May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
FIMD - Outer membrane usher protein FimD
UniProt: P30130 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10311
Length: 878 (803)
Sequences: 1257
Seq/Len: 1.57
FIMD
Paralog alert: 0.74 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: ELFC FIMD HTRE SFMD YAGX YBGQ YEHB YFCU YHCD YQIG YRAJ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
108_C 135_C 4.284 1.00
301_I 313_I 4.166 1.00
719_V 750_A 3.915 1.00
309_A 350_E 3.76 1.00
681_N 696_G 3.578 1.00
265_D 279_R 3.189 1.00
711_G 746_V 3.056 1.00
798_L 837_M 2.999 1.00
709_T 740_D 2.885 1.00
374_T 402_H 2.829 1.00
278_F 395_F 2.819 1.00
815_V 843_V 2.748 1.00
683_G 694_Y 2.741 1.00
310_Q 349_K 2.699 1.00
841_G 859_Y 2.692 1.00
701_V 710_L 2.655 1.00
347_T 355_T 2.635 1.00
306_R 354_S 2.632 1.00
226_T 243_W 2.584 1.00
349_K 355_T 2.52 1.00
374_T 400_L 2.486 1.00
815_V 832_V 2.478 1.00
704_H 709_T 2.462 1.00
722_K 789_E 2.448 1.00
306_R 356_Q 2.43 1.00
541_S 566_L 2.415 1.00
813_A 845_V 2.391 1.00
703_A 708_V 2.319 1.00
446_S 492_T 2.285 0.99
348_I 356_Q 2.285 0.99
345_Q 357_I 2.275 0.99
314_K 319_D 2.25 0.99
219_A 252_R 2.221 0.99
720_L 744_Y 2.202 0.99
802_L 857_A 2.192 0.99
184_A 785_I 2.171 0.99
313_I 332_I 2.168 0.99
191_F 209_L 2.113 0.99
96_F 107_P 2.097 0.99
544_Y 565_G 2.096 0.99
568_T 575_W 2.086 0.99
137_P 140_T 2.069 0.99
222_L 250_L 2.06 0.99
650_S 670_T 2.057 0.99
411_Y 440_D 2.052 0.99
83_Y 155_R 2.045 0.99
182_I 720_L 2.033 0.98
621_Y 633_N 2.033 0.98
80_V 96_F 2.011 0.98
214_G 223_R 2.005 0.98
80_V 149_L 1.967 0.98
440_D 460_R 1.967 0.98
718_V 785_I 1.945 0.98
706_N 722_K 1.923 0.98
652_Q 668_Y 1.905 0.97
314_K 347_T 1.882 0.97
700_G 711_G 1.873 0.97
700_G 714_L 1.853 0.97
172_Y 175_P 1.853 0.97
680_A 697_V 1.849 0.97
722_K 787_R 1.833 0.96
312_T 319_D 1.818 0.96
222_L 248_T 1.798 0.96
704_H 744_Y 1.795 0.96
756_N 780_P 1.792 0.96
578_S 595_A 1.759 0.95
273_F 413_G 1.745 0.95
458_S 482_S 1.735 0.95
678_G 697_V 1.723 0.94
458_S 480_R 1.714 0.94
843_V 857_A 1.714 0.94
159_T 326_P 1.713 0.94
796_I 839_L 1.702 0.94
815_V 845_V 1.694 0.94
251_E 260_R 1.667 0.93
378_I 398_S 1.658 0.93
723_A 792_A 1.651 0.93
63_D 67_F 1.646 0.93
802_L 832_V 1.641 0.92
120_N 123_S 1.639 0.92
723_A 726_A 1.639 0.92
282_Q 377_S 1.638 0.92
148_H 157_N 1.621 0.92
768_N 796_I 1.619 0.92
262_T 284_A 1.617 0.92
135_C 368_L 1.614 0.92
254_I 257_L 1.612 0.91
716_D 782_R 1.611 0.91
714_L 718_V 1.61 0.91
108_C 368_L 1.604 0.91
705_A 787_R 1.602 0.91
458_S 553_W 1.593 0.91
360_V 368_L 1.588 0.91
266_G 379_T 1.587 0.91
288_N 782_R 1.586 0.91
701_V 708_V 1.576 0.90
221_R 781_T 1.571 0.90
700_G 746_V 1.57 0.90
700_G 718_V 1.563 0.90
312_T 349_K 1.561 0.90
810_P 813_A 1.549 0.89
729_A 739_T 1.538 0.89
345_Q 359_T 1.537 0.89
215_L 222_L 1.534 0.89
802_L 845_V 1.533 0.89
302_H 331_T 1.532 0.88
528_K 550_Q 1.527 0.88
298_A 370_R 1.522 0.88
170_R 336_Y 1.517 0.88
567_N 576_T 1.515 0.88
301_I 344_L 1.514 0.88
348_I 358_F 1.504 0.87
726_A 792_A 1.503 0.87
266_G 278_F 1.496 0.87
443_Q 457_Q 1.491 0.87
809_L 845_V 1.488 0.86
82_I 94_V 1.479 0.86
77_T 93_D 1.47 0.86
780_P 786_V 1.462 0.85
287_D 375_R 1.454 0.85
804_H 809_L 1.451 0.85
183_N 215_L 1.447 0.84
719_V 758_V 1.439 0.84
366_P 395_F 1.438 0.84
675_G 678_G 1.434 0.84
755_E 777_N 1.431 0.83
180_P 255_I 1.43 0.83
186_L 718_V 1.427 0.83
147_A 158_L 1.419 0.83
287_D 373_H 1.418 0.83
422_A 442_T 1.408 0.82
305_A 325_V 1.408 0.82
79_R 93_D 1.397 0.81
224_D 245_H 1.396 0.81
408_W 429_K 1.388 0.81
278_F 379_T 1.387 0.81
110_T 113_Q 1.383 0.80
702_L 785_I 1.379 0.80
187_L 213_S 1.373 0.80
702_L 720_L 1.372 0.80
135_C 360_V 1.362 0.79
292_D 754_R 1.349 0.78
472_T 481_Y 1.346 0.78
83_Y 88_Y 1.339 0.77
702_L 718_V 1.337 0.77
182_I 785_I 1.335 0.77
253_D 781_T 1.335 0.77
542_T 832_V 1.334 0.77
278_F 282_Q 1.33 0.77
308_T 350_E 1.33 0.77
253_D 260_R 1.324 0.76
193_G 695_Y 1.32 0.76
150_D 157_N 1.316 0.76
191_F 207_A 1.316 0.76
470_S 535_Q 1.311 0.75
723_A 729_A 1.311 0.75
620_S 636_G 1.311 0.75
404_L 799_L 1.311 0.75
537_L 541_S 1.31 0.75
745_A 748_P 1.307 0.75
795_G 836_G 1.303 0.75
183_N 705_A 1.301 0.75
371_E 406_A 1.3 0.74
545_L 564_A 1.299 0.74
165_M 281_A 1.299 0.74
626_D 629_G 1.298 0.74
274_D 488_N 1.295 0.74
703_A 720_L 1.293 0.74
798_L 861_L 1.291 0.74
706_N 787_R 1.29 0.74
382_E 394_R 1.29 0.74
800_M 873_L 1.283 0.73
704_H 707_G 1.283 0.73
415_Q 489_F 1.282 0.73
477_V 531_L 1.279 0.73
108_C 360_V 1.274 0.72
740_D 746_V 1.274 0.72
81_D 84_L 1.273 0.72
75_P 663_S 1.27 0.72
348_I 360_V 1.268 0.72
183_N 785_I 1.267 0.72
813_A 847_W 1.265 0.72
810_P 847_W 1.258 0.71
403_G 435_G 1.251 0.70
182_I 705_A 1.248 0.70
314_K 345_Q 1.244 0.70
771_L 774_A 1.243 0.70
216_N 223_R 1.243 0.70
804_H 807_K 1.242 0.70
675_G 680_A 1.238 0.69
731_V 747_L 1.238 0.69
581_L 592_Q 1.238 0.69
224_D 248_T 1.235 0.69
625_H 630_R 1.234 0.69
857_A 875_A 1.233 0.69
135_C 489_F 1.231 0.69
312_T 322_N 1.229 0.68
113_Q 117_M 1.229 0.68
411_Y 426_G 1.228 0.68
310_Q 322_N 1.227 0.68
309_A 352_D 1.227 0.68
426_G 435_G 1.217 0.67
722_K 744_Y 1.214 0.67
83_Y 157_N 1.212 0.67
709_T 742_R 1.208 0.66
279_R 384_R 1.207 0.66
747_L 758_V 1.2 0.66
470_S 477_V 1.191 0.65
739_T 797_K 1.191 0.65
855_C 877_C 1.189 0.65
346_V 360_V 1.186 0.64
212_Q 225_N 1.186 0.64
262_T 266_G 1.183 0.64
549_H 560_E 1.178 0.64
253_D 360_V 1.177 0.63
802_L 826_V 1.175 0.63
363_S 368_L 1.175 0.63
299_P 426_G 1.171 0.63
712_Q 736_G 1.169 0.63
206_Y 263_L 1.165 0.62
458_S 479_Y 1.165 0.62
842_K 856_V 1.163 0.62
724_P 739_T 1.159 0.62
254_I 283_L 1.154 0.61
81_D 91_T 1.147 0.61
724_P 742_R 1.146 0.60
84_L 165_M 1.145 0.60
526_R 553_W 1.142 0.60
532_T 597_N 1.14 0.60
158_L 204_S 1.14 0.60
403_G 409_T 1.139 0.60
474_I 532_T 1.137 0.60
114_L 119_L 1.136 0.59
457_Q 483_T 1.135 0.59
704_H 720_L 1.135 0.59
371_E 405_P 1.135 0.59
189_Y 699_G 1.128 0.59
167_N 333_N 1.127 0.59
781_T 784_A 1.124 0.58
536_Q 626_D 1.122 0.58
411_Y 460_R 1.118 0.58
570_F 575_W 1.116 0.57
626_D 630_R 1.116 0.57
146_T 602_F 1.115 0.57
537_L 566_L 1.112 0.57
462_L 475_Q 1.11 0.57
641_L 649_Y 1.108 0.57
253_D 753_Y 1.108 0.57
180_P 219_A 1.108 0.57
252_R 261_L 1.106 0.56
797_K 835_S 1.105 0.56
714_L 785_I 1.104 0.56
709_T 720_L 1.103 0.56
259_S 376_Y 1.102 0.56
531_L 545_L 1.1 0.56
817_S 821_Q 1.1 0.56
828_D 835_S 1.099 0.56
330_F 350_E 1.098 0.56
848_G 851_E 1.098 0.56
124_V 164_F 1.095 0.55
800_M 834_L 1.092 0.55
142_V 145_A 1.091 0.55
115_A 166_S 1.091 0.55
274_D 458_S 1.089 0.55
159_T 327_P 1.088 0.55
149_L 154_Q 1.086 0.54
606_L 615_R 1.085 0.54
181_G 315_Q 1.084 0.54
108_C 717_T 1.08 0.54
479_Y 482_S 1.078 0.53
86_N 677_Y 1.078 0.53
253_D 290_L 1.076 0.53
842_K 858_N 1.073 0.53
441_M 543_L 1.07 0.53
178_W 811_F 1.07 0.53
401_L 797_K 1.069 0.53
299_P 403_G 1.069 0.53
115_A 731_V 1.068 0.52
286_D 782_R 1.066 0.52
77_T 95_T 1.065 0.52
347_T 357_I 1.064 0.52
440_D 458_S 1.061 0.52
119_L 142_V 1.06 0.52
186_L 702_L 1.059 0.51
332_I 748_P 1.058 0.51
73_L 151_V 1.058 0.51
709_T 744_Y 1.057 0.51
442_T 482_S 1.056 0.51
299_P 552_Y 1.055 0.51
475_Q 479_Y 1.055 0.51
276_I 415_Q 1.053 0.51
162_Q 296_G 1.052 0.51
623_M 631_M 1.051 0.51
259_S 285_S 1.05 0.51
472_T 535_Q 1.049 0.50
140_T 313_I 1.049 0.50
672_N 679_N 1.048 0.50
178_W 779_V 1.048 0.50
527_G 551_T 1.048 0.50
272_I 424_N 1.048 0.50
382_E 392_K 1.047 0.50
185_G 703_A 1.046 0.50
253_D 356_Q 1.045 0.50
249_W 783_G 1.044 0.50
446_S 576_T 1.044 0.50
721_V 845_V 1.043 0.50
795_G 833_Y 1.041 0.50
142_V 164_F 1.041 0.50
475_Q 530_Q 1.04 0.49
296_G 338_A 1.04 0.49
190_N 731_V 1.037 0.49
245_H 265_D 1.034 0.49
185_G 215_L 1.034 0.49
534_T 544_Y 1.033 0.49
73_L 105_I 1.033 0.49
263_L 281_A 1.031 0.49
704_H 740_D 1.031 0.49
644_D 731_V 1.031 0.49
261_L 283_L 1.031 0.49
541_S 568_T 1.03 0.48
182_I 702_L 1.03 0.48
435_G 463_Y 1.03 0.48
366_P 464_N 1.029 0.48
75_P 355_T 1.028 0.48
870_L 873_L 1.028 0.48
466_S 471_G 1.027 0.48
274_D 553_W 1.027 0.48
411_Y 811_F 1.026 0.48
644_D 738_R 1.026 0.48
169_A 293_S 1.026 0.48
472_T 533_V 1.025 0.48
53_F 464_N 1.024 0.48
712_Q 737_V 1.023 0.48
442_T 458_S 1.023 0.48
706_N 710_L 1.023 0.48
814_M 822_S 1.021 0.48
210_N 340_N 1.021 0.48
154_Q 369_Q 1.02 0.47
383_Y 493_T 1.02 0.47
411_Y 553_W 1.02 0.47
636_G 668_Y 1.018 0.47
293_S 723_A 1.018 0.47
796_I 871_T 1.017 0.47
840_A 860_Q 1.017 0.47
307_G 422_A 1.016 0.47
274_D 411_Y 1.016 0.47
664_G 669_A 1.014 0.47
177_L 755_E 1.014 0.47
438_S 462_L 1.013 0.47
186_L 785_I 1.012 0.47
484_S 758_V 1.012 0.47
802_L 809_L 1.012 0.47
460_R 836_G 1.011 0.46
164_F 329_P 1.01 0.46
295_R 754_R 1.01 0.46
551_T 558_V 1.008 0.46
186_L 700_G 1.007 0.46
848_G 853_A 1.007 0.46
783_G 811_F 1.007 0.46
534_T 778_V 1.003 0.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3rfzB20.93511000.141Contact Map0.691
3fipA20.54781000.499Contact Map0.7
3fcgA20.10251000.847Contact Map0.779
4b0mA10.15151000.859Contact Map0.851
3bwuD10.142499.90.874Contact Map0.864
2xetA20.095799.80.909Contact Map0.856
3l48A50.095799.70.916Contact Map0.931
3e8vA10.084379.80.978Contact Map0.401
4kdwA10.128772.50.979Contact Map0.485
3pe9A40.1059280.984Contact Map0.701
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.1137 seconds.