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OPENSEQ.org
YHCD - Uncharacterized outer membrane usher protein YhcD
UniProt: P45420 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12810
Length: 793 (761)
Sequences: 1381
Seq/Len: 1.81
YHCD
Paralog alert: 0.81 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: ELFC FIMD HTRE SFMD YAGX YBGQ YEHB YFCU YHCD YQIG YRAJ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
259_V 272_I 4.22 1.00
85_C 106_C 4.102 1.00
633_A 666_I 3.521 1.00
593_S 609_T 3.521 1.00
268_A 309_E 3.458 1.00
45_I 49_F 3.127 1.00
624_S 662_V 3.115 1.00
226_E 240_Y 2.977 1.00
239_I 351_V 2.823 1.00
269_R 308_V 2.799 1.00
159_L 176_A 2.797 1.00
306_T 314_S 2.774 1.00
714_A 754_I 2.662 1.00
595_A 607_N 2.612 1.00
622_T 656_D 2.599 1.00
616_V 621_V 2.583 1.00
636_K 705_G 2.55 1.00
758_M 773_L 2.543 1.00
732_I 760_L 2.538 1.00
308_V 314_S 2.454 1.00
468_G 493_W 2.426 1.00
45_I 48_Y 2.42 1.00
264_N 313_S 2.419 1.00
141_L 333_G 2.367 1.00
264_N 315_H 2.33 1.00
730_V 762_I 2.307 1.00
46_S 49_F 2.255 1.00
732_I 749_V 2.232 1.00
614_I 623_F 2.228 1.00
400_S 443_A 2.228 1.00
273_R 278_L 2.221 0.99
495_K 502_V 2.221 0.99
44_N 48_Y 2.183 0.99
193_Q 204_N 2.145 0.99
304_N 316_N 2.115 0.99
617_H 622_T 2.114 0.99
307_V 315_H 2.082 0.99
634_I 660_N 2.078 0.99
186_D 213_R 2.073 0.99
613_G 624_S 2.069 0.99
189_L 211_L 2.039 0.99
65_S 126_A 2.017 0.99
272_I 291_I 1.999 0.99
718_I 771_I 1.999 0.99
152_A 701_V 1.972 0.99
565_Y 582_S 1.939 0.98
108_D 111_L 1.919 0.98
367_N 394_S 1.905 0.98
636_K 703_K 1.904 0.98
189_L 209_T 1.877 0.98
271_E 278_L 1.872 0.98
712_R 756_P 1.865 0.98
62_L 120_P 1.862 0.98
632_F 701_V 1.856 0.98
619_Q 636_K 1.85 0.98
181_G 190_R 1.843 0.97
234_L 369_G 1.839 0.97
150_G 634_I 1.826 0.97
333_G 430_L 1.824 0.97
46_S 333_G 1.814 0.97
44_N 49_F 1.811 0.97
44_N 47_H 1.793 0.97
760_L 771_I 1.79 0.97
394_S 413_R 1.75 0.96
471_N 492_N 1.745 0.96
273_R 306_T 1.743 0.96
62_L 78_F 1.717 0.96
250_L 253_S 1.703 0.95
78_F 84_I 1.7 0.95
336_F 354_A 1.699 0.95
567_N 580_N 1.694 0.95
130_I 285_P 1.693 0.95
271_E 308_V 1.672 0.95
637_M 708_A 1.662 0.95
592_V 610_M 1.658 0.94
223_R 245_A 1.654 0.94
97_K 100_S 1.651 0.94
243_E 335_R 1.648 0.94
45_I 333_G 1.648 0.94
212_Q 221_L 1.645 0.94
59_E 75_A 1.638 0.94
590_T 610_M 1.621 0.94
672_S 696_Q 1.616 0.93
617_H 660_N 1.614 0.93
119_T 128_D 1.612 0.93
684_N 712_R 1.603 0.93
630_D 698_R 1.592 0.93
141_L 430_L 1.59 0.93
159_L 174_S 1.582 0.92
637_M 641_I 1.565 0.92
614_I 621_V 1.56 0.92
259_V 303_L 1.551 0.91
718_I 749_V 1.546 0.91
726_L 762_I 1.531 0.91
227_V 239_I 1.521 0.90
613_G 662_V 1.521 0.90
188_M 697_G 1.506 0.90
182_I 189_L 1.505 0.90
249_A 698_R 1.505 0.90
87_D 90_F 1.497 0.89
151_T 182_I 1.493 0.89
263_A 284_V 1.489 0.89
411_K 433_S 1.484 0.89
505_N 524_Y 1.475 0.88
718_I 762_I 1.474 0.88
587_L 590_T 1.473 0.88
227_V 337_A 1.459 0.88
214_T 221_L 1.457 0.88
732_I 762_I 1.457 0.88
340_R 350_W 1.448 0.87
304_N 318_I 1.448 0.87
307_V 317_Y 1.433 0.87
618_D 703_K 1.416 0.86
720_L 726_L 1.415 0.86
154_L 632_F 1.415 0.86
523_F 541_T 1.413 0.85
633_A 674_V 1.41 0.85
118_I 129_I 1.408 0.85
235_E 439_E 1.398 0.85
191_S 206_N 1.389 0.84
215_F 218_L 1.388 0.84
613_G 632_F 1.382 0.84
148_T 216_T 1.38 0.84
378_A 396_Q 1.367 0.83
696_Q 702_G 1.367 0.83
411_K 431_T 1.363 0.83
61_S 75_A 1.358 0.82
260_T 290_T 1.351 0.82
46_S 141_L 1.35 0.82
469_G 749_V 1.342 0.81
239_I 337_A 1.326 0.80
615_A 701_V 1.326 0.80
191_S 209_T 1.326 0.80
43_P 49_F 1.324 0.80
45_I 141_L 1.323 0.80
644_V 655_T 1.322 0.80
397_I 410_Q 1.321 0.80
49_F 333_G 1.321 0.80
161_S 608_G 1.315 0.79
472_I 491_I 1.314 0.79
455_T 477_T 1.312 0.79
543_H 547_K 1.31 0.79
641_I 708_A 1.31 0.79
539_L 550_Y 1.31 0.79
454_S 478_Y 1.306 0.79
151_T 618_D 1.303 0.78
364_S 385_L 1.299 0.78
646_I 663_I 1.296 0.78
716_L 788_A 1.292 0.78
494_N 503_S 1.291 0.78
508_H 521_D 1.289 0.77
615_A 632_F 1.285 0.77
671_T 693_M 1.284 0.77
359_N 365_A 1.278 0.77
409_G 416_A 1.276 0.76
687_I 690_G 1.267 0.76
155_L 180_G 1.266 0.76
497_F 502_V 1.266 0.76
183_N 190_R 1.264 0.75
239_I 243_E 1.263 0.75
426_L 459_G 1.263 0.75
409_G 428_T 1.258 0.75
714_A 775_F 1.253 0.75
215_F 244_I 1.251 0.74
727_P 730_V 1.251 0.74
476_K 485_D 1.246 0.74
720_L 724_K 1.244 0.74
64_V 76_T 1.243 0.74
711_Q 753_N 1.242 0.74
90_F 94_A 1.241 0.74
257_V 359_N 1.24 0.73
267_Q 309_E 1.237 0.73
476_K 487_S 1.236 0.73
619_Q 703_K 1.233 0.73
273_R 304_N 1.232 0.73
251_Q 418_Y 1.227 0.72
661_A 664_P 1.227 0.72
734_D 738_N 1.226 0.72
271_E 281_S 1.225 0.72
121_L 128_D 1.222 0.72
46_S 50_S 1.222 0.72
65_S 128_D 1.22 0.72
718_I 726_L 1.219 0.72
325_N 417_N 1.218 0.72
214_T 697_G 1.216 0.71
120_P 125_E 1.214 0.71
635_A 762_I 1.213 0.71
622_T 658_R 1.212 0.71
48_Y 333_G 1.21 0.71
151_T 701_V 1.208 0.71
173_Y 224_A 1.208 0.71
269_R 281_S 1.205 0.70
637_M 644_V 1.203 0.70
410_Q 434_D 1.202 0.70
635_A 646_I 1.201 0.70
250_L 409_G 1.196 0.70
663_I 674_V 1.195 0.69
628_I 632_F 1.185 0.69
716_L 751_L 1.183 0.68
371_I 440_L 1.183 0.68
360_L 715_L 1.182 0.68
157_Y 612_G 1.18 0.68
91_L 96_L 1.177 0.68
145_N 671_T 1.176 0.68
411_K 480_Y 1.175 0.68
136_I 242_I 1.175 0.68
769_C 792_C 1.17 0.67
759_V 770_R 1.169 0.67
771_I 790_G 1.168 0.67
587_L 592_V 1.165 0.67
464_N 468_G 1.164 0.67
213_R 222_M 1.158 0.66
615_A 634_I 1.156 0.66
153_A 182_I 1.153 0.65
256_G 331_F 1.147 0.65
85_C 319_V 1.146 0.65
305_V 319_V 1.145 0.65
367_N 382_R 1.144 0.65
44_N 333_G 1.144 0.65
331_F 416_A 1.14 0.64
150_G 701_V 1.14 0.64
240_Y 342_D 1.138 0.64
66_V 136_I 1.137 0.64
223_R 227_V 1.134 0.64
57_P 578_S 1.134 0.64
636_K 660_N 1.134 0.64
718_I 743_S 1.131 0.63
727_P 764_D 1.13 0.63
332_Q 362_R 1.126 0.63
419_N 423_S 1.124 0.63
150_G 618_D 1.121 0.62
268_A 311_D 1.12 0.62
435_R 674_V 1.119 0.62
655_T 713_R 1.117 0.62
43_P 47_H 1.115 0.62
182_I 196_T 1.115 0.62
458_L 472_I 1.114 0.62
63_I 66_V 1.113 0.61
502_V 525_V 1.113 0.61
135_A 288_A 1.113 0.61
252_T 670_R 1.111 0.61
622_T 634_I 1.109 0.61
55_F 122_P 1.108 0.61
459_G 526_N 1.108 0.61
113_Y 135_A 1.107 0.61
424_L 432_R 1.106 0.61
656_D 662_V 1.103 0.60
140_G 253_S 1.097 0.60
655_T 751_L 1.097 0.60
442_E 445_D 1.093 0.59
553_G 580_N 1.092 0.59
330_S 416_A 1.091 0.59
538_T 553_G 1.09 0.59
43_P 333_G 1.088 0.59
45_I 355_S 1.087 0.59
65_S 70_K 1.087 0.59
638_D 658_R 1.086 0.59
45_I 52_S 1.085 0.59
295_P 609_T 1.085 0.59
74_I 93_Q 1.083 0.58
322_T 329_E 1.083 0.58
359_N 389_P 1.078 0.58
598_A 604_R 1.078 0.58
68_G 589_Y 1.076 0.58
638_D 655_T 1.075 0.57
341_V 444_I 1.075 0.57
411_K 429_S 1.074 0.57
617_H 620_G 1.073 0.57
325_N 409_G 1.073 0.57
613_G 628_I 1.068 0.57
91_L 437_Y 1.068 0.57
247_D 698_R 1.065 0.56
214_T 319_V 1.063 0.56
616_V 634_I 1.063 0.56
44_N 141_L 1.062 0.56
319_V 329_E 1.062 0.56
153_A 616_V 1.06 0.56
464_N 493_W 1.06 0.56
697_G 700_A 1.06 0.56
459_G 473_S 1.059 0.56
325_N 351_V 1.052 0.55
330_S 409_G 1.052 0.55
713_R 752_N 1.05 0.55
147_A 150_G 1.049 0.55
154_L 701_V 1.049 0.55
329_E 411_K 1.049 0.55
307_V 485_D 1.047 0.54
731_A 739_Y 1.043 0.54
424_L 462_W 1.041 0.54
307_V 319_V 1.041 0.54
409_G 414_L 1.04 0.54
48_Y 52_S 1.039 0.54
396_Q 433_S 1.039 0.54
66_V 114_P 1.038 0.53
332_Q 361_T 1.035 0.53
179_E 192_H 1.03 0.53
267_Q 286_A 1.028 0.52
206_N 633_A 1.027 0.52
250_L 411_K 1.025 0.52
214_T 315_H 1.024 0.52
138_P 292_P 1.023 0.52
634_I 703_K 1.023 0.52
409_G 423_S 1.023 0.52
730_V 764_D 1.022 0.52
355_S 560_D 1.022 0.52
583_I 594_L 1.02 0.52
504_V 525_V 1.02 0.52
503_S 526_N 1.019 0.51
688_G 707_S 1.019 0.51
758_M 775_F 1.018 0.51
136_I 285_P 1.018 0.51
113_Y 116_T 1.015 0.51
146_A 695_K 1.015 0.51
148_T 186_D 1.013 0.51
417_N 427_T 1.013 0.51
613_G 697_G 1.012 0.51
438_R 624_S 1.011 0.51
154_L 615_A 1.011 0.51
327_H 416_A 1.01 0.50
409_G 425_G 1.009 0.50
221_L 247_D 1.008 0.50
57_P 314_S 1.007 0.50
360_L 366_M 1.007 0.50
440_L 443_A 1.006 0.50
43_P 48_Y 1.005 0.50
43_P 46_S 1.005 0.50
430_L 558_V 1.003 0.50
47_H 52_S 1.001 0.49
214_T 669_W 1 0.49
507_Q 522_L 1 0.49
106_C 319_V 1 0.49
289_F 309_E 1 0.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3rfzB20.95211000.022Contact Map0.719
3fipA20.57631000.42Contact Map0.711
3fcgA20.10971000.831Contact Map0.812
4b0mA10.150199.90.848Contact Map0.663
3bwuD10.143899.90.858Contact Map0.786
2xetA20.103499.70.891Contact Map0.895
3l48A50.105999.70.896Contact Map1
3e8vA10.0921630.976Contact Map0.428
4kdwA10.1461.90.976Contact Map0.499
2chhA10.136244.30.979Contact Map0.525
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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