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MALK - Maltose/maltodextrin import ATP-binding protein MalK
UniProt: P68187 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10558
Length: 371 (355)
Sequences: 8998
Seq/Len: 25.35
MALK
Paralog alert: 0.82 [within 20: 0.12] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
216_G 220_E 4.642 1.00
33_V 201_A 4.469 1.00
119_E 124_A 4.143 1.00
30_E 203_K 3.867 1.00
59_D 66_R 3.801 1.00
213_A 227_D 3.714 1.00
302_G 318_I 3.391 1.00
5_Q 25_D 3.293 1.00
111_N 115_N 3.151 1.00
7_Q 59_D 3.082 1.00
106_K 109_V 2.978 1.00
305_Q 319_Q 2.846 1.00
8_N 21_D 2.805 1.00
126_L 129_R 2.715 1.00
20_K 211_R 2.705 1.00
93_A 128_D 2.656 1.00
8_N 23_N 2.649 1.00
93_A 97_S 2.635 1.00
118_A 127_L 2.613 1.00
113_R 151_E 2.545 1.00
93_A 115_N 2.526 1.00
205_V 212_V 2.475 1.00
63_G 153_S 2.455 1.00
178_R 182_R 2.455 1.00
93_A 114_V 2.44 1.00
32_V 205_V 2.435 1.00
217_K 220_E 2.414 1.00
117_V 149_V 2.412 1.00
48_M 60_L 2.401 1.00
303_E 342_T 2.399 1.00
301_E 342_T 2.389 1.00
62_I 67_M 2.345 1.00
19_S 48_M 2.301 1.00
65_K 153_S 2.265 1.00
93_A 111_N 2.262 1.00
4_V 154_V 2.203 1.00
49_I 188_I 2.159 1.00
6_L 9_V 2.118 1.00
17_V 20_K 2.108 1.00
205_V 215_V 2.095 1.00
27_H 30_E 2.087 1.00
208_D 213_A 2.085 1.00
97_S 114_V 2.038 1.00
76_G 153_S 2.035 1.00
5_Q 61_F 1.979 1.00
338_E 341_A 1.972 1.00
228_R 282_S 1.95 1.00
157_L 187_M 1.95 1.00
303_E 319_Q 1.945 1.00
47_R 53_E 1.914 1.00
301_E 344_A 1.909 1.00
94_E 101_K 1.897 1.00
61_F 66_R 1.884 1.00
10_T 21_D 1.882 1.00
112_Q 116_Q 1.877 1.00
122_Q 171_Q 1.833 1.00
121_L 145_G 1.831 1.00
109_V 112_Q 1.823 1.00
12_A 17_V 1.815 1.00
7_Q 61_F 1.808 1.00
10_T 17_V 1.8 1.00
10_T 57_S 1.796 1.00
6_L 49_I 1.794 1.00
96_M 145_G 1.791 1.00
87_Y 99_G 1.744 1.00
97_S 110_I 1.74 1.00
206_V 230_V 1.732 1.00
11_K 48_M 1.719 1.00
110_I 114_V 1.714 1.00
65_K 70_T 1.701 1.00
222_Y 288_E 1.694 1.00
245_K 280_N 1.648 1.00
11_K 53_E 1.635 1.00
108_E 112_Q 1.621 1.00
228_R 232_G 1.62 1.00
48_M 55_I 1.605 1.00
19_S 45_L 1.602 1.00
228_R 241_F 1.602 1.00
239_M 284_G 1.592 1.00
32_V 215_V 1.582 1.00
105_A 110_I 1.582 1.00
105_A 109_V 1.568 1.00
91_S 94_E 1.567 1.00
6_L 24_L 1.519 1.00
232_G 241_F 1.517 1.00
40_C 207_L 1.5 1.00
241_F 282_S 1.488 1.00
67_M 70_T 1.484 1.00
99_G 150_A 1.478 1.00
115_N 127_L 1.477 1.00
71_P 74_E 1.475 1.00
11_K 56_T 1.474 1.00
313_E 330_R 1.461 1.00
116_Q 151_E 1.457 1.00
61_F 64_E 1.448 1.00
318_I 345_I 1.439 1.00
243_P 280_N 1.437 1.00
96_M 118_A 1.436 1.00
32_V 203_K 1.433 1.00
22_I 45_L 1.431 1.00
109_V 113_R 1.431 1.00
113_R 116_Q 1.413 1.00
117_V 148_L 1.4 0.99
116_Q 119_E 1.399 0.99
220_E 224_Y 1.382 0.99
27_H 203_K 1.371 0.99
59_D 68_N 1.362 0.99
24_L 205_V 1.358 0.99
55_I 60_L 1.356 0.99
307_V 316_I 1.356 0.99
289_H 351_R 1.341 0.99
91_S 130_K 1.34 0.99
66_R 69_D 1.333 0.99
177_S 200_L 1.33 0.99
12_A 57_S 1.322 0.99
6_L 45_L 1.321 0.99
219_L 223_H 1.317 0.99
180_H 185_R 1.313 0.99
161_L 176_I 1.31 0.99
5_Q 64_E 1.303 0.99
244_V 281_M 1.3 0.99
55_I 68_N 1.274 0.99
180_H 187_M 1.271 0.99
115_N 119_E 1.271 0.99
19_S 22_I 1.25 0.99
208_D 229_F 1.244 0.98
78_G 150_A 1.238 0.98
291_L 346_G 1.236 0.98
98_F 102_L 1.228 0.98
115_N 124_A 1.219 0.98
161_L 189_Y 1.212 0.98
24_L 215_V 1.211 0.98
31_F 180_H 1.211 0.98
101_K 107_K 1.2 0.98
107_K 111_N 1.194 0.98
151_E 182_R 1.193 0.98
31_F 200_L 1.189 0.98
34_F 205_V 1.169 0.97
304_V 316_I 1.166 0.97
243_P 282_S 1.16 0.97
10_T 20_K 1.152 0.97
78_G 187_M 1.144 0.97
224_Y 353_H 1.143 0.97
203_K 215_V 1.133 0.97
319_Q 322_S 1.13 0.97
223_H 309_Q 1.121 0.97
9_V 55_I 1.116 0.96
12_A 18_V 1.116 0.96
28_E 63_G 1.105 0.96
70_T 74_E 1.095 0.96
8_N 57_S 1.09 0.96
290_L 347_L 1.089 0.96
84_Y 163_N 1.089 0.96
9_V 48_M 1.085 0.96
116_Q 182_R 1.083 0.96
87_Y 150_A 1.08 0.95
60_L 67_M 1.076 0.95
167_A 232_G 1.069 0.95
216_G 221_L 1.066 0.95
293_S 344_A 1.064 0.95
348_P 351_R 1.063 0.95
122_Q 175_E 1.06 0.95
40_C 45_L 1.055 0.95
194_Q 233_F 1.053 0.95
214_Q 230_V 1.049 0.94
94_E 97_S 1.048 0.94
96_M 117_V 1.047 0.94
285_I 290_L 1.042 0.94
7_Q 23_N 1.035 0.94
302_G 343_F 1.034 0.94
118_A 123_L 1.032 0.94
45_L 207_L 1.027 0.94
291_L 348_P 1.019 0.93
177_S 181_K 1.004 0.93
318_I 329_Y 1.004 0.93
206_V 221_L 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3rlfA211000.188Contact Map0.819
1v43A10.95151000.192Contact Map0.842
2it1A20.96771000.193Contact Map0.857
2yyzA10.95961000.207Contact Map0.773
1g29120.95421000.208Contact Map0.871
1oxxK10.91371000.208Contact Map0.724
3fvqA20.94881000.226Contact Map0.742
3d31A20.91371000.23Contact Map0.731
1z47A20.91911000.249Contact Map0.833
3gd7A40.96771000.288Contact Map0.704
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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