| UniProt: | P0A9P0 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10543 | ||
| Length: | 474 (462) | ||
| Sequences: | 7410 | ||
| Seq/Len: | 16.04 |
| DLDH
Paralog alert: 0.89 [within 20: 0.08] - ratio of genomes with paralogs Cluster includes: DHNA DLDH GSHR HCAD NORW STHA TRXB YKGC |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 298_D | 302_R | 4.954 | 1.00 | |
| 179_L | 264_Y | 4.149 | 1.00 | |
| 200_Q | 231_N | 3.539 | 1.00 | |
| 288_E | 296_R | 3.409 | 1.00 | |
| 7_T | 111_K | 3.272 | 1.00 | |
| 177_R | 200_Q | 3.251 | 1.00 | |
| 411_G | 425_I | 3.239 | 1.00 | |
| 37_R | 116_L | 3.144 | 1.00 | |
| 121_G | 124_T | 3.102 | 1.00 | |
| 202_D | 233_M | 3.04 | 1.00 | |
| 223_T | 227_S | 2.895 | 1.00 | |
| 21_A | 142_I | 2.844 | 1.00 | |
| 148_R | 278_K | 2.832 | 1.00 | |
| 281_D | 284_K | 2.812 | 1.00 | |
| 373_S | 404_E | 2.636 | 1.00 | |
| 7_T | 33_V | 2.568 | 1.00 | |
| 373_S | 403_K | 2.557 | 1.00 | |
| 424_E | 443_H | 2.551 | 1.00 | |
| 177_R | 265_D | 2.543 | 1.00 | |
| 407_R | 432_G | 2.525 | 1.00 | |
| 174_V | 199_S | 2.451 | 1.00 | |
| 10_V | 136_I | 2.421 | 1.00 | |
| 240_A | 251_T | 2.404 | 1.00 | |
| 17_A | 311_I | 2.388 | 1.00 | |
| 402_D | 405_S | 2.331 | 1.00 | |
| 138_F | 141_A | 2.319 | 1.00 | |
| 118_K | 126_E | 2.317 | 1.00 | |
| 362_L | 367_A | 2.302 | 1.00 | |
| 374_Y | 400_I | 2.299 | 1.00 | |
| 216_K | 365_K | 2.298 | 1.00 | |
| 179_L | 250_V | 2.287 | 1.00 | |
| 10_V | 125_L | 2.271 | 1.00 | |
| 150_I | 274_V | 2.255 | 1.00 | |
| 188_L | 203_V | 2.228 | 1.00 | |
| 179_L | 204_V | 2.218 | 1.00 | |
| 148_R | 276_N | 2.214 | 1.00 | |
| 75_V | 82_D | 2.11 | 1.00 | |
| 10_V | 35_V | 2.099 | 1.00 | |
| 413_I | 418_G | 2.097 | 1.00 | |
| 124_T | 135_V | 2.079 | 1.00 | |
| 33_V | 113_V | 2.072 | 1.00 | |
| 208_D | 235_E | 2.046 | 1.00 | |
| 9_V | 25_C | 2.041 | 1.00 | |
| 123_N | 307_H | 2.034 | 1.00 | |
| 362_L | 370_K | 2.03 | 1.00 | |
| 364_E | 398_K | 2.024 | 1.00 | |
| 6_K | 139_D | 2.017 | 1.00 | |
| 406_H | 436_E | 2.002 | 1.00 | |
| 428_A | 433_C | 1.997 | 1.00 | |
| 367_A | 374_Y | 1.977 | 1.00 | |
| 126_E | 135_V | 1.934 | 1.00 | |
| 375_E | 403_K | 1.925 | 1.00 | |
| 299_K | 341_Y | 1.924 | 1.00 | |
| 237_K | 253_E | 1.923 | 1.00 | |
| 195_H | 200_Q | 1.92 | 1.00 | |
| 12_L | 117_G | 1.915 | 1.00 | |
| 35_V | 136_I | 1.912 | 1.00 | |
| 164_D | 167_D | 1.887 | 1.00 | |
| 242_E | 251_T | 1.882 | 1.00 | |
| 399_L | 411_G | 1.858 | 1.00 | |
| 82_D | 85_K | 1.852 | 1.00 | |
| 148_R | 274_V | 1.849 | 1.00 | |
| 239_T | 253_E | 1.834 | 1.00 | |
| 140_N | 307_H | 1.824 | 1.00 | |
| 142_I | 335_I | 1.822 | 1.00 | |
| 290_D | 294_F | 1.816 | 1.00 | |
| 143_I | 314_I | 1.815 | 1.00 | |
| 176_E | 200_Q | 1.812 | 1.00 | |
| 249_Y | 263_R | 1.811 | 1.00 | |
| 8_Q | 31_E | 1.81 | 1.00 | |
| 364_E | 368_K | 1.803 | 1.00 | |
| 209_Q | 219_V | 1.788 | 1.00 | |
| 6_K | 137_N | 1.777 | 1.00 | |
| 119_F | 141_A | 1.761 | 1.00 | |
| 115_G | 127_V | 1.752 | 1.00 | |
| 302_R | 306_P | 1.75 | 1.00 | |
| 242_E | 249_Y | 1.747 | 1.00 | |
| 162_I | 241_V | 1.724 | 1.00 | |
| 124_T | 137_N | 1.664 | 1.00 | |
| 12_L | 143_I | 1.638 | 1.00 | |
| 10_V | 33_V | 1.626 | 1.00 | |
| 331_A | 335_I | 1.607 | 1.00 | |
| 233_M | 236_T | 1.594 | 1.00 | |
| 31_E | 111_K | 1.593 | 1.00 | |
| 206_M | 237_K | 1.58 | 1.00 | |
| 163_W | 171_L | 1.575 | 1.00 | |
| 120_T | 126_E | 1.566 | 1.00 | |
| 399_L | 456_A | 1.562 | 1.00 | |
| 8_Q | 139_D | 1.561 | 1.00 | |
| 178_L | 199_S | 1.557 | 1.00 | |
| 10_V | 138_F | 1.556 | 1.00 | |
| 365_K | 369_E | 1.545 | 1.00 | |
| 218_I | 396_M | 1.533 | 1.00 | |
| 178_L | 194_Y | 1.522 | 1.00 | |
| 367_A | 400_I | 1.511 | 1.00 | |
| 119_F | 125_L | 1.492 | 1.00 | |
| 33_V | 136_I | 1.491 | 1.00 | |
| 183_G | 210_V | 1.483 | 1.00 | |
| 75_V | 80_K | 1.481 | 1.00 | |
| 239_T | 251_T | 1.478 | 1.00 | |
| 120_T | 135_V | 1.459 | 1.00 | |
| 85_K | 88_T | 1.459 | 1.00 | |
| 188_L | 353_T | 1.452 | 1.00 | |
| 287_V | 295_I | 1.446 | 1.00 | |
| 9_V | 30_L | 1.445 | 1.00 | |
| 7_T | 113_V | 1.442 | 1.00 | |
| 244_K | 247_G | 1.432 | 1.00 | |
| 328_G | 332_A | 1.416 | 1.00 | |
| 176_E | 265_D | 1.412 | 1.00 | |
| 225_R | 228_K | 1.401 | 0.99 | |
| 356_E | 419_G | 1.399 | 0.99 | |
| 376_T | 400_I | 1.392 | 0.99 | |
| 302_R | 307_H | 1.386 | 0.99 | |
| 113_V | 136_I | 1.386 | 0.99 | |
| 215_D | 398_K | 1.383 | 0.99 | |
| 142_I | 311_I | 1.38 | 0.99 | |
| 41_L | 112_V | 1.376 | 0.99 | |
| 301_L | 315_V | 1.373 | 0.99 | |
| 216_K | 220_K | 1.371 | 0.99 | |
| 372_I | 409_I | 1.369 | 0.99 | |
| 34_I | 105_A | 1.368 | 0.99 | |
| 102_A | 114_N | 1.358 | 0.99 | |
| 221_V | 414_V | 1.355 | 0.99 | |
| 309_F | 334_V | 1.354 | 0.99 | |
| 223_T | 232_L | 1.354 | 0.99 | |
| 434_D | 437_D | 1.348 | 0.99 | |
| 425_I | 452_V | 1.343 | 0.99 | |
| 163_W | 266_A | 1.333 | 0.99 | |
| 9_V | 142_I | 1.328 | 0.99 | |
| 145_A | 314_I | 1.319 | 0.99 | |
| 203_V | 232_L | 1.31 | 0.99 | |
| 251_T | 261_P | 1.308 | 0.99 | |
| 218_I | 414_V | 1.307 | 0.99 | |
| 196_A | 229_K | 1.302 | 0.99 | |
| 364_E | 374_Y | 1.301 | 0.99 | |
| 24_R | 333_E | 1.28 | 0.99 | |
| 357_V | 414_V | 1.279 | 0.99 | |
| 241_V | 267_V | 1.267 | 0.99 | |
| 366_E | 369_E | 1.265 | 0.99 | |
| 119_F | 143_I | 1.26 | 0.99 | |
| 202_D | 231_N | 1.245 | 0.98 | |
| 305_V | 308_I | 1.24 | 0.98 | |
| 181_M | 267_V | 1.238 | 0.98 | |
| 287_V | 304_N | 1.238 | 0.98 | |
| 279_N | 282_A | 1.237 | 0.98 | |
| 105_A | 110_V | 1.233 | 0.98 | |
| 217_D | 378_T | 1.222 | 0.98 | |
| 140_N | 335_I | 1.219 | 0.98 | |
| 227_S | 231_N | 1.219 | 0.98 | |
| 373_S | 402_D | 1.213 | 0.98 | |
| 399_L | 425_I | 1.212 | 0.98 | |
| 177_R | 263_R | 1.212 | 0.98 | |
| 244_K | 249_Y | 1.205 | 0.98 | |
| 252_M | 262_Q | 1.199 | 0.98 | |
| 62_V | 65_E | 1.198 | 0.98 | |
| 224_K | 227_S | 1.198 | 0.98 | |
| 297_V | 315_V | 1.197 | 0.98 | |
| 282_A | 287_V | 1.193 | 0.98 | |
| 223_T | 234_L | 1.192 | 0.98 | |
| 204_V | 252_M | 1.189 | 0.98 | |
| 295_I | 314_I | 1.185 | 0.98 | |
| 300_Q | 334_V | 1.181 | 0.98 | |
| 331_A | 334_V | 1.175 | 0.98 | |
| 224_K | 228_K | 1.169 | 0.97 | |
| 277_G | 289_V | 1.167 | 0.97 | |
| 118_K | 281_D | 1.165 | 0.97 | |
| 288_E | 304_N | 1.164 | 0.97 | |
| 285_A | 305_V | 1.161 | 0.97 | |
| 150_I | 271_I | 1.155 | 0.97 | |
| 17_A | 324_G | 1.155 | 0.97 | |
| 222_F | 414_V | 1.152 | 0.97 | |
| 24_R | 28_L | 1.148 | 0.97 | |
| 217_D | 398_K | 1.145 | 0.97 | |
| 75_V | 85_K | 1.143 | 0.97 | |
| 177_R | 199_S | 1.142 | 0.97 | |
| 187_G | 205_E | 1.137 | 0.97 | |
| 358_A | 422_L | 1.136 | 0.97 | |
| 349_S | 359_W | 1.135 | 0.97 | |
| 364_E | 376_T | 1.132 | 0.97 | |
| 142_I | 331_A | 1.132 | 0.97 | |
| 290_D | 296_R | 1.126 | 0.97 | |
| 209_Q | 216_K | 1.125 | 0.97 | |
| 381_W | 415_G | 1.125 | 0.97 | |
| 302_R | 334_V | 1.122 | 0.97 | |
| 204_V | 233_M | 1.113 | 0.96 | |
| 214_A | 349_S | 1.109 | 0.96 | |
| 118_K | 284_K | 1.106 | 0.96 | |
| 119_F | 138_F | 1.103 | 0.96 | |
| 247_G | 263_R | 1.103 | 0.96 | |
| 25_C | 332_A | 1.09 | 0.96 | |
| 91_E | 95_N | 1.087 | 0.96 | |
| 181_M | 269_V | 1.085 | 0.96 | |
| 343_D | 430_E | 1.085 | 0.96 | |
| 151_Q | 164_D | 1.082 | 0.96 | |
| 11_V | 22_A | 1.081 | 0.95 | |
| 129_G | 133_K | 1.08 | 0.95 | |
| 397_T | 451_S | 1.079 | 0.95 | |
| 372_I | 402_D | 1.075 | 0.95 | |
| 8_Q | 33_V | 1.074 | 0.95 | |
| 222_F | 357_V | 1.066 | 0.95 | |
| 210_V | 232_L | 1.065 | 0.95 | |
| 423_G | 444_A | 1.063 | 0.95 | |
| 119_F | 285_A | 1.058 | 0.95 | |
| 119_F | 281_D | 1.052 | 0.95 | |
| 236_T | 254_G | 1.051 | 0.94 | |
| 154_F | 157_H | 1.049 | 0.94 | |
| 48_V | 166_T | 1.049 | 0.94 | |
| 204_V | 262_Q | 1.046 | 0.94 | |
| 58_H | 62_V | 1.046 | 0.94 | |
| 431_M | 437_D | 1.043 | 0.94 | |
| 95_N | 99_G | 1.043 | 0.94 | |
| 249_Y | 261_P | 1.041 | 0.94 | |
| 330_V | 342_F | 1.04 | 0.94 | |
| 87_R | 91_E | 1.04 | 0.94 | |
| 318_P | 347_I | 1.04 | 0.94 | |
| 127_V | 136_I | 1.04 | 0.94 | |
| 205_E | 234_L | 1.04 | 0.94 | |
| 45_C | 50_C | 1.038 | 0.94 | |
| 363_T | 366_E | 1.037 | 0.94 | |
| 35_V | 127_V | 1.036 | 0.94 | |
| 188_L | 226_I | 1.035 | 0.94 | |
| 406_H | 435_A | 1.033 | 0.94 | |
| 366_E | 370_K | 1.026 | 0.94 | |
| 178_L | 266_A | 1.025 | 0.93 | |
| 367_A | 372_I | 1.017 | 0.93 | |
| 66_A | 69_L | 1.014 | 0.93 | |
| 101_L | 105_A | 1.009 | 0.93 | |
| 141_A | 308_I | 1.006 | 0.93 | |
| 204_V | 236_T | 1.004 | 0.93 | |
| 84_D | 172_K | 1.002 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4jdrA | 2 | 1 | 100 | 0.211 | Contact Map | 0.78 |
| 1ojtA | 1 | 0.9852 | 100 | 0.22 | Contact Map | 0.772 |
| 1zmdA | 8 | 0.9768 | 100 | 0.222 | Contact Map | 0.847 |
| 3ladA | 2 | 0.9852 | 100 | 0.228 | Contact Map | 0.852 |
| 2eq6A | 2 | 0.9705 | 100 | 0.238 | Contact Map | 0.844 |
| 3urhA | 2 | 0.9789 | 100 | 0.241 | Contact Map | 0.831 |
| 2qaeA | 2 | 0.9705 | 100 | 0.245 | Contact Map | 0.804 |
| 1ebdA | 2 | 0.9557 | 100 | 0.248 | Contact Map | 0.872 |
| 1dxlA | 4 | 0.9789 | 100 | 0.251 | Contact Map | 0.82 |
| 2a8xA | 2 | 0.9641 | 100 | 0.254 | Contact Map | 0.827 |
Sequence Conservation (Image Generated using WebLogo v3)