| UniProt: | P77485 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13642 | ||
| Length: | 480 (468) | ||
| Sequences: | 6825 | ||
| Seq/Len: | 14.58 |
| CUSS
Paralog alert: 0.78 [within 20: 0.11] - ratio of genomes with paralogs Cluster includes: ATOS BAES BASS CPXA CREC CUSS DCUS DPIB ENVZ GLRK NTRB PHOQ PHOR QSEC RSTB YEDV ZRAS |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 414_N | 418_P | 4.578 | 1.00 | |
| 453_K | 457_V | 4.297 | 1.00 | |
| 413_E | 473_R | 4.217 | 1.00 | |
| 92_D | 96_K | 3.641 | 1.00 | |
| 452_V | 463_V | 3.607 | 1.00 | |
| 424_L | 467_S | 3.547 | 1.00 | |
| 379_A | 455_I | 3.434 | 1.00 | |
| 391_T | 415_P | 3.316 | 1.00 | |
| 281_I | 309_T | 3.312 | 1.00 | |
| 461_G | 478_L | 3.297 | 1.00 | |
| 465_V | 474_F | 3.295 | 1.00 | |
| 428_F | 463_V | 3.294 | 1.00 | |
| 284_T | 304_N | 3.26 | 1.00 | |
| 456_V | 461_G | 3.159 | 1.00 | |
| 456_V | 476_I | 3.021 | 1.00 | |
| 391_T | 395_E | 3.014 | 1.00 | |
| 426_R | 429_D | 2.772 | 1.00 | |
| 264_N | 268_D | 2.691 | 1.00 | |
| 371_G | 459_H | 2.653 | 1.00 | |
| 407_L | 477_T | 2.633 | 1.00 | |
| 48_I | 149_R | 2.632 | 1.00 | |
| 371_G | 376_L | 2.623 | 1.00 | |
| 419_I | 427_L | 2.587 | 1.00 | |
| 420_A | 423_H | 2.522 | 1.00 | |
| 464_A | 475_V | 2.465 | 1.00 | |
| 467_S | 472_T | 2.451 | 1.00 | |
| 379_A | 456_V | 2.436 | 1.00 | |
| 466_T | 475_V | 2.41 | 1.00 | |
| 400_R | 413_E | 2.398 | 1.00 | |
| 400_R | 411_I | 2.38 | 1.00 | |
| 396_T | 415_P | 2.355 | 1.00 | |
| 411_I | 475_V | 2.335 | 1.00 | |
| 398_V | 413_E | 2.329 | 1.00 | |
| 379_A | 476_I | 2.291 | 1.00 | |
| 231_R | 253_E | 2.272 | 1.00 | |
| 462_T | 477_T | 2.257 | 1.00 | |
| 409_Q | 477_T | 2.239 | 1.00 | |
| 455_I | 459_H | 2.238 | 1.00 | |
| 411_I | 473_R | 2.233 | 1.00 | |
| 334_K | 373_P | 2.193 | 1.00 | |
| 336_L | 371_G | 2.158 | 1.00 | |
| 427_L | 465_V | 2.146 | 1.00 | |
| 353_A | 388_L | 2.141 | 1.00 | |
| 361_R | 398_V | 2.14 | 1.00 | |
| 428_F | 474_F | 2.08 | 1.00 | |
| 380_L | 410_V | 2.064 | 1.00 | |
| 231_R | 256_E | 2.033 | 1.00 | |
| 13_A | 207_H | 2.013 | 1.00 | |
| 382_N | 452_V | 2.007 | 1.00 | |
| 466_T | 473_R | 1.998 | 1.00 | |
| 424_L | 465_V | 1.992 | 1.00 | |
| 395_E | 415_P | 1.989 | 1.00 | |
| 359_E | 396_T | 1.981 | 1.00 | |
| 423_H | 432_Y | 1.976 | 1.00 | |
| 335_M | 368_Q | 1.954 | 1.00 | |
| 465_V | 472_T | 1.919 | 1.00 | |
| 288_L | 302_Y | 1.906 | 1.00 | |
| 385_S | 389_R | 1.906 | 1.00 | |
| 281_I | 312_A | 1.9 | 1.00 | |
| 456_V | 463_V | 1.88 | 1.00 | |
| 285_E | 305_L | 1.845 | 1.00 | |
| 447_I | 451_I | 1.824 | 1.00 | |
| 335_M | 370_A | 1.819 | 1.00 | |
| 421_P | 424_L | 1.812 | 1.00 | |
| 281_I | 305_L | 1.809 | 1.00 | |
| 390_Y | 433_R | 1.781 | 1.00 | |
| 345_V | 384_L | 1.75 | 1.00 | |
| 91_A | 97_T | 1.746 | 1.00 | |
| 222_N | 227_D | 1.742 | 1.00 | |
| 337_N | 340_D | 1.732 | 1.00 | |
| 337_N | 366_K | 1.718 | 1.00 | |
| 344_K | 373_P | 1.71 | 1.00 | |
| 268_D | 430_R | 1.707 | 1.00 | |
| 423_H | 426_R | 1.697 | 1.00 | |
| 89_S | 168_Y | 1.667 | 1.00 | |
| 293_S | 296_E | 1.663 | 1.00 | |
| 344_K | 377_R | 1.659 | 1.00 | |
| 223_I | 251_M | 1.651 | 1.00 | |
| 262_Q | 266_S | 1.647 | 1.00 | |
| 342_V | 380_L | 1.637 | 1.00 | |
| 346_F | 399_V | 1.606 | 1.00 | |
| 428_F | 465_V | 1.594 | 1.00 | |
| 435_D | 438_R | 1.583 | 1.00 | |
| 419_I | 472_T | 1.581 | 1.00 | |
| 336_L | 376_L | 1.58 | 1.00 | |
| 256_E | 260_T | 1.577 | 1.00 | |
| 423_H | 434_V | 1.567 | 1.00 | |
| 280_L | 308_L | 1.556 | 1.00 | |
| 361_R | 396_T | 1.555 | 1.00 | |
| 404_V | 409_Q | 1.537 | 1.00 | |
| 152_N | 168_Y | 1.536 | 1.00 | |
| 383_L | 452_V | 1.529 | 1.00 | |
| 383_L | 474_F | 1.517 | 1.00 | |
| 414_N | 472_T | 1.516 | 1.00 | |
| 468_D | 471_G | 1.505 | 1.00 | |
| 280_L | 304_N | 1.503 | 1.00 | |
| 349_F | 381_S | 1.498 | 1.00 | |
| 202_V | 206_V | 1.495 | 1.00 | |
| 338_L | 408_V | 1.491 | 1.00 | |
| 284_T | 308_L | 1.488 | 1.00 | |
| 284_T | 301_L | 1.488 | 1.00 | |
| 90_L | 167_L | 1.486 | 1.00 | |
| 223_I | 252_I | 1.485 | 1.00 | |
| 402_Q | 411_I | 1.483 | 1.00 | |
| 11_S | 14_T | 1.48 | 1.00 | |
| 428_F | 453_K | 1.47 | 1.00 | |
| 424_L | 428_F | 1.468 | 1.00 | |
| 410_V | 476_I | 1.462 | 1.00 | |
| 233_D | 249_N | 1.458 | 1.00 | |
| 181_N | 185_N | 1.448 | 1.00 | |
| 402_Q | 409_Q | 1.435 | 1.00 | |
| 461_G | 479_P | 1.435 | 1.00 | |
| 229_D | 256_E | 1.435 | 1.00 | |
| 312_A | 316_S | 1.434 | 1.00 | |
| 409_Q | 475_V | 1.433 | 1.00 | |
| 342_V | 401_C | 1.421 | 1.00 | |
| 342_V | 410_V | 1.419 | 1.00 | |
| 237_V | 242_E | 1.413 | 1.00 | |
| 456_V | 478_L | 1.402 | 0.99 | |
| 288_L | 305_L | 1.391 | 0.99 | |
| 408_V | 480_A | 1.387 | 0.99 | |
| 294_Q | 297_L | 1.386 | 0.99 | |
| 265_F | 269_I | 1.385 | 0.99 | |
| 427_L | 474_F | 1.376 | 0.99 | |
| 398_V | 415_P | 1.372 | 0.99 | |
| 457_V | 462_T | 1.353 | 0.99 | |
| 426_R | 432_Y | 1.353 | 0.99 | |
| 464_A | 477_T | 1.347 | 0.99 | |
| 288_L | 298_E | 1.34 | 0.99 | |
| 369_V | 408_V | 1.338 | 0.99 | |
| 440_R | 443_E | 1.334 | 0.99 | |
| 337_N | 368_Q | 1.332 | 0.99 | |
| 36_I | 184_M | 1.326 | 0.99 | |
| 372_D | 375_M | 1.313 | 0.99 | |
| 414_N | 471_G | 1.313 | 0.99 | |
| 375_M | 378_R | 1.313 | 0.99 | |
| 282_T | 286_I | 1.308 | 0.99 | |
| 421_P | 467_S | 1.302 | 0.99 | |
| 404_V | 477_T | 1.297 | 0.99 | |
| 221_Q | 243_Q | 1.287 | 0.99 | |
| 403_T | 480_A | 1.283 | 0.99 | |
| 239_I | 242_E | 1.279 | 0.99 | |
| 217_S | 243_Q | 1.279 | 0.99 | |
| 33_W | 37_H | 1.278 | 0.99 | |
| 358_V | 397_I | 1.271 | 0.99 | |
| 390_Y | 417_T | 1.268 | 0.99 | |
| 220_I | 247_S | 1.265 | 0.99 | |
| 213_I | 244_L | 1.256 | 0.99 | |
| 192_S | 196_I | 1.253 | 0.99 | |
| 231_R | 249_N | 1.241 | 0.98 | |
| 353_A | 358_V | 1.238 | 0.98 | |
| 284_T | 305_L | 1.236 | 0.98 | |
| 313_K | 374_L | 1.23 | 0.98 | |
| 216_V | 245_V | 1.229 | 0.98 | |
| 379_A | 452_V | 1.216 | 0.98 | |
| 413_E | 468_D | 1.215 | 0.98 | |
| 39_V | 183_L | 1.214 | 0.98 | |
| 231_R | 252_I | 1.21 | 0.98 | |
| 232_L | 249_N | 1.209 | 0.98 | |
| 213_I | 241_L | 1.208 | 0.98 | |
| 419_I | 424_L | 1.185 | 0.98 | |
| 214_R | 217_S | 1.185 | 0.98 | |
| 433_R | 444_G | 1.184 | 0.98 | |
| 238_P | 242_E | 1.184 | 0.98 | |
| 467_S | 470_R | 1.183 | 0.98 | |
| 463_V | 474_F | 1.182 | 0.98 | |
| 407_L | 462_T | 1.182 | 0.98 | |
| 339_A | 343_G | 1.173 | 0.98 | |
| 220_I | 248_F | 1.173 | 0.98 | |
| 217_S | 247_S | 1.171 | 0.98 | |
| 333_K | 370_A | 1.163 | 0.97 | |
| 367_C | 408_V | 1.16 | 0.97 | |
| 375_M | 459_H | 1.157 | 0.97 | |
| 380_L | 384_L | 1.151 | 0.97 | |
| 454_S | 457_V | 1.149 | 0.97 | |
| 418_P | 472_T | 1.147 | 0.97 | |
| 287_A | 301_L | 1.143 | 0.97 | |
| 414_N | 417_T | 1.141 | 0.97 | |
| 375_M | 455_I | 1.14 | 0.97 | |
| 281_I | 308_L | 1.139 | 0.97 | |
| 255_I | 258_V | 1.139 | 0.97 | |
| 227_D | 230_V | 1.137 | 0.97 | |
| 383_L | 476_I | 1.134 | 0.97 | |
| 367_C | 401_C | 1.131 | 0.97 | |
| 348_F | 377_R | 1.126 | 0.97 | |
| 429_D | 453_K | 1.122 | 0.97 | |
| 293_S | 297_L | 1.12 | 0.96 | |
| 419_I | 465_V | 1.11 | 0.96 | |
| 305_L | 309_T | 1.101 | 0.96 | |
| 277_I | 308_L | 1.097 | 0.96 | |
| 353_A | 397_I | 1.096 | 0.96 | |
| 222_N | 230_V | 1.094 | 0.96 | |
| 92_D | 98_V | 1.087 | 0.96 | |
| 353_A | 360_L | 1.087 | 0.96 | |
| 392_P | 415_P | 1.085 | 0.96 | |
| 55_S | 59_E | 1.083 | 0.96 | |
| 220_I | 224_T | 1.08 | 0.95 | |
| 384_L | 399_V | 1.073 | 0.95 | |
| 281_I | 285_E | 1.072 | 0.95 | |
| 419_I | 425_P | 1.063 | 0.95 | |
| 331_P | 372_D | 1.059 | 0.95 | |
| 417_T | 472_T | 1.056 | 0.95 | |
| 203_L | 207_H | 1.055 | 0.95 | |
| 404_V | 407_L | 1.051 | 0.94 | |
| 427_L | 432_Y | 1.05 | 0.94 | |
| 321_L | 325_D | 1.05 | 0.94 | |
| 292_R | 297_L | 1.047 | 0.94 | |
| 208_K | 211_A | 1.047 | 0.94 | |
| 454_S | 458_A | 1.042 | 0.94 | |
| 317_D | 375_M | 1.037 | 0.94 | |
| 387_A | 397_I | 1.037 | 0.94 | |
| 199_V | 203_L | 1.031 | 0.94 | |
| 363_V | 400_R | 1.028 | 0.94 | |
| 223_I | 231_R | 1.023 | 0.93 | |
| 221_Q | 250_H | 1.023 | 0.93 | |
| 380_L | 412_V | 1.023 | 0.93 | |
| 273_I | 311_M | 1.022 | 0.93 | |
| 216_V | 248_F | 1.021 | 0.93 | |
| 307_E | 310_R | 1.017 | 0.93 | |
| 304_N | 308_L | 1.017 | 0.93 | |
| 342_V | 399_V | 1.008 | 0.93 | |
| 421_P | 468_D | 1.007 | 0.93 | |
| 251_M | 255_I | 1.001 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4i5sA | 2 | 0.6396 | 100 | 0.439 | Contact Map | 0.805 |
| 2btzA | 1 | 0.6333 | 100 | 0.548 | Contact Map | 0.57 |
| 4ew8A | 2 | 0.5229 | 100 | 0.552 | Contact Map | 0.799 |
| 3jz3A | 2 | 0.4437 | 100 | 0.56 | Contact Map | 0.671 |
| 2q8gA | 1 | 0.6562 | 100 | 0.57 | Contact Map | 0.568 |
| 2c2aA | 1 | 0.4958 | 100 | 0.572 | Contact Map | 0.738 |
| 4e01A | 1 | 0.7188 | 100 | 0.572 | Contact Map | 0.63 |
| 2e0aA | 2 | 0.6396 | 100 | 0.572 | Contact Map | 0.61 |
| 3d36A | 2 | 0.4646 | 100 | 0.581 | Contact Map | 0.77 |
| 1y8oA | 1 | 0.6792 | 100 | 0.581 | Contact Map | 0.576 |
Sequence Conservation (Image Generated using WebLogo v3)