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OPENSEQ.org
NAGC - N-acetylglucosamine repressor
UniProt: P0AF20 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10636
Length: 406 (388)
Sequences: 2361
Seq/Len: 6.09
NAGC
Paralog alert: 0.63 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: ALSK MAK MLC NAGC NAGK NANK YPHH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
104_D 108_K 3.906 1.00
257_C 264_C 3.505 1.00
259_C 264_C 3.305 1.00
217_L 341_A 3.256 1.00
63_K 82_E 3.015 1.00
193_G 236_I 2.882 1.00
27_I 33_I 2.682 1.00
247_H 264_C 2.651 1.00
265_L 325_T 2.635 1.00
89_I 133_I 2.633 1.00
177_G 180_E 2.622 1.00
149_A 390_V 2.615 1.00
247_H 257_C 2.585 1.00
27_I 62_I 2.532 1.00
248_I 328_I 2.474 1.00
247_H 259_C 2.463 1.00
216_I 329_A 2.416 1.00
319_G 323_G 2.377 1.00
63_K 80_V 2.268 1.00
257_C 260_G 2.266 1.00
23_V 38_I 2.258 1.00
260_G 264_C 2.254 1.00
150_I 186_F 2.233 1.00
57_I 64_E 2.196 1.00
200_A 229_I 2.104 1.00
218_V 326_I 2.064 1.00
326_I 338_I 2.053 1.00
239_N 334_N 1.983 1.00
53_T 79_I 1.982 1.00
35_R 79_I 1.973 1.00
38_I 49_V 1.96 1.00
215_S 229_I 1.915 1.00
199_L 217_L 1.913 1.00
90_G 383_A 1.908 1.00
16_K 19_N 1.898 1.00
237_G 242_V 1.891 1.00
147_L 188_V 1.891 1.00
257_C 263_G 1.885 1.00
223_G 244_E 1.876 1.00
103_F 387_F 1.875 1.00
323_G 358_C 1.869 1.00
20_S 55_Q 1.856 1.00
247_H 260_G 1.847 1.00
130_L 185_R 1.842 1.00
224_T 269_A 1.835 1.00
53_T 62_I 1.814 1.00
113_E 135_Q 1.807 1.00
194_H 244_E 1.798 1.00
20_S 59_R 1.775 1.00
159_D 162_S 1.77 1.00
249_Q 328_I 1.762 1.00
168_M 171_I 1.747 1.00
237_G 243_G 1.743 1.00
203_E 207_G 1.733 1.00
230_S 235_F 1.708 1.00
153_I 198_S 1.707 1.00
316_E 354_A 1.693 1.00
214_D 336_Q 1.685 1.00
100_I 136_F 1.659 1.00
320_R 358_C 1.626 1.00
87_H 110_L 1.623 1.00
27_I 38_I 1.622 1.00
19_N 52_I 1.594 0.99
180_E 184_E 1.594 0.99
213_E 231_N 1.587 0.99
22_A 42_S 1.58 0.99
259_C 263_G 1.574 0.99
57_I 62_I 1.566 0.99
90_G 386_A 1.56 0.99
150_I 188_V 1.558 0.99
179_V 183_E 1.555 0.99
337_K 374_V 1.551 0.99
64_E 79_I 1.544 0.99
64_E 77_I 1.541 0.99
193_G 198_S 1.524 0.99
206_F 388_A 1.511 0.99
101_T 383_A 1.493 0.99
303_A 308_D 1.487 0.99
319_G 354_A 1.486 0.99
356_E 360_N 1.482 0.99
19_N 44_L 1.482 0.99
68_Q 76_A 1.47 0.99
200_A 215_S 1.45 0.99
212_C 337_K 1.447 0.99
91_V 100_I 1.44 0.99
277_R 317_Y 1.438 0.99
91_V 129_L 1.427 0.99
194_H 223_G 1.423 0.98
247_H 263_G 1.422 0.98
209_S 215_S 1.411 0.98
127_H 185_R 1.408 0.98
37_Q 41_Q 1.407 0.98
200_A 227_G 1.407 0.98
57_I 79_I 1.406 0.98
256_R 262_F 1.405 0.98
152_V 182_L 1.392 0.98
255_E 268_I 1.39 0.98
386_A 390_V 1.387 0.98
260_G 263_G 1.383 0.98
304_A 315_I 1.382 0.98
216_I 228_I 1.381 0.98
15_V 19_N 1.38 0.98
112_E 380_H 1.374 0.98
319_G 355_I 1.372 0.98
251_E 254_G 1.37 0.98
238_R 336_Q 1.36 0.98
153_I 382_S 1.358 0.98
254_G 268_I 1.344 0.98
151_S 198_S 1.34 0.98
257_C 267_T 1.339 0.98
264_C 267_T 1.339 0.98
89_I 147_L 1.338 0.98
90_G 151_S 1.337 0.98
84_R 104_D 1.33 0.97
134_A 144_L 1.327 0.97
193_G 197_R 1.326 0.97
324_K 328_I 1.31 0.97
44_L 49_V 1.305 0.97
213_E 336_Q 1.304 0.97
157_L 168_M 1.297 0.97
218_V 245_I 1.291 0.97
182_L 190_C 1.284 0.97
134_A 185_R 1.278 0.96
46_P 50_T 1.277 0.96
113_E 139_S 1.265 0.96
102_L 136_F 1.257 0.96
259_C 267_T 1.249 0.96
199_L 341_A 1.234 0.95
183_E 187_K 1.225 0.95
86_F 148_I 1.219 0.95
35_R 64_E 1.215 0.95
65_V 80_V 1.211 0.95
20_S 52_I 1.203 0.95
100_I 132_A 1.202 0.95
302_K 306_K 1.202 0.95
37_Q 40_E 1.196 0.94
88_A 390_V 1.194 0.94
181_A 184_E 1.193 0.94
352_L 356_E 1.188 0.94
381_R 385_G 1.187 0.94
66_D 78_S 1.186 0.94
385_G 390_V 1.178 0.94
197_R 234_I 1.169 0.93
26_L 33_I 1.167 0.93
26_L 42_S 1.165 0.93
176_W 181_A 1.161 0.93
299_T 303_A 1.157 0.93
33_I 41_Q 1.153 0.93
91_V 133_I 1.153 0.93
221_H 343_E 1.153 0.93
91_V 150_I 1.15 0.93
225_G 244_E 1.13 0.92
26_L 41_Q 1.124 0.92
202_A 378_L 1.124 0.92
195_D 225_G 1.116 0.91
24_Y 81_T 1.115 0.91
353_P 357_S 1.114 0.91
304_A 307_G 1.112 0.91
156_G 266_E 1.112 0.91
90_G 101_T 1.108 0.91
204_H 215_S 1.099 0.90
354_A 357_S 1.098 0.90
304_A 350_V 1.098 0.90
25_R 29_Q 1.095 0.90
32_P 78_S 1.094 0.90
207_G 210_Q 1.093 0.90
61_L 85_N 1.092 0.90
208_A 211_D 1.091 0.90
203_E 378_L 1.077 0.89
60_G 82_E 1.073 0.89
339_V 376_S 1.07 0.89
109_V 112_E 1.067 0.89
177_G 181_A 1.065 0.88
35_R 46_P 1.065 0.88
34_S 64_E 1.063 0.88
316_E 357_S 1.061 0.88
348_D 352_L 1.059 0.88
173_V 176_W 1.054 0.88
352_L 375_R 1.045 0.87
203_E 377_E 1.044 0.87
358_C 362_Q 1.043 0.87
92_R 194_H 1.036 0.86
245_I 265_L 1.035 0.86
27_I 79_I 1.032 0.86
296_T 299_T 1.032 0.86
36_I 76_A 1.029 0.86
223_G 266_E 1.026 0.86
99_T 114_H 1.025 0.86
278_V 314_V 1.022 0.85
19_N 22_A 1.02 0.85
353_P 356_E 1.018 0.85
198_S 386_A 1.015 0.85
111_A 136_F 1.007 0.84
143_K 146_E 1.004 0.84
323_G 327_A 1.002 0.84
383_A 386_A 1 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1z05A10.99511000.142Contact Map0.688
1z6rA40.99511000.152Contact Map0.738
4ijaA20.95571000.215Contact Map0.708
2hoeA10.91871000.239Contact Map0.64
2yhwA10.82021000.397Contact Map0.702
4db3A10.77591000.403Contact Map0.639
2ap1A10.77091000.406Contact Map0.648
3o8mA10.95571000.412Contact Map0.341
2qm1A40.78081000.413Contact Map0.736
3vglA10.7661000.422Contact Map0.689
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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