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DPPF - Dipeptide transport ATP-binding protein DppF
UniProt: P37313 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12628
Length: 334 (319)
Sequences: 11277
Seq/Len: 35.35
DPPF
Paralog alert: 0.93 [within 20: 0.78] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
49_K 231_E 4.476 1.00
100_K 181_D 3.964 1.00
14_Q 44_N 3.626 1.00
16_I 78_E 3.591 1.00
17_D 40_G 3.445 1.00
144_M 177_M 3.149 1.00
244_G 249_I 3.085 1.00
52_A 229_A 2.832 1.00
20_K 67_L 2.824 1.00
147_K 211_L 2.824 1.00
78_E 85_D 2.699 1.00
51_L 233_M 2.66 1.00
233_M 240_C 2.642 1.00
245_T 248_Q 2.639 1.00
82_Q 181_D 2.631 1.00
206_D 210_E 2.588 1.00
231_E 243_K 2.574 1.00
147_K 210_E 2.565 1.00
47_R 181_D 2.539 1.00
39_D 239_R 2.528 1.00
85_D 88_K 2.447 1.00
140_K 143_S 2.434 1.00
303_F 325_A 2.421 1.00
305_P 309_L 2.396 1.00
133_S 136_Q 2.311 1.00
46_E 49_K 2.268 1.00
90_D 93_A 2.259 1.00
14_Q 80_Y 2.219 1.00
123_E 141_A 2.194 1.00
84_Q 93_A 2.183 1.00
140_K 179_D 2.159 1.00
70_M 94_Q 2.155 1.00
21_H 36_K 2.118 1.00
15_A 18_L 2.086 1.00
82_Q 100_K 2.031 1.00
19_K 40_G 2.03 1.00
123_E 137_R 1.932 1.00
17_D 42_S 1.929 1.00
65_G 218_I 1.899 1.00
219_S 225_V 1.846 1.00
109_Y 167_R 1.844 1.00
142_L 155_Y 1.841 1.00
122_L 145_M 1.822 1.00
146_A 152_T 1.81 1.00
36_K 39_D 1.805 1.00
154_H 157_R 1.802 1.00
204_M 215_Y 1.793 1.00
15_A 43_F 1.79 1.00
22_Y 63_T 1.787 1.00
296_N 307_T 1.773 1.00
162_F 170_I 1.761 1.00
104_V 185_A 1.721 1.00
11_P 46_E 1.708 1.00
50_T 208_Q 1.67 1.00
19_K 76_G 1.666 1.00
248_Q 252_N 1.664 1.00
127_L 137_R 1.644 1.00
53_V 216_V 1.633 1.00
52_A 225_V 1.61 1.00
154_H 162_F 1.606 1.00
119_G 155_Y 1.586 1.00
45_L 216_V 1.583 1.00
179_D 211_L 1.578 1.00
143_S 147_K 1.574 1.00
45_L 182_V 1.57 1.00
16_I 44_N 1.559 1.00
16_I 80_Y 1.545 1.00
302_R 307_T 1.537 1.00
239_R 310_Q 1.535 1.00
201_L 224_V 1.535 1.00
233_M 243_K 1.531 1.00
122_L 177_M 1.503 1.00
185_A 215_Y 1.499 1.00
205_M 208_Q 1.49 1.00
137_R 141_A 1.487 1.00
138_R 142_L 1.463 1.00
39_D 294_A 1.463 1.00
305_P 324_F 1.444 1.00
138_R 156_D 1.44 1.00
84_Q 89_H 1.431 1.00
116_K 120_Q 1.429 1.00
43_F 64_L 1.421 1.00
89_H 93_A 1.416 1.00
239_R 322_A 1.409 1.00
304_G 307_T 1.401 0.99
94_Q 98_R 1.395 0.99
119_G 156_D 1.392 0.99
41_V 64_L 1.388 0.99
157_R 161_M 1.387 0.99
138_R 155_Y 1.386 0.99
15_A 68_L 1.365 0.99
117_K 156_D 1.365 0.99
51_L 243_K 1.353 0.99
145_M 155_Y 1.342 0.99
47_R 212_G 1.338 0.99
239_R 294_A 1.332 0.99
304_G 308_Q 1.33 0.99
313_L 322_A 1.327 0.99
97_R 101_I 1.322 0.99
12_L 182_V 1.309 0.99
64_L 235_M 1.305 0.99
291_P 296_N 1.296 0.99
16_I 42_S 1.295 0.99
45_L 51_L 1.294 0.99
17_D 76_G 1.273 0.99
139_E 143_S 1.269 0.99
183_V 215_Y 1.259 0.99
70_M 73_M 1.25 0.99
41_V 240_C 1.25 0.99
80_Y 85_D 1.246 0.98
147_K 206_D 1.243 0.98
19_K 36_K 1.235 0.98
293_C 299_C 1.234 0.98
119_G 138_R 1.23 0.98
149_G 206_D 1.224 0.98
81_Y 182_V 1.221 0.98
299_C 306_C 1.209 0.98
12_L 81_Y 1.206 0.98
122_L 141_A 1.203 0.98
217_F 228_I 1.202 0.98
81_Y 100_K 1.201 0.98
259_Q 301_R 1.197 0.98
243_K 320_L 1.191 0.98
143_S 146_A 1.186 0.98
247_D 251_N 1.185 0.98
19_K 39_D 1.18 0.98
43_F 233_M 1.179 0.98
20_K 72_E 1.176 0.98
21_H 34_L 1.172 0.98
89_H 94_Q 1.171 0.98
50_T 215_Y 1.164 0.97
117_K 120_Q 1.163 0.97
112_L 170_I 1.158 0.97
69_T 103_I 1.156 0.97
142_L 152_T 1.15 0.97
136_Q 139_E 1.141 0.97
232_V 246_K 1.136 0.97
50_T 229_A 1.136 0.97
150_L 154_H 1.134 0.97
315_D 318_G 1.123 0.97
22_Y 37_A 1.116 0.96
11_P 14_Q 1.111 0.96
208_Q 230_D 1.1 0.96
21_H 39_D 1.097 0.96
135_E 139_E 1.09 0.96
130_T 140_K 1.086 0.96
53_V 233_M 1.08 0.95
315_D 320_L 1.071 0.95
256_P 259_Q 1.061 0.95
321_V 326_V 1.059 0.95
54_V 225_V 1.058 0.95
259_Q 263_S 1.056 0.95
47_R 82_Q 1.055 0.95
47_R 214_S 1.055 0.95
309_L 324_F 1.051 0.94
24_V 27_G 1.04 0.94
84_Q 100_K 1.04 0.94
112_L 167_R 1.039 0.94
51_L 231_E 1.035 0.94
120_Q 123_E 1.032 0.94
10_Q 47_R 1.03 0.94
149_G 199_Q 1.027 0.94
294_A 310_Q 1.027 0.94
222_L 250_F 1.027 0.94
11_P 47_R 1.022 0.93
132_L 137_R 1.018 0.93
101_I 182_V 1.014 0.93
21_H 75_T 1.012 0.93
153_E 157_R 1.011 0.93
126_L 177_M 1.009 0.93
65_G 184_I 1.008 0.93
151_K 154_H 1.005 0.93
293_C 306_C 1.004 0.93
93_A 96_L 1.004 0.93
69_T 101_I 1.003 0.93
293_C 323_C 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4fwiB10.95511000.162Contact Map0.768
3tuiC40.93411000.374Contact Map0.856
1oxxK10.93111000.381Contact Map0.757
2it1A20.91021000.383Contact Map0.794
1g29120.92811000.389Contact Map0.823
2yyzA10.91021000.39Contact Map0.742
1v43A10.92811000.398Contact Map0.78
3rlfA20.91021000.398Contact Map0.778
3fvqA20.92811000.404Contact Map0.692
1z47A20.92811000.409Contact Map0.79
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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