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OPENSEQ.org
MLC - Protein mlc
UniProt: P50456 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13156
Length: 406 (391)
Sequences: 2371
Seq/Len: 6.06
MLC
Paralog alert: 0.64 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: ALSK MAK MLC NAGC NAGK NANK YPHH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
103_D 107_K 3.913 1.00
257_C 264_C 3.544 1.00
259_C 264_C 3.262 1.00
217_Q 341_G 3.199 1.00
148_S 390_V 3.163 1.00
61_Q 81_E 3.013 1.00
193_Q 236_H 2.935 1.00
25_I 31_V 2.762 1.00
88_L 132_I 2.704 1.00
247_H 257_C 2.678 1.00
177_P 180_E 2.658 1.00
247_H 264_C 2.625 1.00
25_I 60_V 2.598 1.00
248_T 328_I 2.52 1.00
265_L 325_I 2.501 1.00
247_H 259_C 2.435 1.00
216_I 329_M 2.433 1.00
102_R 387_A 2.357 1.00
257_C 260_G 2.324 1.00
319_G 323_G 2.307 1.00
149_I 186_T 2.277 1.00
61_Q 79_V 2.259 1.00
21_V 36_L 2.222 1.00
260_G 264_C 2.207 1.00
111_E 381_Q 2.178 1.00
55_L 62_E 2.139 1.00
200_T 229_I 2.114 1.00
239_S 334_N 2.046 1.00
89_S 383_T 2.015 1.00
218_V 326_L 2.008 1.00
158_D 161_N 1.98 1.00
146_L 188_V 1.973 1.00
215_V 229_I 1.96 1.00
36_L 47_I 1.959 1.00
33_R 78_L 1.948 1.00
223_N 244_E 1.931 1.00
89_S 386_G 1.921 1.00
51_V 78_L 1.919 1.00
224_V 269_A 1.901 1.00
326_L 338_I 1.9 1.00
199_W 217_Q 1.861 1.00
257_C 263_G 1.855 1.00
237_A 242_L 1.853 1.00
14_K 17_N 1.848 1.00
18_A 53_E 1.841 1.00
112_E 134_Q 1.827 1.00
323_G 358_S 1.825 1.00
247_H 260_G 1.815 1.00
167_M 170_Y 1.806 1.00
129_I 185_H 1.804 1.00
51_V 60_V 1.799 1.00
18_A 57_A 1.792 1.00
194_H 244_E 1.78 1.00
203_E 207_G 1.762 1.00
206_F 388_A 1.747 1.00
249_Q 328_I 1.744 1.00
316_T 354_V 1.743 1.00
230_T 235_L 1.727 1.00
237_A 243_V 1.717 1.00
25_I 36_L 1.706 1.00
320_A 358_S 1.688 1.00
214_D 336_Q 1.686 1.00
180_E 184_Q 1.676 1.00
100_A 383_T 1.67 1.00
259_C 263_G 1.634 1.00
152_T 198_A 1.634 1.00
303_A 308_D 1.604 0.99
20_A 40_A 1.599 0.99
17_N 50_I 1.584 0.99
86_H 109_V 1.579 0.99
90_L 128_I 1.579 0.99
149_I 188_V 1.57 0.99
55_L 60_V 1.552 0.99
277_L 317_G 1.546 0.99
337_K 374_E 1.534 0.99
99_L 135_F 1.532 0.99
62_E 76_V 1.53 0.99
213_R 231_D 1.524 0.99
193_Q 198_A 1.523 0.99
62_E 78_L 1.518 0.99
179_G 183_E 1.515 0.99
126_D 185_H 1.514 0.99
212_A 337_K 1.51 0.99
319_G 355_I 1.504 0.99
260_G 263_G 1.497 0.99
319_G 354_V 1.489 0.99
83_E 103_D 1.484 0.99
151_I 182_L 1.483 0.99
200_T 227_G 1.48 0.99
194_H 223_N 1.465 0.99
200_T 215_V 1.464 0.99
90_L 99_L 1.454 0.99
17_N 42_L 1.446 0.99
55_L 78_L 1.433 0.99
13_I 17_N 1.424 0.98
255_K 268_I 1.415 0.98
356_S 360_R 1.413 0.98
182_L 190_V 1.411 0.98
257_C 267_T 1.396 0.98
238_G 336_Q 1.391 0.98
150_A 198_A 1.385 0.98
193_Q 197_S 1.36 0.98
254_G 268_I 1.358 0.98
67_E 75_A 1.358 0.98
42_L 47_I 1.357 0.98
251_D 254_G 1.352 0.98
216_I 228_V 1.341 0.98
35_D 39_L 1.341 0.98
213_R 336_Q 1.33 0.97
264_C 267_T 1.329 0.97
247_H 263_G 1.326 0.97
89_S 150_A 1.324 0.97
87_Y 390_V 1.323 0.97
324_R 328_I 1.317 0.97
209_S 215_V 1.315 0.97
18_A 50_I 1.304 0.97
88_L 146_L 1.293 0.97
218_V 245_I 1.274 0.96
44_P 48_T 1.273 0.96
304_A 307_G 1.273 0.96
199_W 341_G 1.255 0.96
112_E 138_R 1.252 0.96
35_D 38_R 1.247 0.96
304_A 315_I 1.246 0.96
256_R 262_H 1.243 0.96
133_D 185_H 1.238 0.96
183_E 187_G 1.233 0.95
352_F 356_S 1.219 0.95
63_L 79_V 1.217 0.95
197_S 234_L 1.216 0.95
259_C 267_T 1.211 0.95
99_L 131_H 1.207 0.95
101_L 135_F 1.191 0.94
24_L 40_A 1.182 0.94
181_A 184_Q 1.18 0.94
348_A 352_F 1.175 0.94
133_D 143_L 1.173 0.94
24_L 31_V 1.166 0.93
156_I 167_M 1.165 0.93
204_A 215_V 1.165 0.93
33_R 62_E 1.162 0.93
302_Q 306_R 1.162 0.93
278_A 314_I 1.157 0.93
24_L 39_L 1.154 0.93
22_Y 80_V 1.15 0.93
85_W 147_T 1.146 0.92
225_G 244_E 1.145 0.92
90_L 149_I 1.138 0.92
221_D 343_P 1.126 0.92
296_T 299_S 1.122 0.91
59_L 84_A 1.119 0.91
31_V 39_L 1.116 0.91
155_G 266_E 1.103 0.90
148_S 387_A 1.102 0.90
89_S 100_A 1.102 0.90
64_E 77_G 1.099 0.90
108_L 111_E 1.098 0.90
58_H 81_E 1.094 0.90
33_R 44_P 1.091 0.90
195_D 225_G 1.087 0.90
23_R 27_Q 1.083 0.89
304_A 350_I 1.075 0.89
142_K 145_R 1.075 0.89
323_G 327_A 1.071 0.89
316_T 357_D 1.07 0.89
207_G 210_R 1.069 0.89
90_L 132_I 1.069 0.89
98_F 113_S 1.065 0.88
176_M 181_A 1.065 0.88
173_V 176_M 1.063 0.88
177_P 181_A 1.061 0.88
352_F 375_S 1.058 0.88
208_A 211_G 1.053 0.88
17_N 20_A 1.048 0.87
71_R 74_P 1.046 0.87
323_G 362_Q 1.045 0.87
357_D 361_Q 1.038 0.87
34_I 75_A 1.037 0.86
274_I 318_V 1.031 0.86
32_S 62_E 1.029 0.86
203_E 377_Q 1.027 0.86
260_G 267_T 1.022 0.85
198_A 386_G 1.018 0.85
274_I 314_I 1.016 0.85
30_P 77_G 1.016 0.85
196_I 227_G 1.004 0.84
196_I 199_W 1.002 0.84
353_P 356_S 1.001 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1z05A10.99751000.132Contact Map0.698
1z6rA411000.133Contact Map0.741
4ijaA20.95071000.212Contact Map0.715
2hoeA10.92121000.234Contact Map0.652
2yhwA10.82511000.393Contact Map0.711
4db3A10.77831000.395Contact Map0.655
2ap1A10.77831000.395Contact Map0.661
3o8mA10.95071000.406Contact Map0.353
2qm1A40.78081000.414Contact Map0.746
3vovA40.73891000.417Contact Map0.743
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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