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OPENSEQ.org
YKGC - Probable pyridine nucleotide-disulfide oxidoreductase YkgC
UniProt: P77212 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13580
Length: 441 (435)
Sequences: 7917
Seq/Len: 18.20
YKGC
Paralog alert: 0.89 [within 20: 0.09] - ratio of genomes with paralogs
Cluster includes: DHNA DLDH GSHR HCAD NORW STHA TRXB YKGC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
277_D 281_H 4.855 1.00
162_G 243_V 4.124 1.00
34_Q 98_Q 3.832 1.00
183_K 215_D 3.514 1.00
267_A 275_V 3.446 1.00
185_T 217_I 3.285 1.00
160_H 183_K 3.282 1.00
4_Y 93_D 3.237 1.00
392_A 406_V 3.195 1.00
103_N 106_S 3.094 1.00
206_A 210_R 3.038 1.00
18_L 124_F 2.86 1.00
260_H 263_N 2.829 1.00
130_Q 257_A 2.811 1.00
354_D 385_K 2.57 1.00
405_I 424_F 2.531 1.00
4_Y 30_A 2.514 1.00
354_D 384_N 2.485 1.00
7_V 118_I 2.475 1.00
160_H 244_D 2.458 1.00
14_A 290_M 2.371 1.00
157_L 182_S 2.365 1.00
388_R 413_G 2.341 1.00
162_G 234_V 2.322 1.00
132_V 253_Q 2.309 1.00
383_D 386_T 2.285 1.00
130_Q 255_A 2.282 1.00
120_G 123_I 2.27 1.00
343_M 348_A 2.266 1.00
137_P 224_R 2.249 1.00
171_V 186_I 2.247 1.00
199_R 346_E 2.244 1.00
162_G 187_L 2.236 1.00
100_E 108_R 2.217 1.00
394_L 399_S 2.166 1.00
224_R 235_H 2.154 1.00
7_V 107_L 2.145 1.00
355_I 381_I 2.144 1.00
30_A 95_I 2.074 1.00
108_R 117_E 2.066 1.00
343_M 351_S 2.051 1.00
7_V 32_I 2.033 1.00
191_S 219_N 2.021 1.00
105_H 286_N 2.02 1.00
106_S 117_E 1.985 1.00
3_K 121_E 1.98 1.00
6_A 22_L 1.972 1.00
32_I 118_I 1.962 1.00
122_K 286_N 1.942 1.00
9_I 99_A 1.921 1.00
348_A 355_I 1.913 1.00
345_E 379_K 1.909 1.00
356_Q 384_N 1.906 1.00
5_Q 28_R 1.899 1.00
226_S 233_Q 1.855 1.00
159_G 183_K 1.845 1.00
310_V 314_L 1.842 1.00
147_D 150_G 1.823 1.00
97_G 109_V 1.807 1.00
125_I 293_V 1.804 1.00
130_Q 253_Q 1.8 1.00
269_N 273_A 1.786 1.00
345_E 349_R 1.784 1.00
281_H 285_D 1.769 1.00
192_L 202_A 1.766 1.00
178_A 183_K 1.765 1.00
226_S 235_H 1.757 1.00
223_E 235_H 1.752 1.00
233_Q 242_A 1.748 1.00
63_D 66_R 1.737 1.00
101_F 123_I 1.728 1.00
9_I 125_I 1.716 1.00
380_A 392_A 1.71 1.00
145_V 225_I 1.7 1.00
124_F 314_L 1.694 1.00
3_K 119_H 1.686 1.00
28_R 93_D 1.684 1.00
106_S 119_H 1.676 1.00
5_Q 121_E 1.673 1.00
409_V 414_L 1.67 1.00
189_A 221_H 1.664 1.00
387_Q 417_S 1.659 1.00
221_H 237_E 1.654 1.00
7_V 30_A 1.616 1.00
178_A 214_V 1.609 1.00
217_I 220_A 1.589 1.00
346_E 350_E 1.552 1.00
223_E 237_E 1.545 1.00
161_L 182_S 1.525 1.00
201_I 377_V 1.508 1.00
7_V 120_G 1.507 1.00
30_A 118_I 1.502 1.00
102_I 108_R 1.496 1.00
161_L 177_F 1.492 1.00
348_A 381_I 1.484 1.00
166_G 193_F 1.482 1.00
102_I 117_E 1.478 1.00
357_V 381_I 1.471 1.00
198_D 379_K 1.451 1.00
338_L 395_L 1.451 1.00
124_F 290_M 1.449 1.00
66_R 69_Q 1.445 1.00
101_F 107_L 1.44 1.00
146_Y 245_A 1.437 1.00
146_Y 154_L 1.431 1.00
4_Y 95_I 1.429 1.00
267_A 283_T 1.428 1.00
83_F 87_A 1.428 1.00
208_I 211_D 1.427 1.00
206_A 216_I 1.407 0.99
6_A 27_W 1.405 0.99
95_I 118_I 1.402 0.99
171_V 334_M 1.397 0.99
32_I 99_A 1.397 0.99
199_R 203_D 1.397 0.99
228_H 231_Q 1.39 0.99
337_P 400_H 1.389 0.99
185_T 215_D 1.386 0.99
21_T 312_D 1.384 0.99
39_Y 94_V 1.384 0.99
269_N 295_G 1.375 0.99
288_W 313_E 1.37 0.99
186_I 216_I 1.364 0.99
127_T 293_V 1.352 0.99
281_H 286_N 1.341 0.99
6_A 124_F 1.34 0.99
347_Q 350_E 1.329 0.99
159_G 244_D 1.328 0.99
204_N 395_L 1.327 0.99
353_A 390_L 1.316 0.99
280_L 294_T 1.291 0.99
5_Q 30_A 1.291 0.99
307_Y 311_R 1.29 0.99
284_A 287_I 1.284 0.99
201_I 395_L 1.283 0.99
310_V 313_E 1.276 0.99
266_I 274_I 1.272 0.99
164_L 246_L 1.265 0.99
264_A 284_A 1.255 0.99
179_N 212_Q 1.254 0.99
101_F 263_N 1.253 0.99
210_R 215_D 1.239 0.98
207_T 210_R 1.238 0.98
101_F 125_I 1.234 0.98
345_E 355_I 1.231 0.98
225_I 246_L 1.219 0.98
228_H 233_Q 1.212 0.98
266_I 283_T 1.209 0.98
406_V 433_L 1.209 0.98
160_H 242_A 1.205 0.98
415_P 418_I 1.199 0.98
8_I 19_A 1.183 0.98
258_S 261_P 1.181 0.98
354_D 383_D 1.178 0.98
220_A 238_H 1.176 0.98
200_D 359_T 1.174 0.98
160_H 182_S 1.17 0.97
345_E 357_V 1.169 0.97
206_A 218_L 1.16 0.97
261_P 266_I 1.16 0.97
233_Q 240_Q 1.157 0.97
279_R 313_E 1.155 0.97
404_N 425_T 1.147 0.97
207_T 211_D 1.146 0.97
236_S 239_A 1.144 0.97
380_A 406_V 1.141 0.97
100_E 260_H 1.14 0.97
170_G 188_E 1.139 0.97
231_Q 242_A 1.137 0.97
274_I 293_V 1.134 0.97
122_K 314_L 1.131 0.97
95_I 116_L 1.127 0.97
164_L 248_I 1.12 0.96
256_T 268_V 1.12 0.96
347_Q 351_S 1.117 0.96
132_V 250_S 1.115 0.96
269_N 275_V 1.112 0.96
188_E 218_L 1.105 0.96
192_L 199_R 1.105 0.96
235_H 240_Q 1.103 0.96
205_I 395_L 1.102 0.96
21_T 25_A 1.101 0.96
14_A 303_S 1.1 0.96
309_I 313_E 1.097 0.96
362_V 396_C 1.088 0.96
276_V 294_T 1.087 0.96
101_F 120_G 1.087 0.96
82_N 87_A 1.087 0.96
200_D 379_K 1.08 0.95
281_H 288_W 1.08 0.95
187_L 217_I 1.078 0.95
268_V 275_V 1.066 0.95
46_I 149_T 1.059 0.95
171_V 209_L 1.057 0.95
281_H 313_E 1.056 0.95
339_S 403_I 1.051 0.94
101_F 264_A 1.05 0.94
378_L 432_S 1.049 0.94
22_L 311_R 1.049 0.94
82_N 85_N 1.041 0.94
278_K 322_T 1.041 0.94
193_F 216_I 1.039 0.94
72_N 76_N 1.033 0.94
264_A 287_I 1.031 0.94
331_S 425_T 1.031 0.94
197_E 330_Y 1.029 0.94
82_N 86_L 1.026 0.94
161_L 245_A 1.025 0.93
101_F 260_H 1.016 0.93
43_C 48_C 1.015 0.93
339_S 399_S 1.014 0.93
220_A 236_S 1.012 0.93
398_D 401_E 1.006 0.93
25_A 312_D 1.004 0.93
123_I 287_I 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ojtA10.98641000.226Contact Map0.78
1zmdA80.98641000.226Contact Map0.84
3ic9A40.98411000.229Contact Map0.801
3ladA20.99091000.23Contact Map0.86
3l8kA20.97281000.232Contact Map0.762
4dnaA20.97961000.233Contact Map0.793
4jdrA20.98411000.235Contact Map0.782
1ebdA20.98411000.235Contact Map0.879
3urhA20.98641000.236Contact Map0.823
2r9zA20.97731000.237Contact Map0.779
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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