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OPENSEQ.org
DCUS - Sensor histidine kinase DcuS
UniProt: P0AEC8 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12465
Length: 543 (524)
Sequences: 3934
Seq/Len: 7.51
DCUS
Paralog alert: 0.79 [within 20: 0.06] - ratio of genomes with paralogs
Cluster includes: ATOS BAES BASS CPXA CREC CUSS DCUS DPIB ENVZ GLRK NTRB PHOQ PHOR QSEC RSTB YEDV ZRAS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
475_D 479_G 4.601 1.00
508_K 512_E 4.285 1.00
474_N 529_Q 4.218 1.00
511_V 532_V 4.025 1.00
520_V 530_F 3.888 1.00
438_T 510_Q 3.793 1.00
522_S 528_T 3.715 1.00
450_L 476_D 3.621 1.00
102_D 106_L 3.566 1.00
485_I 522_S 3.375 1.00
362_L 374_I 3.241 1.00
507_V 518_I 3.083 1.00
450_L 458_I 2.994 1.00
519_A 531_F 2.973 1.00
450_L 456_G 2.953 1.00
485_I 520_V 2.818 1.00
468_W 533_Q 2.771 1.00
523_E 526_I 2.742 1.00
510_Q 514_L 2.692 1.00
456_G 476_D 2.686 1.00
470_H 533_Q 2.668 1.00
471_C 532_V 2.613 1.00
511_V 516_G 2.61 1.00
489_F 518_I 2.575 1.00
489_F 530_F 2.571 1.00
487_H 490_D 2.537 1.00
461_T 472_E 2.494 1.00
416_I 457_E 2.491 1.00
516_G 534_I 2.485 1.00
359_L 379_N 2.483 1.00
239_D 243_E 2.457 1.00
459_S 474_N 2.424 1.00
522_S 526_I 2.408 1.00
414_T 457_E 2.359 1.00
464_Y 536_W 2.349 1.00
461_T 474_N 2.346 1.00
418_N 461_T 2.341 1.00
472_E 531_F 2.309 1.00
480_I 488_I 2.306 1.00
480_I 484_K 2.265 1.00
481_A 484_K 2.244 1.00
408_A 458_I 2.189 1.00
517_S 533_Q 2.158 1.00
450_L 453_E 2.097 1.00
469_L 536_W 2.061 1.00
397_I 400_F 2.049 1.00
457_E 476_D 2.048 1.00
511_V 518_I 2.043 1.00
438_T 511_V 2.017 1.00
427_G 432_V 2.007 1.00
521_E 531_F 1.995 1.00
472_E 529_Q 1.992 1.00
427_G 514_L 1.926 1.00
418_N 459_S 1.917 1.00
438_T 532_V 1.883 1.00
522_S 525_G 1.852 1.00
416_I 459_S 1.84 1.00
396_V 427_G 1.824 1.00
488_I 530_F 1.795 1.00
481_A 524_P 1.778 1.00
351_F 381_Y 1.74 1.00
463_H 470_H 1.74 1.00
442_L 473_V 1.733 1.00
521_E 529_Q 1.729 1.00
502_V 506_L 1.729 1.00
398_A 471_C 1.722 1.00
444_E 448_E 1.694 1.00
327_V 331_M 1.68 1.00
358_I 374_I 1.676 1.00
480_I 528_T 1.662 1.00
97_F 166_G 1.648 1.00
475_D 527_F 1.632 1.00
439_L 471_C 1.618 1.00
399_G 462_L 1.617 1.00
532_V 535_P 1.617 1.00
439_L 473_V 1.616 1.00
511_V 534_I 1.595 1.00
100_V 163_V 1.575 1.00
438_T 514_L 1.564 1.00
151_P 161_G 1.564 1.00
408_A 415_L 1.557 1.00
459_S 476_D 1.556 1.00
448_E 496_K 1.542 1.00
484_K 493_V 1.534 1.00
402_I 439_L 1.516 0.99
495_T 498_S 1.502 0.99
439_L 443_I 1.486 0.99
484_K 487_H 1.481 0.99
516_G 535_P 1.481 0.99
482_P 485_I 1.479 0.99
431_Q 437_T 1.479 0.99
465_R 470_H 1.476 0.99
16_K 19_T 1.475 0.99
519_A 533_Q 1.454 0.99
153_Y 159_Q 1.445 0.99
56_A 59_V 1.44 0.99
346_E 491_K 1.44 0.99
428_S 431_Q 1.433 0.99
382_Q 386_G 1.429 0.99
363_H 375_L 1.418 0.99
358_I 362_L 1.412 0.99
362_L 375_L 1.405 0.99
479_G 527_F 1.405 0.99
423_L 462_L 1.403 0.99
470_H 531_F 1.391 0.99
512_E 517_S 1.378 0.99
357_V 361_L 1.378 0.99
22_I 26_S 1.376 0.99
359_L 378_A 1.376 0.99
359_L 382_Q 1.375 0.99
208_I 211_G 1.373 0.99
350_E 437_T 1.371 0.99
82_I 100_V 1.37 0.99
353_N 449_A 1.368 0.99
326_E 329_K 1.368 0.99
347_R 388_L 1.36 0.99
377_T 380_N 1.346 0.99
463_H 472_E 1.345 0.98
397_I 422_Q 1.329 0.98
100_V 152_I 1.326 0.98
419_S 462_L 1.324 0.98
522_S 529_Q 1.323 0.98
206_K 209_L 1.322 0.98
350_E 354_K 1.317 0.98
383_E 430_D 1.314 0.98
198_T 202_V 1.295 0.98
358_I 378_A 1.287 0.98
101_T 164_A 1.286 0.98
360_G 378_A 1.284 0.98
398_A 469_L 1.284 0.98
154_D 158_K 1.283 0.98
475_D 528_T 1.279 0.98
480_I 486_D 1.278 0.98
488_I 520_V 1.265 0.98
441_N 507_V 1.262 0.97
352_M 386_G 1.261 0.97
348_S 351_F 1.255 0.97
442_L 507_V 1.243 0.97
489_F 520_V 1.241 0.97
467_G 536_W 1.24 0.97
480_I 530_F 1.239 0.97
340_Y 344_L 1.235 0.97
491_K 502_V 1.229 0.97
362_L 378_A 1.211 0.97
254_L 301_L 1.211 0.97
453_E 476_D 1.209 0.96
22_I 25_V 1.203 0.96
474_N 523_E 1.202 0.96
449_A 478_P 1.198 0.96
465_R 533_Q 1.198 0.96
479_G 528_T 1.185 0.96
408_A 447_L 1.176 0.96
99_V 164_A 1.176 0.96
442_L 532_V 1.17 0.96
351_F 354_K 1.17 0.96
520_V 528_T 1.163 0.95
337_L 343_A 1.163 0.95
350_E 377_T 1.148 0.95
442_L 530_F 1.144 0.95
443_I 458_I 1.138 0.95
348_S 392_I 1.138 0.95
112_E 115_R 1.135 0.95
107_R 111_P 1.131 0.94
361_L 373_Y 1.129 0.94
215_Y 218_S 1.127 0.94
432_V 435_L 1.124 0.94
471_C 534_I 1.122 0.94
44_I 48_T 1.121 0.94
482_P 523_E 1.119 0.94
360_G 364_L 1.118 0.94
343_A 346_E 1.107 0.94
73_L 108_Y 1.104 0.93
449_A 494_S 1.101 0.93
353_N 448_E 1.099 0.93
469_L 534_I 1.099 0.93
395_P 426_S 1.098 0.93
438_T 507_V 1.095 0.93
248_N 251_A 1.093 0.93
15_M 23_L 1.084 0.93
60_A 64_A 1.079 0.92
480_I 485_I 1.077 0.92
15_M 19_T 1.075 0.92
390_G 393_K 1.068 0.92
87_E 90_R 1.067 0.92
236_V 244_V 1.067 0.92
443_I 460_V 1.066 0.92
344_L 347_R 1.064 0.92
366_S 372_D 1.062 0.92
336_G 352_M 1.06 0.91
337_L 341_A 1.059 0.91
149_F 164_A 1.057 0.91
86_A 100_V 1.057 0.91
448_E 495_T 1.05 0.91
345_R 492_G 1.045 0.91
228_L 235_V 1.045 0.91
446_A 458_I 1.044 0.91
348_S 448_E 1.043 0.91
264_E 268_T 1.041 0.90
418_N 463_H 1.039 0.90
335_D 346_E 1.039 0.90
250_A 253_E 1.037 0.90
486_D 508_K 1.037 0.90
425_D 469_L 1.036 0.90
343_A 352_M 1.03 0.90
147_R 166_G 1.027 0.90
378_A 381_Y 1.025 0.90
465_R 468_W 1.025 0.90
45_S 49_R 1.023 0.89
73_L 163_V 1.021 0.89
29_L 33_L 1.021 0.89
468_W 517_S 1.021 0.89
354_K 381_Y 1.019 0.89
341_A 449_A 1.017 0.89
328_R 332_Q 1.017 0.89
236_V 251_A 1.015 0.89
336_G 343_A 1.014 0.89
453_E 456_G 1.012 0.89
348_S 381_Y 1.012 0.89
355_L 385_I 1.01 0.89
52_L 56_A 1.01 0.89
105_S 108_Y 1.007 0.88
402_I 460_V 1.004 0.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4i5sA20.66111000.513Contact Map0.771
3a0rA10.58931000.53Contact Map0.582
4gczA20.60411000.533Contact Map0.687
3d36A20.38861000.646Contact Map0.727
2c2aA10.40151000.648Contact Map0.725
4ew8A20.43831000.653Contact Map0.776
3jz3A20.35911000.656Contact Map0.682
2btzA10.51571000.66Contact Map0.581
2q8gA10.52671000.662Contact Map0.576
4e01A10.62061000.662Contact Map0.622
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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