May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
MPGP - Putative mannosyl-3-phosphoglycerate phosphatase
UniProt: P76329 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14039
Length: 271 (250)
Sequences: 5190
Seq/Len: 20.76
MPGP
Paralog alert: 0.74 [within 20: 0.15] - ratio of genomes with paralogs
Cluster includes: COF MPGP SUPH YBHA YBJI YIDA YIGL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
202_L 207_P 3.988 1.00
21_S 256_G 3.894 1.00
253_Q 262_E 3.82 1.00
222_L 228_A 3.484 1.00
211_G 225_M 3.383 1.00
8_L 208_T 2.977 1.00
254_R 257_P 2.961 1.00
196_I 209_T 2.924 1.00
47_S 54_M 2.848 1.00
12_S 43_V 2.736 1.00
28_P 265_D 2.527 1.00
11_F 192_A 2.439 1.00
28_P 258_E 2.256 1.00
187_G 220_P 2.253 1.00
20_D 24_Y 2.245 1.00
35_R 38_E 2.244 1.00
202_L 208_T 2.163 1.00
219_A 241_L 2.16 1.00
193_N 224_V 2.157 1.00
236_R 243_D 2.148 1.00
253_Q 257_P 2.136 1.00
30_A 60_T 2.103 1.00
203_S 224_V 2.081 1.00
27_Q 31_P 2.03 1.00
9_L 44_I 1.985 1.00
241_L 247_A 1.902 1.00
236_R 242_H 1.87 1.00
35_R 39_A 1.85 1.00
211_G 222_L 1.836 1.00
35_R 265_D 1.799 1.00
194_W 197_A 1.788 1.00
69_I 191_A 1.779 1.00
193_N 197_A 1.761 1.00
33_L 43_V 1.759 1.00
14_L 19_L 1.723 1.00
11_F 46_C 1.678 1.00
229_V 263_G 1.658 1.00
230_I 234_L 1.651 1.00
230_I 248_R 1.64 1.00
96_S 99_E 1.614 1.00
228_A 249_V 1.606 1.00
31_P 35_R 1.555 1.00
250_W 267_F 1.55 1.00
216_P 235_N 1.529 1.00
190_Q 193_N 1.526 1.00
91_I 194_W 1.525 1.00
252_T 259_G 1.524 1.00
216_P 240_H 1.522 1.00
225_M 228_A 1.521 1.00
12_S 212_L 1.507 1.00
36_L 41_V 1.459 1.00
207_P 226_D 1.453 1.00
26_W 258_E 1.448 1.00
219_A 247_A 1.444 1.00
41_V 210_L 1.44 1.00
196_I 201_Q 1.434 1.00
196_I 203_S 1.433 1.00
223_E 247_A 1.426 1.00
10_V 36_L 1.418 1.00
42_P 199_Y 1.417 1.00
189_D 224_V 1.412 1.00
260_W 264_L 1.409 1.00
192_A 221_L 1.402 0.99
9_L 196_I 1.398 0.99
9_L 201_Q 1.39 0.99
252_T 263_G 1.355 0.99
26_W 29_A 1.342 0.99
34_T 38_E 1.339 0.99
74_A 183_D 1.318 0.99
219_A 223_E 1.315 0.99
47_S 70_A 1.289 0.99
210_L 229_V 1.287 0.99
28_P 32_W 1.283 0.99
212_L 260_W 1.283 0.99
194_W 198_T 1.263 0.99
44_I 195_I 1.253 0.99
234_L 241_L 1.248 0.99
203_S 209_T 1.244 0.98
30_A 34_T 1.232 0.98
227_Y 250_W 1.232 0.98
250_W 263_G 1.221 0.98
227_Y 249_V 1.199 0.98
211_G 221_L 1.182 0.98
37_R 64_Q 1.173 0.98
10_V 264_L 1.173 0.98
171_Q 220_P 1.17 0.97
203_S 207_P 1.164 0.97
192_A 211_G 1.162 0.97
20_D 256_G 1.158 0.97
93_S 194_W 1.154 0.97
222_L 241_L 1.151 0.97
250_W 266_H 1.146 0.97
171_Q 185_S 1.145 0.97
9_L 209_T 1.144 0.97
50_T 71_E 1.136 0.97
196_I 224_V 1.127 0.97
210_L 263_G 1.124 0.97
232_K 254_R 1.122 0.97
28_P 262_E 1.12 0.96
187_G 190_Q 1.12 0.96
235_N 240_H 1.118 0.96
11_F 209_T 1.107 0.96
162_T 166_N 1.106 0.96
105_N 109_E 1.091 0.96
183_D 186_A 1.089 0.96
209_T 225_M 1.088 0.96
99_E 102_L 1.088 0.96
229_V 252_T 1.088 0.96
189_D 220_P 1.079 0.95
240_H 243_D 1.076 0.95
263_G 267_F 1.074 0.95
74_A 186_A 1.073 0.95
231_V 252_T 1.066 0.95
29_A 32_W 1.059 0.95
76_I 191_A 1.055 0.95
195_I 199_Y 1.055 0.95
93_S 183_D 1.055 0.95
253_Q 259_G 1.052 0.95
32_W 261_R 1.052 0.95
234_L 242_H 1.051 0.94
11_F 44_I 1.05 0.94
54_M 68_L 1.049 0.94
157_R 160_Q 1.049 0.94
209_T 224_V 1.048 0.94
102_L 169_G 1.038 0.94
236_R 240_H 1.037 0.94
210_L 267_F 1.033 0.94
250_W 262_E 1.027 0.94
228_A 241_L 1.017 0.93
242_H 251_R 1.015 0.93
34_T 62_G 1.014 0.93
99_E 169_G 1.009 0.93
7_P 210_L 1.009 0.93
212_L 263_G 1.008 0.93
182_L 187_G 1.002 0.92
209_T 226_D 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3pgvA40.93731000.25Contact Map0.756
1nrwA10.91511000.257Contact Map0.795
2b30A40.93361000.27Contact Map0.755
1rkqA20.93361000.292Contact Map0.822
3l7yA10.93361000.298Contact Map0.793
3dnpA10.92991000.301Contact Map0.806
1nf2A30.91141000.308Contact Map0.843
1xviA20.96681000.308Contact Map0.637
3fzqA20.91141000.311Contact Map0.846
1rlmA40.91881000.312Contact Map0.838
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0964 seconds.