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OPENSEQ.org
DPPD - Dipeptide transport ATP-binding protein DppD
UniProt: P0AAG0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12627
Length: 327 (317)
Sequences: 12404
Seq/Len: 39.13
DPPD
Paralog alert: 0.93 [within 20: 0.81] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
34_E 223_K 4.439 1.00
90_E 173_K 3.927 1.00
7_D 67_K 3.498 1.00
8_K 25_R 3.381 1.00
5_N 29_S 3.352 1.00
134_L 169_A 2.991 1.00
236_G 241_I 2.961 1.00
137_Q 203_E 2.876 1.00
11_V 52_A 2.748 1.00
37_G 221_A 2.727 1.00
24_D 231_Q 2.66 1.00
36_V 225_I 2.653 1.00
71_N 173_K 2.607 1.00
223_K 235_T 2.594 1.00
198_E 202_K 2.588 1.00
225_I 232_V 2.582 1.00
237_D 240_A 2.54 1.00
67_K 74_D 2.512 1.00
32_Q 173_K 2.487 1.00
137_Q 202_K 2.463 1.00
74_D 77_R 2.443 1.00
130_R 133_D 2.334 1.00
5_N 69_E 2.211 1.00
296_R 300_E 2.21 1.00
79_S 82_E 2.181 1.00
31_K 34_E 2.175 1.00
55_G 83_R 2.165 1.00
294_T 317_Y 2.162 1.00
123_N 126_T 2.161 1.00
130_R 171_R 2.131 1.00
10_S 25_R 2.072 1.00
73_Q 82_E 2.068 1.00
113_M 131_A 2.064 1.00
136_N 144_A 2.063 1.00
12_H 21_R 2.042 1.00
6_V 9_L 2.025 1.00
113_M 127_R 1.983 1.00
50_S 210_I 1.957 1.00
71_N 90_E 1.945 1.00
211_T 217_V 1.926 1.00
21_R 24_D 1.921 1.00
146_R 149_V 1.869 1.00
8_K 27_S 1.863 1.00
99_M 159_S 1.855 1.00
196_L 207_L 1.848 1.00
13_F 48_V 1.832 1.00
112_I 135_L 1.803 1.00
6_V 28_Y 1.788 1.00
132_I 147_L 1.781 1.00
37_G 217_V 1.768 1.00
171_R 203_E 1.718 1.00
94_I 177_A 1.692 1.00
35_V 200_Q 1.646 1.00
287_N 298_R 1.645 1.00
154_L 162_V 1.638 1.00
306_M 309_D 1.632 1.00
2_A 31_K 1.618 1.00
133_D 137_Q 1.617 1.00
240_A 244_A 1.614 1.00
146_R 154_L 1.574 1.00
10_S 65_A 1.569 1.00
197_L 200_Q 1.55 1.00
193_I 216_L 1.548 1.00
109_G 147_L 1.547 1.00
7_D 29_S 1.543 1.00
117_K 127_R 1.542 1.00
38_I 208_V 1.534 1.00
30_V 174_L 1.533 1.00
7_D 69_E 1.522 1.00
177_A 207_L 1.5 1.00
225_I 235_T 1.494 1.00
30_V 208_V 1.494 1.00
83_R 87_V 1.451 1.00
78_I 82_E 1.439 1.00
127_R 131_A 1.421 1.00
142_D 145_S 1.414 1.00
293_A 298_R 1.412 1.00
109_G 148_D 1.404 0.99
106_Y 110_F 1.402 0.99
149_V 153_Q 1.401 0.99
24_D 285_L 1.398 0.99
28_Y 49_S 1.389 0.99
128_R 147_L 1.384 0.99
231_Q 301_E 1.359 0.99
7_D 27_S 1.352 0.99
112_I 169_A 1.35 0.99
73_Q 78_I 1.349 0.99
132_I 144_A 1.34 0.99
32_Q 204_N 1.337 0.99
128_R 132_I 1.332 0.99
296_R 316_H 1.325 0.99
107_T 148_D 1.321 0.99
128_R 148_D 1.318 0.99
6_V 53_I 1.315 0.99
30_V 36_V 1.312 0.99
36_V 235_T 1.309 0.99
139_G 198_E 1.301 0.99
26_I 49_S 1.3 0.99
231_Q 314_K 1.297 0.99
295_D 298_R 1.287 0.99
12_H 64_M 1.278 0.99
137_Q 198_E 1.272 0.99
284_C 290_C 1.27 0.99
175_L 207_L 1.27 0.99
304_L 314_K 1.266 0.99
135_L 147_L 1.252 0.99
13_F 22_A 1.248 0.99
49_S 227_M 1.245 0.98
3_L 174_L 1.244 0.98
295_D 299_A 1.227 0.98
239_H 243_H 1.226 0.98
231_Q 285_L 1.223 0.98
15_D 18_A 1.221 0.98
35_V 207_L 1.218 0.98
70_F 90_E 1.211 0.98
109_G 128_R 1.211 0.98
129_Q 133_D 1.21 0.98
26_I 232_V 1.206 0.98
69_E 74_D 1.204 0.98
112_I 131_A 1.197 0.98
10_S 21_R 1.197 0.98
290_C 297_C 1.194 0.98
145_S 149_V 1.185 0.98
140_I 146_R 1.185 0.98
8_K 65_A 1.185 0.98
28_Y 225_I 1.184 0.98
3_L 70_F 1.183 0.98
50_S 176_I 1.181 0.98
248_P 251_Q 1.18 0.98
133_D 136_N 1.165 0.97
120_Q 130_R 1.161 0.97
35_V 221_A 1.158 0.97
86_L 91_V 1.158 0.97
224_I 238_A 1.158 0.97
209_L 220_A 1.151 0.97
54_M 93_M 1.15 0.97
11_V 57_I 1.143 0.97
282_N 287_N 1.143 0.97
10_S 24_D 1.138 0.97
70_F 174_L 1.124 0.97
102_L 159_S 1.12 0.96
102_L 162_V 1.116 0.96
78_I 83_R 1.115 0.96
107_T 110_F 1.11 0.96
235_T 312_Q 1.107 0.96
12_H 19_P 1.098 0.96
32_Q 71_N 1.092 0.96
126_T 129_Q 1.086 0.96
12_H 24_D 1.082 0.96
284_C 297_C 1.078 0.95
55_G 58_D 1.077 0.95
139_G 191_Q 1.076 0.95
251_Q 292_Y 1.07 0.95
57_I 61_G 1.066 0.95
82_E 85_N 1.057 0.95
200_Q 222_H 1.051 0.94
125_S 129_Q 1.051 0.94
11_V 23_V 1.05 0.94
38_I 225_I 1.044 0.94
175_L 205_M 1.038 0.94
251_Q 255_R 1.027 0.94
54_M 91_V 1.018 0.93
57_I 60_P 1.018 0.93
300_E 316_H 1.017 0.93
214_L 242_F 1.016 0.93
39_V 217_V 1.014 0.93
32_Q 206_A 1.01 0.93
284_C 315_C 1.008 0.93
91_V 174_L 1.006 0.93
36_V 223_K 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4fwiB10.99391000.136Contact Map0.761
3tuiC40.94191000.363Contact Map0.859
2it1A20.93581000.38Contact Map0.792
1oxxK10.95411000.383Contact Map0.761
2yyzA10.93581000.386Contact Map0.747
1g29120.9481000.389Contact Map0.833
1v43A10.92971000.393Contact Map0.779
3rlfA20.93581000.398Contact Map0.777
1z47A20.92351000.407Contact Map0.799
2oljA20.74011000.416Contact Map0.853
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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