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OPENSEQ.org
OPPF - Oligopeptide transport ATP-binding protein OppF
UniProt: P77737 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10678
Length: 334 (318)
Sequences: 10911
Seq/Len: 34.31
OPPF
Paralog alert: 0.89 [within 20: 0.77] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
51_E 234_R 4.494 1.00
102_D 184_K 3.952 1.00
15_A 80_H 3.523 1.00
13_E 46_R 3.489 1.00
16_D 42_G 3.41 1.00
247_G 252_V 3.183 1.00
147_M 180_I 3.149 1.00
19_V 69_A 2.913 1.00
54_G 232_S 2.847 1.00
150_K 214_M 2.83 1.00
84_L 184_K 2.682 1.00
80_H 87_E 2.651 1.00
53_L 236_L 2.604 1.00
236_L 243_A 2.595 1.00
248_T 251_E 2.595 1.00
234_R 246_L 2.592 1.00
150_K 213_E 2.571 1.00
209_Q 213_E 2.523 1.00
41_D 242_H 2.51 1.00
49_E 184_K 2.497 1.00
143_R 146_A 2.407 1.00
308_G 330_K 2.377 1.00
310_E 314_T 2.371 1.00
87_E 90_G 2.365 1.00
48_Y 51_E 2.292 1.00
92_K 95_E 2.25 1.00
136_S 139_E 2.223 1.00
13_E 82_A 2.194 1.00
125_A 144_V 2.165 1.00
143_R 182_E 2.136 1.00
20_H 38_K 2.135 1.00
72_G 96_W 2.132 1.00
84_L 102_D 2.086 1.00
86_K 95_E 2.075 1.00
14_I 17_L 2.064 1.00
18_K 42_G 2.007 1.00
67_A 221_I 1.984 1.00
222_A 228_V 1.924 1.00
145_K 158_I 1.883 1.00
16_D 44_T 1.871 1.00
125_A 140_V 1.866 1.00
149_L 155_P 1.857 1.00
111_L 170_C 1.847 1.00
14_I 45_L 1.846 1.00
106_I 188_C 1.842 1.00
207_L 218_L 1.83 1.00
301_R 312_A 1.791 1.00
21_F 65_T 1.781 1.00
157_L 160_R 1.771 1.00
124_I 148_M 1.754 1.00
165_F 173_I 1.74 1.00
38_K 41_D 1.736 1.00
10_V 48_Y 1.716 1.00
54_G 228_V 1.707 1.00
18_K 78_D 1.691 1.00
52_T 211_Q 1.674 1.00
157_L 165_F 1.673 1.00
55_V 219_I 1.642 1.00
129_R 140_V 1.64 1.00
146_A 150_K 1.621 1.00
121_G 158_I 1.61 1.00
188_C 218_L 1.607 1.00
251_E 255_N 1.574 1.00
307_A 312_A 1.565 1.00
47_L 185_L 1.56 1.00
47_L 219_I 1.552 1.00
15_A 82_A 1.551 1.00
242_H 315_R 1.536 1.00
204_V 227_V 1.534 1.00
236_L 246_L 1.53 1.00
182_E 214_M 1.525 1.00
208_Q 211_Q 1.519 1.00
41_D 299_V 1.51 1.00
15_A 46_R 1.465 1.00
124_I 180_I 1.459 1.00
141_R 145_K 1.452 1.00
86_K 91_M 1.445 1.00
242_H 327_S 1.444 1.00
310_E 329_L 1.437 1.00
45_L 66_F 1.437 1.00
160_R 164_E 1.436 1.00
121_G 159_N 1.426 1.00
140_V 144_V 1.422 1.00
309_P 312_A 1.397 0.99
43_V 66_F 1.396 0.99
141_R 159_N 1.385 0.99
91_M 95_E 1.382 0.99
118_M 122_E 1.382 0.99
96_W 100_R 1.376 0.99
14_I 70_I 1.374 0.99
53_L 246_L 1.372 0.99
141_R 158_I 1.364 0.99
298_C 304_C 1.359 0.99
242_H 299_V 1.352 0.99
304_C 311_C 1.351 0.99
142_E 146_A 1.341 0.99
318_L 327_S 1.341 0.99
119_T 159_N 1.338 0.99
49_E 215_G 1.333 0.99
99_V 103_I 1.331 0.99
309_P 313_K 1.326 0.99
11_L 185_L 1.315 0.99
148_M 158_I 1.31 0.99
15_A 44_T 1.292 0.99
186_I 218_L 1.292 0.99
66_F 238_M 1.29 0.99
296_S 301_R 1.284 0.99
72_G 75_K 1.278 0.99
150_K 209_Q 1.243 0.98
16_D 78_D 1.232 0.98
121_G 141_R 1.224 0.98
246_L 325_S 1.222 0.98
47_L 53_L 1.217 0.98
262_R 306_I 1.215 0.98
52_T 218_L 1.214 0.98
146_A 149_L 1.213 0.98
43_V 243_A 1.211 0.98
152_G 209_Q 1.208 0.98
82_A 87_E 1.189 0.98
250_D 254_H 1.185 0.98
11_L 83_W 1.184 0.98
83_W 185_L 1.181 0.98
298_C 311_C 1.176 0.98
20_H 36_T 1.174 0.98
114_L 173_I 1.169 0.97
83_W 102_D 1.166 0.97
45_L 236_L 1.162 0.97
18_K 38_K 1.161 0.97
124_I 144_V 1.161 0.97
19_V 74_V 1.16 0.97
139_E 142_E 1.159 0.97
132_H 135_M 1.155 0.97
10_V 13_E 1.153 0.97
18_K 41_D 1.153 0.97
91_M 96_W 1.144 0.97
52_T 232_S 1.143 0.97
71_I 105_M 1.135 0.97
298_C 328_C 1.135 0.97
220_F 231_I 1.124 0.97
20_H 41_D 1.122 0.97
138_Q 142_E 1.117 0.96
119_T 122_E 1.113 0.96
235_V 249_Y 1.108 0.96
311_C 328_C 1.106 0.96
145_K 155_P 1.106 0.96
211_Q 233_D 1.093 0.96
55_V 236_L 1.092 0.96
314_T 329_L 1.079 0.95
56_V 228_V 1.078 0.95
320_G 325_S 1.073 0.95
320_G 323_R 1.073 0.95
299_V 315_R 1.06 0.95
49_E 84_L 1.057 0.95
10_V 49_E 1.054 0.95
259_P 262_R 1.036 0.94
122_E 125_A 1.036 0.94
71_I 103_I 1.035 0.94
86_K 102_D 1.035 0.94
154_L 157_L 1.032 0.94
262_R 266_S 1.031 0.94
103_I 185_L 1.031 0.94
67_A 187_I 1.028 0.94
114_L 170_C 1.025 0.93
266_S 282_Q 1.023 0.93
53_L 234_R 1.019 0.93
225_L 253_Y 1.019 0.93
135_M 140_V 1.018 0.93
132_H 143_R 1.018 0.93
49_E 217_S 1.015 0.93
20_H 77_T 1.014 0.93
153_L 157_L 1.014 0.93
95_E 98_A 1.012 0.93
304_C 328_C 1.008 0.93
10_V 46_R 1.007 0.93
21_F 39_A 1.007 0.93
9_K 49_E 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4fwiB10.94311000.139Contact Map0.763
3tuiC40.92511000.366Contact Map0.862
2it1A20.89821000.371Contact Map0.791
1oxxK10.91621000.372Contact Map0.754
2yyzA10.90421000.377Contact Map0.742
1g29120.91621000.379Contact Map0.825
1v43A10.92221000.383Contact Map0.778
3rlfA20.90421000.39Contact Map0.773
3fvqA20.91921000.395Contact Map0.694
1z47A20.91021000.399Contact Map0.797
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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