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OPENSEQ.org
YEDV - Probable sensor-like histidine kinase YedV
UniProt: P76339 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14044
Length: 452 (448)
Sequences: 4647
Seq/Len: 10.37
YEDV
Paralog alert: 0.79 [within 20: 0.08] - ratio of genomes with paralogs
Cluster includes: ATOS BAES BASS CPXA CREC CUSS DCUS DPIB ENVZ GLRK NTRB PHOQ PHOR QSEC RSTB YEDV ZRAS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
388_S 392_K 4.729 1.00
423_K 427_E 4.241 1.00
435_Y 444_F 3.825 1.00
422_V 433_A 3.807 1.00
364_S 368_S 3.792 1.00
400_F 433_A 3.591 1.00
431_G 448_L 3.491 1.00
352_M 425_I 3.459 1.00
258_N 278_N 3.263 1.00
426_A 431_G 3.206 1.00
344_A 349_L 3.129 1.00
388_S 393_I 3.014 1.00
426_A 446_I 3.011 1.00
255_L 283_E 2.948 1.00
388_S 391_T 2.927 1.00
396_P 437_Y 2.866 1.00
344_A 429_H 2.772 1.00
398_K 401_R 2.697 1.00
380_S 386_I 2.69 1.00
436_H 445_R 2.552 1.00
352_M 446_I 2.487 1.00
358_V 362_R 2.391 1.00
385_D 443_V 2.368 1.00
391_T 399_L 2.344 1.00
238_Q 242_D 2.29 1.00
399_L 435_Y 2.258 1.00
381_Y 447_T 2.238 1.00
387_A 443_V 2.233 1.00
426_A 433_A 2.203 1.00
352_M 426_A 2.18 1.00
7_T 181_R 2.159 1.00
432_S 447_T 2.156 1.00
205_P 227_H 2.109 1.00
437_Y 442_N 2.094 1.00
392_K 395_E 2.062 1.00
425_I 429_H 2.013 1.00
355_N 422_V 1.989 1.00
407_D 410_R 1.96 1.00
308_D 346_K 1.956 1.00
434_T 445_R 1.952 1.00
382_L 386_I 1.94 1.00
42_D 126_D 1.932 1.00
197_L 225_M 1.919 1.00
337_E 373_T 1.903 1.00
267_S 270_E 1.894 1.00
373_T 385_D 1.861 1.00
316_V 353_L 1.85 1.00
333_C 369_R 1.844 1.00
363_Y 405_R 1.815 1.00
399_L 444_F 1.813 1.00
310_L 349_L 1.797 1.00
255_L 279_I 1.793 1.00
388_S 441_H 1.772 1.00
356_L 444_F 1.77 1.00
311_S 314_K 1.768 1.00
400_F 444_F 1.736 1.00
310_L 344_A 1.734 1.00
435_Y 442_N 1.725 1.00
335_K 371_H 1.721 1.00
236_L 240_A 1.717 1.00
88_N 91_V 1.713 1.00
318_N 346_K 1.701 1.00
205_P 230_V 1.683 1.00
395_E 398_K 1.678 1.00
258_N 282_L 1.671 1.00
434_T 447_T 1.651 1.00
398_K 404_W 1.644 1.00
371_H 387_A 1.643 1.00
327_S 361_I 1.642 1.00
242_D 402_R 1.613 1.00
335_K 369_R 1.609 1.00
389_P 392_K 1.6 1.00
431_G 449_P 1.599 1.00
258_N 275_I 1.598 1.00
436_H 443_V 1.564 1.00
176_S 180_I 1.561 1.00
356_L 422_V 1.547 1.00
417_L 421_L 1.541 1.00
259_Q 279_I 1.541 1.00
155_E 159_I 1.531 1.00
319_L 357_I 1.53 1.00
126_D 129_R 1.524 1.00
383_N 445_R 1.523 1.00
196_A 201_D 1.486 1.00
400_F 435_Y 1.484 1.00
316_V 374_S 1.472 1.00
386_I 393_I 1.466 1.00
353_L 357_I 1.457 1.00
255_L 286_S 1.454 1.00
196_A 204_E 1.44 1.00
386_I 390_G 1.435 1.00
266_R 271_Y 1.431 1.00
427_E 432_S 1.43 1.00
309_S 343_F 1.427 1.00
166_I 170_V 1.42 1.00
229_L 232_D 1.419 1.00
396_P 435_Y 1.407 0.99
348_L 351_R 1.404 0.99
364_S 389_P 1.401 0.99
318_N 350_Q 1.397 0.99
342_I 448_L 1.391 0.99
262_L 279_I 1.389 0.99
376_L 450_Q 1.384 0.99
254_L 282_L 1.382 0.99
10_L 14_F 1.377 0.99
190_L 219_G 1.372 0.99
400_F 423_K 1.372 0.99
381_Y 386_I 1.37 0.99
309_S 341_Q 1.366 0.99
332_I 370_I 1.364 0.99
194_T 222_L 1.341 0.99
426_A 448_L 1.34 0.99
230_V 234_E 1.335 0.99
234_E 238_Q 1.33 0.99
286_S 290_E 1.324 0.99
287_R 347_I 1.323 0.99
251_I 282_L 1.316 0.99
357_I 372_I 1.316 0.99
251_I 286_S 1.314 0.99
33_L 157_Y 1.296 0.99
388_S 394_N 1.284 0.99
27_W 31_N 1.284 0.99
323_L 354_S 1.281 0.99
203_R 230_V 1.278 0.99
207_E 223_N 1.263 0.99
262_L 272_Q 1.262 0.99
173_S 177_P 1.262 0.99
208_V 220_Q 1.249 0.99
313_N 317_E 1.246 0.98
393_I 396_P 1.241 0.98
262_L 276_A 1.241 0.98
373_T 387_A 1.24 0.98
85_D 89_K 1.238 0.98
268_I 271_Y 1.231 0.98
316_V 384_I 1.23 0.98
269_A 272_Q 1.227 0.98
240_A 288_L 1.221 0.98
254_L 278_N 1.22 0.98
305_V 345_D 1.217 0.98
320_L 372_I 1.211 0.98
386_I 392_K 1.207 0.98
187_I 215_L 1.198 0.98
348_L 428_L 1.197 0.98
395_E 404_W 1.193 0.98
225_M 229_L 1.19 0.98
239_F 243_L 1.188 0.98
295_L 299_D 1.187 0.98
386_I 391_T 1.18 0.98
316_V 372_I 1.179 0.98
348_L 429_H 1.158 0.97
177_P 181_R 1.157 0.97
222_L 225_M 1.151 0.97
180_I 183_G 1.145 0.97
405_R 414_G 1.139 0.97
14_F 176_S 1.131 0.97
5_S 8_V 1.129 0.97
185_R 188_K 1.123 0.97
248_R 290_E 1.123 0.97
193_V 207_E 1.118 0.96
389_P 393_I 1.116 0.96
191_S 221_A 1.115 0.96
182_T 185_R 1.115 0.96
195_E 217_P 1.115 0.96
279_I 283_E 1.114 0.96
36_E 40_R 1.113 0.96
262_L 275_I 1.111 0.96
83_H 88_N 1.111 0.96
345_D 348_L 1.104 0.96
194_T 221_A 1.101 0.96
396_P 400_F 1.1 0.96
373_T 383_N 1.097 0.96
129_R 142_T 1.097 0.96
383_N 386_I 1.096 0.96
261_T 271_Y 1.08 0.95
352_M 422_V 1.075 0.95
380_S 384_I 1.07 0.95
257_Q 277_G 1.069 0.95
191_S 217_P 1.069 0.95
239_F 244_A 1.066 0.95
24_G 27_W 1.061 0.95
30_Y 158_K 1.057 0.95
227_H 231_K 1.057 0.95
391_T 442_N 1.05 0.94
44_T 145_K 1.05 0.94
348_L 425_I 1.049 0.94
299_D 402_R 1.048 0.94
11_T 15_I 1.045 0.94
201_D 204_E 1.041 0.94
197_L 205_P 1.04 0.94
365_P 368_S 1.038 0.94
375_F 383_N 1.036 0.94
385_D 445_R 1.035 0.94
368_S 389_P 1.034 0.94
278_N 282_L 1.033 0.94
211_L 219_G 1.031 0.94
401_R 423_K 1.029 0.94
400_F 404_W 1.025 0.93
83_H 87_I 1.019 0.93
291_N 348_L 1.019 0.93
256_G 260_V 1.016 0.93
422_V 426_A 1.016 0.93
83_H 86_S 1.016 0.93
119_I 122_D 1.013 0.93
281_E 284_N 1.012 0.93
349_L 448_L 1.01 0.93
42_D 45_L 1.01 0.93
320_L 334_F 1.01 0.93
240_A 243_L 1.008 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4i5sA20.67481000.466Contact Map0.728
2btzA10.66371000.57Contact Map0.542
4ew8A20.55531000.571Contact Map0.753
3jz3A20.47351000.573Contact Map0.638
4e01A10.76991000.59Contact Map0.561
2e0aA20.67921000.594Contact Map0.581
2q8gA10.69251000.596Contact Map0.545
2c2aA10.52211000.597Contact Map0.668
3d36A20.49341000.601Contact Map0.67
1y8oA10.71461000.606Contact Map0.544
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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