084 | 0.96 | |
| 260_D | 264_Q | 1.083 | 0.96 | |
| 395_A | 426_Y | 1.074 | 0.95 | |
| 79_V | 377_I | 1.073 | 0.95 | |
| 237_H | 276_H | 1.071 | 0.95 | |
| 132_R | 405_N | 1.07 | 0.95 | |
| 216_P | 264_Q | 1.07 | 0.95 | |
| 247_W | 250_S | 1.065 | 0.95 | |
| 216_P | 220_A | 1.064 | 0.95 | |
| 191_E | 194_E | 1.064 | 0.95 | |
| 136_T | 387_D | 1.063 | 0.95 | |
| 15_F | 380_F | 1.062 | 0.95 | |
| 354_L | 362_L | 1.058 | 0.95 | |
| 131_L | 165_A | 1.049 | 0.94 | |
| 344_Y | 359_A | 1.049 | 0.94 | |
| 398_L | 424_S | 1.041 | 0.94 | |
| 219_M | 236_T | 1.039 | 0.94 | |
| 69_Y | 427_R | 1.037 | 0.94 | |
| 233_W | 271_N | 1.036 | 0.94 | |
| 283_K | 287_R | 1.034 | 0.94 | |
| 369_K | 379_N | 1.033 | 0.94 | |
| 274_F | 288_L | 1.027 | 0.94 | |
| 184_S | 188_Q | 1.023 | 0.93 | |
| 277_C | 280_L | 1.022 | 0.93 | |
| 350_Q | 422_D | 1.014 | 0.93 | |
| 52_E | 55_N | 1.003 | 0.93 | |
| 225_L | 229_Y | 1.002 | 0.92 | |
| 190_K | 229_Y | 1.002 | 0.92 | |
| 41_L | 63_T | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4dzhA | 1 | 0.9362 | 100 | 0.246 | Contact Map | 0.756 |
| 2oodA | 1 | 0.9841 | 100 | 0.251 | Contact Map | 0.716 |
| 2i9uA | 2 | 0.9453 | 100 | 0.27 | Contact Map | 0.732 |
| 4gbdA | 2 | 0.9339 | 100 | 0.273 | Contact Map | 0.789 |
| 4f0rA | 1 | 0.9317 | 100 | 0.275 | Contact Map | 0.826 |
| 3lnpA | 1 | 0.9271 | 100 | 0.281 | Contact Map | 0.777 |
| 2pajA | 1 | 0.9339 | 100 | 0.293 | Contact Map | 0.714 |
| 3ls9A | 2 | 0.9226 | 100 | 0.295 | Contact Map | 0.762 |
| 4aqlA | 1 | 0.9727 | 100 | 0.301 | Contact Map | 0.746 |
| 3h4uA | 2 | 0.9408 | 100 | 0.312 | Contact Map | 0.769 |
Sequence Conservation (Image Generated using WebLogo v3)