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HCAD - 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin--NAD(+) reductase component
UniProt: P77650 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13460
Length: 400 (385)
Sequences: 9369
Seq/Len: 24.34
HCAD
Paralog alert: 0.87 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: DHNA DLDH GSHR HCAD NORW STHA TRXB YKGC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
260_D 264_R 4.612 1.00
148_V 230_A 4.552 1.00
146_S 169_K 3.553 1.00
363_A 375_I 3.512 1.00
171_T 204_L 3.419 1.00
169_K 202_R 3.24 1.00
193_L 197_Q 3.224 1.00
252_D 258_V 3.148 1.00
18_A 105_F 3.049 1.00
89_R 269_A 3.001 1.00
111_A 244_Q 2.925 1.00
4_K 74_H 2.675 1.00
113_R 240_S 2.643 1.00
148_V 220_L 2.578 1.00
111_A 242_N 2.573 1.00
7_I 91_L 2.539 1.00
101_W 104_L 2.519 1.00
85_G 88_T 2.476 1.00
146_S 231_D 2.472 1.00
211_H 221_T 2.462 1.00
14_A 273_G 2.404 1.00
86_R 267_D 2.399 1.00
103_Q 269_A 2.387 1.00
32_H 76_H 2.294 1.00
5_T 30_E 2.292 1.00
7_I 99_W 2.27 1.00
148_V 173_I 2.238 1.00
6_I 22_L 2.23 1.00
105_F 306_M 2.191 1.00
90_E 98_S 2.18 1.00
359_V 382_G 2.165 1.00
36_D 79_V 2.163 1.00
36_D 80_T 2.147 1.00
118_L 211_H 2.119 1.00
157_L 172_V 2.064 1.00
4_K 32_H 2.061 1.00
7_I 34_F 2.057 1.00
177_A 206_N 2.044 1.00
34_F 99_W 2.037 1.00
164_T 169_K 2.001 1.00
213_V 221_T 1.985 1.00
5_T 32_H 1.943 1.00
378_W 383_K 1.906 1.00
178_T 189_Q 1.884 1.00
111_A 240_S 1.878 1.00
208_A 223_Q 1.856 1.00
86_R 270_I 1.854 1.00
175_L 208_A 1.841 1.00
30_E 74_H 1.84 1.00
92_V 98_S 1.829 1.00
5_T 102_D 1.826 1.00
204_L 226_E 1.824 1.00
140_V 168_C 1.823 1.00
193_L 203_I 1.808 1.00
219_E 229_Q 1.793 1.00
186_P 335_R 1.768 1.00
210_E 221_T 1.757 1.00
358_G 386_D 1.749 1.00
147_V 163_A 1.748 1.00
271_F 305_A 1.736 1.00
302_A 306_M 1.73 1.00
105_F 273_G 1.729 1.00
90_E 100_H 1.711 1.00
254_A 278_I 1.691 1.00
145_R 169_K 1.684 1.00
106_I 276_V 1.68 1.00
221_T 227_T 1.665 1.00
152_A 179_V 1.635 1.00
210_E 223_Q 1.631 1.00
264_R 268_P 1.623 1.00
213_V 219_E 1.6 1.00
337_D 356_Q 1.591 1.00
147_V 168_C 1.587 1.00
125_C 212_V 1.584 1.00
299_A 303_A 1.576 1.00
164_T 201_V 1.571 1.00
8_I 19_A 1.568 1.00
9_V 106_I 1.562 1.00
219_E 227_T 1.559 1.00
186_P 190_R 1.529 1.00
252_D 266_C 1.517 1.00
7_I 32_H 1.51 1.00
261_E 312_P 1.506 1.00
197_Q 202_R 1.502 1.00
204_L 207_N 1.499 1.00
11_G 35_S 1.493 1.00
171_T 202_R 1.491 1.00
81_I 92_V 1.488 1.00
337_D 355_L 1.48 1.00
7_I 101_W 1.477 1.00
195_R 198_Q 1.468 1.00
103_Q 306_M 1.46 1.00
165_Q 199_A 1.407 0.99
264_R 269_A 1.398 0.99
130_H 133_D 1.395 0.99
93_L 99_W 1.392 0.99
263_C 302_A 1.389 0.99
257_I 276_V 1.381 0.99
110_A 239_I 1.373 0.99
83_T 92_V 1.37 0.99
207_N 224_S 1.368 0.99
263_C 277_A 1.367 0.99
222_L 228_L 1.353 0.99
152_A 174_E 1.351 0.99
354_N 357_N 1.351 0.99
147_V 232_V 1.342 0.99
32_H 99_W 1.34 0.99
150_I 233_V 1.333 0.99
65_A 77_S 1.329 0.99
6_I 105_F 1.329 0.99
338_D 352_W 1.322 0.99
21_S 25_Q 1.321 0.99
21_S 304_A 1.318 0.99
173_I 228_L 1.313 0.99
146_S 229_Q 1.306 0.99
193_L 205_L 1.304 0.99
212_V 233_V 1.301 0.99
25_Q 304_A 1.301 0.99
108_T 276_V 1.299 0.99
145_R 231_D 1.285 0.99
87_D 90_E 1.281 0.99
194_Q 197_Q 1.28 0.99
194_Q 198_Q 1.269 0.99
76_H 97_E 1.267 0.99
22_L 303_A 1.267 0.99
174_E 205_L 1.264 0.99
302_A 305_A 1.26 0.99
6_I 306_M 1.254 0.99
65_A 69_Q 1.251 0.99
172_V 203_I 1.24 0.98
191_Y 366_L 1.236 0.98
262_A 305_A 1.233 0.98
264_R 305_A 1.232 0.98
253_T 258_V 1.229 0.98
267_D 270_I 1.226 0.98
66_N 70_E 1.218 0.98
113_R 237_I 1.217 0.98
103_Q 271_F 1.214 0.98
9_V 80_T 1.213 0.98
214_D 217_K 1.202 0.98
178_T 186_P 1.199 0.98
137_L 232_V 1.198 0.98
249_A 267_D 1.197 0.98
76_H 99_W 1.197 0.98
207_N 223_Q 1.194 0.98
34_F 93_L 1.193 0.98
126_F 232_V 1.189 0.98
79_V 95_N 1.185 0.98
82_K 91_L 1.18 0.98
156_G 174_E 1.178 0.98
14_A 295_A 1.175 0.98
251_L 266_C 1.175 0.98
328_L 366_L 1.164 0.97
33_L 68_W 1.163 0.97
303_A 307_L 1.159 0.97
18_A 302_A 1.151 0.97
82_K 104_L 1.148 0.97
173_I 222_L 1.147 0.97
34_F 76_H 1.137 0.97
4_K 76_H 1.135 0.97
254_A 258_V 1.13 0.97
204_L 228_L 1.126 0.97
146_S 171_T 1.122 0.97
265_T 272_A 1.112 0.96
327_N 369_G 1.108 0.96
68_W 73_V 1.105 0.96
32_H 74_H 1.103 0.96
157_L 196_H 1.102 0.96
148_V 228_L 1.1 0.96
251_L 257_I 1.099 0.96
259_I 277_A 1.093 0.96
146_S 168_C 1.091 0.96
6_I 27_F 1.088 0.96
85_G 90_E 1.084 0.96
126_F 140_V 1.083 0.96
384_T 387_A 1.076 0.95
157_L 324_Y 1.071 0.95
262_A 310_P 1.07 0.95
301_I 305_A 1.066 0.95
21_S 24_Q 1.064 0.95
246_A 249_A 1.058 0.95
173_I 204_L 1.056 0.95
64_P 68_W 1.053 0.95
190_R 193_L 1.05 0.94
147_V 234_I 1.05 0.94
41_P 45_P 1.042 0.94
179_V 203_I 1.041 0.94
177_A 186_P 1.035 0.94
360_L 379_I 1.029 0.94
179_V 205_L 1.027 0.94
217_K 229_Q 1.027 0.94
273_G 302_A 1.024 0.93
39_H 75_L 1.023 0.93
27_F 31_L 1.021 0.93
105_F 302_A 1.019 0.93
207_N 222_L 1.019 0.93
150_I 235_Y 1.018 0.93
34_F 81_I 1.004 0.93
304_A 309_L 1.002 0.92
18_A 273_G 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3lxdA10.9951000.253Contact Map0.725
1q1rA20.99251000.256Contact Map0.773
3ef6A10.99251000.26Contact Map0.755
2gqwA10.97751000.27Contact Map0.721
3fg2P10.9851000.274Contact Map0.785
3iwaA10.9951000.283Contact Map0.752
4fx9A20.98751000.296Contact Map0.701
3ntdA20.98751000.303Contact Map0.8
3kljA10.93251000.31Contact Map0.749
3icsA20.991000.314Contact Map0.801
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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