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OPENSEQ.org
YFCU - Putative outer membrane usher protein YfcU
UniProt: P77196 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14124
Length: 881 (797)
Sequences: 1241
Seq/Len: 1.56
YFCU
Paralog alert: 0.75 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: ELFC FIMD HTRE SFMD YAGX YBGQ YEHB YFCU YHCD YQIG YRAJ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
96_C 123_C 4.387 1.00
297_I 309_V 4.348 1.00
687_L 719_V 3.863 1.00
305_A 345_E 3.664 1.00
646_D 662_S 3.54 1.00
261_E 275_V 3.245 1.00
675_A 709_N 3.059 1.00
369_V 397_W 2.881 1.00
274_Y 390_F 2.811 1.00
306_K 344_E 2.765 1.00
677_H 715_V 2.753 1.00
785_V 813_M 2.732 1.00
767_A 807_V 2.705 1.00
648_S 660_G 2.685 1.00
342_R 350_V 2.651 1.00
667_A 676_L 2.639 1.00
302_H 349_Q 2.623 1.00
441_T 492_Y 2.485 1.00
690_D 758_K 2.453 1.00
302_H 351_Q 2.445 1.00
344_E 350_V 2.434 1.00
670_T 675_A 2.424 1.00
171_G 754_I 2.397 1.00
218_Y 239_W 2.391 1.00
369_V 395_A 2.367 1.00
783_A 815_V 2.362 1.00
207_P 248_R 2.302 0.99
785_V 802_V 2.291 0.99
669_L 674_G 2.284 0.99
310_S 315_V 2.235 0.99
309_V 328_I 2.215 0.99
343_I 351_Q 2.19 0.99
688_L 713_K 2.179 0.99
83_W 95_A 2.159 0.99
522_G 547_L 2.151 0.99
620_Q 635_Y 2.143 0.99
771_L 825_I 2.14 0.99
340_H 352_E 2.133 0.99
69_Q 142_A 2.116 0.99
435_D 460_R 2.106 0.99
406_Y 435_D 2.099 0.99
169_I 688_L 2.084 0.99
622_N 633_D 2.016 0.98
594_Y 605_S 1.997 0.98
269_F 408_G 1.969 0.98
66_L 83_W 1.955 0.98
686_R 754_I 1.901 0.97
159_W 162_P 1.897 0.97
66_L 136_A 1.885 0.97
308_T 315_V 1.881 0.97
214_W 246_A 1.861 0.97
666_G 680_Q 1.861 0.97
666_G 677_H 1.855 0.97
672_H 690_D 1.853 0.97
310_S 342_R 1.841 0.97
813_M 825_I 1.816 0.96
670_T 713_K 1.777 0.95
765_Q 809_P 1.773 0.95
373_I 393_A 1.768 0.95
645_V 663_L 1.753 0.95
771_L 802_V 1.748 0.95
690_D 756_Y 1.728 0.95
684_G 751_E 1.724 0.94
343_I 353_Y 1.715 0.94
785_V 815_V 1.706 0.94
157_P 332_G 1.699 0.94
458_S 482_S 1.695 0.94
258_A 280_S 1.686 0.94
49_D 53_F 1.676 0.93
691_A 694_V 1.673 0.93
146_S 322_P 1.667 0.93
737_N 765_Q 1.64 0.92
671_T 756_Y 1.64 0.92
247_W 256_K 1.635 0.92
278_S 372_K 1.629 0.92
725_N 749_L 1.627 0.92
472_S 481_F 1.62 0.92
458_S 480_R 1.619 0.92
771_L 815_V 1.618 0.92
262_D 274_Y 1.607 0.91
96_C 363_L 1.606 0.91
250_L 253_L 1.603 0.91
294_A 365_R 1.596 0.91
262_D 374_M 1.592 0.91
691_A 761_V 1.583 0.90
666_G 686_R 1.578 0.90
458_S 535_W 1.576 0.90
134_I 145_I 1.575 0.90
123_C 363_L 1.575 0.90
135_K 144_V 1.573 0.90
298_S 327_R 1.573 0.90
202_G 215_Q 1.567 0.90
457_N 483_E 1.565 0.90
284_Q 751_E 1.56 0.90
340_H 354_D 1.56 0.90
108_K 111_V 1.559 0.89
526_Y 546_M 1.553 0.89
643_A 663_L 1.55 0.89
549_H 559_M 1.543 0.89
666_G 715_V 1.54 0.89
308_T 344_E 1.535 0.89
697_V 708_T 1.535 0.89
274_Y 374_M 1.527 0.88
355_I 363_L 1.522 0.88
173_I 686_R 1.518 0.88
667_A 674_G 1.514 0.88
297_I 339_L 1.51 0.87
438_H 457_N 1.503 0.87
680_Q 686_R 1.496 0.87
65_N 80_D 1.494 0.87
546_M 549_H 1.485 0.86
714_A 717_S 1.484 0.86
509_M 532_H 1.484 0.86
417_S 437_T 1.48 0.86
199_G 561_V 1.468 0.85
823_C 843_C 1.461 0.85
687_L 727_A 1.453 0.85
123_C 355_I 1.452 0.84
549_H 554_G 1.451 0.84
518_F 522_G 1.45 0.84
68_V 81_I 1.449 0.84
274_Y 278_S 1.446 0.84
249_A 750_T 1.445 0.84
203_V 214_W 1.441 0.84
767_A 827_L 1.44 0.84
361_P 390_F 1.44 0.84
668_T 754_I 1.44 0.84
174_A 201_V 1.432 0.83
779_P 815_V 1.425 0.83
593_S 608_G 1.421 0.83
699_V 716_V 1.421 0.83
63_K 80_D 1.42 0.83
749_L 755_G 1.42 0.83
283_D 368_Q 1.418 0.83
524_S 802_V 1.417 0.82
403_W 424_R 1.416 0.82
170_S 203_V 1.412 0.82
167_D 251_P 1.409 0.82
771_L 796_V 1.406 0.82
170_S 671_T 1.403 0.82
724_R 746_Q 1.401 0.81
410_L 489_M 1.398 0.81
668_T 688_L 1.393 0.81
341_I 355_I 1.393 0.81
825_I 841_L 1.391 0.81
152_L 277_G 1.39 0.81
694_V 761_V 1.382 0.80
668_T 686_R 1.37 0.79
672_H 756_Y 1.367 0.79
96_C 355_I 1.366 0.79
377_R 389_F 1.361 0.79
283_D 370_R 1.36 0.79
169_I 754_I 1.359 0.79
98_T 101_L 1.355 0.78
288_P 723_Y 1.353 0.78
216_T 241_W 1.35 0.78
170_S 754_I 1.346 0.78
270_D 488_T 1.343 0.78
69_Q 74_P 1.337 0.77
366_P 401_N 1.329 0.77
249_A 355_I 1.326 0.76
773_L 779_P 1.325 0.76
180_A 661_L 1.325 0.76
764_G 806_G 1.317 0.76
196_S 199_G 1.312 0.75
740_A 743_S 1.312 0.75
670_T 673_G 1.311 0.75
474_V 513_T 1.311 0.75
691_A 697_V 1.311 0.75
101_L 105_F 1.31 0.75
470_L 516_Q 1.309 0.75
70_L 152_L 1.307 0.75
343_I 355_I 1.302 0.74
304_T 345_E 1.302 0.74
527_L 545_I 1.298 0.74
675_A 711_F 1.294 0.74
780_P 783_A 1.291 0.74
249_A 256_K 1.29 0.73
67_Q 70_L 1.284 0.73
769_A 839_L 1.282 0.73
669_L 688_L 1.278 0.72
477_A 512_A 1.276 0.72
275_V 379_Q 1.27 0.72
709_N 715_V 1.267 0.72
172_I 203_V 1.254 0.70
214_W 244_Y 1.254 0.70
421_G 430_G 1.253 0.70
640_G 643_A 1.253 0.70
680_Q 754_I 1.246 0.70
458_S 479_Y 1.241 0.69
308_T 318_E 1.239 0.69
470_L 529_Y 1.23 0.68
399_I 768_M 1.225 0.68
310_S 340_H 1.218 0.67
773_L 777_S 1.216 0.67
560_S 581_S 1.204 0.66
151_Y 325_P 1.204 0.66
136_A 141_S 1.203 0.66
491_E 494_D 1.203 0.66
769_A 804_L 1.203 0.66
69_Q 144_V 1.2 0.65
692_D 711_F 1.199 0.65
812_H 824_D 1.198 0.65
306_K 318_E 1.195 0.65
783_A 817_W 1.194 0.65
154_Y 329_Q 1.189 0.64
129_L 132_V 1.188 0.64
508_E 533_T 1.182 0.64
518_F 547_L 1.18 0.64
112_A 151_Y 1.18 0.64
771_L 779_P 1.179 0.63
255_A 281_T 1.173 0.63
488_T 491_E 1.173 0.63
137_D 144_V 1.172 0.63
766_K 805_A 1.172 0.63
102_V 107_L 1.171 0.63
281_T 286_L 1.166 0.62
640_G 645_V 1.163 0.62
780_P 817_W 1.163 0.62
675_A 688_L 1.163 0.62
690_D 713_K 1.159 0.62
398_G 430_G 1.156 0.61
470_L 477_A 1.155 0.61
670_T 688_L 1.154 0.61
361_P 464_S 1.154 0.61
750_T 753_A 1.153 0.61
167_D 207_P 1.151 0.61
258_A 262_D 1.151 0.61
472_S 516_Q 1.15 0.61
178_I 197_G 1.149 0.61
169_I 671_T 1.149 0.61
366_P 400_A 1.148 0.60
708_T 766_K 1.148 0.60
692_D 708_T 1.148 0.60
328_I 717_S 1.144 0.60
59_V 138_L 1.144 0.60
250_L 279_V 1.142 0.60
270_D 458_S 1.139 0.60
818_S 821_A 1.138 0.59
249_A 351_Q 1.138 0.59
406_Y 781_F 1.132 0.59
291_R 723_Y 1.129 0.59
811_E 827_L 1.128 0.58
475_T 511_T 1.127 0.58
358_A 363_L 1.127 0.58
255_A 371_Y 1.126 0.58
326_F 345_E 1.124 0.58
399_I 405_L 1.121 0.58
406_Y 460_R 1.118 0.57
377_R 387_G 1.118 0.57
596_G 603_D 1.117 0.57
406_Y 535_W 1.116 0.57
165_W 781_F 1.115 0.57
282_D 751_E 1.114 0.57
103_A 153_E 1.114 0.57
303_T 417_S 1.113 0.57
608_G 633_D 1.112 0.57
688_L 756_Y 1.11 0.57
305_A 347_N 1.105 0.56
149_Q 292_G 1.105 0.56
396_S 766_K 1.102 0.56
462_S 475_T 1.102 0.56
199_G 614_D 1.101 0.56
447_T 454_L 1.1 0.56
165_W 748_T 1.099 0.55
335_V 708_T 1.098 0.55
559_M 563_L 1.097 0.55
61_P 631_S 1.097 0.55
798_D 805_A 1.096 0.55
164_R 724_R 1.092 0.55
272_F 410_L 1.091 0.55
435_D 458_S 1.09 0.55
512_A 527_L 1.089 0.54
241_W 261_E 1.088 0.54
489_M 492_Y 1.082 0.54
531_R 541_T 1.082 0.54
437_T 458_S 1.082 0.54
526_Y 529_Y 1.08 0.53
301_A 321_V 1.075 0.53
72_K 642_L 1.074 0.53
248_R 257_L 1.072 0.53
764_G 803_Y 1.071 0.53
559_M 613_V 1.07 0.52
196_S 561_V 1.07 0.52
147_L 309_V 1.07 0.52
213_D 764_G 1.067 0.52
295_P 398_G 1.065 0.52
433_A 462_S 1.063 0.52
433_A 795_L 1.062 0.52
99_P 730_D 1.053 0.51
307_V 321_V 1.053 0.51
204_N 215_Q 1.053 0.51
96_C 685_T 1.05 0.50
507_K 535_W 1.05 0.50
388_G 492_Y 1.05 0.50
672_H 676_L 1.049 0.50
169_I 668_T 1.047 0.50
306_K 320_Q 1.046 0.50
129_L 151_Y 1.045 0.50
145_I 192_S 1.045 0.50
246_A 259_L 1.042 0.50
332_G 662_S 1.04 0.49
156_W 289_N 1.04 0.49
323_A 601_G 1.039 0.49
578_M 596_G 1.038 0.49
687_L 755_G 1.036 0.49
295_P 421_G 1.035 0.49
67_Q 77_E 1.035 0.49
430_G 463_Y 1.034 0.49
466_D 471_N 1.034 0.49
458_S 477_A 1.033 0.49
436_V 525_V 1.032 0.48
39_F 464_S 1.032 0.48
277_G 417_S 1.032 0.48
259_L 277_G 1.032 0.48
293_Y 358_A 1.031 0.48
441_T 487_M 1.031 0.48
434_F 459_F 1.031 0.48
675_A 713_K 1.03 0.48
670_T 709_N 1.029 0.48
270_D 535_W 1.029 0.48
173_I 668_T 1.029 0.48
475_T 479_Y 1.026 0.48
637_S 644_Q 1.025 0.48
548_S 560_S 1.024 0.48
179_T 657_T 1.023 0.48
61_P 350_V 1.022 0.47
525_V 593_S 1.022 0.47
307_V 326_F 1.021 0.47
59_V 93_S 1.019 0.47
268_I 419_A 1.018 0.47
168_G 311_Q 1.017 0.47
198_N 567_R 1.015 0.47
645_V 664_Q 1.014 0.47
624_G 631_S 1.013 0.46
152_L 322_P 1.013 0.46
716_V 727_A 1.011 0.46
107_L 129_L 1.011 0.46
815_V 825_I 1.005 0.46
213_D 750_T 1.005 0.46
35_F 40_L 1.004 0.46
290_L 293_Y 1.004 0.46
765_Q 837_N 1.003 0.45
201_V 619_Y 1.002 0.45
547_L 554_G 1 0.45
487_M 677_H 1 0.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3rfzB20.90241000.201Contact Map0.675
3fipA20.54941000.509Contact Map0.654
3fcgA20.1011000.853Contact Map0.765
4b0mA10.15211000.866Contact Map0.82
3bwuD10.140799.90.882Contact Map0.834
3l48A50.106799.70.916Contact Map0.93
2xetA20.095399.70.917Contact Map0.839
3e8vA10.08455.10.983Contact Map0.418
4kdwA10.127139.50.984Contact Map0.499
3pe9A40.105614.90.987Contact Map0.708
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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