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FTSE - Cell division ATP-binding protein FtsE
UniProt: P0A9R7 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10340
Length: 222 (216)
Sequences: 70614
Seq/Len: 326.92

FTSE
Paralog alert: 0.94 [within 20: 0.84] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
32_F 204_S 3.218 1.00
3_R 24_H 3.066 1.00
29_E 206_R 3.043 1.00
130_K 133_N 2.933 1.00
58_K 65_D 2.901 1.00
5_E 58_K 2.857 1.00
6_H 20_G 2.814 1.00
31_A 208_L 2.713 1.00
123_D 128_L 2.644 1.00
16_Q 19_Q 2.639 1.00
3_R 60_W 2.603 1.00
80_Q 157_A 2.433 1.00
26_Q 29_E 2.423 1.00
19_Q 214_H 2.392 1.00
8_S 20_G 2.221 1.00
9_K 47_L 2.167 1.00
4_F 7_V 2.162 1.00
10_A 16_Q 2.157 1.00
117_R 155_K 2.154 1.00
8_S 16_Q 2.076 1.00
62_S 157_A 2.058 1.00
8_S 56_A 2.049 1.00
119_S 131_A 2.043 1.00
122_L 131_A 1.99 1.00
96_V 138_L 1.977 1.00
5_E 60_W 1.964 1.00
208_L 215_L 1.865 1.00
97_Y 132_K 1.853 1.00
97_Y 131_A 1.8 1.00
97_Y 119_S 1.759 1.00
27_P 157_A 1.757 1.00
155_K 188_V 1.74 1.00
182_E 186_V 1.737 1.00
29_E 205_Y 1.728 1.00
124_K 182_E 1.715 1.00
6_H 22_T 1.699 1.00
11_Y 17_A 1.633 1.00
120_A 124_K 1.601 1.00
9_K 55_S 1.596 1.00
97_Y 118_V 1.559 1.00
115_R 119_S 1.542 1.00
124_K 186_V 1.531 1.00
97_Y 115_R 1.481 1.00
117_R 120_A 1.48 1.00
110_S 113_D 1.478 1.00
97_Y 101_A 1.471 1.00
86_Q 140_G 1.464 1.00
9_K 52_E 1.443 1.00
10_A 55_S 1.44 1.00
133_N 137_Q 1.421 1.00
184_N 205_Y 1.414 1.00
60_W 65_D 1.412 1.00
128_L 131_A 1.387 0.99
45_L 193_A 1.375 0.99
25_M 31_A 1.369 0.99
4_F 48_I 1.347 0.99
23_F 208_L 1.342 0.99
5_E 24_H 1.339 0.99
101_A 118_V 1.322 0.99
116_R 120_A 1.318 0.99
47_L 54_P 1.311 0.99
45_L 160_L 1.307 0.99
101_A 114_I 1.302 0.99
18_L 47_L 1.3 0.99
119_S 123_D 1.271 0.99
8_S 19_Q 1.265 0.99
194_T 200_I 1.263 0.99
70_K 73_E 1.253 0.99
161_A 180_F 1.248 0.99
7_V 54_P 1.235 0.98
4_F 23_F 1.23 0.98
95_T 98_D 1.206 0.98
100_V 153_V 1.193 0.98
119_S 128_L 1.187 0.98
5_E 22_T 1.181 0.98
101_A 115_R 1.169 0.97
96_V 146_V 1.163 0.97
184_N 190_V 1.154 0.97
26_Q 206_R 1.147 0.97
130_K 142_E 1.139 0.97
65_D 68_R 1.137 0.97
48_I 191_L 1.135 0.97
30_M 184_N 1.134 0.97
117_R 121_A 1.131 0.97
99_N 150_R 1.131 0.97
4_F 44_L 1.098 0.96
94_R 98_D 1.092 0.96
181_E 184_N 1.09 0.96
44_L 210_L 1.09 0.96
1_M 62_S 1.09 0.96
121_A 153_V 1.086 0.96
46_K 52_E 1.081 0.95
30_M 190_V 1.079 0.95
9_K 43_T 1.078 0.95
177_L 199_L 1.074 0.95
211_S 216_H 1.067 0.95
21_V 44_L 1.063 0.95
179_L 182_E 1.062 0.95
125_V 149_A 1.061 0.95
31_A 206_R 1.056 0.95
27_P 62_S 1.052 0.95
11_Y 43_T 1.048 0.94
84_I 148_I 1.048 0.94
173_S 199_L 1.044 0.94
100_V 122_L 1.042 0.94
138_L 146_V 1.038 0.94
62_S 80_Q 1.031 0.94
157_A 188_V 1.024 0.93
120_A 123_D 1.022 0.93
49_C 83_M 1.018 0.93
161_A 190_V 1.018 0.93
122_L 127_L 1.016 0.93
47_L 59_I 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiC41100-0.05Contact Map0.894
1oxxK11100-0.04Contact Map0.82
1v43A10.973100-0.04Contact Map0.819
1g29120.9955100-0.039Contact Map0.902
2it1A20.973100-0.039Contact Map0.871
2yyzA10.973100-0.038Contact Map0.812
3fvqA20.991100-0.033Contact Map0.777
1z47A20.973100-0.033Contact Map0.832
3rlfA20.973100-0.033Contact Map0.851
3d31A20.955100-0.019Contact Map0.824

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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