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OPENSEQ.org
NAGK - N-acetyl-D-glucosamine kinase
UniProt: P75959 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13442
Length: 303 (293)
Sequences: 5477
Seq/Len: 18.69
NAGK
Paralog alert: 0.80 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: ALSK MAK MLC NAGC NAGK NANK YPHH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
18_D 22_Q 3.527 1.00
103_D 146_T 3.145 1.00
87_P 90_A 3.018 1.00
26_E 290_A 2.898 1.00
149_S 245_D 2.703 1.00
179_C 184_C 2.658 1.00
185_I 236_C 2.564 1.00
44_C 95_R 2.553 1.00
126_M 240_I 2.507 1.00
110_A 137_G 2.404 1.00
59_S 300_H 2.346 1.00
15_G 293_M 2.335 1.00
119_F 125_V 2.253 1.00
127_G 252_G 2.226 1.00
158_M 239_N 2.197 1.00
122_Y 248_L 2.195 1.00
109_F 127_G 2.185 1.00
17_F 297_A 2.181 1.00
248_L 283_E 2.171 1.00
3_Y 47_V 2.147 1.00
231_D 268_R 2.105 1.00
177_C 184_C 2.087 1.00
69_E 72_D 2.077 1.00
89_R 93_S 2.07 1.00
124_L 247_D 2.065 1.00
90_A 94_A 2.06 1.00
227_E 264_Q 2.054 1.00
110_A 139_I 2.037 1.00
60_V 96_L 2.007 1.00
140_F 145_I 1.977 1.00
103_D 108_C 1.966 1.00
4_G 293_M 1.931 1.00
41_D 95_R 1.93 1.00
237_L 249_V 1.921 1.00
157_H 179_C 1.919 1.00
116_D 298_F 1.918 1.00
230_L 234_A 1.877 1.00
103_D 107_N 1.857 1.00
234_A 268_R 1.81 1.00
112_S 287_H 1.779 1.00
14_L 46_L 1.759 1.00
62_I 92_L 1.743 1.00
157_H 184_C 1.742 1.00
128_L 237_L 1.741 1.00
177_C 180_G 1.71 1.00
27_K 49_E 1.69 1.00
91_D 94_A 1.643 1.00
134_V 189_L 1.643 1.00
230_L 264_Q 1.643 1.00
123_P 141_N 1.628 1.00
197_L 228_R 1.615 1.00
86_K 91_D 1.611 1.00
269_L 282_I 1.609 1.00
148_K 247_D 1.583 1.00
262_T 284_R 1.565 1.00
230_L 265_L 1.563 1.00
241_L 269_L 1.563 1.00
268_R 271_R 1.547 1.00
63_G 108_C 1.472 1.00
126_M 138_L 1.469 1.00
214_L 219_D 1.463 1.00
157_H 177_C 1.463 1.00
248_L 281_R 1.448 1.00
266_A 270_P 1.447 1.00
176_R 182_H 1.431 1.00
159_R 239_N 1.426 1.00
235_V 239_N 1.41 1.00
114_A 125_V 1.408 1.00
130_L 233_L 1.401 0.99
32_P 42_A 1.395 0.99
11_K 191_G 1.389 0.99
113_E 117_D 1.389 0.99
147_G 152_T 1.386 0.99
262_T 266_A 1.365 0.99
4_G 61_G 1.354 0.99
5_F 14_L 1.351 0.99
122_Y 247_D 1.331 0.99
125_V 139_I 1.329 0.99
48_A 95_R 1.324 0.99
169_G 174_L 1.322 0.99
207_Q 210_E 1.319 0.99
209_P 213_A 1.317 0.99
240_I 243_I 1.3 0.99
123_P 247_D 1.292 0.99
216_D 260_A 1.291 0.99
198_Y 222_A 1.288 0.99
213_A 217_Q 1.282 0.99
267_D 271_R 1.247 0.99
35_S 38_A 1.24 0.98
194_F 229_Y 1.24 0.98
227_E 267_D 1.234 0.98
15_G 23_L 1.224 0.98
14_L 50_A 1.222 0.98
124_L 140_F 1.22 0.98
48_A 96_L 1.218 0.98
234_A 272_H 1.215 0.98
241_L 249_V 1.211 0.98
268_R 272_H 1.202 0.98
110_A 125_V 1.201 0.98
259_P 284_R 1.199 0.98
63_G 292_G 1.197 0.98
87_P 91_D 1.193 0.98
198_Y 225_H 1.19 0.98
259_P 263_T 1.189 0.98
124_L 145_I 1.179 0.98
227_E 268_R 1.178 0.98
215_Y 218_G 1.164 0.97
44_C 96_L 1.162 0.97
118_E 286_R 1.16 0.97
147_G 245_D 1.146 0.97
180_G 184_C 1.144 0.97
60_V 98_R 1.139 0.97
64_I 68_P 1.136 0.97
25_W 50_A 1.132 0.97
41_D 45_E 1.132 0.97
92_L 100_V 1.124 0.97
117_D 121_Q 1.122 0.97
4_G 296_A 1.119 0.96
264_Q 267_D 1.115 0.96
5_F 47_V 1.112 0.96
117_D 120_T 1.109 0.96
157_H 180_G 1.102 0.96
44_C 48_A 1.101 0.96
106_A 129_I 1.096 0.96
27_K 46_L 1.092 0.96
108_C 296_A 1.084 0.96
138_L 145_I 1.082 0.96
9_G 132_T 1.08 0.95
93_S 100_V 1.071 0.95
125_V 250_V 1.066 0.95
210_E 214_L 1.046 0.94
184_C 187_N 1.04 0.94
114_A 139_I 1.039 0.94
40_L 91_D 1.039 0.94
107_N 144_P 1.039 0.94
106_A 137_G 1.038 0.94
215_Y 226_V 1.029 0.94
138_L 153_G 1.023 0.93
131_G 254_G 1.021 0.93
115_W 298_F 1.017 0.93
11_K 28_R 1.014 0.93
133_G 154_E 1.008 0.93
263_T 267_D 1.008 0.93
42_A 45_E 1.007 0.93
27_K 53_R 1.006 0.93
93_S 97_D 1.006 0.93
234_A 238_G 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ap1A111000.165Contact Map0.734
1z05A10.96041000.168Contact Map0.709
4db3A111000.17Contact Map0.687
1z6rA40.96371000.174Contact Map0.752
3vovA40.96041000.188Contact Map0.824
3vglA10.95711000.191Contact Map0.737
2yhwA10.95381000.195Contact Map0.768
2qm1A40.96371000.199Contact Map0.823
4ijaA20.94391000.199Contact Map0.729
2aa4A20.94391000.212Contact Map0.767
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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