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OPENSEQ.org
CREC - Sensor protein CreC
UniProt: P08401 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10730
Length: 474 (470)
Sequences: 4709
Seq/Len: 10.02
CREC
Paralog alert: 0.74 [within 20: 0.08] - ratio of genomes with paralogs
Cluster includes: ATOS BAES BASS CPXA CREC CUSS DCUS DPIB ENVZ GLRK NTRB PHOQ PHOR QSEC RSTB YEDV ZRAS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
406_D 410_G 4.813 1.00
278_A 297_I 4.151 1.00
405_L 464_L 4.097 1.00
443_S 447_R 3.898 1.00
371_A 445_V 3.865 1.00
455_L 465_A 3.806 1.00
99_D 103_K 3.715 1.00
383_T 407_T 3.652 1.00
416_L 457_N 3.513 1.00
383_T 387_G 3.32 1.00
420_F 453_V 3.316 1.00
275_R 302_A 3.285 1.00
451_G 469_L 3.232 1.00
442_V 453_V 3.21 1.00
446_A 451_G 3.169 1.00
446_A 467_L 3.06 1.00
363_A 368_L 3.046 1.00
457_N 463_V 3.012 1.00
371_A 446_A 3.001 1.00
458_V 461_G 2.984 1.00
219_S 224_K 2.752 1.00
399_H 468_R 2.632 1.00
418_R 421_E 2.565 1.00
445_V 449_F 2.49 1.00
329_D 358_E 2.466 1.00
403_K 466_S 2.375 1.00
406_D 462_G 2.368 1.00
363_A 449_F 2.355 1.00
351_T 388_C 2.349 1.00
392_S 405_L 2.324 1.00
416_L 455_L 2.296 1.00
382_F 425_S 2.296 1.00
371_A 467_L 2.277 1.00
420_F 465_A 2.27 1.00
388_C 407_T 2.237 1.00
387_G 407_T 2.233 1.00
377_D 381_D 2.21 1.00
412_P 415_A 2.186 1.00
258_Q 262_A 2.18 1.00
419_I 455_L 2.173 1.00
452_E 468_R 2.161 1.00
390_T 405_L 2.143 1.00
446_A 453_V 2.127 1.00
454_T 466_S 2.085 1.00
392_S 403_K 2.083 1.00
337_V 376_L 2.075 1.00
411_I 419_I 2.075 1.00
400_V 471_R 2.056 1.00
326_T 365_P 2.035 1.00
401_T 468_R 2.02 1.00
375_L 404_V 2.019 1.00
372_L 402_L 2.017 1.00
328_V 363_A 2.005 1.00
403_K 464_L 1.999 1.00
415_A 424_Y 1.999 1.00
334_F 372_L 1.99 1.00
327_A 360_N 1.989 1.00
395_V 471_R 1.969 1.00
456_R 466_S 1.969 1.00
345_L 380_I 1.962 1.00
286_P 289_V 1.956 1.00
353_H 390_T 1.95 1.00
396_D 401_T 1.945 1.00
234_S 237_R 1.886 1.00
329_D 332_A 1.875 1.00
457_N 461_G 1.861 1.00
374_N 442_V 1.849 1.00
367_L 370_Q 1.829 1.00
419_I 465_A 1.824 1.00
353_H 388_C 1.824 1.00
361_V 400_V 1.821 1.00
275_R 305_Q 1.806 1.00
456_R 464_L 1.799 1.00
455_L 463_V 1.797 1.00
262_A 422_R 1.793 1.00
457_N 460_E 1.777 1.00
336_R 365_P 1.764 1.00
394_E 401_T 1.7 1.00
282_R 298_L 1.674 1.00
406_D 463_V 1.643 1.00
364_E 367_L 1.638 1.00
451_G 470_H 1.635 1.00
411_I 463_V 1.632 1.00
220_V 246_M 1.63 1.00
330_V 400_V 1.617 1.00
390_T 407_T 1.612 1.00
275_R 298_L 1.607 1.00
420_F 455_L 1.602 1.00
232_G 237_R 1.599 1.00
278_A 294_T 1.591 1.00
306_A 366_A 1.591 1.00
243_L 246_M 1.587 1.00
375_L 465_A 1.581 1.00
415_A 418_R 1.574 1.00
274_I 301_N 1.574 1.00
259_Y 263_L 1.573 1.00
288_E 291_A 1.555 1.00
413_D 416_L 1.552 1.00
336_R 369_E 1.552 1.00
279_E 298_L 1.545 1.00
338_S 391_L 1.531 1.00
98_T 104_V 1.53 1.00
372_L 404_V 1.518 1.00
282_R 295_D 1.514 1.00
274_I 297_I 1.514 1.00
410_G 462_G 1.507 1.00
437_L 441_F 1.501 1.00
420_F 443_S 1.495 1.00
278_A 301_N 1.49 1.00
327_A 362_A 1.488 1.00
300_Q 303_R 1.486 1.00
330_V 402_L 1.469 1.00
345_L 389_I 1.454 1.00
368_L 449_F 1.432 1.00
359_V 393_A 1.418 1.00
381_D 432_Q 1.415 1.00
334_F 391_L 1.414 1.00
416_L 420_F 1.411 1.00
401_T 466_S 1.406 0.99
213_L 243_L 1.402 0.99
287_P 290_V 1.395 0.99
341_R 373_G 1.392 0.99
345_L 352_L 1.391 0.99
305_Q 309_E 1.391 0.99
415_A 426_L 1.389 0.99
355_T 392_S 1.388 0.99
375_L 442_V 1.384 0.99
446_A 469_L 1.381 0.99
371_A 442_V 1.377 0.99
402_L 467_L 1.376 0.99
412_P 426_L 1.372 0.99
371_A 449_F 1.363 0.99
453_V 465_A 1.361 0.99
345_L 350_I 1.358 0.99
275_R 301_N 1.353 0.99
454_T 468_R 1.35 0.99
367_L 448_L 1.345 0.99
399_H 452_E 1.34 0.99
359_V 400_V 1.321 0.99
376_L 391_L 1.314 0.99
329_D 360_N 1.311 0.99
277_A 296_N 1.288 0.99
410_G 463_V 1.278 0.99
350_I 389_I 1.275 0.99
328_V 368_L 1.271 0.99
314_Q 318_E 1.268 0.99
227_P 248_V 1.264 0.99
447_R 452_E 1.261 0.99
409_S 463_V 1.258 0.99
334_F 402_L 1.238 0.98
260_V 264_T 1.234 0.98
422_R 425_S 1.234 0.98
382_F 409_S 1.233 0.98
259_Y 312_L 1.229 0.98
214_T 242_A 1.216 0.98
209_S 212_R 1.214 0.98
156_D 159_R 1.21 0.98
97_M 164_L 1.206 0.98
372_L 376_L 1.189 0.98
325_L 362_A 1.185 0.98
208_R 211_A 1.181 0.98
217_A 243_L 1.177 0.98
425_S 434_S 1.176 0.98
276_G 280_I 1.176 0.98
220_V 247_R 1.173 0.98
367_L 445_V 1.172 0.98
199_G 203_V 1.171 0.98
213_L 240_A 1.168 0.97
94_H 107_D 1.167 0.97
355_T 390_T 1.165 0.97
406_D 409_S 1.163 0.97
217_A 242_A 1.154 0.97
418_R 424_Y 1.151 0.97
384_P 387_G 1.148 0.97
361_V 469_L 1.146 0.97
394_E 403_K 1.141 0.97
396_D 399_H 1.114 0.96
457_N 464_L 1.114 0.96
325_L 450_N 1.113 0.96
413_D 457_N 1.106 0.96
210_I 236_L 1.105 0.96
244_E 247_R 1.099 0.96
233_S 237_R 1.098 0.96
396_D 468_R 1.09 0.96
413_D 458_V 1.087 0.96
367_L 449_F 1.086 0.96
368_L 372_L 1.085 0.96
310_T 367_L 1.074 0.95
271_L 305_Q 1.074 0.95
411_I 415_A 1.072 0.95
96_Y 165_S 1.07 0.95
324_V 364_E 1.07 0.95
375_L 467_L 1.065 0.95
278_A 298_L 1.063 0.95
201_G 205_W 1.061 0.95
218_D 238_K 1.058 0.95
214_T 238_K 1.058 0.95
275_R 279_E 1.047 0.94
453_V 467_L 1.046 0.94
340_A 369_E 1.046 0.94
400_V 469_L 1.04 0.94
443_S 453_V 1.04 0.94
411_I 417_S 1.031 0.94
384_P 407_T 1.029 0.94
331_A 335_R 1.026 0.94
217_A 239_L 1.025 0.93
334_F 356_P 1.022 0.93
98_T 165_S 1.022 0.93
49_L 164_L 1.021 0.93
271_L 301_N 1.015 0.93
412_P 459_Q 1.014 0.93
411_I 420_F 1.014 0.93
277_A 293_F 1.009 0.93
420_F 424_Y 1.008 0.93
364_E 449_F 1.007 0.93
228_L 240_A 1.006 0.93
295_D 299_T 1.003 0.93
4_G 204_W 1.003 0.93
178_K 182_R 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4i5sA20.64351000.449Contact Map0.813
2btzA10.63081000.543Contact Map0.589
4e01A10.72151000.553Contact Map0.61
4ew8A20.52951000.554Contact Map0.781
3jz3A20.45361000.554Contact Map0.664
2e0aA20.63711000.562Contact Map0.616
3d36A20.47681000.563Contact Map0.745
2q8gA10.6541000.564Contact Map0.59
2c2aA10.51000.57Contact Map0.736
4gczA20.75741000.57Contact Map0.688
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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