| UniProt: | P27306 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11428 | ||
| Length: | 466 (457) | ||
| Sequences: | 7876 | ||
| Seq/Len: | 17.23 |
| STHA
Paralog alert: 0.88 [within 20: 0.09] - ratio of genomes with paralogs Cluster includes: DHNA DLDH GSHR HCAD NORW STHA TRXB YKGC |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 296_N | 300_Q | 4.886 | 1.00 | |
| 180_L | 262_A | 4.262 | 1.00 | |
| 37_R | 116_N | 3.795 | 1.00 | |
| 201_K | 233_V | 3.459 | 1.00 | |
| 286_E | 294_K | 3.362 | 1.00 | |
| 178_H | 201_K | 3.31 | 1.00 | |
| 203_D | 235_R | 3.276 | 1.00 | |
| 7_Y | 111_E | 3.181 | 1.00 | |
| 121_D | 124_T | 3.126 | 1.00 | |
| 410_I | 424_G | 3.114 | 1.00 | |
| 224_S | 228_W | 2.99 | 1.00 | |
| 21_A | 143_V | 2.961 | 1.00 | |
| 149_R | 276_D | 2.862 | 1.00 | |
| 279_A | 282_N | 2.833 | 1.00 | |
| 178_H | 263_D | 2.547 | 1.00 | |
| 372_P | 403_E | 2.5 | 1.00 | |
| 7_Y | 33_A | 2.488 | 1.00 | |
| 406_E | 431_K | 2.44 | 1.00 | |
| 242_K | 253_H | 2.439 | 1.00 | |
| 423_I | 445_F | 2.42 | 1.00 | |
| 10_I | 137_L | 2.393 | 1.00 | |
| 17_G | 309_V | 2.389 | 1.00 | |
| 372_P | 402_R | 2.351 | 1.00 | |
| 217_Q | 364_Q | 2.311 | 1.00 | |
| 175_E | 200_V | 2.289 | 1.00 | |
| 139_A | 142_F | 2.272 | 1.00 | |
| 149_R | 274_N | 2.265 | 1.00 | |
| 401_H | 404_T | 2.247 | 1.00 | |
| 180_L | 252_M | 2.232 | 1.00 | |
| 151_Y | 272_T | 2.223 | 1.00 | |
| 189_C | 204_L | 2.185 | 1.00 | |
| 361_K | 366_L | 2.184 | 1.00 | |
| 180_L | 205_I | 2.182 | 1.00 | |
| 33_A | 113_L | 2.133 | 1.00 | |
| 118_R | 126_A | 2.112 | 1.00 | |
| 124_T | 136_T | 2.098 | 1.00 | |
| 9_A | 25_L | 2.096 | 1.00 | |
| 10_I | 35_I | 2.078 | 1.00 | |
| 373_Y | 399_L | 2.077 | 1.00 | |
| 209_D | 237_N | 2.073 | 1.00 | |
| 126_A | 136_T | 2.073 | 1.00 | |
| 412_C | 417_A | 2.072 | 1.00 | |
| 141_K | 305_H | 2.046 | 1.00 | |
| 10_I | 125_L | 2.007 | 1.00 | |
| 361_K | 369_M | 2.003 | 1.00 | |
| 363_E | 397_K | 1.988 | 1.00 | |
| 430_Q | 435_N | 1.977 | 1.00 | |
| 405_K | 438_E | 1.956 | 1.00 | |
| 196_R | 201_K | 1.951 | 1.00 | |
| 6_D | 140_E | 1.929 | 1.00 | |
| 12_I | 117_A | 1.925 | 1.00 | |
| 8_D | 31_R | 1.917 | 1.00 | |
| 244_E | 253_H | 1.914 | 1.00 | |
| 251_I | 261_K | 1.906 | 1.00 | |
| 35_I | 137_L | 1.896 | 1.00 | |
| 143_V | 333_L | 1.875 | 1.00 | |
| 165_D | 168_S | 1.859 | 1.00 | |
| 149_R | 272_T | 1.816 | 1.00 | |
| 82_S | 85_D | 1.8 | 1.00 | |
| 177_R | 201_K | 1.794 | 1.00 | |
| 366_L | 373_Y | 1.793 | 1.00 | |
| 12_I | 144_I | 1.79 | 1.00 | |
| 427_I | 435_N | 1.789 | 1.00 | |
| 210_R | 220_S | 1.78 | 1.00 | |
| 398_I | 410_I | 1.775 | 1.00 | |
| 374_E | 402_R | 1.77 | 1.00 | |
| 144_I | 312_V | 1.769 | 1.00 | |
| 6_D | 138_T | 1.761 | 1.00 | |
| 156_V | 242_K | 1.738 | 1.00 | |
| 288_D | 292_Q | 1.726 | 1.00 | |
| 363_E | 367_T | 1.715 | 1.00 | |
| 329_A | 333_L | 1.715 | 1.00 | |
| 241_E | 253_H | 1.711 | 1.00 | |
| 123_H | 305_H | 1.69 | 1.00 | |
| 119_F | 142_F | 1.689 | 1.00 | |
| 300_Q | 304_P | 1.689 | 1.00 | |
| 31_R | 111_E | 1.67 | 1.00 | |
| 307_Y | 332_A | 1.663 | 1.00 | |
| 115_G | 127_L | 1.644 | 1.00 | |
| 241_E | 255_K | 1.643 | 1.00 | |
| 10_I | 33_A | 1.639 | 1.00 | |
| 239_E | 255_K | 1.628 | 1.00 | |
| 163_I | 243_I | 1.62 | 1.00 | |
| 184_A | 211_L | 1.62 | 1.00 | |
| 8_D | 140_E | 1.605 | 1.00 | |
| 207_T | 239_E | 1.598 | 1.00 | |
| 124_T | 138_T | 1.598 | 1.00 | |
| 235_R | 238_E | 1.589 | 1.00 | |
| 244_E | 251_I | 1.57 | 1.00 | |
| 219_M | 395_T | 1.557 | 1.00 | |
| 179_V | 195_F | 1.537 | 1.00 | |
| 253_H | 259_K | 1.532 | 1.00 | |
| 10_I | 139_A | 1.528 | 1.00 | |
| 120_V | 126_A | 1.509 | 1.00 | |
| 33_A | 137_L | 1.48 | 1.00 | |
| 8_D | 33_A | 1.473 | 1.00 | |
| 364_Q | 368_A | 1.472 | 1.00 | |
| 164_Y | 172_M | 1.471 | 1.00 | |
| 179_V | 200_V | 1.469 | 1.00 | |
| 224_S | 234_I | 1.455 | 1.00 | |
| 217_Q | 221_D | 1.451 | 1.00 | |
| 196_R | 232_V | 1.441 | 1.00 | |
| 366_L | 399_L | 1.436 | 1.00 | |
| 398_I | 458_A | 1.434 | 1.00 | |
| 143_V | 309_V | 1.432 | 1.00 | |
| 326_G | 330_A | 1.432 | 1.00 | |
| 285_L | 293_L | 1.432 | 1.00 | |
| 189_C | 352_T | 1.428 | 1.00 | |
| 119_F | 125_L | 1.422 | 1.00 | |
| 126_A | 134_V | 1.418 | 1.00 | |
| 7_Y | 113_L | 1.394 | 0.99 | |
| 177_R | 263_D | 1.39 | 0.99 | |
| 129_C | 133_S | 1.388 | 0.99 | |
| 113_L | 137_L | 1.383 | 0.99 | |
| 75_H | 82_S | 1.381 | 0.99 | |
| 375_V | 399_L | 1.379 | 0.99 | |
| 299_Y | 313_I | 1.369 | 0.99 | |
| 164_Y | 264_C | 1.366 | 0.99 | |
| 9_A | 143_V | 1.362 | 0.99 | |
| 85_D | 88_N | 1.359 | 0.99 | |
| 146_C | 312_V | 1.359 | 0.99 | |
| 9_A | 30_A | 1.356 | 0.99 | |
| 355_E | 418_A | 1.355 | 0.99 | |
| 300_Q | 305_H | 1.354 | 0.99 | |
| 371_V | 408_L | 1.351 | 0.99 | |
| 365_Q | 368_A | 1.347 | 0.99 | |
| 102_Q | 114_Q | 1.339 | 0.99 | |
| 222_S | 413_F | 1.338 | 0.99 | |
| 120_V | 136_T | 1.33 | 0.99 | |
| 286_E | 302_A | 1.329 | 0.99 | |
| 226_H | 229_N | 1.329 | 0.99 | |
| 216_D | 397_K | 1.322 | 0.99 | |
| 35_I | 117_A | 1.315 | 0.99 | |
| 246_C | 251_I | 1.304 | 0.99 | |
| 436_T | 439_Y | 1.303 | 0.99 | |
| 243_I | 265_L | 1.292 | 0.99 | |
| 197_G | 230_S | 1.282 | 0.99 | |
| 228_W | 233_V | 1.281 | 0.99 | |
| 203_D | 233_V | 1.277 | 0.99 | |
| 329_A | 332_A | 1.267 | 0.99 | |
| 204_L | 234_I | 1.261 | 0.99 | |
| 178_H | 261_K | 1.26 | 0.99 | |
| 34_V | 105_Y | 1.258 | 0.99 | |
| 356_I | 413_F | 1.255 | 0.99 | |
| 224_S | 236_H | 1.252 | 0.99 | |
| 225_Y | 228_W | 1.243 | 0.98 | |
| 424_G | 454_Y | 1.242 | 0.98 | |
| 24_G | 331_Q | 1.242 | 0.98 | |
| 225_Y | 229_N | 1.24 | 0.98 | |
| 11_V | 22_A | 1.239 | 0.98 | |
| 205_I | 260_L | 1.238 | 0.98 | |
| 119_F | 282_N | 1.234 | 0.98 | |
| 246_C | 249_G | 1.226 | 0.98 | |
| 280_L | 285_L | 1.226 | 0.98 | |
| 285_L | 302_A | 1.219 | 0.98 | |
| 24_G | 28_Q | 1.215 | 0.98 | |
| 182_Y | 265_L | 1.211 | 0.98 | |
| 298_M | 332_A | 1.208 | 0.98 | |
| 303_Q | 306_V | 1.205 | 0.98 | |
| 41_V | 112_I | 1.203 | 0.98 | |
| 218_E | 377_R | 1.198 | 0.98 | |
| 293_L | 312_V | 1.197 | 0.98 | |
| 219_M | 413_F | 1.197 | 0.98 | |
| 141_K | 333_L | 1.195 | 0.98 | |
| 113_L | 135_E | 1.191 | 0.98 | |
| 105_Y | 110_C | 1.19 | 0.98 | |
| 210_R | 217_Q | 1.178 | 0.98 | |
| 151_Y | 269_N | 1.174 | 0.98 | |
| 62_R | 65_E | 1.169 | 0.97 | |
| 287_T | 294_K | 1.166 | 0.97 | |
| 372_P | 401_H | 1.164 | 0.97 | |
| 28_Q | 331_Q | 1.162 | 0.97 | |
| 363_E | 375_V | 1.162 | 0.97 | |
| 297_S | 340_A | 1.157 | 0.97 | |
| 188_G | 206_N | 1.147 | 0.97 | |
| 251_I | 259_K | 1.143 | 0.97 | |
| 17_G | 322_A | 1.143 | 0.97 | |
| 178_H | 200_V | 1.14 | 0.97 | |
| 380_F | 414_G | 1.139 | 0.97 | |
| 288_D | 314_G | 1.139 | 0.97 | |
| 288_D | 294_K | 1.137 | 0.97 | |
| 119_F | 144_I | 1.136 | 0.97 | |
| 283_I | 303_Q | 1.134 | 0.97 | |
| 118_R | 279_A | 1.131 | 0.97 | |
| 295_V | 313_I | 1.13 | 0.97 | |
| 365_Q | 369_M | 1.117 | 0.96 | |
| 235_R | 258_K | 1.117 | 0.96 | |
| 300_Q | 332_A | 1.113 | 0.96 | |
| 66_F | 69_N | 1.109 | 0.96 | |
| 249_G | 261_K | 1.103 | 0.96 | |
| 205_I | 235_R | 1.092 | 0.96 | |
| 128_D | 134_V | 1.092 | 0.96 | |
| 211_L | 234_I | 1.089 | 0.96 | |
| 48_W | 167_D | 1.086 | 0.96 | |
| 422_H | 446_N | 1.084 | 0.96 | |
| 205_I | 238_E | 1.083 | 0.96 | |
| 152_H | 165_D | 1.075 | 0.95 | |
| 205_I | 254_L | 1.073 | 0.95 | |
| 169_I | 195_F | 1.072 | 0.95 | |
| 215_L | 348_T | 1.07 | 0.95 | |
| 357_S | 421_I | 1.062 | 0.95 | |
| 363_E | 373_Y | 1.061 | 0.95 | |
| 275_T | 287_T | 1.059 | 0.95 | |
| 125_L | 305_H | 1.059 | 0.95 | |
| 189_C | 227_F | 1.057 | 0.95 | |
| 223_L | 413_F | 1.055 | 0.95 | |
| 398_I | 424_G | 1.054 | 0.95 | |
| 25_L | 330_A | 1.053 | 0.95 | |
| 206_N | 236_H | 1.053 | 0.95 | |
| 254_L | 260_L | 1.05 | 0.94 | |
| 285_L | 303_Q | 1.046 | 0.94 | |
| 119_F | 139_A | 1.045 | 0.94 | |
| 396_L | 453_A | 1.041 | 0.94 | |
| 182_Y | 267_Y | 1.04 | 0.94 | |
| 342_L | 429_E | 1.038 | 0.94 | |
| 12_I | 278_L | 1.035 | 0.94 | |
| 405_K | 437_I | 1.034 | 0.94 | |
| 103_G | 107_R | 1.029 | 0.94 | |
| 430_Q | 439_Y | 1.027 | 0.94 | |
| 119_F | 279_A | 1.024 | 0.93 | |
| 238_E | 256_S | 1.021 | 0.93 | |
| 362_T | 365_Q | 1.017 | 0.93 | |
| 179_V | 266_L | 1.016 | 0.93 | |
| 299_Y | 329_A | 1.012 | 0.93 | |
| 250_V | 265_L | 1.008 | 0.93 | |
| 142_F | 306_V | 1.007 | 0.93 | |
| 238_E | 254_L | 1.007 | 0.93 | |
| 88_N | 92_N | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1zmdA | 8 | 0.9914 | 100 | 0.242 | Contact Map | 0.85 |
| 1ojtA | 1 | 0.9893 | 100 | 0.244 | Contact Map | 0.771 |
| 3ladA | 2 | 0.985 | 100 | 0.247 | Contact Map | 0.849 |
| 4jdrA | 2 | 0.985 | 100 | 0.25 | Contact Map | 0.785 |
| 3ic9A | 4 | 0.9764 | 100 | 0.257 | Contact Map | 0.795 |
| 2eq6A | 2 | 0.9721 | 100 | 0.257 | Contact Map | 0.845 |
| 2qaeA | 2 | 0.9828 | 100 | 0.259 | Contact Map | 0.805 |
| 3urhA | 2 | 0.9871 | 100 | 0.259 | Contact Map | 0.83 |
| 4dnaA | 2 | 0.9721 | 100 | 0.262 | Contact Map | 0.782 |
| 1ebdA | 2 | 0.97 | 100 | 0.263 | Contact Map | 0.863 |
Sequence Conservation (Image Generated using WebLogo v3)