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YPHH - Uncharacterized protein YphH
UniProt: P76586 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13469
Length: 397 (387)
Sequences: 2720
Seq/Len: 7.03
YPHH
Paralog alert: 0.66 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: ALSK MAK MLC NAGC NAGK NANK YPHH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
99_N 103_S 3.942 1.00
250_C 257_C 3.668 1.00
252_C 257_C 3.489 1.00
142_N 389_Y 3.302 1.00
210_V 335_Y 3.139 1.00
187_D 229_R 2.977 1.00
171_E 174_Y 2.973 1.00
84_L 129_W 2.803 1.00
58_V 77_A 2.789 1.00
258_L 319_S 2.718 1.00
209_C 323_F 2.62 1.00
313_A 317_G 2.495 1.00
240_H 250_C 2.471 1.00
98_A 386_G 2.453 1.00
22_L 28_A 2.444 1.00
240_H 257_C 2.442 1.00
143_L 180_L 2.424 1.00
107_E 379_A 2.354 1.00
22_L 57_V 2.329 1.00
241_T 322_N 2.323 1.00
85_C 382_V 2.301 1.00
320_L 332_I 2.267 1.00
96_Q 382_V 2.248 1.00
232_L 328_N 2.243 1.00
250_C 253_G 2.23 1.00
240_H 252_C 2.215 1.00
58_V 75_L 2.077 1.00
152_D 155_T 2.062 1.00
126_E 179_K 2.048 1.00
253_G 257_C 2.029 1.00
174_Y 178_E 1.982 1.00
173_K 177_E 1.968 1.00
52_E 59_N 1.953 1.00
18_I 33_L 1.95 1.00
194_A 222_V 1.933 1.00
123_S 179_K 1.894 1.00
223_I 228_Y 1.881 1.00
217_I 262_A 1.88 1.00
193_L 210_V 1.877 1.00
48_L 74_W 1.862 1.00
310_D 348_T 1.861 1.00
208_F 222_V 1.836 1.00
187_D 191_V 1.829 1.00
216_G 237_Q 1.821 1.00
240_H 253_G 1.785 1.00
317_G 352_Q 1.781 1.00
200_Q 387_Y 1.774 1.00
33_L 44_V 1.773 1.00
30_K 74_W 1.767 1.00
211_I 320_L 1.757 1.00
230_G 235_S 1.741 1.00
242_I 322_N 1.731 1.00
188_N 237_Q 1.726 1.00
15_K 50_E 1.723 1.00
15_K 54_E 1.72 1.00
250_C 256_G 1.718 1.00
207_D 330_N 1.716 1.00
314_N 352_Q 1.702 1.00
318_L 322_N 1.682 1.00
145_L 176_L 1.676 1.00
95_C 132_H 1.675 1.00
194_A 220_S 1.675 1.00
194_A 208_F 1.656 1.00
48_L 57_V 1.655 1.00
146_A 192_M 1.654 1.00
187_D 192_M 1.653 1.00
140_T 182_I 1.63 1.00
11_R 14_N 1.626 1.00
331_Q 372_G 1.614 1.00
63_E 71_S 1.608 1.00
346_L 350_I 1.599 1.00
17_V 37_A 1.591 1.00
82_W 105_K 1.58 1.00
270_Q 311_R 1.572 1.00
313_A 349_I 1.567 1.00
205_E 331_Q 1.561 1.00
86_L 95_C 1.554 1.00
206_R 224_N 1.552 1.00
231_S 330_N 1.538 0.99
230_G 236_G 1.537 0.99
22_L 33_L 1.529 0.99
248_V 261_V 1.519 0.99
249_V 255_Y 1.518 0.99
59_N 72_G 1.511 0.99
52_E 57_V 1.5 0.99
313_A 348_T 1.48 0.99
85_C 385_I 1.469 0.99
59_N 74_W 1.454 0.99
206_R 330_N 1.445 0.99
247_G 261_V 1.431 0.99
175_L 178_E 1.411 0.99
95_C 128_C 1.406 0.99
86_L 125_I 1.398 0.99
108_F 131_R 1.397 0.99
343_E 347_N 1.384 0.99
14_N 47_I 1.375 0.99
253_G 256_G 1.372 0.99
14_N 39_I 1.372 0.99
52_E 74_W 1.369 0.98
146_A 381_Q 1.369 0.98
143_L 182_I 1.365 0.98
86_L 143_L 1.358 0.98
209_C 221_F 1.354 0.98
197_E 201_N 1.348 0.98
161_M 164_A 1.341 0.98
85_C 144_A 1.338 0.98
39_I 44_V 1.322 0.98
32_T 36_L 1.314 0.98
240_H 256_G 1.313 0.98
346_L 373_F 1.306 0.98
257_C 260_T 1.306 0.98
299_Q 344_N 1.299 0.98
176_L 184_V 1.298 0.98
144_A 192_M 1.292 0.98
192_M 385_I 1.291 0.98
171_E 175_L 1.288 0.98
252_C 256_G 1.288 0.98
244_N 247_G 1.281 0.97
10_I 14_N 1.279 0.97
177_E 181_G 1.275 0.97
188_N 216_G 1.272 0.97
250_C 260_T 1.271 0.97
150_Q 161_M 1.267 0.97
203_S 208_F 1.259 0.97
97_V 132_H 1.252 0.97
342_G 346_L 1.251 0.97
267_L 312_S 1.249 0.97
207_D 224_N 1.244 0.97
86_L 129_W 1.226 0.96
298_W 344_N 1.224 0.96
296_A 300_S 1.22 0.96
297_A 302_E 1.215 0.96
211_I 238_I 1.212 0.96
41_I 45_S 1.206 0.96
252_C 260_T 1.198 0.96
377_S 380_Q 1.194 0.96
353_T 371_I 1.19 0.96
130_H 179_K 1.187 0.95
193_L 335_Y 1.172 0.95
196_A 376_L 1.171 0.95
30_K 59_N 1.17 0.95
32_T 35_R 1.169 0.95
170_V 175_L 1.165 0.95
198_K 208_F 1.155 0.95
21_L 37_A 1.154 0.94
191_V 227_I 1.154 0.94
84_L 140_T 1.153 0.94
79_E 99_N 1.151 0.94
108_F 135_L 1.146 0.94
21_L 36_L 1.142 0.94
21_L 28_A 1.136 0.94
60_I 75_L 1.135 0.94
317_G 321_Y 1.128 0.94
85_C 96_Q 1.126 0.93
15_K 47_I 1.119 0.93
61_D 73_T 1.118 0.93
267_L 308_W 1.112 0.93
347_N 351_R 1.103 0.93
176_L 180_L 1.095 0.92
298_W 301_G 1.094 0.92
271_A 305_I 1.093 0.92
298_W 309_V 1.092 0.92
27_R 73_T 1.089 0.92
126_E 180_L 1.083 0.92
324_L 353_T 1.083 0.92
347_N 350_I 1.081 0.92
19_L 76_I 1.08 0.91
28_A 36_L 1.08 0.91
350_I 354_G 1.079 0.91
243_V 258_L 1.077 0.91
292_A 296_A 1.074 0.91
331_Q 370_Q 1.065 0.91
83_T 389_Y 1.06 0.90
218_G 237_Q 1.06 0.90
244_N 248_V 1.056 0.90
130_H 180_L 1.055 0.90
238_I 258_L 1.045 0.90
189_D 218_G 1.043 0.90
191_V 220_S 1.039 0.89
208_F 333_W 1.039 0.89
30_K 41_I 1.038 0.89
14_N 17_V 1.029 0.89
376_L 380_Q 1.026 0.88
310_D 351_R 1.025 0.88
214_D 337_R 1.021 0.88
185_M 389_Y 1.018 0.88
190_C 220_S 1.014 0.88
55_K 77_A 1.014 0.88
271_A 308_W 1.013 0.88
205_E 330_N 1.011 0.87
248_V 260_T 1.005 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1z05A10.98241000.145Contact Map0.697
1z6rA40.97981000.16Contact Map0.75
4ijaA20.93951000.197Contact Map0.725
2hoeA10.92191000.216Contact Map0.67
4db3A10.79351000.38Contact Map0.649
2yhwA10.83121000.381Contact Map0.724
2ap1A10.78841000.383Contact Map0.668
2qm1A40.7961000.398Contact Map0.763
3vglA10.77831000.399Contact Map0.706
3o8mA10.96221000.403Contact Map0.357
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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