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OPENSEQ.org

YIGL - Pyridoxal phosphate phosphatase YigL
UniProt: P27848 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11470
Length: 266 (262)
Sequences: 5550
Seq/Len: 21.18

YIGL
Paralog alert: 0.75 [within 20: 0.19] - ratio of genomes with paralogs
Cluster includes: COF MPGP SUPH YBHA YBJI YIDA YIGL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
16_P 252_A 4.609 1.00
249_G 258_H 4.079 1.00
250_T 253_D 3.364 1.00
211_A 225_A 3.356 1.00
222_L 228_G 3.156 1.00
23_Y 261_R 2.905 1.00
15_S 19_T 2.794 1.00
199_A 209_C 2.79 1.00
3_Q 208_D 2.766 1.00
7_S 38_F 2.647 1.00
23_Y 254_D 2.639 1.00
42_T 49_V 2.622 1.00
236_Q 240_D 2.61 1.00
21_S 254_D 2.521 1.00
219_A 238_L 2.497 1.00
6_A 195_L 2.297 1.00
190_S 220_E 2.249 1.00
30_L 33_A 2.22 1.00
249_G 253_D 2.213 1.00
238_L 241_L 2.208 1.00
219_A 241_L 2.108 1.00
25_K 55_N 2.075 1.00
4_V 39_V 2.068 1.00
206_L 224_M 2.066 1.00
230_I 242_H 2.063 1.00
22_P 26_E 2.058 1.00
196_E 224_M 2.047 1.00
223_S 241_L 2.028 1.00
205_S 208_D 2.021 1.00
216_M 237_R 2 1.00
236_Q 239_K 1.98 1.00
228_G 243_P 1.933 1.00
229_C 259_Y 1.874 1.00
197_A 200_K 1.843 1.00
216_M 235_H 1.804 1.00
30_L 261_R 1.801 1.00
28_L 38_F 1.753 1.00
30_L 34_R 1.752 1.00
211_A 222_L 1.725 1.00
196_E 200_K 1.705 1.00
9_L 14_L 1.652 1.00
193_H 196_E 1.65 1.00
84_D 87_I 1.639 1.00
6_A 41_A 1.625 1.00
2_Y 210_I 1.619 1.00
232_G 250_T 1.582 1.00
7_S 212_F 1.571 1.00
63_I 194_A 1.552 1.00
5_V 260_L 1.53 1.00
227_K 243_P 1.49 1.00
230_I 234_A 1.477 1.00
21_S 24_A 1.464 1.00
207_K 226_G 1.443 1.00
192_G 224_M 1.442 1.00
244_E 263_L 1.441 1.00
256_V 260_L 1.426 1.00
248_I 255_A 1.411 1.00
227_K 244_E 1.408 1.00
26_E 30_L 1.397 0.99
195_L 221_M 1.391 0.99
31_L 36_I 1.386 0.99
5_V 31_L 1.376 0.99
79_F 197_A 1.375 0.99
212_F 256_V 1.348 0.99
15_S 252_A 1.34 0.99
225_A 228_G 1.339 0.99
29_K 33_A 1.338 0.99
4_V 199_A 1.329 0.99
37_N 202_L 1.321 0.99
90_D 171_R 1.321 0.99
199_A 206_L 1.318 0.99
4_V 204_Y 1.317 0.99
199_A 204_Y 1.296 0.99
135_E 138_L 1.281 0.99
27_T 257_P 1.28 0.99
211_A 221_M 1.273 0.99
72_D 76_N 1.266 0.99
222_L 238_L 1.262 0.99
2_Y 227_K 1.251 0.99
42_T 64_T 1.249 0.99
212_F 259_Y 1.247 0.99
237_R 240_D 1.244 0.98
39_V 198_V 1.24 0.98
24_A 254_D 1.239 0.98
2_Y 36_I 1.238 0.98
219_A 223_S 1.229 0.98
32_T 59_K 1.227 0.98
23_Y 27_T 1.215 0.98
16_P 251_N 1.209 0.98
229_C 248_I 1.208 0.98
248_I 259_Y 1.207 0.98
234_A 239_K 1.206 0.98
2_Y 208_D 1.198 0.98
234_A 238_L 1.198 0.98
36_I 210_I 1.195 0.98
206_L 209_C 1.185 0.98
210_I 259_Y 1.183 0.98
197_A 201_K 1.179 0.98
233_S 251_N 1.179 0.98
23_Y 258_H 1.172 0.98
186_A 189_V 1.165 0.97
244_E 248_I 1.164 0.97
244_E 259_Y 1.155 0.97
161_E 165_N 1.15 0.97
210_I 229_C 1.144 0.97
25_K 29_K 1.141 0.97
87_I 171_R 1.139 0.97
173_N 188_G 1.133 0.97
175_S 185_M 1.132 0.97
81_H 197_A 1.115 0.96
87_I 90_D 1.114 0.96
68_A 186_A 1.113 0.96
173_N 220_E 1.106 0.96
6_A 39_V 1.103 0.96
95_V 149_F 1.098 0.96
230_I 238_L 1.087 0.96
4_V 209_C 1.084 0.96
228_G 238_L 1.073 0.95
5_V 36_I 1.067 0.95
249_G 255_A 1.057 0.95
215_G 235_H 1.049 0.94
192_G 220_E 1.036 0.94
87_I 172_V 1.035 0.94
239_K 247_V 1.031 0.94
77_L 80_A 1.031 0.94
6_A 209_C 1.028 0.94
210_I 263_L 1.026 0.94
68_A 189_V 1.017 0.93
190_S 193_H 1.015 0.93
185_M 190_S 1.011 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3pgvA411000.127Contact Map0.782
1nrwA10.97371000.17Contact Map0.806
3l7yA10.9851000.192Contact Map0.788
1nf2A30.98121000.195Contact Map0.853
1rkqA20.9851000.196Contact Map0.826
2b30A40.98121000.196Contact Map0.766
3daoA20.97371000.202Contact Map0.761
2rbkA10.95861000.212Contact Map0.754
1rlmA40.98121000.217Contact Map0.849
3dnpA10.98121000.221Contact Map0.811

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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