May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
QSEC - Sensor protein QseC
UniProt: P40719 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13027
Length: 449 (444)
Sequences: 5806
Seq/Len: 13.08
QSEC
Paralog alert: 0.77 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: ATOS BAES BASS CPXA CREC CUSS DCUS DPIB ENVZ GLRK NTRB PHOQ PHOR QSEC RSTB YEDV ZRAS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
423_Q 427_K 4.142 1.00
387_D 391_G 4.133 1.00
422_V 433_V 4.093 1.00
397_L 437_N 3.802 1.00
401_G 433_V 3.661 1.00
386_R 444_E 3.652 1.00
259_T 279_L 3.496 1.00
426_A 431_M 3.417 1.00
368_S 388_N 3.357 1.00
92_T 96_R 3.315 1.00
256_K 284_D 3.275 1.00
356_L 425_I 3.266 1.00
435_F 445_A 3.191 1.00
368_S 372_S 3.146 1.00
431_M 449_W 3.137 1.00
426_A 447_V 2.802 1.00
348_G 429_H 2.719 1.00
399_R 402_E 2.715 1.00
239_R 243_D 2.71 1.00
392_V 400_I 2.699 1.00
348_G 353_L 2.689 1.00
356_L 447_V 2.583 1.00
400_I 435_F 2.512 1.00
375_D 386_R 2.498 1.00
45_D 130_R 2.497 1.00
377_T 384_I 2.484 1.00
356_L 426_A 2.397 1.00
393_T 396_A 2.389 1.00
309_A 350_P 2.365 1.00
373_V 388_N 2.279 1.00
357_V 383_F 2.273 1.00
372_S 388_N 2.268 1.00
438_A 441_G 2.265 1.00
387_D 442_G 2.225 1.00
377_T 386_R 2.219 1.00
436_G 446_K 2.19 1.00
425_I 429_H 2.167 1.00
311_I 348_G 2.123 1.00
362_D 366_R 2.111 1.00
426_A 433_V 2.099 1.00
310_E 345_K 2.096 1.00
312_P 343_S 2.094 1.00
384_I 446_K 2.083 1.00
435_F 443_F 2.066 1.00
328_A 365_V 2.021 1.00
359_N 422_V 2.001 1.00
317_L 357_V 1.976 1.00
434_E 446_K 1.965 1.00
10_R 183_G 1.962 1.00
436_G 444_E 1.944 1.00
310_E 347_T 1.942 1.00
268_D 271_A 1.94 1.00
401_G 445_A 1.938 1.00
338_T 377_T 1.9 1.00
384_I 444_E 1.898 1.00
312_P 315_D 1.871 1.00
396_A 405_Y 1.856 1.00
394_P 397_L 1.85 1.00
417_L 421_I 1.816 1.00
397_L 435_F 1.811 1.00
437_N 443_F 1.805 1.00
367_Y 406_R 1.804 1.00
432_N 448_S 1.804 1.00
396_A 407_P 1.801 1.00
317_L 378_L 1.796 1.00
256_K 287_T 1.794 1.00
237_E 241_T 1.789 1.00
320_S 361_L 1.783 1.00
91_F 97_M 1.782 1.00
319_S 350_P 1.771 1.00
206_P 231_H 1.762 1.00
259_T 283_I 1.745 1.00
311_I 353_L 1.733 1.00
260_E 280_H 1.729 1.00
336_R 375_D 1.711 1.00
321_V 376_V 1.696 1.00
263_Q 277_L 1.672 1.00
397_L 401_G 1.66 1.00
334_D 373_V 1.656 1.00
263_Q 280_H 1.652 1.00
256_K 280_H 1.649 1.00
206_P 228_A 1.619 1.00
375_D 388_N 1.605 1.00
401_G 435_F 1.558 1.00
243_D 403_R 1.548 1.00
382_N 448_S 1.528 1.00
399_R 405_Y 1.523 1.00
437_N 441_G 1.519 1.00
410_Q 413_T 1.519 1.00
317_L 383_F 1.51 1.00
361_L 376_V 1.507 1.00
89_A 144_V 1.503 1.00
437_N 440_Q 1.497 1.00
178_M 182_L 1.478 1.00
198_M 203_S 1.468 1.00
231_H 235_V 1.458 1.00
382_N 446_K 1.452 1.00
396_A 399_R 1.444 1.00
240_F 244_A 1.443 1.00
199_R 226_L 1.428 1.00
401_G 423_Q 1.411 1.00
90_I 143_I 1.41 1.00
255_L 283_I 1.406 0.99
267_D 272_R 1.406 0.99
255_L 279_L 1.387 0.99
324_I 358_R 1.383 0.99
212_V 217_R 1.382 0.99
189_L 219_L 1.382 0.99
319_S 354_S 1.381 0.99
338_T 375_D 1.367 0.99
391_G 442_G 1.358 0.99
336_R 373_V 1.353 0.99
400_I 445_A 1.352 0.99
192_L 220_V 1.341 0.99
360_L 422_V 1.332 0.99
223_L 226_L 1.328 0.99
259_T 276_L 1.314 0.99
379_N 384_I 1.311 0.99
269_P 272_R 1.31 0.99
282_G 285_R 1.302 0.99
394_P 437_N 1.301 0.99
30_F 34_K 1.297 0.99
288_R 351_L 1.281 0.99
168_L 172_P 1.278 0.99
312_P 345_K 1.271 0.99
360_L 445_A 1.269 0.99
268_D 272_R 1.268 0.99
189_L 216_V 1.266 0.99
344_I 378_L 1.262 0.99
392_V 443_F 1.259 0.99
392_V 397_L 1.257 0.99
333_I 374_V 1.257 0.99
199_R 206_P 1.246 0.98
402_E 423_Q 1.24 0.98
263_Q 273_K 1.233 0.98
352_L 425_I 1.225 0.98
427_K 432_N 1.224 0.98
270_Q 273_K 1.216 0.98
258_Q 278_Q 1.207 0.98
280_H 284_D 1.206 0.98
213_P 217_R 1.201 0.98
379_N 382_N 1.2 0.98
434_E 448_S 1.197 0.98
352_L 355_L 1.195 0.98
257_V 261_V 1.189 0.98
214_S 217_R 1.188 0.98
367_Y 390_P 1.185 0.98
314_E 318_Q 1.185 0.98
259_T 280_H 1.185 0.98
287_T 291_D 1.184 0.98
279_L 283_I 1.18 0.98
262_A 276_L 1.18 0.98
256_K 283_I 1.168 0.97
392_V 401_G 1.162 0.97
205_K 231_H 1.161 0.97
433_V 445_A 1.16 0.97
39_N 43_L 1.159 0.97
308_V 347_T 1.152 0.97
184_R 187_A 1.152 0.97
92_T 95_G 1.15 0.97
424_R 427_K 1.149 0.97
369_P 372_S 1.148 0.97
357_V 361_L 1.147 0.97
392_V 398_A 1.142 0.97
349_Q 352_L 1.141 0.97
296_L 300_D 1.137 0.97
133_W 144_V 1.132 0.97
249_R 291_D 1.122 0.97
332_K 370_Q 1.122 0.97
356_L 422_V 1.121 0.97
8_S 11_V 1.115 0.96
208_N 224_N 1.113 0.96
193_A 222_S 1.108 0.96
317_L 376_V 1.107 0.96
356_L 429_H 1.106 0.96
352_L 428_L 1.105 0.96
321_V 335_V 1.096 0.96
383_F 447_V 1.087 0.96
308_V 430_G 1.084 0.96
253_T 257_V 1.083 0.96
313_L 383_F 1.082 0.96
197_R 225_Q 1.081 0.95
197_R 218_P 1.075 0.95
300_D 403_R 1.073 0.95
91_F 144_V 1.073 0.95
338_T 379_N 1.071 0.95
179_M 183_G 1.071 0.95
36_T 159_I 1.07 0.95
226_L 230_T 1.06 0.95
193_A 218_P 1.059 0.95
230_T 233_M 1.054 0.95
157_L 161_A 1.053 0.95
386_R 438_A 1.05 0.94
323_D 354_S 1.047 0.94
263_Q 276_L 1.047 0.94
422_V 426_A 1.032 0.94
369_P 388_N 1.03 0.94
14_T 18_L 1.026 0.94
360_L 447_V 1.022 0.93
381_D 448_S 1.019 0.93
254_A 257_V 1.017 0.93
364_A 374_V 1.015 0.93
396_A 400_I 1.015 0.93
262_A 272_R 1.013 0.93
320_S 358_R 1.012 0.93
212_V 220_V 1.01 0.93
187_A 191_K 1.01 0.93
239_R 403_R 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4i5sA20.66821000.439Contact Map0.802
3jz3A20.47661000.537Contact Map0.685
4ew8A20.55461000.541Contact Map0.801
2btzA10.66591000.545Contact Map0.579
4e01A10.76391000.568Contact Map0.606
2e0aA20.67481000.568Contact Map0.622
2q8gA10.68821000.569Contact Map0.584
2c2aA10.51671000.571Contact Map0.712
1y8oA10.71271000.575Contact Map0.587
3d36A20.48551000.579Contact Map0.748
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0575 seconds.