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OPENSEQ.org
ALSK - D-allose kinase
UniProt: P32718 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11956
Length: 309 (295)
Sequences: 5485
Seq/Len: 18.59
ALSK
Paralog alert: 0.81 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: ALSK MAK MLC NAGC NAGK NANK YPHH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
24_T 28_E 3.683 1.00
113_S 155_T 3.222 1.00
97_D 100_D 3.099 1.00
32_C 286_F 2.986 1.00
158_H 238_D 2.772 1.00
184_L 229_A 2.702 1.00
178_C 183_C 2.683 1.00
50_G 105_T 2.652 1.00
135_L 233_S 2.633 1.00
66_G 296_A 2.624 1.00
21_C 289_A 2.446 1.00
9_A 53_I 2.405 1.00
120_L 146_A 2.366 1.00
136_A 245_G 2.296 1.00
23_R 293_A 2.256 1.00
167_I 232_T 2.251 1.00
241_A 279_I 2.232 1.00
119_Q 136_A 2.23 1.00
99_A 103_E 2.225 1.00
131_Q 241_A 2.215 1.00
176_C 183_C 2.203 1.00
100_D 104_N 2.125 1.00
67_L 106_L 2.102 1.00
133_L 240_D 2.097 1.00
76_S 79_K 2.086 1.00
149_M 154_W 2.055 1.00
113_S 118_L 2.047 1.00
47_S 105_T 2.023 1.00
230_I 242_V 1.947 1.00
113_S 117_N 1.941 1.00
10_G 289_A 1.935 1.00
166_H 178_C 1.913 1.00
227_A 262_M 1.875 1.00
20_F 52_M 1.85 1.00
120_L 148_W 1.841 1.00
69_M 102_L 1.826 1.00
176_C 179_G 1.809 1.00
101_K 104_N 1.791 1.00
219_V 223_L 1.76 1.00
260_V 264_Q 1.753 1.00
33_E 55_E 1.747 1.00
137_A 230_I 1.741 1.00
166_H 183_C 1.736 1.00
143_M 188_C 1.713 1.00
157_A 240_D 1.7 1.00
123_D 126_E 1.692 1.00
132_Q 150_N 1.681 1.00
224_E 262_M 1.68 1.00
256_R 280_A 1.676 1.00
128_R 134_V 1.622 1.00
96_Y 101_K 1.619 1.00
175_H 181_P 1.615 1.00
70_G 118_L 1.597 1.00
256_R 260_V 1.585 1.00
135_L 147_V 1.571 1.00
54_D 105_T 1.518 1.00
220_Q 258_T 1.516 1.00
262_M 265_K 1.506 1.00
263_T 278_F 1.503 1.00
241_A 277_R 1.478 1.00
234_I 263_T 1.475 1.00
131_Q 240_D 1.475 1.00
166_H 176_C 1.471 1.00
168_P 232_T 1.469 1.00
54_D 106_L 1.433 1.00
17_H 190_G 1.426 1.00
11_V 20_F 1.423 1.00
10_G 68_V 1.404 0.99
38_A 48_G 1.389 0.99
10_G 292_A 1.389 0.99
20_F 56_Q 1.388 0.99
156_G 161_A 1.364 0.99
41_I 44_G 1.348 0.99
132_Q 240_D 1.348 0.99
233_S 236_L 1.344 0.99
234_I 242_V 1.342 0.99
134_V 148_W 1.336 0.99
253_A 257_E 1.316 0.99
207_R 211_V 1.305 0.99
257_E 261_A 1.299 0.99
133_L 149_M 1.298 0.99
21_C 29_T 1.294 0.99
122_W 125_V 1.293 0.99
261_A 265_K 1.281 0.99
67_L 108_C 1.265 0.99
205_P 208_D 1.252 0.99
133_L 154_W 1.245 0.98
262_M 266_Y 1.226 0.98
47_S 51_E 1.215 0.98
116_V 138_Y 1.21 0.98
113_S 295_L 1.208 0.98
31_H 59_R 1.201 0.98
212_H 216_A 1.2 0.98
214_E 253_A 1.184 0.98
102_L 110_V 1.18 0.98
252_P 256_R 1.171 0.98
156_G 238_D 1.169 0.97
50_G 106_L 1.167 0.97
97_D 101_K 1.166 0.97
179_G 183_C 1.163 0.97
223_L 227_A 1.161 0.97
71_F 75_V 1.158 0.97
174_Q 187_N 1.156 0.97
50_G 54_D 1.155 0.97
122_W 283_S 1.155 0.97
124_V 134_V 1.152 0.97
11_V 53_I 1.151 0.97
139_L 226_A 1.147 0.97
120_L 134_V 1.146 0.97
256_R 259_L 1.143 0.97
228_R 232_T 1.138 0.97
131_Q 134_V 1.137 0.97
103_E 110_V 1.136 0.97
31_H 56_Q 1.133 0.97
134_V 243_I 1.123 0.97
17_H 34_K 1.123 0.97
22_L 56_Q 1.118 0.96
140_G 247_G 1.117 0.96
46_V 101_K 1.113 0.96
252_P 280_A 1.111 0.96
223_L 258_T 1.101 0.96
208_D 212_H 1.093 0.96
70_G 288_G 1.093 0.96
227_A 266_Y 1.091 0.96
126_E 294_I 1.089 0.96
147_V 162_G 1.085 0.96
123_D 127_N 1.082 0.96
258_T 261_A 1.082 0.96
147_V 154_W 1.073 0.95
15_A 141_T 1.068 0.95
33_E 52_M 1.068 0.95
13_M 49_I 1.067 0.95
219_V 222_L 1.066 0.95
117_N 153_P 1.062 0.95
68_V 118_L 1.062 0.95
243_I 279_I 1.054 0.95
258_T 262_M 1.053 0.95
76_S 83_I 1.052 0.95
135_L 145_F 1.052 0.95
118_L 292_A 1.05 0.94
116_V 146_A 1.042 0.94
230_I 244_L 1.041 0.94
74_L 85_T 1.029 0.94
134_V 241_A 1.027 0.94
103_E 107_N 1.026 0.94
33_E 59_R 1.019 0.93
11_V 67_L 1.018 0.93
48_G 51_E 1.015 0.93
220_Q 262_M 1.013 0.93
11_V 49_I 1.012 0.93
133_L 157_A 1.007 0.93
23_R 29_T 1.006 0.93
142_G 163_E 1.004 0.93
196_W 221_S 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3htvA111000.146Contact Map0.65
1z05A10.98381000.179Contact Map0.72
1z6rA40.98711000.184Contact Map0.759
3vovA40.95151000.225Contact Map0.826
4ijaA20.96121000.229Contact Map0.736
2qm1A40.96761000.23Contact Map0.817
2ap1A10.94171000.232Contact Map0.738
2yhwA10.94821000.233Contact Map0.793
4db3A10.94171000.234Contact Map0.696
3vglA10.96121000.235Contact Map0.727
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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