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OPENSEQ.org
MAK - Fructokinase
UniProt: P23917 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11288
Length: 302 (291)
Sequences: 5466
Seq/Len: 18.78
MAK
Paralog alert: 0.80 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: ALSK MAK MLC NAGC NAGK NANK YPHH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
18_G 22_E 3.534 1.00
103_A 146_I 3.128 1.00
87_P 90_K 3.053 1.00
26_R 289_S 2.954 1.00
149_N 244_D 2.655 1.00
44_A 95_R 2.579 1.00
184_I 235_S 2.549 1.00
178_C 183_C 2.521 1.00
126_F 239_V 2.473 1.00
110_A 137_G 2.435 1.00
15_I 292_V 2.379 1.00
3_I 47_V 2.292 1.00
119_A 125_V 2.291 1.00
122_A 247_V 2.269 1.00
127_A 251_G 2.245 1.00
109_L 127_A 2.207 1.00
17_L 296_A 2.168 1.00
158_N 238_H 2.134 1.00
89_D 93_S 2.126 1.00
176_C 183_C 2.104 1.00
230_L 267_L 2.077 1.00
60_V 96_L 2.069 1.00
247_V 282_R 2.062 1.00
110_A 139_A 2.052 1.00
124_T 246_D 2.048 1.00
69_S 72_T 2.043 1.00
90_K 94_A 2.019 1.00
103_A 108_C 1.977 1.00
140_F 145_H 1.975 1.00
41_E 95_R 1.95 1.00
116_D 297_W 1.94 1.00
236_L 248_I 1.926 1.00
233_A 267_L 1.921 1.00
4_G 292_V 1.898 1.00
229_E 233_A 1.871 1.00
103_A 107_N 1.868 1.00
14_V 46_L 1.797 1.00
157_H 178_C 1.788 1.00
226_R 263_T 1.773 1.00
62_M 92_L 1.762 1.00
157_H 183_C 1.756 1.00
176_C 179_G 1.746 1.00
112_S 286_H 1.717 1.00
128_V 236_L 1.707 1.00
91_D 94_A 1.678 1.00
27_H 49_M 1.677 1.00
169_R 173_E 1.631 1.00
134_C 188_I 1.626 1.00
196_D 227_R 1.621 1.00
123_Q 141_N 1.621 1.00
86_Q 91_D 1.606 1.00
148_G 246_D 1.59 1.00
229_E 264_V 1.585 1.00
175_P 181_Q 1.567 1.00
63_G 108_C 1.519 1.00
213_L 218_D 1.506 1.00
240_V 268_I 1.479 1.00
267_L 270_Q 1.473 1.00
265_G 269_K 1.461 1.00
126_F 138_V 1.452 1.00
157_H 176_C 1.435 1.00
114_A 125_V 1.435 1.00
258_D 262_Q 1.431 1.00
268_I 281_V 1.403 0.99
234_K 238_H 1.397 0.99
159_P 238_H 1.39 0.99
32_P 42_T 1.375 0.99
11_K 190_G 1.374 0.99
113_E 117_G 1.367 0.99
197_Y 221_A 1.353 0.99
206_K 209_E 1.347 0.99
5_I 14_V 1.345 0.99
4_G 61_G 1.344 0.99
48_D 95_R 1.342 0.99
193_F 228_Y 1.335 0.99
48_D 96_L 1.333 0.99
147_G 152_A 1.332 0.99
239_V 242_I 1.326 0.99
125_V 139_A 1.325 0.99
130_I 232_L 1.322 0.99
208_S 212_R 1.318 0.99
122_A 246_D 1.315 0.99
14_V 50_A 1.314 0.99
197_Y 224_A 1.304 0.99
123_Q 246_D 1.297 0.99
212_R 216_E 1.295 0.99
266_Q 270_Q 1.268 0.99
226_R 266_Q 1.262 0.99
240_V 248_I 1.254 0.99
35_D 38_Q 1.242 0.98
124_T 140_F 1.233 0.98
60_V 98_R 1.223 0.98
247_V 280_P 1.217 0.98
110_A 125_V 1.216 0.98
15_I 23_Q 1.216 0.98
263_T 266_Q 1.212 0.98
179_G 183_C 1.204 0.98
87_P 91_D 1.199 0.98
226_R 267_L 1.192 0.98
267_L 271_F 1.19 0.98
233_A 271_F 1.187 0.98
41_E 45_T 1.184 0.98
147_G 244_D 1.183 0.98
229_E 263_T 1.174 0.98
44_A 96_L 1.169 0.97
25_Y 50_A 1.163 0.97
124_T 145_H 1.16 0.97
214_V 217_S 1.154 0.97
118_A 285_K 1.143 0.97
64_I 68_I 1.134 0.97
215_E 259_R 1.132 0.97
4_G 295_A 1.131 0.97
258_D 283_K 1.129 0.97
157_H 179_G 1.123 0.97
92_L 100_V 1.12 0.96
27_H 53_A 1.119 0.96
5_I 47_V 1.118 0.96
108_C 295_A 1.11 0.96
63_G 291_G 1.097 0.96
117_G 121_G 1.094 0.96
117_G 120_A 1.086 0.96
125_V 249_V 1.08 0.95
106_A 129_I 1.078 0.95
93_S 100_V 1.073 0.95
115_V 297_W 1.072 0.95
138_V 145_H 1.071 0.95
9_G 132_T 1.064 0.95
25_Y 53_A 1.061 0.95
44_A 48_D 1.061 0.95
40_I 91_D 1.057 0.95
16_A 50_A 1.043 0.94
214_V 225_L 1.04 0.94
11_K 28_R 1.04 0.94
77_N 80_S 1.036 0.94
103_A 298_L 1.035 0.94
5_I 43_I 1.031 0.94
131_G 253_G 1.031 0.94
42_T 45_T 1.03 0.94
211_I 225_L 1.027 0.94
27_H 46_L 1.027 0.94
107_N 144_A 1.026 0.94
106_A 137_G 1.022 0.93
114_A 139_A 1.022 0.93
7_L 43_I 1.02 0.93
233_A 237_A 1.018 0.93
8_G 132_T 1.012 0.93
93_S 97_Q 1.007 0.93
133_G 154_E 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1z05A10.96361000.136Contact Map0.707
1z6rA40.96691000.14Contact Map0.743
2ap1A10.98341000.143Contact Map0.743
4db3A10.98341000.145Contact Map0.685
3vovA40.96361000.152Contact Map0.815
3vglA10.96031000.161Contact Map0.727
2yhwA10.9571000.163Contact Map0.767
2qm1A40.96691000.166Contact Map0.809
4ijaA20.9471000.167Contact Map0.706
2aa4A20.9471000.172Contact Map0.767
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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