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OPENSEQ.org
YRAJ - Uncharacterized outer membrane usher protein YraJ
UniProt: P42915 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12775
Length: 838 (792)
Sequences: 1331
Seq/Len: 1.68
YRAJ
Paralog alert: 0.81 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: ELFC FIMD HTRE SFMD YAGX YBGQ YEHB YFCU YHCD YQIG YRAJ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
105_Q 133_I 4.174 1.00
293_V 305_I 3.954 1.00
677_A 708_L 3.816 1.00
301_A 342_E 3.759 1.00
639_S 654_G 3.572 1.00
669_S 704_V 3.249 1.00
257_E 271_T 3.132 1.00
366_L 395_Y 2.99 1.00
270_F 388_F 2.947 1.00
756_V 796_I 2.942 1.00
774_A 803_W 2.882 1.00
667_T 698_D 2.766 1.00
641_G 652_N 2.693 1.00
339_T 347_Q 2.651 1.00
302_I 341_E 2.644 1.00
661_I 666_V 2.643 1.00
680_D 747_R 2.623 1.00
800_S 819_F 2.616 1.00
298_N 346_T 2.587 1.00
659_V 668_L 2.569 1.00
366_L 393_A 2.567 1.00
512_V 537_V 2.479 1.00
341_E 347_Q 2.466 1.00
224_S 235_W 2.449 1.00
774_A 791_L 2.442 1.00
612_S 628_N 2.438 1.00
439_T 485_A 2.371 1.00
662_H 667_T 2.365 1.00
298_N 348_R 2.353 1.00
772_A 805_V 2.345 1.00
340_I 348_R 2.291 1.00
306_R 311_V 2.25 0.99
217_P 244_R 2.205 0.99
189_F 207_L 2.196 0.99
337_E 349_R 2.194 0.99
614_E 626_S 2.183 0.99
539_G 546_Y 2.181 0.99
678_L 702_Y 2.148 0.99
305_I 324_I 2.11 0.99
760_V 817_F 2.098 0.99
658_G 669_S 2.088 0.99
94_F 104_P 2.066 0.99
182_T 743_M 2.045 0.99
220_L 242_L 2.031 0.99
212_G 221_R 2.02 0.99
180_I 678_L 2.018 0.99
81_W 153_Q 2.008 0.99
583_Y 595_H 1.95 0.98
680_D 745_A 1.945 0.98
78_V 147_F 1.944 0.98
170_Y 173_P 1.932 0.98
135_S 138_Q 1.929 0.98
404_Y 433_D 1.926 0.98
433_D 453_R 1.913 0.98
664_H 680_D 1.894 0.98
515_Y 536_G 1.894 0.98
306_R 339_T 1.891 0.98
370_A 391_A 1.873 0.97
676_F 743_M 1.846 0.97
658_G 672_L 1.83 0.97
304_T 311_V 1.825 0.97
78_V 94_F 1.823 0.97
220_L 240_S 1.814 0.97
265_F 406_G 1.785 0.96
243_Q 252_Q 1.775 0.96
803_W 817_F 1.757 0.96
662_H 702_Y 1.751 0.96
636_G 655_V 1.737 0.95
638_F 655_V 1.736 0.95
213_A 220_L 1.731 0.95
451_Q 473_R 1.716 0.95
681_A 750_A 1.715 0.95
674_N 740_R 1.706 0.95
549_N 565_S 1.688 0.94
61_D 65_F 1.683 0.94
117_K 120_E 1.668 0.94
754_Y 798_S 1.652 0.94
714_N 738_P 1.648 0.93
274_Q 369_S 1.629 0.93
658_G 704_V 1.624 0.93
246_I 249_L 1.622 0.93
219_R 739_N 1.621 0.93
451_Q 475_T 1.62 0.93
157_S 318_S 1.617 0.93
146_E 155_N 1.602 0.92
258_S 270_F 1.573 0.91
762_D 768_L 1.57 0.91
304_T 341_E 1.569 0.91
672_L 676_F 1.56 0.91
258_S 371_T 1.555 0.91
254_L 276_A 1.554 0.90
145_A 156_L 1.554 0.90
340_I 350_F 1.552 0.90
280_N 740_R 1.548 0.90
774_A 805_V 1.546 0.90
768_L 805_V 1.543 0.90
352_Q 360_M 1.539 0.90
582_S 598_R 1.534 0.90
681_A 684_A 1.528 0.89
760_V 791_L 1.527 0.89
133_I 360_M 1.522 0.89
184_F 676_F 1.516 0.89
294_R 323_E 1.516 0.89
168_R 328_Y 1.514 0.89
663_P 745_A 1.502 0.88
293_V 336_L 1.501 0.88
279_D 367_K 1.499 0.88
105_Q 360_M 1.498 0.88
659_V 666_V 1.495 0.88
279_D 365_H 1.491 0.88
436_R 450_Y 1.489 0.88
75_T 91_K 1.485 0.88
738_P 744_V 1.481 0.87
726_N 754_Y 1.473 0.87
181_P 213_A 1.47 0.87
633_S 636_G 1.467 0.87
290_A 362_R 1.466 0.87
538_S 547_S 1.464 0.87
451_Q 524_W 1.464 0.87
297_A 317_V 1.46 0.86
760_V 805_V 1.46 0.86
658_G 676_F 1.458 0.86
337_E 351_I 1.455 0.86
107_T 110_Q 1.426 0.85
508_I 512_V 1.415 0.84
245_D 252_Q 1.394 0.83
499_E 521_Q 1.393 0.83
358_P 388_F 1.384 0.82
222_N 237_T 1.383 0.82
77_Q 91_K 1.382 0.82
222_N 240_S 1.375 0.82
713_E 735_F 1.372 0.81
178_D 247_K 1.37 0.81
677_A 716_L 1.368 0.81
80_I 92_I 1.366 0.81
769_P 772_A 1.361 0.81
513_S 791_L 1.351 0.80
415_A 435_N 1.347 0.80
270_F 371_T 1.344 0.80
185_T 211_N 1.344 0.80
300_S 342_E 1.335 0.79
516_A 535_V 1.329 0.78
465_T 474_Y 1.328 0.78
463_T 470_S 1.326 0.78
81_W 86_K 1.322 0.78
266_S 481_S 1.319 0.78
815_C 837_C 1.311 0.77
245_D 739_N 1.309 0.77
756_V 821_T 1.307 0.77
191_G 653_Y 1.304 0.77
703_A 706_P 1.304 0.77
684_A 750_A 1.302 0.76
148_D 155_N 1.297 0.76
401_F 422_G 1.296 0.76
105_Q 352_Q 1.295 0.76
660_V 678_L 1.291 0.76
270_F 274_Q 1.29 0.75
758_V 833_G 1.287 0.75
396_G 428_G 1.282 0.75
689_I 705_V 1.28 0.75
687_V 697_T 1.28 0.75
284_N 712_Q 1.27 0.74
397_L 757_L 1.268 0.74
682_N 697_T 1.264 0.73
587_S 592_P 1.263 0.73
306_R 337_E 1.263 0.73
762_D 766_K 1.262 0.73
404_Y 419_G 1.257 0.73
374_R 387_E 1.255 0.73
679_I 805_V 1.254 0.73
419_G 428_G 1.253 0.72
760_V 768_L 1.248 0.72
588_Q 591_R 1.246 0.72
214_N 221_R 1.245 0.72
73_P 624_N 1.244 0.72
664_H 745_A 1.243 0.72
271_T 376_R 1.241 0.71
180_I 743_M 1.241 0.71
552_Y 562_R 1.239 0.71
363_P 399_N 1.238 0.71
181_P 743_M 1.237 0.71
304_T 314_Q 1.235 0.71
187_Y 657_G 1.234 0.71
660_V 676_F 1.233 0.71
244_R 253_L 1.231 0.71
662_H 665_G 1.223 0.70
753_G 795_G 1.222 0.70
181_P 663_P 1.22 0.70
254_L 258_S 1.218 0.69
681_A 687_V 1.216 0.69
110_Q 114_L 1.215 0.69
301_A 344_D 1.213 0.69
121_I 162_A 1.212 0.69
138_Q 305_I 1.212 0.69
705_V 716_L 1.203 0.68
680_D 702_Y 1.198 0.68
338_V 352_Q 1.197 0.67
133_I 352_Q 1.194 0.67
340_I 352_Q 1.191 0.67
698_D 704_V 1.189 0.67
463_T 518_G 1.188 0.67
633_S 638_F 1.187 0.67
408_L 482_F 1.187 0.67
817_F 835_A 1.186 0.66
111_L 116_I 1.186 0.66
467_I 503_N 1.185 0.66
147_F 152_Q 1.184 0.66
140_I 143_T 1.183 0.66
396_G 402_T 1.183 0.66
520_Q 531_R 1.183 0.66
291_P 419_G 1.181 0.66
667_T 700_F 1.175 0.65
660_V 743_M 1.174 0.65
81_W 155_N 1.173 0.65
498_S 522_D 1.173 0.65
165_R 325_N 1.172 0.65
697_T 755_R 1.171 0.65
729_L 732_T 1.17 0.65
670_Q 694_G 1.165 0.64
364_G 428_G 1.164 0.64
79_D 89_Q 1.162 0.64
769_P 807_W 1.162 0.64
682_N 700_F 1.16 0.64
79_D 82_L 1.16 0.64
760_V 785_V 1.157 0.64
180_I 663_P 1.153 0.63
302_I 314_Q 1.149 0.63
507_T 588_Q 1.14 0.62
204_R 255_L 1.14 0.62
245_D 711_Y 1.139 0.62
502_F 516_A 1.139 0.62
189_F 205_Q 1.138 0.62
163_L 273_V 1.137 0.62
339_T 349_R 1.134 0.61
463_T 506_Q 1.134 0.61
522_D 529_K 1.133 0.61
404_Y 453_R 1.131 0.61
450_Y 476_N 1.129 0.61
758_V 793_L 1.129 0.61
245_D 352_Q 1.128 0.61
324_I 706_P 1.127 0.61
497_K 524_W 1.127 0.61
210_Q 223_Y 1.127 0.61
541_Q 546_Y 1.126 0.60
71_Q 149_F 1.124 0.60
71_Q 102_L 1.12 0.60
455_Q 468_A 1.118 0.60
679_I 689_I 1.117 0.60
82_L 163_L 1.116 0.59
672_L 743_M 1.115 0.59
375_Y 486_N 1.112 0.59
661_I 678_L 1.112 0.59
772_A 807_W 1.11 0.59
188_S 689_I 1.108 0.59
75_T 93_T 1.108 0.59
183_L 213_A 1.106 0.58
363_P 398_N 1.105 0.58
629_A 640_A 1.105 0.58
472_Y 475_T 1.103 0.58
84_K 635_Y 1.1 0.58
662_H 678_L 1.1 0.58
801_Q 816_Q 1.098 0.58
808_G 811_A 1.097 0.57
184_F 743_M 1.095 0.57
520_Q 529_K 1.091 0.57
322_F 342_E 1.089 0.57
355_S 360_M 1.089 0.57
251_S 368_Y 1.086 0.56
667_T 678_L 1.083 0.56
755_R 794_S 1.081 0.56
515_Y 518_G 1.075 0.55
394_I 755_R 1.074 0.55
319_A 591_R 1.073 0.55
246_I 275_L 1.071 0.55
433_D 451_Q 1.07 0.55
291_P 396_G 1.069 0.55
459_D 464_N 1.066 0.54
739_N 742_A 1.065 0.54
62_L 65_F 1.064 0.54
477_D 716_L 1.064 0.54
667_T 702_Y 1.062 0.54
432_M 452_W 1.059 0.53
278_D 740_R 1.058 0.53
632_R 670_Q 1.058 0.53
470_S 502_F 1.054 0.53
439_T 547_S 1.053 0.53
178_D 217_P 1.052 0.53
434_I 514_L 1.049 0.52
472_Y 658_G 1.048 0.52
753_G 792_Y 1.047 0.52
299_S 415_A 1.046 0.52
105_Q 675_A 1.046 0.52
603_L 611_Y 1.046 0.52
251_S 277_S 1.045 0.52
176_W 737_V 1.045 0.52
220_L 548_L 1.045 0.52
435_N 451_Q 1.042 0.52
70_A 102_L 1.042 0.52
546_Y 566_L 1.04 0.51
241_Y 741_G 1.038 0.51
644_Y 649_S 1.036 0.51
133_I 482_F 1.036 0.51
283_P 396_G 1.036 0.51
468_A 501_Q 1.035 0.51
509_F 512_V 1.035 0.51
428_G 456_Y 1.035 0.51
180_I 660_V 1.034 0.51
451_Q 472_Y 1.034 0.51
245_D 348_R 1.032 0.51
237_T 257_E 1.03 0.50
305_I 568_L 1.03 0.50
156_L 202_S 1.029 0.50
773_L 782_Q 1.028 0.50
344_D 803_W 1.027 0.50
263_S 367_K 1.026 0.50
260_T 645_G 1.025 0.50
152_Q 361_Q 1.025 0.50
358_P 457_I 1.025 0.50
424_L 513_S 1.024 0.50
662_H 698_D 1.023 0.50
421_G 431_S 1.023 0.50
264_I 417_G 1.023 0.50
564_L 585_M 1.021 0.49
434_I 545_G 1.021 0.49
787_E 794_S 1.021 0.49
678_L 745_A 1.019 0.49
344_D 743_M 1.019 0.49
179_G 307_Q 1.016 0.49
287_R 388_F 1.016 0.49
681_A 697_T 1.01 0.48
468_A 472_Y 1.009 0.48
184_F 660_V 1.008 0.48
176_W 770_F 1.008 0.48
318_S 484_E 1.006 0.48
403_L 819_F 1.005 0.48
266_S 404_Y 1.004 0.48
451_Q 470_S 1.003 0.48
484_E 487_T 1.003 0.48
162_A 321_A 1.002 0.47
268_Y 408_L 1.002 0.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3rfzB20.94151000.106Contact Map0.703
3fipA20.56321000.476Contact Map0.699
3fcgA20.10741000.842Contact Map0.782
4b0mA10.15871000.856Contact Map0.852
3bwuD10.14899.90.872Contact Map0.89
2xetA20.100299.70.907Contact Map0.889
3l48A50.100299.60.915Contact Map0.95
3e8vA10.089568.80.979Contact Map0.485
4kdwA10.13660.80.98Contact Map0.488
3pe9A40.11132.30.983Contact Map0.693
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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