| UniProt: | P06715 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10412 | ||
| Length: | 450 (446) | ||
| Sequences: | 7380 | ||
| Seq/Len: | 16.55 |
| GSHR
Paralog alert: 0.88 [within 20: 0.08] - ratio of genomes with paralogs Cluster includes: DHNA DLDH GSHR HCAD NORW STHA TRXB YKGC |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 288_D | 292_N | 4.945 | 1.00 | |
| 171_A | 254_V | 4.228 | 1.00 | |
| 192_K | 224_Q | 3.501 | 1.00 | |
| 278_K | 286_V | 3.418 | 1.00 | |
| 405_I | 419_F | 3.208 | 1.00 | |
| 5_Y | 109_D | 3.195 | 1.00 | |
| 35_A | 114_F | 3.187 | 1.00 | |
| 169_R | 192_K | 3.102 | 1.00 | |
| 194_H | 226_H | 3.053 | 1.00 | |
| 119_D | 122_T | 2.981 | 1.00 | |
| 215_V | 219_N | 2.878 | 1.00 | |
| 271_N | 274_A | 2.843 | 1.00 | |
| 19_S | 136_L | 2.826 | 1.00 | |
| 142_R | 268_D | 2.771 | 1.00 | |
| 5_Y | 31_A | 2.569 | 1.00 | |
| 169_R | 255_D | 2.535 | 1.00 | |
| 418_G | 437_A | 2.524 | 1.00 | |
| 8_I | 130_I | 2.497 | 1.00 | |
| 15_G | 301_V | 2.444 | 1.00 | |
| 166_L | 191_A | 2.422 | 1.00 | |
| 367_Q | 398_S | 2.413 | 1.00 | |
| 396_V | 399_E | 2.386 | 1.00 | |
| 367_Q | 397_G | 2.358 | 1.00 | |
| 401_K | 426_G | 2.349 | 1.00 | |
| 8_I | 123_L | 2.344 | 1.00 | |
| 171_A | 244_L | 2.318 | 1.00 | |
| 132_A | 135_I | 2.313 | 1.00 | |
| 208_P | 357_P | 2.31 | 1.00 | |
| 354_L | 359_A | 2.3 | 1.00 | |
| 233_A | 245_E | 2.292 | 1.00 | |
| 116_R | 124_E | 2.272 | 1.00 | |
| 142_R | 266_A | 2.257 | 1.00 | |
| 171_A | 196_F | 2.248 | 1.00 | |
| 121_K | 297_G | 2.245 | 1.00 | |
| 144_S | 264_E | 2.244 | 1.00 | |
| 31_A | 111_I | 2.178 | 1.00 | |
| 180_V | 195_L | 2.131 | 1.00 | |
| 407_G | 412_M | 2.13 | 1.00 | |
| 122_T | 129_T | 2.125 | 1.00 | |
| 73_D | 80_N | 2.121 | 1.00 | |
| 8_I | 33_I | 2.067 | 1.00 | |
| 354_L | 362_Q | 2.057 | 1.00 | |
| 356_E | 392_K | 2.01 | 1.00 | |
| 149_P | 233_A | 1.999 | 1.00 | |
| 7_Y | 23_A | 1.997 | 1.00 | |
| 4_H | 133_D | 1.976 | 1.00 | |
| 200_H | 228_N | 1.957 | 1.00 | |
| 400_E | 430_K | 1.951 | 1.00 | |
| 422_A | 427_A | 1.95 | 1.00 | |
| 168_E | 192_K | 1.88 | 1.00 | |
| 124_E | 129_T | 1.875 | 1.00 | |
| 368_V | 394_V | 1.865 | 1.00 | |
| 10_I | 115_A | 1.85 | 1.00 | |
| 356_E | 360_R | 1.839 | 1.00 | |
| 235_V | 245_E | 1.835 | 1.00 | |
| 137_I | 304_N | 1.828 | 1.00 | |
| 369_K | 397_G | 1.821 | 1.00 | |
| 142_R | 264_E | 1.82 | 1.00 | |
| 201_A | 211_S | 1.814 | 1.00 | |
| 243_T | 253_T | 1.804 | 1.00 | |
| 4_H | 131_T | 1.804 | 1.00 | |
| 33_I | 130_I | 1.802 | 1.00 | |
| 134_H | 297_G | 1.799 | 1.00 | |
| 113_G | 125_V | 1.792 | 1.00 | |
| 393_L | 405_I | 1.777 | 1.00 | |
| 187_N | 192_K | 1.776 | 1.00 | |
| 280_N | 284_Y | 1.776 | 1.00 | |
| 359_A | 368_V | 1.773 | 1.00 | |
| 122_T | 131_T | 1.769 | 1.00 | |
| 117_F | 135_I | 1.761 | 1.00 | |
| 6_D | 29_K | 1.76 | 1.00 | |
| 292_N | 296_E | 1.75 | 1.00 | |
| 156_D | 159_G | 1.748 | 1.00 | |
| 230_I | 247_E | 1.715 | 1.00 | |
| 321_L | 325_L | 1.714 | 1.00 | |
| 80_N | 83_T | 1.704 | 1.00 | |
| 232_K | 247_E | 1.682 | 1.00 | |
| 136_L | 325_L | 1.68 | 1.00 | |
| 6_D | 133_D | 1.647 | 1.00 | |
| 10_I | 137_I | 1.646 | 1.00 | |
| 29_K | 109_D | 1.64 | 1.00 | |
| 226_H | 229_A | 1.617 | 1.00 | |
| 8_I | 31_A | 1.608 | 1.00 | |
| 198_R | 230_I | 1.567 | 1.00 | |
| 118_V | 124_E | 1.561 | 1.00 | |
| 8_I | 132_A | 1.54 | 1.00 | |
| 235_V | 243_T | 1.529 | 1.00 | |
| 31_A | 130_I | 1.525 | 1.00 | |
| 210_I | 390_R | 1.51 | 1.00 | |
| 359_A | 394_V | 1.504 | 1.00 | |
| 357_P | 361_E | 1.497 | 1.00 | |
| 187_N | 223_P | 1.489 | 1.00 | |
| 118_V | 129_T | 1.481 | 1.00 | |
| 117_F | 123_L | 1.48 | 1.00 | |
| 83_T | 86_A | 1.479 | 1.00 | |
| 73_D | 78_K | 1.477 | 1.00 | |
| 170_V | 191_A | 1.475 | 1.00 | |
| 170_V | 186_I | 1.474 | 1.00 | |
| 232_K | 245_E | 1.461 | 1.00 | |
| 318_G | 322_S | 1.446 | 1.00 | |
| 348_P | 413_D | 1.44 | 1.00 | |
| 7_Y | 136_L | 1.429 | 1.00 | |
| 175_A | 202_P | 1.428 | 1.00 | |
| 180_V | 345_S | 1.408 | 1.00 | |
| 299_Y | 324_R | 1.397 | 0.99 | |
| 213_T | 408_I | 1.395 | 0.99 | |
| 155_I | 163_L | 1.393 | 0.99 | |
| 38_L | 110_V | 1.386 | 0.99 | |
| 291_Q | 305_T | 1.384 | 0.99 | |
| 111_I | 130_I | 1.379 | 0.99 | |
| 195_L | 225_L | 1.379 | 0.99 | |
| 245_E | 251_S | 1.376 | 0.99 | |
| 358_Q | 361_E | 1.375 | 0.99 | |
| 7_Y | 28_Q | 1.374 | 0.99 | |
| 207_D | 392_K | 1.373 | 0.99 | |
| 277_V | 285_I | 1.367 | 0.99 | |
| 292_N | 297_G | 1.364 | 0.99 | |
| 5_Y | 111_I | 1.354 | 0.99 | |
| 32_L | 103_L | 1.349 | 0.99 | |
| 210_I | 408_I | 1.339 | 0.99 | |
| 100_E | 112_K | 1.337 | 0.99 | |
| 139_T | 304_N | 1.335 | 0.99 | |
| 280_N | 306_G | 1.331 | 0.99 | |
| 237_N | 243_T | 1.33 | 0.99 | |
| 215_V | 225_L | 1.319 | 0.99 | |
| 168_E | 255_D | 1.319 | 0.99 | |
| 208_P | 212_E | 1.317 | 0.99 | |
| 136_L | 301_V | 1.317 | 0.99 | |
| 349_I | 408_I | 1.315 | 0.99 | |
| 370_V | 394_V | 1.312 | 0.99 | |
| 217_V | 220_A | 1.312 | 0.99 | |
| 188_G | 221_E | 1.311 | 0.99 | |
| 22_R | 323_E | 1.305 | 0.99 | |
| 234_V | 257_L | 1.296 | 0.99 | |
| 155_I | 256_C | 1.27 | 0.99 | |
| 125_V | 130_I | 1.261 | 0.99 | |
| 295_I | 298_I | 1.26 | 0.99 | |
| 363_Y | 366_D | 1.254 | 0.99 | |
| 194_H | 224_Q | 1.253 | 0.99 | |
| 419_F | 446_F | 1.245 | 0.98 | |
| 428_T | 431_D | 1.243 | 0.98 | |
| 73_D | 83_T | 1.235 | 0.98 | |
| 277_V | 294_N | 1.223 | 0.98 | |
| 275_A | 295_I | 1.217 | 0.98 | |
| 59_I | 62_A | 1.215 | 0.98 | |
| 33_I | 125_V | 1.213 | 0.98 | |
| 278_K | 294_N | 1.21 | 0.98 | |
| 196_F | 246_L | 1.206 | 0.98 | |
| 367_Q | 396_V | 1.205 | 0.98 | |
| 144_S | 261_I | 1.205 | 0.98 | |
| 272_L | 277_V | 1.203 | 0.98 | |
| 103_L | 108_V | 1.199 | 0.98 | |
| 366_D | 403_V | 1.19 | 0.98 | |
| 216_E | 219_N | 1.182 | 0.98 | |
| 290_Y | 324_R | 1.181 | 0.98 | |
| 134_H | 325_L | 1.178 | 0.98 | |
| 246_L | 252_E | 1.17 | 0.97 | |
| 393_L | 419_F | 1.169 | 0.97 | |
| 375_F | 409_G | 1.169 | 0.97 | |
| 116_R | 271_N | 1.169 | 0.97 | |
| 417_Q | 438_I | 1.156 | 0.97 | |
| 358_Q | 362_Q | 1.154 | 0.97 | |
| 287_V | 305_T | 1.152 | 0.97 | |
| 117_F | 137_I | 1.152 | 0.97 | |
| 209_M | 372_K | 1.15 | 0.97 | |
| 267_N | 279_T | 1.149 | 0.97 | |
| 214_L | 408_I | 1.149 | 0.97 | |
| 173_V | 257_L | 1.148 | 0.97 | |
| 117_F | 132_A | 1.145 | 0.97 | |
| 196_F | 252_E | 1.139 | 0.97 | |
| 215_V | 227_T | 1.137 | 0.97 | |
| 179_A | 197_V | 1.131 | 0.97 | |
| 321_L | 324_R | 1.127 | 0.97 | |
| 219_N | 224_Q | 1.123 | 0.97 | |
| 237_N | 240_G | 1.118 | 0.96 | |
| 169_R | 191_A | 1.116 | 0.96 | |
| 15_G | 314_A | 1.116 | 0.96 | |
| 6_D | 31_A | 1.114 | 0.96 | |
| 136_L | 321_L | 1.112 | 0.96 | |
| 280_N | 286_V | 1.107 | 0.96 | |
| 320_R | 334_L | 1.101 | 0.96 | |
| 201_A | 208_P | 1.101 | 0.96 | |
| 169_R | 253_T | 1.1 | 0.96 | |
| 214_L | 349_I | 1.1 | 0.96 | |
| 425_M | 431_D | 1.1 | 0.96 | |
| 400_E | 429_K | 1.096 | 0.96 | |
| 23_A | 322_S | 1.089 | 0.96 | |
| 85_I | 89_T | 1.086 | 0.96 | |
| 196_F | 226_H | 1.084 | 0.96 | |
| 206_F | 341_T | 1.084 | 0.96 | |
| 202_P | 225_L | 1.081 | 0.95 | |
| 22_R | 26_Y | 1.079 | 0.95 | |
| 197_V | 227_T | 1.074 | 0.95 | |
| 117_F | 271_N | 1.074 | 0.95 | |
| 89_T | 93_D | 1.07 | 0.95 | |
| 216_E | 220_A | 1.062 | 0.95 | |
| 279_T | 286_V | 1.056 | 0.95 | |
| 180_V | 218_M | 1.056 | 0.95 | |
| 160_F | 186_I | 1.054 | 0.95 | |
| 289_K | 333_H | 1.054 | 0.95 | |
| 116_R | 274_A | 1.051 | 0.94 | |
| 173_V | 259_W | 1.051 | 0.94 | |
| 342_V | 438_I | 1.05 | 0.94 | |
| 226_H | 250_R | 1.047 | 0.94 | |
| 285_I | 304_N | 1.046 | 0.94 | |
| 335_D | 424_K | 1.046 | 0.94 | |
| 9_A | 20_I | 1.043 | 0.94 | |
| 117_F | 275_A | 1.041 | 0.94 | |
| 391_M | 445_E | 1.039 | 0.94 | |
| 45_V | 158_D | 1.039 | 0.94 | |
| 209_M | 392_K | 1.038 | 0.94 | |
| 111_I | 128_E | 1.03 | 0.94 | |
| 411_G | 414_E | 1.03 | 0.94 | |
| 292_N | 299_Y | 1.017 | 0.93 | |
| 10_I | 270_I | 1.016 | 0.93 | |
| 175_A | 197_V | 1.015 | 0.93 | |
| 154_G | 234_V | 1.013 | 0.93 | |
| 292_N | 324_R | 1.012 | 0.93 | |
| 42_C | 47_C | 1.012 | 0.93 | |
| 82_E | 164_P | 1.009 | 0.93 | |
| 218_M | 223_P | 1.009 | 0.93 | |
| 196_F | 229_A | 1.005 | 0.93 | |
| 320_R | 324_R | 1.005 | 0.93 | |
| 308_V | 339_I | 1.005 | 0.93 | |
| 93_D | 97_T | 1.004 | 0.93 | |
| 159_G | 162_A | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4dnaA | 2 | 0.9889 | 100 | 0.205 | Contact Map | 0.787 |
| 2r9zA | 2 | 0.9933 | 100 | 0.206 | Contact Map | 0.773 |
| 2wpfA | 4 | 0.9911 | 100 | 0.217 | Contact Map | 0.829 |
| 1gesA | 2 | 0.9978 | 100 | 0.218 | Contact Map | 0.828 |
| 1onfA | 1 | 0.9844 | 100 | 0.218 | Contact Map | 0.751 |
| 2hqmA | 2 | 0.9956 | 100 | 0.222 | Contact Map | 0.793 |
| 1ojtA | 1 | 0.9867 | 100 | 0.222 | Contact Map | 0.761 |
| 1zmdA | 8 | 0.9889 | 100 | 0.223 | Contact Map | 0.849 |
| 3ic9A | 4 | 0.9933 | 100 | 0.224 | Contact Map | 0.791 |
| 3o0hA | 2 | 0.9889 | 100 | 0.224 | Contact Map | 0.85 |
Sequence Conservation (Image Generated using WebLogo v3)